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Query: [S] KOG4502 Predicted membrane protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSVSTAFLLLLWSSIAGSLPLAPASPDFKADFSKLLKEAHQTDLMPVVEEDELQSLRHNGFQVFYTFHEQLHHLRQKTVGRNSATITEEMARIRNSIEDISEFSLDSNEVDEAINDITVPYGTKMKKSSKFAELSEIHNTDSSNKALPPFAFSEDQQESVDVVEKVEAVPPTTTTTKLTTLPSTTQSTTTRTTTQPSTIVSTRQKYVNVDGDIYVPGKTVISVSSTPIVDRTGTTTPVSIEISTTTLPPMTEIFTTKYSTLSTSYTHTPSPHIFSSSTVRLPIAIPIPTKLPEIMFTTPRPYRGPFITEFTIEPKRSEGRTSLRDRIRSTSQLLNLLGDKIGGIDQKAAGNRAEPKTGVLTNIYDQGVIKKRNLKTKQWGIAGEDPQGVQTYDGQFSGMAYGATKQRGGGYSMRKRMGKRPWQKRGYKSRRLGDKRPEYMRPSTFVEKRTTDVSVPFGSHWREEWVRGVKLSERRNAVRNVSENQKNVAQALLESEEASMRQLKKTLRKIREVVKIKTSSTTADVTTTNKPKTVKRSSLVYQILLSLQKTLSIVYFLVIFILYFYKGAILPYPRYVRVMEFFVIIPFIPIEYLRINWGSRGNLLESTAFLALSTVLSIPIIIILVYLEFFQNYVLFIEEIFTYVMGFFVILETLLSLVLTITFSSSGLast
1 -145.000[S] KOG4502 Predicted membrane protein  ali  100  1MSVSTAFLLLLWSSIAGSLPLAPASPDFKADFSKLLKEAHQTDLMPVVEEDELQSLRHNGFQVFYTFHEQLHHLRQKTVGRNSATITEEMARIRNSIEDISEFSLDSNEVDEAINDITVPYGTKMKKSSKFAELSEIHNTDSSNKALPPFAFSEDQQESVDVVEKVEAVPPTTTTTKLTTLPSTTQSTTTRTTTQPSTIVSTRQKYVNVDGDIYVPGKTVISVSSTPIVDRTGTTTPVSIEISTTTLPPMTEIFTTKYSTLSTSYTHTPSPHIFSSSTVRLPIAIPIPTKLPEIMFTTPRPYRGPFITEFTIEPKRSEGRTSLRDRIRSTSQLLNLLGDKIGGIDQKAAGNRAEPKTGVLTNIYDQGVIKKRNLKTKQWGIAGEDPQGVQTYDGQFSGMAYGATKQRGGGYSMRKRMGKRPWQKRGYKSRRLGDKRPEYMRPSTFVEKRTTDVSVPFGSHWREEWVRGVKLSERRNAVRNVSENQKNVAQALLESEEASMRQLKKTLRKIREVVKIKTSSTTADVTTTNKPKTVKRSSLVYQILLSLQKTLSIVYFLVIFILYFYKGAILPYPRYVRVMEFFVIIPFIPIEYLRINWGSRGNLLESTAFLALSTVLSIPIIIILVYLEFFQNYVLFIEEIFTYVMGFFVILETLLSLVLTITFSSSG 667
2 -60.800[S] KOG4694 Predicted membrane protein  ali follow..  20  21......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DSNRTGPESNEGPENEMVSSLALQMSLYFNTYYFPLWWVSSIMMLHMKYSILPDYYK--FIVITVIILITLIEAIRLYLGYVGNLQEKVPELAGFWLLSLLLQLPLILFLLFNEGLTNLEKAIHIIFTLFLAFQVVAAFLTLRKMVNQ. 168
3 -22.700[TU] KOG3895 Synaptic vesicle protein Synapsin  ali follow..  522...SRSSISEVPEEPSSSGPSTVGGEIANKKRGRTASETSSGSGPGSVPSSAGPGSGFSSSFLGKQFSFAGKGEGVISTQPTQRPSEEPPAIPTTASSAVRPESSVSVSDSRNTDTLTERAGAGYQPVTNYEQQERVNPFDKEPSKSGSAASIHTSSSSSISSSSISSRINRNGNAIQSPPPPAGPPPPPPTNVTAVGSNANSSSGYRNSFSSSLSKDKTSYGNYGSTTSVETITRMDTNTTNIGATATEAGEASGVTAITNISNSDGIVAPTTGTITTSVTTNDWRSAIGMRSASVYSAPAAVTTVLPGDTSGYDSNSIASQGEGLNNPSDLPSYTRPSYS--RSESNASKHSDLDVIFGDSKTTPASYGNGKYTRAAGSISDADMIFGGPPSNYKTDRFGASKSMSMTSGGVGSGNGSGSGLGGYKIYDSIQNAAFSDFSDSGSMSSIGSHTKRWSASKEEDDELDLK..................................................................................................................................................................................................... 986
4 -19.700[R] KOG2350 Zn-finger protein joined to JAZF1 (predicted suppressor)  ali follow..  650.................................................................................SKYAAGQELMQRQREEQLKYWLDVGMHKKQEDPKTLKSPQKPAPPADQASTSSASTSGSGSGSSSMQPPKRMPAHLKRGSAASSPGVQSKGTENGTNGSNSSSSNSKNVAKKSADQPLSTLANTRERRSEYGQKRNVSGSRLAATPASKRKLSSKDVEQAADAPEVLTHSDNAVDVGIIDDECGGFGAVGVMNGVASPVANNSEMDTEAEVEAEPTATKAITIHCQQPVTTPVAAAATANERLPGVAPHRRGPRRADRREEELVASAPGYRCRPSMRGADAGAAAAAAAAPTHPHPHRPPPPPPPQ........................................................................................................................................................................................................................................................................................ 955
5 -15.000[C] KOG4669 NADH dehydrogenase subunit 4L and related proteins  ali follow..  15  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MIDHVYQMPLLAHTISLLGILVYRS---LVSSLLCLEGIILSIVIINTLTALSILAPIIPIILLVFAPCEAAVGFALLVSISNT. 85
