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Query: gi|29345425|ref|NP_808928.1| rteB, two-component system response regulator BT_0015 [Bacteroides thetaiotaomicron VPI-5482], from B.thetaiotaomicron

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKSILIIEDDIVFSRTISNWLVKQGMKTQCVATIAEARRAIAGKPFSLILADMRLPDDNSLSLLEWMRERRCTVPVIIMTNYGEVENAVTAIKLGATDYLRKPVQPDILLELIVGIKEGDSGKPSFYRGESAKAQEMYRQIELIACADISVLLRGASGTGKEHVAHEIHERSHRWNKPYVPVDCGTVPEELAASEFFGHLKGAFTGAESDKAGLFRTADGGTLFLDEIGNLSYRTQVMLLRALQEKRYRPLGDTREYPFDIRLVAATNENLEKAIAEGRFREDLFHRLNEFTIRLPLLAECREDILPLADFFLEEANAELGKRTGGFDREARSRLAAYQWPGNMREMKNTVRGAVLLTPDGERIAAGSLAFSVREADGADASETLALNDAQKEKECIMRALEETGGNRKEAARLLGISRSTLYEKLRKYGFQLast
1 -117.000[T] COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains  ali follow..  35  7.AHLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEGLRVLHREKVDLVISDLRMDEMDGMQLFTEIQKVQPGMPVIILTAHGSIPDAVAATQKGVFSFLTKPIDRDALYKAIDEALEQSAPATDDIVTRSPLMLRLLEQARMVAQSDVSVLINGQSGTGKEIFAQAIHNASPRSNKPFVAINCGALPEQLLESELFGHARGAFTGAVSNREGLFQAAEGGTLFLDEIGDMPAPLQVKLLRVLQERKVRPLGSNRDIDIDVRIISATHRDLPKAMARGEFREDLYYRLNVVSLKIPALAERTEDIPLLANHLLRQSAQRHKPFVRAFSTDAMKRLMTASWPGNVRQLVNVIEQCVALT-SSPVISDALVEQALEGEN--TALPTFAEARNQFELNYLRKLLQITKGNVTHAARMAGRNRTEFYKLLSRHELD 439
2 -97.100[KT] COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  24  45..ELLHDARSRSLFETLKRDIASVSPETEVVSVEIELHNPWEVYACLHDFARGYEFQPEKEDYLIHITTGTHVAQICWFLLAEARYLPARLIQSSPPRKKEQPRGPGEVTIIDLDLSRYNAIASRGIATRNPHFNRMIEQIEKVAKSRAPILLNGPTGAGKSFLARRILELKQARSGAFVEVNCATLRGDTAMSTLFGHVKGAFTGARESREGLLRSANGGMLFLDEIGELGADEQAMLLKAIEEKTFYPFGSDRQVSSDFQLIAGTVRDLRQLVAEGKFREDLYARINLWTFTLPGLRQRQEDIEPNLDYEVERHASLTGDSVRFNTELAFATSPQATWRGNFRELSASVTRMATFA-TSGRITLDVVEDEINRLRYNGAEAENIDLFDRMQLEHVIAICRQAKSLSAAGRQLFDVSRDRLRKYLARFGLT 521
3 -93.600[KT] COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains  ali follow..  30  44...LMSLHNDTLTPLAMQGLTRDTLGRRFVVSEHPRLAQICSADLPVRFAADCPLPDPFDGLLLDSEDDLPMHSCMGLPLHFGEQLLTLDSLKPDAFDHL-SPRSLEILAAIAAATLKMTLTFSEEIIGNSGPMLAMKADIDVVAPSQFNILIHGETGVGKELVARTIHQRSNRKRQPLVYVNCAAIPENLLESELFGHVKGAFTGADRARMGKFALADGGTLFLDEIGELPLSAQSKILRALQNHEIQPVGQDRVQTVDVRILAATNRDLKKEVEAGRFRADLYHRLSVYPIYVPPLRERKGDLSLLAGYFVEQARRKLGITQLKLHGDVLSQLIQYPWPGNVRELEHVINRAALKA-KARQRGRPVTTLKVEDLGEWIGELGLRDATDEFQRHLISETLTQADFNWAEAARRLQTDRANLTRLAKRLGIT 519
4 -88.700[KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  28  81VPVILIKPSGYDVLQALAKAGKLT--SSIGVVTYQETIPALVAFQKTFNLRLDQRSYITEEDARGQINELKANGTEAVVGAGLITDLAEEAGMTGIFIYSAATVRQAFSDALDMTRMSLRHNTHGDMLGQSPQMEQVRQTILLYARSSAAVLIEGETGTGKELAAQAIHRRQGKKSHPFVAVNCGAIAESLLEAELFGYEEGAFTGSRRGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKEVTRVGGHQPVPVDVRVISATHCNLEEDMRQGQFRRDLFYRLSILRLQLPPLRERVADILPLAESFLKVSLAALSAPFRQGLQASETVLVHYDWPGNIRELRNMMERLALFLSVE--PTPDLTPQFLQLLL--PELARESAKIPAPRLLTPQQALEKFNGDKTAAANYLGISRTTFWRRLKS.... 528
