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Query: gi|29345424|ref|NP_808927.1| two-component system histidine kinase with response regulator receiver domain BT_0014 [Bacteroides thetaiotaomicron VPI-5482], from B.thetaiotaomicron

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLILLLGFIIYLFRGERMKRDELKWEMKELGIIRDLTRKTYGHLLELASQGEVVSTWSESDLRLYRERREKTCGVLKELQQFVHTPEQQERIDSLCLLLEQKEMLLSAAMSTFDELENIGETVGEKVPAIVRQVRRQPTRNILAPAVKEAYAGTATTGEEQPEKKKSFLKKVFGGKEKKSAYRQQREQQRAASEKVPSSTTRNSGNNAAVHLLHALSREVTEKQKEQREKLSAQMDSLHLSSRALNKRLNGLVGDFDKVAGERLETRYNAIAADREKSYNTAATLALFVFLLAIVLYTLLHRDVNRCLRYRRELESSDLKNKELLQSRKNMMLTIAHDLRAPLTAIKGYAELLPGEVDEKRKDEYAVHIVRSSDYMIGLVNSLIEFYLLDAGKGKMNVTVFRPLSLFDEIVKLHTPSVRKEGLTLCTDFEGLDTVVEGDRPRIMQIANNLLSNAIKFTRKGKISLQAAYGQGELRFSVQDTGPGMTEDEQKRIFRAFERLDNARYLPGFGLGLAIVSRLTELLGGRITVESPYGTGSLFRVALPLSEVAKHGEDGENGYAEDYGLEGTYVLVIDDDRIQLDITRRMLVRNKVRCECCRTVRELMAALRERTYDLLLSDIQMPDMDGYRILDLLRSSNMENARTIPVLAVTACADDEEHYISFGFAGCLRKPFSMDELISTVSRMVVKTGKKEPDFSFILSGEKDKGRMLDIFIRETEESIHTLENALCGHDRDTIHKVLHKNLPLWETVRMNFPMARLRGLVTHTAAVWEERQYMEVGEIIHAAEKLAESARKIRESIDEEHTDYRGLast
1 -46.700[T] COG5002 Signal transduction histidine kinase  ali follow..  21  252...............................................................................................................................................................................EDAQAMTEGERRKLASVIAYMTDGVIATNRNGAIIL----LNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQ---------DSMLLEIERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMD--------------QERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVRFMSLIIDRFEMTK-EQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYSPEGGFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA........................................................................................................................................................................................................................................................... 611
2 -43.400[T] COG0642 Signal transduction histidine kinase  ali follow..  20  214................................................................................................................................................................................................................................................................................................................DELSHLAIQFDKMVEKLEKLVAKERHLLHHVSHEMRSPLARMQAIVGLIQAQ--PQKQEQYLKRLEGELTRMDTLAGELLTLSRLETSNMALEKESLKLLPFLGNLVEDNQSIAQKNGQTVTLSADG-NTTILANESYLYRAFDNVIRNAVNYSPEGSILINIGQDHKHWIIDVTDNGPGVDEMQLPHIFTAFYRADSSANKPGTGLGLALTQHIIEQHCGKIIAENIKPNGLRMRFILPKKKTGSKTEKSAN.......................................................................................................................................................................................................................................................... 468
3 -36.300[T] COG3852 Signal transduction histidine kinase, nitrogen specific  ali follow..  19  3......................................................................................................................................................................................SGIQPDAGQILNSLINSVLVVDDALAIH----YANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIDLMR-----SLAAGQGFTDNEVTLVIDSRSHILSLTAQRLPDD-----FILLEMAPMDNQRRLSQEQLQHAQQI-----AARDLVRGLAHEIKNPLGGLRGAAQLLSKALPDPALTEYTKVIIEQADRLRNLVDRLLGPQH------PGMHITESIHKVAERVVALVSMEL-PDNVRLIRDYDPSLPELPHDPEQIEQVLLNIVRNALQ-PEGGEITLRTRTARLAARIDVEDNGPGIPPHLQDTLFYPM-----SGREGGTGLGLSIARNLIDQHAGKIEFTSWPG-HTEFSVYLPIRK.................................................................................................................................................................................................................................................................... 349