6 -14.600[Z] KOG3756 Pinin (desmosome-associated protein)  ali follow..  304................................................................KAEQEEGKVAQREEELEETGNQHNDVEIEEAGEEEEKEIAIVHSDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQDSQPEEVMDVLEMVENVKHVIADQEVMETNRVESVEPSENEASKELEPEMEFEIEPDKECKTLSPGKENVSALDMEKESEEKEEKESEPQPEPVAQPQPQSQPQLQLQSQSQPVLQSQPPSQPEDLSLAVLQPTPQVTQEQGHLLPERKDFPVESVKLTEVPVEPVLTVHPESKSKTKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGSKDKNSRSDRKRSISESSRSGKRSSRSERDRKSDRKDKRR............................................................................................................................................................................................. 717
7 -14.400[S] KOG4791 Uncharacterized conserved protein  ali follow..  337............MSADPNNEDATDKVNKVGEIHVKTLEEMLLERASQKHGESQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEEEHRQQEAERQKSKKDTTCIKLKTDSEIKKTVVLPPIVASKGQSEEPAGKTKSMQEVHMKTVEEIKLEKALRVQQSSESSTSSPSQHEATPGARLLLRITKRTWRKEEKKLQEGNEVDFLSRVRMEATEASVETTGVDITKIQVKRCEIMRETRMQKQQEREKSVLTPLQGDVASCNTQVAEKPVLTAVPGITWHLTKQLPTKSSQKVEVETSGIADSLLNVKWSAQTLEKRGEAKPTVNVKQSVVKVVSSPKLAPKRKAVEMHPAVTAAVLSSSSVLQEPPAKKAAVDAVVLLDSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPSSSQMSMKTRRLSSASKPPLSVEDDFEKLTWEIS..................................................................................................................................................................................................................... 782
8 -14.000[C] COG0713 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K)  ali follow..  10  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MITLTHYLVLGALLFGISAMGIFMNRKNVLVLLMSIELMLLAVNFNFIAFSQHLGDTAQIFVFFVLTVAAAESAIGLAIMVLVYRN. 87
9 -13.900[R] KOG4377 Zn-finger protein  ali follow..  1..............................................................................MPKAQHSPQAIFTSFKLERSEYSGPGARLPGGSSSTVATAEDRLSLADHDGSATDLTPSRYRKRGRVWAP----TSSLEQPSKRIVNQPTHFGARSETESRSSRHESLAQPTLQPSEPLETNSSTNLSSTILDKVSVVRAAGTFYPENANSAAQGETPEVVSSRYNSRQESNDLEVDQPEDLSMRPSLPEATATPAVVGPALNMNLLQFKQLIDLYQRQVLLPSFLAAASQPLALPGSAAGPGVSGPLLDMRILLENAAQQKLMLLNAAASATASAVAATTINSGQRTAAKRNRDHDIPS................................................................................................................................................................................................................................................................................................. 296
10 -12.600[R] KOG3253 Predicted alpha/beta hydrolase  ali follow..  427............ASPAAKLPASPSGSEDLSSVSSSPTSSPKTKVTTVTSAQKSSQIGSSQLKRHVQRTEAVLTHKQAQVPISSEPPEEGEKEDLRVQLKRHHPSSPLPGSKTSKRPKIKVSLISQGDTAGGPCAPSQGSAPEAAGGKPITMTLGQASAGAKELTGLLTTAKSSSSEGGVSASPVPSVVSSSTAPSALHTLQSRLVATSPGSSLPGATSASSLLQGLSFSLQDISSKTSGLPANPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPTAIHQLLTNGGLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGAAPSEESSSQVLPSSSQR........................................................................................................................................................................................................................................................................................................ 786
11 -12.500[P] COG2212 Multisubunit Na+/H+ antiporter, MnhF subunit  ali follow..  17  9...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SFSLAQLMLAIAMTISVYRIAIG---RAQDRV--LGMDTLYVNAMLLLLTFGLRTGNDIY-FEASLLIAILGF------VSTVALSKFMMRG 89
