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Query: gi|30260200|ref|NP_842577.1| DNA gyrase subunit B (BA_0005) [Bacillus anthracis str. Ames], from B.anthracis

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEQKQMQENSYDESQIQVLEGLEAVRKRPGMYIGSTSGKGLHHLVWEIVDNSIDEALAGYCDEINVSIEEDNSIRVTDNGRGIPVGIQEKMGRPAVEVIMTVLHAGGKFGGGGYKVSGGLHGVGASVVNALSTELEVFVHREGKIHYQKYERGIPVADLKVIGDTDQTGTITRFKPDPEIFQETTVYEFDTLATRMRELAFLNRNIKLTIEDKREHKQKKEFHYEGGIKSYVEHLNRSKQPIHEEPVYVEGSKDGIQVEVSLQYNEGYTNNIYSFTNNIHTYEGGTHEVGFKTALTRVINDYGRKNSILKDADSNLTGEDVREGLTAIVSIKHPNPQFEGQTKTKLGNSEARTITESVFSEAFEKFLLENPNVARKIVEKGTMAARARVAAKKARELTRRKSALEVSSLPGKLADCSSKDPAISEIYIVEGDSAGGSAKQGRDRHFQAILPLKGKIINVEKARLDKILSNDEVRTIITAIGTNIGGDFDIEKARYHKVIIMTDADVDGAHIRTLLLTFFYRYMRQIIEHGYIYIAQPPLFKVQQGKKIQYAYNEKELEKILAELPAQPKPGIQRYKGLGEMNPTQLWETTMDPEVRSLLQVSLQDAIEADETFEILMGDKVEPRRNFIQENAKYVKNLDILast
1 -149.000[L] COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit  ali follow..  57  2...SETTNDNYGASSIKVLKGLDAVRKRPGMYIGDTDGTGLHHMVFEVVDNAIDEALAGHCSDIIVTIHDDNSVSVQDDGGGIPVDIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSDKLQLTIRRQGHVHEQFYHLGEPQSPLTVIGETEATGTTVRFWPSSDIFAITT-FDYKILAKRLRELSFLNSGVSIRLIDKR-DGSEDHFHYEGGIQAFVEYLNKNKNPIHPKPFYFTAEKDGIGVEVALQWNDGVNENVYCFTNNIPQRDGGTHLAGFRGALTRSLNSYMENEGMLKKEKVATSGDDAREGLVAIISVKVPDPKFSSQTKDKLVSSEVKSAVESAMNEKMQEYLLENPADAKIIVNQIIMAARAREAARKAREMTRRKGALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKVGRDRKTQAILPLKGKILNVEKARFDKMLSSQEVGTLITALGCGIGRDYNPDKLRYHHIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGYVYIAQPPLYKVKKGKQERYIKDADEMEQYELTLASRKGLEVQRYKGLGEMNADQLWETTMDPNSRRMLKVSIKDAVAADQLFTTLMGDEVEPRREFIELNALRA-NLDV 806
2 -16.800[L] COG1389 DNA topoisomerase VI, subunit B  ali follow..  13  2............SGKHREISVAEFFEKNKHILGYSNPAKAIITVVKEAVDNALD-EEAGILPDIFVRISKVDDIVVEDNGPGIPREQIPK--------VFGKLLYGSRF--HEIRQSRGQQGIGISAAVLYAQTVISKTPDEDRAKKVVLKNEPEIVEEGEEEWYLPSGTKIELEVAGNYVRERK----QSVYEYLRETSVINPHAKITFVEPDGTINEFKRVTDDIPQPPKSIKPHPHGIELGTLMSMLKSTR--------------ATTLRRFLKEEFVRVGEKIADDVLRKA------------SGDETPQEMGRDDAAKLLNAFRQTDFLPP--PTDCLSPIGEAMIAKSLMAEFQPEFVYAVTRKPKVYSGLVEVGLAYGGEIKSEKVT------------------------RYANKIPLLYQQGGCALTKAVESVNWKSYGMVQNRGELIPYTSESKESVAAIPEIIDETRLALQEVGRRLKEYLERKSR----QQKKKKKEEMIGKVLPLIAKKVCEILEKE-IDRIVARIMGYLHVERIVEERDGVKVVTIRVSNFTRSKKSIKLYEMCSGNVEADGAKVSGSGYSTVTWSLEVKPDEEVEVSYRL......................... 574
3 -11.100[L] KOG1979 DNA mismatch repair protein - MLH1 family  ali follow..  11  1MDVNSRAKIRPLDQLVINKIAAGEIIERPE------------NAIKELIENSLDAG----STSIDVLLKDGGLLQITDNGSGIQYD---------LPYLCQR-FSTSKFNDLQHLQTFGFRGEALASISHVAKTVVTKLSSDIHAWKAFYVDGALAMSPAPQPCAGKQGTVITAERSRKSALKNGSEEFRRIMILVQKYAIHNDQVSFNCKKVGDTVASLSLSSRLSKADYGPRVASHLRDFSLGEGQSSIVGFSANGFISNADFQDKKSNLILFINN-------VESVELRHALEETYAKYLHKGAS----SLNMSPEQLD------VNVHPSKRIVHFLYDQEIATSICDKLGEILERTDTERSYPLQAMIPSISNTKNAESSSQKAVRTYENYLVRTDPRERSIKSMLSDNFLQRSSNNYDNEIIEKVDSANSNKNATNDIKDLQTEEIVEEGNSIDLESIKSLQKQTNILTEHKYVGL-VCPTRRIAAVQHNIGLYVVDYGKLSYHL-------FYQICLTEFGNYGEFVLETPLSISDLFEIVNGDEDKSESEKFTRLLVSRRDMLKDYF-SI------SVTSGGLLTAVPMLSPKYHPPFEQLPLLISSLTPKFFDWLDE.............. 607
4 -10.000[D] KOG1845 MORC family ATPases  ali follow..  19  80....KAGDDDEAAPVPLYCSNDAAVRVHPQ-FLHANATSHALGALAELLDNSLDEVSNG-ATYVHVDSGKSSILIVEDNGGGMN-----------PSTFRECLSLGYS-RKRNMANRVGQYGNGFKTSTMLGADAIVFSRSRGI................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 214