4 -35.300[T] COG2205 Osmosensitive K+ channel histidine kinase  ali follow..  26  645.................................................................................................................................................................................................................................................................................................................ERLHLARSAELAKLDAER-EQLRNSLLAALSHDLRTPLTVLFGQAEILTLDLEGSRHAPQANQIRQQVLSTTRLVNNLLDMARIQSGGFNLRKEWQSLEEIIGSALYMLETTLSQHQIRVELPDE---VLINCDASLLERVFINLLENAHKYAGHAALGIRAEVQGEWLNVDVWDNGPGVTIGQENLIFDKFSRGNKESAIPGVGLGLAICRAIIDVHGGRIWVEKRQEGGASFRFVLPLEKVPEIDADNIDTNNID..................................................................................................................................................................................................................................................... 901
5 -34.900[T] COG4192 Signal transduction histidine kinase regulating phosphoglycerate transport system  ali follow..  17  381..........................................................................................................................................................................SEQLILYGKKVEEMERTNALSLINNTQASLITCDRYGQ----IESANPSAMATLRLESLAQPLTLWSCFAKHVQPKVGYLRLYLRRYSQGLHDKIIVTITDVTDQEHANRLLEQRVKEKTQSLREKNRELQAEVEERQRAEAHLKKTQGELIQAAKMAVQTMTSLAHELNQPLSAMSAYLFLALEEAPQAQLATSLDHIENLTERMGKIVNSLRHFARKNSSDESLQ--PVRLNSVVEQALVLVQTKAKRQQIKLINTLPD-DLMVMADALSLEQVLINLIVNGCD-FAQPWVKLIAGTEQGMQRIAVIDSGQGFEHEVVDKLFTPF-----TTKEVGLGLGLSICQSLVEKMQGRIALASNLEKGAMVILELQQDEKYRTAD.............................................................................................................................................................................................................................................................. 789
6 -34.500[T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation  ali follow..  18  357...............................................................................................................................................................................LSAKDLIDERRRFSEAVLAGVTAGVIGVDPYGI----VTIVNRSAESMLAISASAALGQN-------SAILPHVGRVFEIGRQSGKPVYREQVTFFRAGTERTFNVQITIEAGDDGSEEKSYVVTVDDITDLVQAQR------------SSAWADVARRIAHEIKNPLTPIQLSAERIKRRYGKVITDQCTDTIIRQVEDIGRMVDEFSAFARMPKPEMK----AIDLRESLREASFLV--EVSRADITFERIFGNEPLKGTFDSRLLAQAFGNVIKNAAE-GSHGIIRIQAGRQNGAIRIDVIDNGKGLPRENRQRLLEPY-----TTREKGTGLGLAIVKKIVEDHGGRLELHDAPGRGAMISIILPLAAVTPLRGEGKTEHERETEKVGNGV............................................................................................................................................................................................................................................. 738
7 -34.000[T] COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system  ali follow..  19  338.....................................................................................................................................................................................................................................................................LRRRQVVAMRSAEERLARNALEASVEERTRDLRMARDRLETEIADHRQTTEKLQAVQQDLVQANRLAIQVAAGVAHEINQPVATIRAYADTFLHRGQTVTAAENMESIAELTERVGAITDELRRFAR----KGHFAAGPTAMKEVVEGALMLLRSRFAGRMDAIRLDLPPDGLQALGNRIRLEQVLINLLQNALE-SEDGAIQVRCEEAAGGIALTVADNGPGIAADVREELFTPF-----TSKEDGLGLGLAISKEIVSDYGGTIEVESGPS-GTTFAVNLKKA..................................................................................................................................................................................................................................................................... 621
8 -31.300[T] COG4999 Uncharacterized domain of BarA-like signal transduction histidine kinases  ali follow..  16  9....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LAGKRLAYVEPNSAAAQCTLDILSETPLEVVYS----PTFSALPPAHYDMMLLGIAVTFREPLTMQHE-RLAKAVSMTDFLMLALPCHAVNAEKLKQDGIGACLLKPLTPTRLLPALTEFCHHKQNTLLPVT............................................................................................................... 136
9 -30.800[T] COG2198 FOG: HPt domain  ali follow..  9  2...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SNEVRAIVLRQLENWGATCI------TPDERQISQEYDLFLTD-NPSNLTA------------------SGLLLSDDEVRKIGPGQLRVNFNMSNAMQ-EAVLQLIEEQLAQEEIPASPLGGDENAELHASGYYALFVDTVPDDVKRLYTEAATSDFAALAQTAHRLKGVFAMLNLVPGKQLCETLEHLIREKDAPGIEKYISDIDAYVKSLL................... 190