12 -12.400[R] KOG2295 C2H2 Zn-finger protein  ali follow..  249................................................................ADALIRVLDTCVIKLEGGTDEDLKVLDEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLDKVKDGQPRALHRTSSILRNLAPSITRSEIEAVCN----RFSGYLRVAIADPLVERRWYRRGWITFMRDVN---------IKEICWGLNNQRLRDCEMGAIVNRDLSRRVRPANGITAHKQVVRSDIKLCAKIALNLDEKFR-----LWAEGPKDDSNSARANESSENGSGSTYGFNSQNPVLQNITDYLIEEASAEEEELLGLTGENKDTEGEPIERDEQLI-LDRLVYLRIVHSVDYY............................................................................................................... 725
13 -11.800[D] COG5072 Serine/threonine kinase of the haspin family  ali follow..  1MLLHFDIVIQLLSSHTLKSHQVEPPMDFETSFEEFVEDKRFIALEVSDNDDDCDTDLTADTADELESSAILKMRESDASLNVTTGNNTSRKTTSNSKKRWSLLSNHSAVSSSKSKKRWSVLSSSFTSESHKDRESRNVLQQKRKSLQSYSSLDTVASNSSISASSSLKRSSTGLSLRQLFTKIGINDDISQPGIGIPQGKENLPPTMGKKNSSIASTSSENRLRTPLKPLVNHSKRPTSQPQQQQPLYNASLSSRRSSISSTVSSSSSSKWRFWKRNKNQTPALLQPDHHSLKTFPAVNRRDSMTPVEPRNMVKHKTSFSDFHKTIFSSNTYSESSDTISSMEITLKNKASSSSLSLNVLKKRNSQSSLKHKSSHASLQKFKRNKGKSSMIAPSTATNSSNDDSCSYSSKNSTLSHRISLPVPDQ.................................................................................................................................................................................................................................................. 425
14 -11.700[T] KOG2381 Phosphatidylinositol 4-kinase  ali follow..  2...............................................................................................................SGARDQTDPPLLQLEDEVDLIGDFAKDQPPPRNQLSPLLNGFESTSNQLTTKVEINTVGMGKRKTRRRGKKAREPMLLSVDDEDDEEEAQEERNHTNGLPPGEESAGGDAVIQKPQLDNLVMHYDDQIDDEDGEEAVLLKRSSNPRNQRLKGSAEDSIDSSSQQPPIICHIAPAKVASSALTSPLKT--------TSHTALARHPHDEADDICLVPEIDFEGMSTDAGSDNRESQPLLGGGNASHGSRISELLGGLGRGHDHVEFVSNTFGAKYQEPSEPRDDEQPTTSKDALESSSSVPSASAAYACICCEHKCPLEKD............................................................................................................................................................................................................................................ 313
15 -11.400[R] COG1380 Putative effector of murein hydrolase LrgA  ali follow..  11  2.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SKSLNIIWQYIRAFVLIYACLYAGIFLASLLPITIPGSII---MLILFVLLALQILPA-------VNPGCYVLIRYMLLFVPIGVGVMYFDLLRAQFGPV-SCAISTLVVFVVVSWSSHLI......... 118
16 -11.400[K] KOG4477 RING1 interactor RYBP and related Zn-finger-containing proteins  ali follow..  10  58.........................................................................TSTRRSTCNDNVVEMQKTITTMVQKQVEKEKSLKRKERSLLKSATRELSEGVSTKEVKIEEPDIASEKPRTPVPEKQEEVSVENVEIEKCETPTKSKSATAKPPSAKKLTKRTDEDKKSSVATKKAKTTEESVPHIESNVNTELVKEENKKPTPEDSIGPVSSDSLTTNQGEDQSTA---QTASTSAPSVVLLPEPTPKISVAETMVVPKALPASIAIPSTSTASVSTHPTEKPKEDSILQHLPERIVKKLNQPSSLNYDLLKVHKRMTGID----PIVAESEAVLLPQDWNRQKVMKELTASFGGNQALSPTTSRQSSETDSSSSE--GNRSFETPLNDASIFNSKSCQIPDYMINREAAQK....................................................................................................................................................................................................................................... 411
17 -11.100[U] KOG1091 Ypt/Rab-specific GTPase-activating protein GYP6  ali follow..  422IQKAKLLQALVLDTDMLSALSINGVFDQSNFVPARTKSCSTSPRSPLIIAPESYWEKKWRVLHKAEEEENKICLEKQTPPTQKKKRWLNVTKLFRAVIDLSHHKLGIGERKANSSPVTQSLLEDSSEQLNVDCHVTVNKENIHPQETEENIMEFHSADEESIVSGSSPSEESSFVSLDPTSPVRCSTKIENDSVSSAGSNLLPDEDDKSIVSISEENSSVSSDPISPAIDSNYSGKYLDCCTGSENDKDQQTSVNSPLSVSPHRRNEYPVTQSDEDVSTDKSVGITKEYKLLHGIVQWFRKLKRTLSSEETSHRKASDATKTNDVKIKKNQ-------IGCYSESHPQALSSGDSSQNLRKTLKNLGQSMLKHIEAIELVFQQEPCLVPAGLIGNLAKTNLIEKGQVTATTALKEKLSN........................................................................................................................................................................................................................................................ 835