5 -83.400[KE] COG3283 Transcriptional regulator of aromatic amino acids metabolism  ali follow..  26  93...VLSLDMKSKVEMANPASCQLFAQSQERM--HHTAAQLINGFNFQRWLDGNPQSSHNEHVVINGQNFLMEITPVHL-NDEYVLTGAVVMLR-----------STIRMGQQLQNLSTQDLSAFSQIIAVSAKMKHVVEQARKLAMLSAPLLITGDTGTGKDLFAYACHQASPRSAKPYLALNCASIPEDAVESELFGHAPEG-------KKGFFEQANGGSVLLDEIGEMSPRMQAKLLRFLNDGTFRRVGEDHEIHVDVRVICATQKNLVELVQKGLFREDLYYRLNVLTLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLSADLSTVLTRYGWPGNVRQLKNAIYRALTQL-EGYELRPQDILLPDYDAATVAVGESLDDITSRFERSVLTQLYR-SYPSTRKLAKRLGVSHTAIANKLREYGLS 507
6 -79.700[KT] COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains  ali follow..  38  250........................................................................................................AFHQSHTSFSVANAPDEPHIEQLVGECRVMRQLKRLISRIAPSPSSVMVVGESGTGKEVVARAIHKLSGRRNKPFIAINCAAIPEQLLESELFGYVKGAFTGASANKTGLIQAANTGTLFLDEIGDMPLMLQAKLLRAIEAREILPIGASSPIQVDIRIISATNQNLAQFIAEGKFREDLFYRLNVIPITLPPLRERQEDIELLVHYFLHLHTRRLGSVYPGIAPDVVEILRKHRWPGNLRELSNLMEYLVNVVPSGEVIDSTLLPPNLLNNGTTEQSDAGGTALEEMEKQMIREALSRH-NSKKQVADELGIGIATLYRKIKKYELL 590
7 -74.400[QK] COG3284 Transcriptional activator of acetoin/glycerol metabolism  ali follow..  35  330............................................................................................................................RRLGGDAPVIAALQAKAAKLARTRLPILIQGETGTGKEHLARAIHEGSGL-EGPFVAINCAAIPEQLIESELFGYLPGAFTGASAKRKGLIEQADGGTLFLDEIGDMPLALQSRLLRVLAEGEVLPVGGTAPRKVRIRIVSASHRPLQTLVSQGAFREDLYYRLNAATLTLPALRDR-PDFDWVLEQLLKRH----GDGELILSPAALSALKAHDWPGNIRELDNVIGVAAALA-ENGVVELGDLPDQLLANADT--------VGGNEASATLSLTLTACNWNISEAARRLGLDRSTVHRQIKRYRLK 623
8 -45.200[TK] COG4567 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain  ali follow..  24  16.PTLLLVDDDKPFLQRLARAMESRGFQVTTAESVEEGIAAVKTSAPAYAVVDMRLGDGNGLNIIEAIRSRRADTRAIVLTGYGNIATAVNAVKLGAIDYLSKPADADEVFAALTRRPGEKVAPPENPM-RWEHIQRVYEMCERNVSETARRL-----NMHRRTLQRILAKRAPR.................................................................................................................................................................................................................................................................. 187
9 -29.600[T] COG4566 Response regulator  ali follow..  19  24.SIVVVVDDDAAVREGLSELILSAGFQPVSFASTQELLNAVDIDGPGCLILDVHMPGESGLDLQHHLAERGIGKPIIFLTGRGDIPMTVQAMKDGAVDFLTKPVSDRTLLDAVIAAIALDQTQRA----EAIVVKRNVERLKTLTRREREVL----RGRLNKQIAFDLGISEVT-----VKLHRANVMRKMEVRSI............................................................................................................................................................................................................................................ 211
10 -28.700[KT] COG4565 Response regulator of citrate/malate metabolism  ali follow..  19  4LIDVLIVEDETSIADVHSFYLKQTA--VGVAQSINEARNMVRILKPKLIFLDNYLPDGRGIEFLKELTHQPQAPDVIFITAASDMETVREAVRCGVFDYLLKPIAYDRVQNSLERYLKYISSLRANDSVNQRHVDELFNFQAKTDQLDGLP-----KGIDELTLIKIQEIYHHEPQAAYTAELLGQ...................................................................................................................................................................................................................................................... 186