10 -26.300[T] KOG0787 Dehydrogenase kinase  ali follow..  12  142.................................................................................................................................................................................................................................................................................................................ETDFSDQDNGVDCNWPESLLKFNSNFAYLLNTIRTRHDNVAVEIALDIQENQIDNSIQIFLDRFYMSRIGIRMLLGQYIALVPPRENYVGVISTRANIYQIIEGAAENAKYICRLAYGLFEAPICDPSLEMMYVESHLNHAVFEILKNSLRATVEFHIKVIVAKGQEDITIKISDEGGGISRRNIPLVWSYMFTTNSTTPMAGFGFGLPLARLYTRYFGGDLELISMEGYGTDVYIHLN....................................................................................................................................................................................................................................................................... 415
11 -25.100[T] COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism  ali follow..  19  213.................................................................................................................................................................................EPYEISTLFEQRQAMLQSIKEGVVAVDDRGEVTLINDAAQELLN------RKSQDDEKLSTLSHSWSQVVDVSEVLRDGTPRRDEEITIKDRLL----------LINTVPVRSNGVIIGAISTFRDKTEVRKLMQRLDGLVNYADA--------LRERSHEFMNKLHVILGLLHL-------KSYKQLEDYILKTANNYQEEIGSLLGKIK---------------SPVIAGFLISKINRATDLGHTLILNSES-DSGSEDQVATLITTLGNLIENALEALPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDK------STKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIPWDGERSN................................................................................................................................................................................................................................................................ 542
12 -22.600[TK] COG4567 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain  ali follow..  19  17........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TLLLVDDDKPFLQRLARAMESRGFQVTTAESVEEGIAAVKTSAPAYAVVDMRLGDGNGLNIIEAIRSRR----ADTRAIVLTGYGNIATNAVKLGAIDYLSKPADADEVFAALTRRPGEKVAPPENPMSADRRWEHIQRVYEMCERNVSETARRLNM-----HRRTLQRILAK.................................................................. 183
13 -22.100[T] COG4251 Bacteriophytochrome (light-regulated signal transduction histidine kinase)  ali follow..  16  498.......................................................................................................................................................................................................................................................................................................................HHSELMAGERERAEVRQRMLNEELNHRVKNVLAIIKSLVGNPSQE--GKTLQEYVTALKGRIQALSFAHDQIIRGEGGGA-----------LRDLLEAELSPHRSPETTVKLE------PQITLDSRAFSVMALVLHELATNAAKYGAGGQLHVRWDVENRDCEISWRETLLTTLPAPSRA---------------GFGTAL-ISRSIPYDLGGRSTIRYLPN-GLEAEILLPFRHVSSVSAAFETKTEAETLPQPRR.............................................................................................................................................................................................................................................. 725
14 -21.200[TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain  ali follow..  16  4........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HVLVVEDDLVTRSKLSGYFQNEGYQVTEAESGAQMREALELNDIDLVLLDINLPGEDGLLLTRELRSQS-----EIGIILVTGRTDSIDKILEMGADDYVTKPVDLRELQVRVKNLLWRISLAQRERITDKHDDKLVH--WTFDVQRRALSRNGEPVKLTKAEYELLVALSSYPNQVLSR-------RILNMISHRVDAPNDRTIDVLIRRMRAKMEM..................... 213
15 -20.100[T] COG4564 Signal transduction histidine kinase  ali follow..  11  58.........................................................................................................................................................................NDEDAMEKVRAILTSNVVHPRQLFRPGHNWLNLTDPDGDRV----IANLIAKAKEGGGLHRYKWEKPSSHEMADKLSDKWKWMLGTGVYLDDVYAQTAAANADFRANIRTTFLIVSLIAVPAVMLVFATCMLLNLRERRMADTKLKELAQRIIDTQEEERARLARELHDISQNLVGVRYAIDLASRQVRTGSGG-----APQAIEKASDALNGAIK----EVRRLSHDLRPRILDDL--GLTVALKALCERTGIETRFKADSLQETIKPESTALYRVVQEALTNVERHSGATRVDIRLKGAHGKVTMTIADNGNGFAVRGLKD--------------PLSGLGLRNMQERMAHFGGVLLVET-SADGTQLTARLPKSATERRLEPEVA.......................................................................................................................................................................................................................................................... 439