18 -11.100[Y] KOG2992 Nucleolar GTPase/ATPase p130  ali follow..  69.....................SEDSDSDSESDAAPKKPATAPALTNGKAVKKAASSTSEDSDSEEEKKPAAKATPAKAVGKKAKSSSEDSSSEEEAPKKAAPVKAPPAKAAPAKKVESSSEDSSSEEEPAKPAVKATTTKVAPAKKADSSSEESSSDEETKPAAKPVAKAAPAKKAASSSEESDSDDEPAAKKPAVQPAAKPAPKAAASSSEDSSSEEEVKPAAKSAAKLAPAKKGASSSDDSSSEDEAPKKAATLAKPISKAAPTKKADSSTEDSSSEDDAPKKVAPAKATPAKAIPAKKAASSDDSSSEEEAPKKAAPAKATPAKATPAKKAASSDDSSSEEEAPKKAAAPAKATPAKKAKSSSEDSDSDEEEAPKKPAAKAVAKAASSEDSDSSEDEKPAKAAPKALAKSAKAASSDSDDSSDEETPAVKPAVKKTAAPAKKADSSSDESDSGEESGEVKPNSATNGNEKTAQKRKFSGG........................................................................................................................................................................................ 530
19 -11.000[S] KOG4615 Uncharacterized conserved protein  ali follow..  177............NENVPPRRSPTLSPNNRRSMRRSGNVPGSDKLRRHAIRRRSRSCGRQLLPEFEETVNLTRSISSPVNFLPEISSTPCTEKQKEEVAKNTTRVETDKPAEKPMELSQEPEPENPLQTKVTSPARNPILAAEIEQICKERQSSFHKNVLQLDYSGRAPYSRPPTPSSPSVAGLRRTYTMEKGPAPGQLLLSPSHRYDTPSKMPVVKAKRFNQELMVPDTPERQSHDPAWQSEPQPEFVVPETQPQDLGELVQTLSRSAISPIVVINTSNSNRSVRRDAVAMKSVPTSPVTALSSPPIAPSPRRSAAASPQKSIAQLPRVEENMDAIMTDDESDEHPSTVPLNLAPSGGNTTRQRRLRSSNRARATIESQESSMRLLNLHKSVNAKKSKPR---KTAIPLNKAPSAPINGEQFARERMSNYEILDLRKRNSHRNHRSEKLILEEEIQRELLRRNLMDEAEAMIDRRDEGD............................................................................................................................................................................................ 651
20 -11.000[S] KOG3100 Uncharacterized conserved protein  ali follow..  4.......................TRSARAKASIQAASAESSGQKSFAANGIQAHPESSTGSDARTTDESQTTGKQSLIPRTPKARKSKSRTTGSLPKGTEPSTDGETSEAESNYSVSEHHDTILRVTRRRQILIACSPVSSVRKKPKVTPTKESYTEEIVSEAESHVSGISRIVLPTEKTTGARRSKAKSLTDPSQESHTEAISDAETSSSDISFSGIATRRTRSMQRKLKAQTEKKDSKIVPGNEKQIVGTPVNSEDSDTRQTSHLQARSLSEINKPNFYNNDFDDDFSHRSSENILTVHEQANVESLKETKQNCKDLDEDANGITDEGKEINEKSSQLKNLSELQDTSLQQLVSQRHSTPQNKNAVSVHSNLNSEAVMKSLTQTFATVEVGRWNNNKKSPIKASDLTKFGDCGGSDDEEESTVISVSEDMNSEGNVDFECDTKLYTSAPNTSQGKDNSVLLVLSSDESQQSENSENEEDTL........................................................................................................................................................................................ 463
21 -11.000[Z] KOG4462 WASP-interacting protein VRP1/WIP, contains WH2 domain  ali follow..  1................................................................................................MAPAPPPPPPAPAPAAAAPAPPLMTGDRSALLNSIQKGKKLKKATTNDRSAPVVGGGVVGERKSNTPKSFAAPPVPTGAPSLPTSSNNTQQAEERPSMPALGGLFAGGMPKLRHIGKSSASAAPPSAPAPPTPQSELRPPTSAPPRPSIPPPSPASAPPIPSKAPPIPSSLPPPAQPAAPVKSPPSAPSLPSAVPPMPPKVPPPPLSQAPVANTSSRPSSFAPPAGHAPNVTSESPKFPNRGPSIPSASVPPVPPSSYVLQQRPN.................................................................................................................................................................................................................................................................................................................. 265
22 -11.000[S] KOG4511 Uncharacterized conserved protein  ali follow..  218...IRKEEILLQQALDEGARAQNQNQNQGTSSTQTDGVNAPLRSVAAMMAATFAIDTATSTDDVTYKFLDQSTGTMTSSTGVSVGTLTNTGVSSGTMTSGVDTGTDADGTVGRPKSAKRVGSAVGKRSVSKGTPSEDAKKSSGSSSPDEAEKSKRERPGTSVKKAIGIVAANSEMSSNGTQMDVPVDEEGTKKRPGTTSKKSIATVTASPEMSSKTTQMEPEQDGEGKKRPETSKGANERKYSNAGLEDIVGPKSSPHEEKKSSHPSSRKGSKATDENAPATRPPSRKAAGGSHEPRAKTPNQKNKDERPTTRRSSVDKNAPKRNDSVPRERKSSVSHDESKPPKPIGPLRGNKYDGDVVLGRAESPGIDHGPRRKNLNDVNSHLVDTNRLNSSDVRVRAQYLREQRDKLLQMKNAERIKQMTDIQQNASLERPKTAARAREILDKDKKEA........................................................................................................................................................................................................................ 665