11 -28.000[TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain  ali follow..  16  3.YHVLVVEDDLVTRSKLSGYFQNEGYQVTEAESGAQMREALELNDIDLVLLDINLPGEDGLLLTRELRSQS-EIGIILVTGRTDSIDKIVGLEMGADDYVTKPVDLRELQVRVKNLLWRISLAQRERITDKHDDKLVHFGEWTFDVQRRALSRNGEP----KLTKAEYELLVALSSYPNQVLSRERILNMISHRVDAPNDR....................................................................................................................................................................................................................................... 198
12 -25.400[KL] COG2901 Factor for inversion stimulation Fis, transcriptional activator  ali follow..  33  4......................................................................................................................................................................................................................................................................................................................................................QQRNPADALTVSVLNSQS--QVTNKPLRDSVKQADGQDVNELYELVLAEVEHPMLDMVMQYTRGNQTRAATMLGINRGTLRKKLKKYGMG 99
13 -25.400[T] COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain  ali follow..  11  1MINVLIVDDEQIEREGLKLFLDRPNIHIVEASNGRQAIEKALETQPDLMMMDIKMPGVDGVQAVKEIKQQLPETEFIMVSAFDTFEYAREVMRYGVKEYLLKPTTKEDVLTALDRIVGEIEQAREEKNDQYKLQQRLEQISSFVQTESILYLLMDHIQDYE-FSFHQQGKEIRKTEKQQWHARIKKEIGLQLPKSTVGFFSTSYREALLALDIIYDHKQASYYFYDKNVKLPIERENKLIEAIKSGDGEKA--LRCSKHPLHDMRKYLQQLFIILGRLLNEMGLHWETAQDFARFSTVHQVTEHGKSEILHIVRTLQEWRTTDEQSLMLLARDYVHDH-FREPL-TLDDLAKHIGL-------------PYYVSKLFKERFDLTFSEYVTQLRVEHAKQLLSLTQKSLKEITYEIGYKDPNYFSRVFK.... 503
14 -24.100[TK] COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain  ali follow..  18  1MYKILIADDHPLFREAIHNVIADG--EVMETADLDSALGLTQEDDLDLILLDLNMPGMHGLNGLMNLRNEAPTIPVVIVSAEQDKQVVLQAITYGAVGFITKSSPRAQMTEAIEQILNGNVYLPSDVIRTHEEHGISPELLQALTRKQLLVLERMTKGESNKQIAYNLDIAETTVKAHVSAILRKLKVHNRVQAILSAGDID...................................................................................................................................................................................................................................... 214
15 -23.200[KT] COG3279 Response regulator of the LytR/AlgR family  ali follow..  15  1MLRVIIVDDEQPAREDLRERLNEEH--VAECSNALEAIPAIQRLQPDVVFLDIQMPRINGLELASMLNPESMPH-IVFVTAYD--EYAIRAFEEHAFDYLLKPLDHQRLAKTLTRLSRDLIVKNNLHKVIKPILRHIIEEVEYLSSELSGVHVV--GTVQSGYTQLSLKTLEEK---PFIRCHRQYMVNTEQLGEIQLMDNGAAE................................................................................................................................................................................................................................... 212
