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Query: gi|30260201|ref|NP_842578.1| DNA gyrase subunit A (BA_0006) [Bacillus anthracis str. Ames], from B.anthracis

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSDNQQQARIREINISHEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMNDLGITADKAYKKSARIVGEVIGKYHPHGDSAVYETMVRMAQDFSQRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMELIRDISKNTIDYQDNYDGSEREPIVLPARFPNLLVNGTTGIAVGMATNIPPHQLGEVIDGVLALSHNPDITIAELMECIPGPDFPTAGLILGRSGIRRAYETGRGSIILRAKVEIEEKSNGKQSIIVTELPYQVNKARLIEKIAELVRDKKIEGITDLRDESDRNGMRIVMEVRRDANANVLLNNLYKHTALQTSFGINMLSLVNGEPQVLNLKQNLYHYLEHQKVVIRRRTAYELEKAEARAHILEGLRIALDHLDEVITLIRSSKTAEIAKQGLMERFGLSEKQAQAILDMRLQRLTGLEREKIEQEYQDLMKLIAELKAILADEEKVLEIIREELTEVKERFNDKRRTEITIGGMESIEDEDLIPEQNIAITLTHNGYIKRLPASTYKTQNRGGRGVQGMGTNDDDFVEHLLTTSTHDHILFFTNKGKVYRTKGYEIPEYSRTAKGIPIINLLGVDKGEWINAIIPIREFGDDEFLFFTTKQGISKRTPLSSFANIRTNGLIAISLREEDEVISVRLTSGDKDIIVGTSNGMLIRFNEQDVRSMGRNAAGVKAITLGEEDQVVGMEIVEEDVNVLIVTKNGYGKRTPIDEYRLQSRGGKGLKTCNITDKNGKLVAVKSVTGEEDIMLITAAGVIIRMPVDQISQMGRNTQGVRLIRLEDEQEVATVAKAQKDDEEETSEEVSSEELast
1 -158.000[L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit  ali follow..  45  2...FNKDEIIVPKNLEEEMKESYLRYSMSVIISRALPDIRDGLKPSQRRVLYAMKQLSLSPGAKHRKCAKICGDTSGDYHPHGESVIYPTLVRMAQNWAMRYPLVDGQGNFGSIDGDPPAAMRYTEARLTHSAMYLMEDLDKDTVDIVPNYDETKHEPVVFPSKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLLLANPQASVDEILQVMPGPDFPTGGIICGSEGIRSAYTTGRGKIKVRARLHVEENEKHRESIIITEMPYNVNKSRLIEQIANLVNEKTLAGISDVRDESDKDGIRVVLEIKKGESSEIIINRLYKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRKEVIRRRTRYELNKAETRAHVLEGYLKALSCLDALVKTIRESGNKEHAKERIIESFGFTEPQALAILELRLYQLTGLEAEKIQKEYEELLNKIAYYKQVLSDEGLVKDIIRNELQDLLKHHKVARRTTIEFDADDIRDIEDIITNESVIITISGDDYVKRMPVKVFKEQRRGGHGVTGFDMKGAGFLKAVYSAFTKDYLLIFTNFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEELAILNIKNFDNAGFLFLATKRGVVKKVSLDAFSNPRKKGIRALEIDEGDEIAACHIVSDEEKVMLFTHLGMAVRFPHEKVRPMGRTARGVRGVSLNEEDKVVSCQIVTENQSVLIVCDQGFGKRSLVEDFRETNRGGVGVRSILINERNGNVLGAIPVTDHDSILLMSSQGQAIRINMQDVRVMGRSTQGVRLVHLKEGDALVSMEKLSSNENDD......... 817
2 -9.150[L] COG0417 DNA polymerase elongation subunit (family B)  ali follow..  11  492LAIYCLKDAYLPQRLMDKLMCFVNYTEMARVTGVPFNFLLARGQQVISQLFRKALQHDVPNIRVNGTDEQYEGATV--IEP--IKGYYDTPI-ATLDFSSLYPSIMQAHNYTTLLDSTPNGDYFVKPHVRKLLPIILADLARKKAKADLKKETDPFKKAVLDGR--KVSANGFTGATNGISSSVTSYG-RQMIEKTKDVVEKRYRIENGYAVVIYG-DTDSVMVKFGVKTLPEAMKLGE-SDQFPNPIKLEFEKVYFPYLLISKKRY----AGLFWTRTDTYDKMDSKGIETVR----RDNCPLVSYVIDT-----ALRKMLIDQDVEGAQLFTKKVISDLLQNKIDMSQLV---------ITKALSKTDYAAKMAHVELAERMRKRDAGSDRVAYVIIKGAQGDQFYMRSEDPIYVLENNIPIDAKYYLENQLSKPLLRIFEPIL......................................................................................................................................................................................................................................................................................................................................................................................... 957