23 -11.000[S] KOG2465 Uncharacterized conserved protein  ali follow..  340..............TKNSNNQDMVGSGTSPSVGAKARSENEGLDSLASEVSEIEAGDLRDDQQRPAFSASAAKLHPNPNCETHKLATGDQEKLTQESPRESTSSAPAEVAVPAVTPPPLSAAVEVTVSGDVSVTGHSSTTGCNCFGGKKCKKRWASAKNTDTPEMSEVYCPSCEDPSNESPACLAKMPDKRPTRLKPKSSILSVESELLVGKRSSFRLPSEIKRKQQGGSITRSASLSAADRRTSLPVATKRIIPPRLRTAKAKDLEKDKEKEKDKNKENDKKSSNQKVN----GSATNFLAKMSPKRLKAGKEKDKDKDGNKEKEKDKFKAMDAAKKKAVNNNNPKPDISKSEEYEIADDATSLNGSESEPVGAAKMVILSESDSKLMISVRGREELPVVDSPKTPPKRFEKCVSLPVEPESHLLQPDENNENEQSDITNVISPTELTPMLDVANGNGEANSATLPRTAKQAHVSKMLHLVPKRRTPDGTNIYYWCDVPKKAIKELDDGAYNPLWTSRGFTQS-------ENRRQQSTPLNAFL----TYVTLWSIAKDLLDHRETPILTF............................................................................................... 889
24 -11.000[O] KOG2231 Predicted E3 ubiquitin ligase  ali follow..  358............QFPTLRGASTAPSVSLVRPPPPSMRNLSGTSGLARTKENFPALGGGNGGGVTGPTSSSIAARAAQSQHPVAAVFKKPTSAAGSGSRSGPPGNGMLLHVSNRSAAVPKKAATPQVDFPALPGKGNKKNLRNLEEDMLPSGSPVPMANISAKHRSLADDYVSVASPSTFQKLQMVQKEEDEAKARQEALKKSAPKLTAAEFPSLGPSASASSSRTTAPKPSSGSPSLNWSKPANEKKQRELENRKAKVAPAPVLPSPTSKPAPKASNNNVQEQQANKKDKKQKDKKSNQENQPKTAKPKERNNNNEQKTNGAPSTPIRAPPGLKPGGPLKPPPGFVSNVTVNSVAKLPNNLTFTNSLGESYDIVPSPYTYTDPPDTEVRNQKLVDEVMSLLKTPEALNEFRLLSSKFRDGSCSGQAY--PELLAMLPDISKQQELYLVHKQHLNSLPPAERKSVPA-KQILITADLKSHQQAHELTKNFPVLGSSASNTHRN..................................................................................................................................................................... 867
25 -10.800[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  68.HISTEKEELVGLVLTHVAQVDRSRGSNASSNSPGRGQANPIDSLKQSCQNFFSNLSDNISDSLASFDSKVTTKPPESRQPEVPTHIFEQPRVSTREIPTYASAVNGGPQHVHVQQQATTTNGGSQSSSSPSTSTQSSNNRDASSSSQAHVAHQEARNEEQEDAQSKSDCECSDEEIMATFSERVSISLKTDTSGRRVNAAAEPSPVDLANVDNGPAGNTAPSPGCSKPGSSSSKADASSQSSFEELGAIGGISDESKANTDTNSSHLDQWQVLEVNRIEAVEETPTTS-----------------AADEILEVTLRSRPAVEGDDSEMGESTQALNVNQRPANPSPAFYPAVPQRTKKVTRRRSDGYLNRRYHSSDDESPVAPGGPGLSLGLSTLSEHP........................................................................................................................................................................................................................................................................... 453
26 -10.800[R] KOG4834 Predicted DNA-binding protein, contains SANT domain  ali follow..  37.........................................................................................................................SLSIKNRTVSQIRQALKKKAFEDAGIPAKQVPVQQVQHVLQTLPQQQPQQPLQQPPPQVFKSQPIVQHVQLVAQPKQIILHPQSNTTTTGTTVTVKQYQQMQKAAALAAAQAAASTANNTPTITENIIIQQPTSTTATVVQQPHMVSTCSSTQIVVPVVSAVSTVPTVLSPTVVIADDVVSTSNPPAAAATVGSPAGAPAGLKCDVSMTLNRINVQENEVD..................................................................................................................................................................................................................................................................................................................................... 259
27 -10.600[K] KOG4661 Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B)  ali follow..  37IDLRADKSVLMERLKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGAR-------------------------GFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSG.............................................................................................................................................................. 533