16 -23.200[KT] COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain  ali follow..  18  71.CTILIVDDSPDNIAFMSQGL-AQYYRIKAARSGKVALEILAQYPIDLVLLDIVMPEMSGYEVINQIKHNPEHIPVIFLTGKSNPEDEQLGFELGAVDYVFKPVSIPLLKSRVHTHLQNKRSKDILLNQNDYLETEVLRRSGELDRMQDAVVFA-DPETGNHLYVKVLAQRLATTDKYRDVLSPTVIDTYFKAAPLHDIGKVGIPDNILLKPGKLTPDE-GKLALEKAEKL-SGACTALINVAKEEKWDGSGKGDDIPLSARLMALA--DVYDALICRRVYKEPMSHEEAKAIILQGRGSHFD--PMVIDAFLI...................................................................................................................... 411
17 -22.500[T] COG3707 Response regulator with putative antiterminator output domain  ali follow..  14  16..TILVIDENAIRASIIEEGLREAGYQRVVIHEVNGVARTIETLQPDVIFIDLENPNRDMMEHLFQLTRTVG-RPIAMFVDRSDTASIEAAVEAGVSAYVVDGLKKERVKPILDMAVSRFN-AFSRLQRELADAKSALEERKVIERAKG--ILMKMRGLSEEEAFALLRQTAMNEKKKISEI-----AQSVVTAA............................................................................................................................................................................................................................................. 200
18 -21.800[T] COG2766 Putative Ser protein kinase  ali follow..  13  1............................................................MNIFDHYRQRYEAAKDEEFTLQDFLTICRQSAYANAAERLLMAIQEPRLSRLFSNRVIARYPAFEEFYGMEDAIEQIVSYLKHAAEKKQILYLLGPVGGGKSSLAERLKSRSPVNDHPLCLFNNQDISALVGKVDIRKLEHHAQNDPDAGYSGALCRANQGIMEFVEMFKAPIKVLHPLLTATQEGNYNGTEGISALPFNGIILAHSNESEWVTFRNNKNNEAFLDRVYI--VKVPYCLRISEEIKIYEKLLNHSELAHAP-----CAPGTLETLSRFSILSRLKEPENIYSKMRVYDGESLKDTDPKAKSYQEYRDYAGVDEGMNGLSTRFAFKILSRVFNFDHAEVAANPVHL---FYVLEQQIEREQF. 459
19 -20.500[T] COG4999 Uncharacterized domain of BarA-like signal transduction histidine kinases  ali follow..  13  12.KRLAYVEPNSAAAQCTLDILSETPLEVVYS----PTFSALPPAHYDMMLLGIAVTFREPLTMQHERLAKAVDFLMLALPCHA-QVNAEKLKQDGIGACLLKPLTPTRLLPALTEFCHHKQNTLLPVTDESK............................................................................................................................................................................................................................................................................................................ 140
20 -19.500[T] COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain  ali follow..  17  140..SVLVVDDARTARSGLVEILERQNFKVSEAHSGNRALEILSQDSIQLVITDYHMPDMDGYELTRRIRDSRSDLRVIGISSSTDRLLSASFLKAGASDFVYRPFVPEELQCRIDNNIE---------------TLKQLKRLRELAERDHLTGLPNRRSFFERTRALMDVINDNDESGAVAILDIDHFKK----NDTLGHDAGELLQGMCDEQRHIPARLGGEEFAVFLRGLDARFCEELREQVEKNGRQLSGSSLALTISLNQLNAADQLLYLAKANGRNR....................................................................................................................................................... 427
21 -18.900[NT] COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain  ali follow..  15  5..RVLSVDDSALMRQIMTEIINSHS--VATAPDPLVARDLIKKFNPDVLTLDVEMPRMDGLDFLEKLMRLRP-MPVVMVSSLTGSEVTLRALELGAIDFVTKP-IREGMLAYSEMIAEKVRTAARARIAAHKPMAAPTTLKAGPLLSSEKLIAIGASTGGTEAIRHVL----------------QPLPLSSPAVIITQHMPPGFTRSFAER-------------LNKLCQI---------------SVKEAEDGERVLPGHAYIAPGDKHMELARSGANYQIKI-----------PPVNRHRPSVDVLFHSVAKHAGRNVGVILTGMGNDGAAGMLAMYQAG-----------AWTIAQNEASCVVFGMPREAINMGGVSEVVDLSQVSQQMLAKI.................................... 341