16 -19.700[S] COG5385 Uncharacterized protein conserved in bacteria  ali follow..  13  6..................................................................................................................................................................................................................................................................................................................................SALDLGALLCSRICHDIISPVGAINNGLELLEEGSADEDA---MALIKSSARNA----SARLQFARIAFGAAG----SAGVQIDTGDAQNVATEYFRNEKPEFTWEGARVL------PKNKVKLLLNMLLIGNGAIPRGAVRLEGGDTDPRFVITVKGRMLRVPPKFLELHSGAAP----EEPIDAHSVQPYYTLLLAEEAGMKISIHATAE-DIVFSAE......................................................................................................................................................................................................................................................................... 207
17 -19.200[KT] COG4565 Response regulator of citrate/malate metabolism  ali follow..  20  2....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MELIDVLIVEDETSIADVHSFYLKQTA--VGVAQSINEARNMVRILKPKLIFLDNYLPDGRGIEFLKELTHQP----QAPDVIFITAASDMEREAVRCGVFDYLLKPIAYDRVQNSLERYLKYISSLR................................................................................................................... 129
18 -18.800[T] COG3851 Signal transduction histidine kinase, glucose-6-phosphate specific  ali follow..  14  160.................................................................................................................................................................................WHYLANNTWLPLGPSLVSQPINWRGRHLVWYLL----LFVISLWLQLGLPDELSRFTPFCLALPIIALAWHYG---------QGALIATLMNAIALIASQTWRDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARAERLLETEESVRRDVARELHDDIGQTIQAGIVQRLAADNASVKQSGQLIEQLSLGVYDAVRRLL--GRLRPRQLD----DLTLEQAIRSLMREM--ELEGRGIVSHLEWRIDESALSENRVTLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLPPGSGQQ-----------------GFGLTGMRERVTALGGTLHISC--LHGTRVSVSLPQRYV................................................................................................................................................................................................................................................................... 501
19 -17.400[L] COG1389 DNA topoisomerase VI, subunit B  ali follow..  12  2................................................................................................................................................................................................................................................................................................................................................................................................................................SGKHREISVAEFFEKNKHIL-NPAKAIITVVKEAVDNALDACEEADIFVRISKVDDHFKIVVEDNGPGIPREQIPKVFGKLLYGSRRQSRGQQGIGISAAVLYAQLTTGKTVISKTPDEDRAKKVVLYINTKKNEPEIVEEGEEEWYLPSGTKIELEGNYVRERKQSVYEYLRETSVINPHAKITFVEPDGTINEFKRVTDDIPQPPKSGIELGTLMSMLKSTRATTL-FLKEEFVRVGEKIADDVLRKAGFSGDETPQEMAAKLLNAFRQTDFLPPPTDCLSGEAMIAKSLMAEFQPEFVYAVTRVEVGLAYGGVESVNWKSYGMVQNRGELPSAPAVILIHLASTSESKESVAAIPEIIDETRLALQEVGRRLKEYLERKSRQ...... 459
20 -17.200[T] COG3707 Response regulator with putative antiterminator output domain  ali follow..  13  3...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RCVINADMTLRDLTILVIDENAIRASIIEEGLREAGYQRTVIHEVNGVARTIETLQPDVIFIDLENPNRDMMEHLFQLTRT-----VGRPIAMFVDRSDTAEAAVEAGVSAYVVDGLKKERVKPILDMAVSRFNAFSRLQRELADAKSALEEILMKMRGLSEEEAFALLRQTAMNEKKKISEIAQSVVTAAGLL.......................................................... 203
21 -17.200[NT] COG0643 Chemotaxis protein histidine kinase and related kinases  ali follow..  15  240..........................................................................................................................................................................................................................................................................................................................LAAEQAPTGRVEREKTTRSNESTSIRVAVEKVDQLINLVGELVITQSMLAQRGDLITSMGQLQRNARDLQE------SVMSIRMMP--MEYVFSRYPRLVRDLAGKLGKQVELTLVGSSTEL--DKSLIERILTHLVRNSLDHNSVGNLILSAEHQGGNICIEVTDDGAGLNRERILAIFAPFSTAEQVTDVSGRGVGMDVVKRNIQKMGGHVEIQSKQGTGTTIRILLPLTLA----------------LDGMSVRVADEVILPLNAVMESLQPREADLHPLAGGERVLE----------VRGEYLPIV---ELWKVFNVAGAKTEATQGIVVILQSGGRRYALL-IGQHQVVVKNLE...................................................................................................................................... 611