3 -8.620[D] COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins  ali follow..  17  336.......................................KRLLHKNAEKLRKTLESFGVK--------AHVSGPAVTKYEVNPHVGVVSRIVNLADDLALALAAIPGKSAIGEVPNQEVAIVTLREV--NVLSVGLGRDISGEPV-----------------NKMPHLLVAGATGIITSILLKAKPHEVK------LMMIDPKMVELN-LTPVVTEPKKASQALKKVVAEMERRYDSHSGTRNIEGYNEMITRQNEKEDAKQPTLPYIV----IVDELADLVASGDVEDIARLAQMARAAGIHMILATQRDVITGVIKANIPSRIAFGVSSQTDSRTILDGAEKLLGRGDML--YLPMGATKPTR---------------VQGAFLSDEEVETIVEFVVAQQKAQYAEEMTPTNLVIEMNSASVSMLQRRFRIGYTRAARLIDEMEA........................................................................................................................................................................................................................................................................................................................................................................................ 762
4 -7.830[T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain  ali follow..  15  326......ALVTKEVEAENRIRQLAHYDTLTGLANRTNEQLDARLAAPEARLGLLYIDLD-----------KLVNDTKG--HRAGDALLERVAQRLRAVCDRPGMAIARLG------GDEFAVL--DADRAATLATALIEALG---------------APYALGAD--NVRIGASIGIALAPAHGRDTENLLARADIALYAAKQPIVDVAT-REALVRWHHAERGWVPPDEFVPIAEQSG-GRFVLHRACREATRWEDGARVAVNVSPMQLGKATLAQTVHAALI------------DSGLAPDRLEIEVTETANEAESFEDLRQLYDMGVRVALDDFGT--GYSSLAHLRAFPFDKIKIDRSFVR-----DLLERPDSAVLVRAIADLGRQLG--VTTVAEGVETQAHVRGIREA......................................................................................................................................................................................................................................................................................................................................................................................................................... 736
5 -7.560[L] COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)  ali follow..  14  379LTAENDKGEREPSEAARFYQEQF---------HEVLVDEYQDTNLVQESILQLVTSGPEETGNLF-----MVGDV--------KQSIYGRKIDLNKNFRSRADILDSGGKIGEVDYDEQAELKYPDNDETETELLLINAEDTDASEEAEELETVQFEAKAIAKEIRKLISSPFRDIVI-IMEELRAQGIPVYANLTSGYFEAVEVVALSVLKVIDNPDIPLASVL-------------RSPIV------------GADENELSLIRLENKKAPYYEAMKDYLAAGDRSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTK----YMDYVGGMPGGKQRQANLRVLYDRARQYESTAFRGLFRF-IERMQERGDDLGTARGLSEQEDVVLMTIHSSKGLEVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMRRELLSEELRVLYVALTRAKEK........................................................................................................................................................................................................................................................................................................................................................ 877
6 -7.510[L] COG4581 Superfamily II RNA helicase  ali follow..  15  229.DLLPDKRSIVSLPPSTLNLHKQPDYAHVVDSSAPIENFQQ-LDNFQKEAIYHLEMGDSVFVAAHTSAGKTV---VAEY--HMTKAIYTSPIKALSNQKFR-DFKHKFEDVGILTGDGSCLLMTTEILRSMLGADLIRDVE-DEVHYVNDLEGVVWEEVILPPHVTLILLS---------AT-VP--NTKEFASWVGRTKKKN-----YVISTLKRP-VPLEHYLWVKQNMMDGYKSANDALKKPDKPVIAKDNKNRDANTWVHLIGHLHKQNLLPVIVFVFSKKRCEEYVDLNNHQEKSEVHVVIELSRGLAVKEIVEILFQRGLVKVLFATETFAMGVNMPAKSVVFSGTQKHDGRNFRDLLPGEYTQCSRAGRRGLDVTGTVIILSR-SELPDTASLRHMIMGPSSKLISQFRLTYNMILNLLRVETLRIEDMIKRSFSELVPQHEEKIKSFEEKLSA.......................................................................................................................................................................................................................................................................................................................................................................... 779