22 -16.000[H] COG1239 Mg-chelatase subunit ChlI  ali follow..  20  12...............................................................................RTLGELLQTPEYAGRKPFDGQRRLVQ-DEVRDNLTRKLRSGEELFPGVVGYDDT---VIPQLVNALLARQNFILLGLRGQAKSRILRAITELVDMPDDPLNPIGAEGATPDVTVADLIGRLGTSLGDTRSMHFGLLPRANRGIFAVNELADLSPKVQVALFNILQEGDVQIKGYPIRLELDVMLVFSAN---EDYTARGKIVTPLKDRIGSIRTHYPTDVQLGMDI............................................................................................................................... 276
23 -15.800[T] COG0784 FOG: CheY-like receiver  ali follow..  22  6.LRVLVVEDESMIAMLIEDTLCELGHEVATASRMQEALDIARKGQFDIAIIDVNLDGEPSYPVADILAER--NVPFIFATGYGSKGLD----RYSNIPLLTKPFLDSELEAVLVQISKE......................................................................................................................................................................................................................................................................................................................... 119
24 -15.000[T] COG3947 Response regulator containing CheY-like receiver and SARP domains  ali follow..  15  1........................................MIQHKPDLIFLDINLPDINGIDFAEQVQSILPEVHIVFITAYD--EYAVKAFELNAIDYVMKPVQRDRLNRTINRITDRKTVEPLRSQTDSKIISCFQTLHAKARELFAYLVQHRKQPVRKDVLLEFF-ESDVKKGYAQLYSAIYQIRKMLLDVEEWERELRQLPNITEDTLPSYRRL-KGDYLAEEAYLWAENERERL----RTLYHSTFNKVTTYYLECGYYTDAITLCQRVQTLHPLMETSYFLL----MQVYAKMGDNHSVKSQYEKLNHVLEAEYGIHTSDSIENWYNEWKK............................................................................................... 334
25 -12.400[L] COG2255 Holliday junction resolvasome, helicase subunit  ali follow..  17  20...................................................................................................................DRAIRPKLLTEYVGQPHVREQMEIFIQAAKQRGDHVLIFGPPGLGKTTLANII--------------------ANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGERSIKLDFTLIGATTRALTSPLRD---RFGIVQRLEFYQ---------VADLEHIVSRSAKCLGLE-------LTPEGAHQLARRS--GTPRITNRLLRRVRDFAEVRAD-GAINGEVAMKALDMLNVDAEGFDFMDRKLLLAVIDKFMGGPVGLDNLAAAIGEERETIEDVLEPYLIQ 307
26 -12.100[R] COG2842 Uncharacterized ATPase, putative transposase  ali follow..  16  1............................................................MTLINKLKQHLSDSQI-LAREAGVNAGALSAYLNDNYKGNIADVEAKLAAYLEKKAVQAREFVEAPAFIETATSRQIFKTLEFAQIANCLATVYGMSGVGKTKAIQEFAKSHANVWLVTASPSRSSLSEILIALELGISDAPRRKGTLSRLIARKIKGTEGLLIVDEADHLPYEA-LEELRIMQEEA------------GIGLVLVGNDKVYTRMKGGISPSHEYARLSRVAKNTSIQKTKKADTQAVAQAWGLETDEEALKVMQSITET----------GGGLRILTQTYACRNGSKR......................................................................... 282
27 -11.400[R] COG2607 Predicted ATPase (AAA+ superfamily)  ali follow..  12  46................................................................................................................LEHLPDPHTFPLVRLAGVGRQTELLVRNTEQFIVGRPAVLMSGARGTGKSSLVKALLHEYADKGLRLIEVDKSDLIGLPYLLTLLKECPEKFI-----------------VFCDDLSFESGDETYKALKTALD------GGLSQRCANVLVYATSNRRMRGEIHQKEAVEEKISLSDRFGLWLSFYPFDQNDYLAAVQNWLEDFGVPYDETAQMAALQWAQTRGSRS-----RSAWQFACDWAGRLPKQRAL.................................................................... 287