22 -16.700[T] COG4566 Response regulator  ali follow..  15  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MRLSQSAGTSAPLLSQRKKSSAESIVVVVDDDAAVREGLSELILSAGFQPVSFASTQELLNAVDILD-GCLILDVHMPGESGLDLQHHLAERGI----GKPIIFLTGRGD---QAMKDGAVDFLTKPVSDRTLLDAVIAAIALDQTQRAEAI----VVKRNVERLKTLTRREREVLREVKQIAFDLGISEVTVKLHRAN-VMRKMEVRSIGELIRVWETL........................................... 221
23 -16.400[KT] COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain  ali follow..  20  57.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MNRMFHMSMEDLSQCTILIVDDSPDNIAFMSQGLAQ-YYRIKAARSGKVALEILAQYPIDLVLLDIVMPEMSGYEVINQIKHN--PHTEHIPVIFLTGNPEDEQLGFELGAVDYVFKPVSIPLLKSRVHTHLQNKRSKDILLNQNDYLETEVLRRSGELDRMQDAVVFALASLAETRDPETLLRTQHYVKVLAQRLA......................................................... 255
24 -16.000[TK] COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain  ali follow..  16  2.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YKILIADDHPLFREAIHNVIADG-SEVMETADLDSALGLTQEDDLDLILLDLNMPGMHGLNGLMNLRN----EAPTIPVVIVSAEQDKQLQAITYGAVGFITKSSPRAQMTEAIEQILNGNVYLPSDVRSGHEEHGISPELLQALTRKQLLVLERMTKGESNKQIAYNLDIAH-VSAILRKLKVHNRVQAI................................................. 207
25 -15.900[S] COG5381 Uncharacterized protein conserved in bacteria  ali follow..  12  1.............................................................................................................................................................................................................................................................................................................................................................................MSTDQTNVRQWGEFLDPIPPSDEFLTLNFSLDRVNRLQRWRNYGLSADFLGDYFATFFPGNGADDG-LSQRDTIKGSVSYIANELLENAVKYSHDCPITITLHLYDHKLIFETSNISPLPTTIDYENFIKVLLEADPLELYEASQIGLLMINDYQAQFGWRFVPVSGSEDLIKVTVMTHLG..................................................................................................................................................................................................................................................................... 196
26 -15.100[KT] COG3279 Response regulator of the LytR/AlgR family  ali follow..  21  2.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LRVIIVDDEQPAREDLRERLNEEH--VAECSNALEAIPAIQRLQPDVVFLDIQMPRINGLELASMLNPESMPH-----IVFVTAYDEYAIRAFEEHAFDYLLKPLDHQRLAKTLTRLSRDLIVKNN.................................................................................................................. 124
27 -15.100[T] COG0784 FOG: CheY-like receiver  ali follow..  17  2...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TERRLRVLVVEDESMIAMLIEDTLCELGHEV-TASRMQEALDIARKGQFDIAIIDVNLDGEPSYPVADILAE------RNVPFIFATGYGSKG---LDTRYSNLLTKPFLDSELEAVLVQISKEV....................................................................................................................... 120
28 -13.900[T] COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain  ali follow..  16  2.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................INVLIVDDEQIEREGLKLFLDRPNIHVGEASNGRQAIEKALETQPDLMMMDIKMPGVDGVQAVKEIKQQL----PETEFIMVSAFDT-AREVMRYGVKEYLLKPTTKEDVLTALDRIVGEIEQAREEKNDQYKLQQRLEQISSFVQTESILYL....................................................................................... 154
29 -13.800[T] COG2202 FOG: PAS/PAC domain  ali follow..  7  2.............................................................................................................................................................KSRESPVYMSNVEEFPLTGRVLTEYEALITSAPTALDAIPGAVYVCDHEGWLV----GYNAEAAELWGRQPSLSAPRERFC-LSDGSPMDHQECPMAEAIKTGVSTRNAEVIIERPDGSRIFALVNIRPLRDHRGVIQGAINCFQDISQQKRIEAEVNCKSKDLEDFFENSAIGLHIVSAAANKAELELLGYPA-------DEYVGRHIAEFHADAPVIGDILDRLSCGEKLDRYPARL---------------------RARDGSIKHVLITSNSRFEDGKFVNTRCFTTDI-------TSLHETENAWRETEERLAATYQAATIGIAESDADGRLLRVNDA--FCTMLGRSREQLLNMTFLDYTHED---RQVSGETDTYAIRKRAVKADGTVIYLDVYSSTVRDRTGRYGVRVLLDVTEAKRMDDRRRESEQHMRDLLEALPAAVYTTDAEGRITFFNKAAVEMAGRTPQIGDKWCVTWRLYRPDGTYLPHDQCPMAVTLKEDEQAVAERPDGTRVPFIPYPTPLHDVAGKLVGAVNMLVDISDREK-AAEYAERLASIVRFSDDAIVSKDTQGIIQTWNK--GAERLFGYSAEEVIGKPINILIPPDRQGEEPGILERIRR......................... 606