28 -10.500[R] KOG0231 Junctional membrane complex protein Junctophilin and related MORN repeat proteins  ali follow..  10  446..........................................................................................................................................................................................................................................................VLSTGTPLQQESPELYRKGTTPSDLTPDDSPLQSFPTSPAATPPPAPAARNKVAHFSRQVSVDEERGGDIQMLLEGRAGDCARSSWGEEQAGGSRGVRSGALRGGLLVDDFRTRGSGRKQPGNPKPRERRTESPPVFTWTSHHRASNHSPGGSRLELQEEKLSNYRMEMKPLLRMETHPQK---------RRYSKGGACRGLGDDHRPEDRGFGVQRLRSKAQNKENFRPASSAEPAVQKASLRLGGAEPRLLRWDLTFSPPQKSLPVALESDEENGDELKSSTGSAPILVVMVILLNIGVAILFI--NFFI......................................................................................................... 748
29 -10.500[S] COG3556 Predicted membrane protein  ali follow..  10  9...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YLHYLSIFTLIVFVTAEAVVLRPDMTPAIRKRLAIYDAASAGAVLISGLLLLFYGAKGN-----IKMGLFVLVALMSIPPTLAILRWKDFVPTPAEIAKVRRWVMLEAHLIIFIPLAAVLMARG 147
30 -10.500[OTK] COG4512 Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide  ali follow..  11  27........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DEEGYLKVKY--GLEIILINVMKFAIVYGIALVT----GLLLQTVTVHLSYLWL---RRYSF--GHATKTLNCTLISLTMFVLAPFIFQNIPSNNWIVLGTFAFILLNMFLFAPAD............... 132
31 -10.300[S] COG3223 Predicted membrane protein  ali follow..  14  62............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VIYFLYFE-------FIALIVKYFKSGLHFP---------LRYFVYIGITAIVRLIIVDHKTPMDVLLYSAAILLLVITLWLC............................................ 128
32 -10.300[DK] KOG4333 Nuclear DEAF-1 related transcriptional regulator (suppressin) and related SAND domain proteins  ali follow..  10  309.................................................................................HTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEEKVVAEMEEH............................................................................................................................................................................................................................................................................................................................................... 559
33 -10.200[R] KOG4227 WD40 repeat protein  ali follow..  479....................................NAFHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHP-------ETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPNNGQNLGELEVVA---YSSPGHSDTDRDNSHKDCCGSEMACETPNAGTREDPTDTPATDSSRAVH--KRQRIELEDTDSENSSSEKKLKT............................................................................................................................................................................ 942
34 -10.200[S] COG3776 Predicted membrane protein  ali follow..  10  1..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MLINIGRLLMLCVWGFLILNLVH-----PFPRPLNIFVNVALIFTVLMHGMQLAL--KSTLPKDGPQMTTAEKVRI------FLFGVFELLAWQKK............................. 84
35 -10.200[S] COG5605 Predicted small integral membrane protein  ali follow..  10  18............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PIGIYLKIWGLLFVLSTLSYLVDYFRVQGLMR-----TLIVALMIAKAGLIVSVFMHMMVYAILIPPLCLLVLMVLMAAEAHHTFGMRALFFH.. 112
36 -10.100[S] COG4331 Predicted membrane protein  ali follow..  11  5..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KNRFSSKNLFGEKNVHAVFELSLLLKASLAMMEIIAGVLTYFVTPQFLLNTLHRITQVSFIE-------IANYLLHAAQHLSISSLHFAASYLFI--AVAVFSLFIVYQLYRYTFT---SLLLILITILDVFVIALTLLEYRR.. 163