7 -7.510[TW] KOG1226 Integrin beta subunit (N-terminal portion of extracellular region)  ali follow..  15  65.....................................DLKENLLK-PESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQDDSKNFSIQVRQVEDYPV-YYLM-----------DLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGF-GAFVDKPVSPYISPPEALENPC--YDMKTTCLPMFGYKHVLT----LTDQVTRFNEEVKKQVSR-DAPEGGF----DAIMQA------------------------TVCDEKIGWRNDASHLLVFTTDIALDGRLAGIVQPNDGQ-----------------HVGSDNHYSASTTMD-------------PSLGLMTEKLS---QKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSVLQLIVDAYGKIRSKVELEVR......................................................................................................................................................................................................................................................................................................................................................................................................................... 386
8 -7.400[A] KOG0119 Splicing factor 1/branch point binding protein (RRM superfamily)  ali follow..  10  1MLNSRSVGSTGSTPLGRRRFDEKPDSLPPLPDANGMS---NGYRDSYKS---RPDGYHDGRGRRAYRKHY------------GHPTPIEEMLPMELETAVK----------SCMTMEQLELYSL-NVRLEEITQKLRTG-RERSPSPPPQYDNHGRRLNTREIRYKKKLEDERHRIIERAMKMVPGFRAPSDYRRPAKTQEKVYVPVKD-------PEINFIGLLIGPRGLKDMEAKSGAKIAIRGKGSVKEGKGRSDPLVTADSEDKINHA--IKLIDNVIQ--TAASVPEGQNDLKRNQLRQLATLNGTLRDD............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 306
9 -7.320[O] KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain  ali follow..  14  651.IDNSTEKLTAKEDFTKALDRSKKRNASALGAPK-VPNVKGGLEDVKTSILDTV-QLPLLHKDLFSSGLRKRSGVL--YGPPGTGKT--LLAKVATECSLNFLSVKGPELINMYIGESEKNVRFEKARSARPCVIFFDELDSLAPARGASGDSGGVMDRVVSQMLAEILSDSSQDLFIIGASNRPPGRFDRVLKALTRKFKSEDVSLYSVAKKCPGADMYA---LCADAWFQAA----KRKVSKSDSGDMPTEEDDPDSVVVEYVDFI----KAMDQLSPSLSITELKKYEMLRDQFQGR........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 971
10 -6.910[R] COG0699 Predicted GTPases (dynamin-related)  ali follow..  14  242.................................KKMIEIRNILQDIQ----------DNNSAVTLPSIV-VIGS-----QSSGKSSVLEAIVGH--EFLPK--------------GSNMVTRRPIELTLVHSADGKITDFSKMAVPSSQGVDDNPIRLTIYASHIPNLSLIDLPGYIQIHSEDQPADLDMKISKLCEKYIREPNI----ILAVCAA-DLANSAAL---RASRRVDPLGLRTIGVVTKMDLVPPSKAISILHNNNYPLHYGYIGVISRIVPTGRFSAGQNLTDLVSTQENSYFS---------------HQQFADARIGNYLGIQSLR---------CLINVLEYTMSKNLQHTADSIRTELEECNYQYKVQ-YNDRVLTADSYIAEGLDI....................................................................................................................................................................................................................................................................................................................................................................................................................................... 569
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 2 5   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.