30 -13.700[T] COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain  ali follow..  13  21..................................................................................................................................................................................................................................................................................................................................................................................................................................................LLIEDSVALSMLLRTRLSDETEA----EVVHCASMAEADALMQANNFTLALTGLNLPDA------------------KGEILTLLSERKVPAIVFTATVDKKIIDYIVKDGHRTVDAVVKTVDRIMTN---KRFSVLVVDDARTARSGLVEILERQNFKVSEAHSGNRALEILSQDSIQLVITDYHMPDMDGYELTRRIRDSR--SSEDLRVIGISSSTDRSASFLKAGASDFVYRPFVPEELQCRIDNNIETLKQLKRLRELAERDRRSFFERTRALMDVINDNDESGAVAILDID-RALKKLAELLQGIPARLGGEEFAVFLRGLDARAAYAFCEELREQVEKN........................... 380
31 -13.500[T] COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific  ali follow..  17  345.......................................................................................................................................................................................................................................................................................................................YFNQAQKHFQQLLLMEERATIARELHDLAQVLSYLRIQLTLLKRPEDNAGAQSIMADFSRALNDAYRQLRELL--------TFRLTLQQADLPSALHEMLEDLQ---SQTPAKLTLDCRLPTLALDAQQVHLLQIVREAVLNAIKHANASEIAVSCVTADGDHTVYIRDNGIGIGEPHEP----------------AGHYGLNIMRERAERLGGTLNFSQPSGGGTLVSISFRSSNKEESQLT............................................................................................................................................................................................................................................................. 566
32 -13.100[T] COG4585 Signal transduction histidine kinase  ali follow..  12  161...............................................................................................................................................................................................................................................................................................................LDEYRKMKRQLLTEEEQARQDERML---IGHEIHDVGHKLTALVMQLEAFRLTA-AEQDKETIESLKVLAERSLEETRRAVK---------SFKHKEVGGLQGVIRLIRKLE-MESFMNIHFSVKHGAFAAPLTGESFAIYRAIQEALTNIMKHSSTREAQVLFESPGGSFRFEVLNAAPPNPFF-------------------QEGYGLKGMRERLEKVGGSLAIVQNER-QFIVTGSIRLFERRGSYDQGIISGRSSNGSPR................................................................................................................................................................................................................................................ 393
33 -13.000[T] COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains  ali follow..  17  5.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KPAHLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEGLRVLHREKVDLVISDLRMDEMDGMQLFTEIQKVQ----PGMPVIILTAHGPDAVAATQKGVFSFLTKPIDRDALYKAIDEALEQSATDDSWRNAIVTRSPLMLRLLEQARMVAQSDVSVLINGQSGTGKEIFAQAIHRSNKPFVAINCGALPEQLLESE............................................. 205
34 -12.800[T] COG3920 Signal transduction histidine kinase  ali follow..  15  323.................................................................................................................................................................................................................................................................RQLRSSIRDLTHMAERIGEGEIVAPVDTKIKEANQVA---IALSNASFDRSQSEER--------------LQLLLHELVHRSKNILTLVQAMIRQLGRENKSIPEKEVDHRLRG-----LGMSIRALAEVQWQGL---------PIRKLIETHLDVFGTVVERFRLE-------------GDDFMLSPVVHELTTNSIKYVPPGKITVS-KDGRQMLHLVWTETG-GPPATEPSR---------------GFGTTV-IKRHAEGAFGGNVTTEYRE-TGFEWSLEAPMRYFIPKRTEQT........................................................................................................................................................................................................................................................... 578