37 -10.100[R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  291VVFKDELELQAHILQEHG-----------NILKGKPKFFQSELSTFISAPSRVIRERDDYDLPSISSLPGSSSGSRTDVRSASSPEESRLRLAERAKYYLENSKEDFNKFSSYNEDYSKGRLSAEKLLESYKLLFTKPNADVYLLIHNLAETFPKNSSKYNNLNAIYEQREQTLARQTSLPSLSSDSSLSMSIGRGHWGGTNDGGSAGAALGVRNIKNLPTLKSPS------ASYDPFATTVKKNTLRPVQNIKRTTPQSVSYRTSTNTVAFSPTYLESKKGSSSTSLNNSKDKLKSLNLPQLPPPKPKVQIPGLNRPQIADPKQWGKKSSTQDTNVHDNLRELNTTSGGNKKKGKQKQL................................................................................................................................................................................................................................................................................................................... 633
38 -10.000[OT] KOG0505 Myosin phosphatase, regulatory subunit  ali follow..  445..................TGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESGGSNPTTS-DSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKQEAQLELADIKSKLEKVAQQKQEKTSD---SSVLEMEKRERRALERKMSEMEEEMKNLHQLKQIQTLEQLQAENR------ALTRVVARLSESIESS................................................................................................ 993
39 -9.870[S] COG4811 Predicted membrane protein  ali follow..  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MTITDLVLILFIAALLAFAIYDQFIMPRRNGPTLLAIPLLVIFVGLIVILIY----NNVTNHGALITTWLLSALALMGFYIFWILSEDGVLVMQLEQRRLLIRVRNIDDLEKIYKLLV..... 149
40 -9.830[R] COG0670 Integral membrane protein, interacts with FtsH  ali follow..  15  104.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DLIMLAFAGTAIVFFACSAYVLTTKKDMSFLSSAM----FALFIVLLLGMVASFFFQIP----------ALSVAISALFVVFSTMTILYETSNI--NYIRATVNIYVSIYNLFLSLLRLLSIFSS. 218
41 -9.800[K] KOG0709 CREB/ATF family transcription factor  ali follow..  10  443.................................................................................NRNAVLNHHNNSKYPASGNQNHHPIALEDLNHPPPTLQPKQSYQQQHQPSMYRRSDETIAMAMAKIGARKGSSTSSSSASSVASSTSTSSATSPIYRTSRTLGAFEDQCDASSDDSNCANMPSLVPMKMSAQPPKRKIVTMNGQPRVTYRAVPASSVNVEQAQYYKVPQQKVQYVTMDRPIKYEVLNDYIKMEEESTIRLPNSW-----------STAGPRLHPQVNASSRTVRPLTVATPVHYNGPSAKKIKTQM.......................................................................................................................................................................................................................................................................................................................................... 687
42 -9.720[KTDL] KOG2043 Signaling protein SWIFT and related BRCT domain proteins  ali follow..  192....................................................................................................................................................................EEEEEEEEEVENEEQDSQNEGSTDEKSSPASSQEGSPSGDQQFSPKSNTEKSKGELMFDDSSDSSPEKQERNLNWTPAEVPQLAAAKRRLPQGKEPGLINLCANVPPVPGNILPPEVRGNLMAAGQNLQSSERSEMIATWSPAVRTLRNITNNADIQQMNRPSNVAHILQTLSAPTKNLEQQVNHSQQGHTNANAVLFSQVKVTPETHMLQQQQQAQQQQQQHPVLHLQPQQIMQLQQQQQQQISQQPYPQQ--PPHPFSQQQQQQQQAHPHQFSQQQLQFPQQQLHPPQQLHRPQQQLQPFQQQHALQQQFHQLQQHQLQQQQLAQLQQQHSLLQQQQQQQIQQQQLQRMHQQQQQQQMQSQTAPHLSQTSQALQHQ............................................................................................................................. 567
43 -9.450[W] KOG3989 Beta-2-glycoprotein I  ali follow..  2............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IKVIFHLVSAVLYAAVCYRDTTIVTGWSRFVW---LTIIDLYMQLLYHTIGFILAVVSPN-KRHIIFDYWARALTGPIGVAVTVLFWGLFPATLARFNHGLHTLPAITAHLDLAIILKGIAVFV... 155
44 -9.440[C] COG2142 Succinate dehydrogenase, hydrophobic anchor subunit  ali follow..  15  3................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SNASALGRNGVHDFILVRATAIVLTLYIIY-MVGFFATSGELTYEVWIGFCA-VFTLLALFSILIHAWIGMWQVLTDYVKPLALRLMLQLVIVVALVVYVIYGFVVV................................ 112