5 -9.470[T] KOG0787 Dehydrogenase kinase  ali follow..  14  290........................................LNHAVFEILKNSLRATVEFHGVDIKVIVAKGQTIKISDEGGGISRRNIPL--------VWSYMFTTAS-SANSTTPMAGF-GFGLPLARLYTRYF-------GGDLELISMEGYGTDVYIHLNRLCESAEPLQ................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 425
6 -8.990[L] COG0323 DNA mismatch repair enzyme (predicted ATPase)  ali follow..  13  8............PEMLANQIAAGEVIERPAS------------VVKELVENAIDAG----SSQIIIEIEEAGLVQITDNGHGIALRRHATSKIKNQADLFRI-------------RTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVE-TPARLKYMKSQQAELSHIIDIVNRLGLAHPEISFSLI--SDGKEMTRTAGTGQLRQAIAGIYGLVSAKKMIEIENSDLDFEISGFVS-ELTRANRNYISLFINGRYIKN---------FLLNRAILDGFGSKLMVGRFPLAVIHIHIDPYLADVVHPTKQEVRISKEKETLVSEAIANSLKEQTLIPDALENLAKSTVRNREKVEQTILPLKENTLYYEKTEPSRPSQTEVADYQVELTDEGQDLTLFAKETLDRLTKPAKLHFAERKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELEFFG-QMHGTYLFAQGRDGLYII----DQHAAQERVKYEEYRESIGNVDQSQQQL--LVPYIFEFPADDALRLKERMPLLEEV--------GVFLAEY-GENQFILREHPIWMAEEEIESGIYEMCDM................................... 561
7 -8.740[L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family  ali follow..  13  2...........SQNKIERISKEVAERLTTAQVV-----VSLSSAIRQLIDNSIDAG----STIIDIRVKNNGSIEVQDNGSGIEAR---------FDALCKPHSTSTQFSDFDKLATLGFRGEALNALCTVSS-VSIFTRASDTEIGTRLTYDHSGNIICRQSAARELGTTIIVNP-RKELERSQKREFVKLLSTVQSFALLCPHIKILCTNNINGKKTNLICTPGGTTSIQDVVANSKIGSGLIPIQQNQPDVEIMTIHSVPMEEMHFFDLFKIRGFVSSCEHGCGRGTSDRQFVYINNRPVEYSRVCSVINDVYKQFNKKQYPIIVLFIDVPPEKIDTPDKKTVMLEKERHLLA-VVRASMMKTYLKIVGSHSTVRSSVEDRRIMNLSQQSFSNASFMSSK............................................................................................................................................................................................................................................. 398
8 -7.850[T] COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase)  ali follow..  17  1MRVHQPETIEMTPAKSEFVGVVRLTVSGIANRLGYDDIEDIKIAVAEACTNVVDHAYDEGGTGLSFHLYEDREIIVTDQGQSFMDAFRESLGPIDGSKPIQDLKEG---------------GLGLFLINTLMDKVEMKEDSGVVLAMTKFLQRDEVDNRVDGISATQT........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 159
9 -7.240[T] COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism  ali follow..  17  402ISKINRATDLGHTLILNSESQLPDSGS-------EDQVATLITTLGNLIENALEALGPEPGGEISVTLHYRHGCEVNDDGPGIAPDKIDH--------IF----------DKGVSTKGSERGVGLALVKQQVENLSIAVESE.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 523
10 -7.230[O] KOG0020 Endoplasmic reticulum glucose-regulated protein (GRP94/endoplasmin), HSP90 family  ali follow..  10  68.IREKAKKFTFQTEVNRMMK-INSLYRNKEIFL-------------ELISNASDSKELETNPELHIRIKADKALHIMDSGIGMTHQDLINNAKSGTADFLAKMQDPSKSEGLDMNDMIGQFGVGFYSAFLVADRVVVTTKHDDKQYIWESDANSFSITEDPRGDTLKRGSVISLYLKEE---AQDFLEEDTVRELIRKYSQFIN-FPIRMWSSKTVEEEVPVE--------------------------------------------------------EEAKPEKSEDDVEDEDAKVEEAEDEKPKTKKVSKTTWDWTLINDSKPIWT-----------RKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAEGEVTFKSLLYVPKVQPSESFNRYGTKSDNIKLYVR---------------RVFITD--------------EFNDMMPIRGVVLNVSRETLQKVIKKKLVRKVLDMLKKIDKEAYEKFWKEFSTNIVMEDPS-NRSRLAKLLLAEYKERMKAIAGANRAEVEKSPFVERLLSKGYEVLYLVEAVDEYCIS-------ALPEFDGFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISK................. 630

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.