35 -12.100[T] COG2972 Predicted signal transduction protein with a C-terminal ATPase domain  ali follow..  14  314...........................................................................................................................................................................................................................................................................................................ITEPIEQLVTAMKSVQHSGIEAGVSLSLPEH-AGMLNRHFTVMMKRINELMEENVEKQLIIKETEL--------KALQAQINPHFLYNTLES--LAKANQQKQISKMVESLGFLLRNSIHMKKVTIQEEADIVRHYMTIQRFRFEETLQPLAENAIQYTRPCAIRIQAKKAKGCVCITVEDNGPGMDGRILEST-------------GGRGIGLWNIRERISLTFGELRIHSEHEKGTRIVITIPCRN.................................................................................................................................................................................................................................................................... 574
36 -11.100[T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain  ali follow..  11  179......................................................................................................................................................AINMALVSFGLLVILMVNYRDFTLMVNAQTEARRREARLLHMIDDMPVAVMTVEPGT---FAINYANNTSKRLIDRIAHLLPIEPDALLGTSIDVFHAHPEHQRRLLADP----ANLPHNTRIRLGPEVLDLKVSAVRANDGSYIGPMLTWALVTKEVEAENRIRQ---------------LAH--YDTLTGLANRTNFREQLDARLAAPEARLGLLYIDLDG---FKLVNDTKGHR---AGDALLERVAQRLRAVCDRPGMAIARLGGDEFAVLVPHDDA------DRAATLATALIEALGAPYALGADQNVRIGASIRDTENLLARADIALYAAKAAGKGLARLFCADMETRIQARALLEAQLRAALVDVATGKVAREAHAERGDEF---VPIAEQSHAALIDSGLAPDRLEIEVTETALIQNEAESFEDLRQ-LYDMGVRVAL-GTGYSSLAHLRAFPFDKIKIDRSF-RPDSAVLVRAI--ADLGRQLGVTTVAEGVETQAHVRGIREGY--YYGRPAPSDEDRPRVEA............................................................................................................................ 761
37 -11.000[T] COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase)  ali follow..  11  1...............................................................................................................................................................................................................................................................................................................................................................................................MRVHQPETIEMTVPAKSEFVGVVRLTVSGIANRLGYTYDDIEDIKIA------------VAEACTNVVDHA--YDEGGTMGLSFHLYEDRMEIIVTDQGQSFDMDAFRESLGPIDGSKPIQDLKEGGLGLFLINTLMD------KVEMKEDSGVVLAMTKFLQRDEVDNRVDGISATQT..................................................................................................................................................................................................................................................... 159
38 -10.900[T] KOG4747 Two-component phosphorelay intermediate involved in MAP kinase cascade regulation  ali follow..  12  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DALIAQLQRQFRDYTISLYQQGFLDGSPDFVSEVLSLFFEDCVKLISNMARALDTTDFSQVGASVHQLKGSSSSVGAKRVKTLCVSFKECCEAKNYEGCVRCLQQVDIEYKALKTKLQDMFNLEKQ....... 142
39 -10.600[NT] COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain  ali follow..  20  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MSKIRVLSVDDSALMRQIMTEIINSHS--VATAPDPLVARDLIKKFNPDVLTLDVEMPRMDGLDFLEKLMRL-----RPMPVVMVSSLTGKGSRALELGAIDFVTKP........................................................................................................................................ 108
40 -10.600[T] COG3275 Putative regulator of cell autolysis  ali follow..  18  339...........................................................................................................................................................................................................................................................................................................MAQGIAQLLSSQILYGEYQQKQILLSRAEIKLLAQVNHFLFNALNTISAV-------------------IRREPDKARELILHLSQFFRSN---LKQNVETVTLREELAHVNAYLTIEKARFSDRLDVEIAIDDALLERNVPSF--TLQPLVENAIKHLEAGKVRIYSEVVEGGMRVVVEDNAGLYQPPSED----------------YDGLGMQIVEKRLTNKFGLLQIEVAPQEYTRMSFVIPQQ..................................................................................................................................................................................................................................................................... 555
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Flexible structure alignment by chaining aligned fragment pairs allowing twists. Bioinformatics. 2003 Oct;19 Suppl 2:II246-II255.