45 -9.420[S] KOG2673 Uncharacterized conserved protein, contains PSP domain  ali follow..  314.................................................................................SSSFPPMHGIRYDHREHNLMAPPRKRTRDLMPKFLNTESFDEFNQRLNNLPAESNVTSDEDAQFLESRKCQSKRWRKEEPLKLNLRSPWNVLCSPESISSAKFIVEKTCLIPVPSFEEAATNARRCLNTSSIPGSSGSASETNSGSDITKQDFKNDSPSDSKKVQGSSTSKSAKPKVIKVYSFVDLVTTTKKGNIQTEESSLNHEKKLGTVV---DIVEPMKCDERSKEVQGSSTSKSAKPKVIKVYSFADVVTTTKKGNIQTEESSLNHEKKLGTVVDIIEPMKCDERSKEVQGSSTSKSAKLKIKVYSFADVVTTTKKGNIQTEESSLNHEKKLGTVVDIVEPMKCDE----SKEVQGSSTSKSEKPKVIKVYSFADVVTTTKKGNIQTEESS............................................................................................................................................................................................... 703
46 -9.400[S] COG0762 Predicted integral membrane protein  ali follow..  12  1............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MNTLTFLLSTVIELYTMVLLLRIWMQWAHCDFPFSQFVIDSASLLVAYILSFIKAIV-----VVTFLPIIWIAGLLILLKTIGLLIFWVLDPLLRPIRRLLPAMMILVLLLYVINMGVA........ 170
47 -9.380[S] COG3431 Predicted membrane protein  ali follow..  14  27............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IQDVIVISLCIGLFSFMAIQVWDMFLSLLPPLDFHVVTAD--ILFLLILVELFRLLI-----LQEQRISIGVAVEVSIVSALREVIVKGVLETNWSQVLATCAFLLVLGILLVL............. 135
48 -9.370[V] KOG1629 Bax-mediated apoptosis inhibitor TEGT/BI-1  ali follow..  119.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SVLVTAFVGTAVAFVCFSAAAMLATRREYLYHGASLACCMSILWWVQIASSI-----------------TVVKFELYFGLLIFVGYIVVDTQMI--DYVQHSFTFFTDFASLFVQILVLNMFRKM. 238
49 -9.280[C] COG0356 F0F1-type ATP synthase, subunit a  ali follow..  13  128..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PTADISGTLGLSIGVFF---LIIFYTIKSKGMSGFVKEYTLHP--NLALESVTLLAKPVSLAFRLF----GNM------YAGELIFILIAVMYMANNFALNSMGIFMHLAWAIFHILVITLQAFIFMMLTVVYLSMG 258
50 -9.210[K] KOG4796 RNA polymerase II elongation factor  ali follow..  276..........................................................................................................SEIDRRSLESVLSRKLNPSQNATGTSRSESPVCSSRDAVSSPQKRLLDSEFIDPLMNKKARISHLTNRVPPTLNGHLNPTSEKSAAGLPLPPAAAAIPTPPPLPSTYLPISHPPQIVNSNSNSPSTPEGRGTQDLPVDSFSQNDSIYEDQQDKYTSRTSLETLPPGSVLLKCPKPMEENHSMSHKKSKKKSKKHKEKDQIKKHDIETIEEKEEDLKREEEIAKLNNSSPNSSGGVKEDCTASMEPSAIELPDYLIKYIAVSYEQRQNYKDD-HARMETVARRFIKLDAQRKRLSPGSKEYQNVHEEVLQEYQKIKQSSPNYHEEK............................................................................................................................................................................................................................................ 611
51 -9.120[S] COG2426 Predicted membrane protein  ali follow..  15  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PFSELRGAIPLALYFGFSPAEAYLLSVL--------GNILPVPFLLLFLDYLVRIATKVELLARIY--RRKGVVERYGYLGLTIFVAIPLPVTGAWTGTLLAFLLQLNRAFLFISAGVCIAGVVVLLASIGII.... 134
52 -9.010[S] KOG4556 Predicted membrane protein  ali follow..  179..........................................................................ASKVAKAPSSTNNSSSGYLNSQYDDLGSSREKVKVTEKKEVKGQFERNSKKKKKNPRPEMPAPDCAPCSSNRSSEEESNLEDVYTQPIKKKIMPLRRPDLEEENRGTNVTSLVSFDPKSATLLRIRQHLEAEPSDRDTPDYDMYERLRSRSSGHSEVAPASTIPLSSDYKSRNASQDSVPSMFAPMLNSPAPSSTTSGSSSRTSGASLAHKTHIVGKGGISLSTVDPSPILSPGIRLSEQLGAKNQSYKSAFRVQKTENARVISHYHAPNEIPLSSDPSVVENESNYPVMTSGGL.......................................................................................................................................................................................................................................................................................................... 473

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Tolerating some redundancy significantly speeds up clustering of large protein databases. Bioinformatics. 2002 Jan;18(1):77-82.