28 -11.300[O] KOG0739 AAA+-type ATPase  ali follow..  16  118...................................................................................................................VMEKPNIRWNDVAGLEGAKEALKEAVTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNST--FFSVSSSDLMSKWLESEKL--VKNLFELARQHKP--------SIIFIDEVDSL--ENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIVLDSAIRR-RFEKRIY-------IPLPEEAARAQMFRLHLGSTPHNLTHELARKTEGYSGADISIIVRDSLMQPVRKVQSATH................................................................................ 354
29 -11.100[O] COG1219 ATP-dependent protease Clp, ATPase subunit  ali follow..  17  67..................................................................................................................APKEIRTILDQYVIGQERAKKVLAVAVDDIELGKSNILMIGPTGSGKTLLAETL---ARLLNVPFTIADAT----TLTEAGYVGEDVENIIQKLQKCDYDVEKAQMGIVYIDEIDKISRGVQQALLKLIEGTVARKHPQQEFLQVDTRICGGAFAGLERVIQNRSLIPEFVGRLPVI-ATLDELDE--AALMQILTEPKNALTKQYAKLFEEFRPDALKAVARKALERKTRGLRSILEGIL............................................................................. 380
30 -11.100[R] COG1223 Predicted ATPase (AAA+ superfamily)  ali follow..  20  98.....................................................................................................................IVRDITLDDVVGQEEAKRKAKVILEYLKWAPKNVLFYGPPGTGKTMMAKAL---SNEAKTPFLSVKSTKLIG-------------EHVGDGARRHELYERARQLAVFLDEFDAIALDRGYQEIRGDVSEIVNAL-DGTNSNEGICTIAATNRELLDASIRSRFEEE-------IEFRLPSYEERLE----ILRRNLEEFPVPVKARLELVAAAS---------EG--RDLVEKVIKASLHK-------------------------AIAEGKDKIETEDLLTAAEKVKMPSRQPPKQMFV............... 352
31 -10.800[L] COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  18  22.....................................................................................................RPQTVEQYI-------------QQHILGPGKPLRRALE-----AGHIHSMILWGPPGTGKTTLAEVAANYANAEVERVSAVTSGV--RAAIEKARENKLSGRRT----------------ILFVDEVHRFNKSQQDAFLPHIEDGT-------------VTFIGATTENPSFELNNA-----LLSRARVYKLT----SLNQQEILQALHQAIADTERGLGKVAAVFADNVLDRLAELV-NGDARMSLNYLELLYDMARED--DQGRKQIDLPLLAEVAGEKVSRFDNKGDIWYDLISAVHKSIRGSDPDAA.................... 275
32 -10.700[O] KOG0737 AAA+-type ATPase  ali follow..  14  414............................................................................................................................ADIGSLDETKESLQELVGGLLKPCRGILLFGPPGTGKTMMAKAI---ANEAGASFINVSMSTITSKWFEDE---NVRALFTLAAKVSP---------IIFVDEVDEAMRKIKNEFMTHWD-------GLMSNAGDRILVLAATNRDLDEAIIRRFERR--------IMVGLPSVESREKILRTLLSK------QELAQMTDGYSGSDLKNFCT---TAAYRPVRELIKQECLKDQERRKREEAEKNSEEGSEAKEEVSEERGITLRPLSMEDMKVAKSQVAASFAAEGAGM................. 701
33 -10.600[T] COG2198 FOG: HPt domain  ali follow..  12  2.........SNEVRAIVLRQLENWGATCI------TPDERQISQEYDLFLTD-NPSNLTA--------------SGLLLSDDESGVRKIGPGQLRVNFNMSNAMQ-EAVLQLIEEQLAQEEIPASPL-NAELHASGYYALFVDTVPDDVKRLYTEAATSDFAALAQTAH----RLKGVFAMLNLVPGKQLCETLEHLIREKD----------------------APGIEKYISDIDAYVKSLL............................................................................................................................................................................................. 190
34 -10.500[L] KOG2028 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  15  108.....................................................................................................RPRTLDDVV-------------QDHLLSPSSLLRSAVE-----SNRLPSIVFWGPPGTGKTSIAKSLNSSKDPSLYRFVSLSAVTSGVKDVRDAV-----------ESAKRLNLEGRKRTVLFMDEVHRFNKSQQDTFLPVIEDGS-------------ILFIGATTENPSFHLITP-----LLSRCRVLTLN----PLKPNHVETLLRRAVDDSERGLPNSVE-VDDSVIEFLANNC-DGDARVALNALEISATMATTR--AGTDAVVSIDDAKEALQCKHLAYDKAGEQHYNLISALHKSMRGGDANAA.................... 365
35 -10.200[O] COG0606 Predicted ATPase with chaperone activity  ali follow..  15  74....................LPKEGFDLPIALGILAASDQIARNKLEEFIGELALSGVKGV-LPAALAANQVERCLVVPHSNGDQAALVGVERHKSAQSLLE-LCGQQTLSLFQSSPSVQQVSQTRDLQDIIGQQQGKRALEIAAAGNHNLLFLGPPGTGKTMLASRLINQHNWKLRPFRAPHHSSSMAALV-------------GGTIPRPGEISLAHNGLLFLDEMPEFERKVLDSLREPLESGEIVRAQGKTRFPARFQLVGALNNPQSILRYLSRLSGPLLDRFD-MSIEIPALPKG--------TLANGGDRGESTAAVRQRVWVARERMLARSGKVNALLQSREIEQYCPLLKADAEFLESALHRLGLSIRAYHRIIKVARTIADLQRPHLAEALGYRAMDRL....................... 498
36 -9.930[O] KOG0728 26S proteasome regulatory complex, ATPase RPT6  ali follow..  14  138..................................................................................................................MVEKVPDSTYEMVGGLDKQIKEIKEVIE--IAQPKGVLLYGPPGTGKTLLARAV---AHHTECTFIRVS----------SELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIES-----GDSEVQRTMLELLNQLDIKVIMATNR--IDILDPALLRPGRIDR--KIEFPPPNEEARLD----ILKIHSRKMNLTRGINLRKIAELM------PGASG--AEVKGVCTEAGMYAERRVHVTQEDFEMAVAKVMQKDSEKNM............................................... 398
37 -9.840[O] COG1222 ATP-dependent 26S proteasome regulatory subunit  ali follow..  13  141.....................................................................................................................AKPDETYEDIGGLERQIEELNEAIV--IKPPKGVLMYGPPGTGKTLMARAC---ASKTNATFLKLA----------PQLVQMYIGDGARLVRDAFALAKERKPTIIFIDEIDAIGAKRSDS-----GDREVQRTMLELLNQLDVKIIAATNR--VDILDPALLRSGRLDR--KIEFPLPNTLGRKR----ILQIHARKMSVRDDVNFDELARST------EGFNG--AQCKAVCVEAGMAAKEKTEISQNDFMDGIQEVLSRKKSK................................................. 396
38 -9.670[O] KOG0727 26S proteasome regulatory complex, ATPase RPT3  ali follow..  14  141..............................................................................................................ISLLSQSEKPDVSYNDIGGCDIQKQEIREAVE--IDPPRGVLLYGPPGTGKTMLAKAV---ANHTTAAFIRVV----------SEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEVDAIATAILMELLNQMDG----------DQTVNVKVIMATNR--ADTLDPALLRPGRLDR--KIEFPLPDRRQKRL----VFQVCTSKMNLSDEVDLEDYVSRP------DKISA--AEIAAICQEAGMHAKNRYVILPKDFEKGYRANVKKPDTD................................................. 403
39 -9.630[O] KOG0726 26S proteasome regulatory complex, ATPase RPT2  ali follow..  14  169.............................................................................................................MVTVMKLEKAPQETYADIGGLDTQIQEIKESVE--IKPPKGVILYGPPGTGKTLLAKAV---ANQTSATFLRVV----------SELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAVGTK-EREIQRTMLELLNQLDGFDSR---DVKVIMATNR--IETLDPALIRPGRIDR--KIEFPLPDEKTKRR----IFTIHTSRMTLAEDVNLSELIMAK------DDLSG--ADIKAICTEAGLMAERRMKVTNEDFKKSKESVLYRKKEGT................................................ 433
40 -9.550[O] KOG0740 AAA+-type ATPase  ali follow..  15  377.....................................................................................................KNLEPKMIELIMNEIMDHGPVNWEDIAGVEFAKATIKEIVTGLRGPPKGILLFGPPGTGKTLIGKCI---ASQSGATFFSISASSLTSKWVEGEKM--VRALFAVARCQQP--------AVIFIDEIDSL--DGEHESSRRIKTEFLVQLDGATTSSEDILVVGATNREIDEAARR-RLVKRLY-------IPLPEASARKQIVINLMSKEQCCLSEQIVQQSDAFSGADMTQLCRGASLGPIRSLQTA-DIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLEL............................................. 662
41 -9.550[O] KOG0652 26S proteasome regulatory complex, ATPase RPT5  ali follow..  15  161..................................................................................................................EVDEKPTEDYNDIGGLEKQIQELVEAIVL-VRPPKGVLLYGPPGTGKTLMARAC---AAQTNATFLKLA----------PQLVQMFIGDGAKLVRDAFQLAKEKAPCIIFIDEIDAIGTK-DREVQRTMLELLNQLDGFSSD---RIKVIAATNR--ADILDPALMRSGRLDR--KIEFPHPTEEARAR----ILQIHSRKMNVHPDVNFEELARST------DDFNG--AQLKAVCVEAGMLARDATEVNHEDFNEGIIQVQAKKKAS................................................. 419
42 -9.530[O] KOG0651 26S proteasome regulatory complex, ATPase RPT4  ali follow..  15  143.....................................................................................................................DPGNISYSDVGGLAEQIRELREVVE--ITPPKGCLLFGPPGTGKTLLARAV---ASQLDCNFLKVV----------SAIVDKYIGESARMIREMFNYARDHQPCIVFMDEIDAIGGR-DREIQRTLMELLNQLDGFDSL---KVKVIMATNR--PDTLDPALLRPGRLDR--KIEIGLPNEQSRLE----ILKIHSNKITKHGEIDFEAVVKLS------DGFSA--ADLRNVCTEAGMFAAEREFVIDEDFMKAVRKVGDAK.................................................... 395
43 -9.410[R] COG0714 MoxR-like ATPases  ali follow..  20  13...........................................................................................................................SQTIVGKDEAIRLVLVAL-----SGGHALLEDVPGVGKTLLAKSL-ARSINGKFQRVQCTPDLLPTDITGTNIWNPSSREFE-----LPGPA----ANILLADEINRATPRTQAALLEVMEEKQVTVDGETRLVPHPFFVIATQN-EYQGTFPLPEAQLDRF--ALSLSLGYPSEAEELKML............................................................................................................................... 181
44 -9.090[LD] KOG2227 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase  ali follow..  12  124............................................................................................................................STILCREDEQIRIFEFVKGCQQKAGSLYICGCPGTGKSLSMEKVVQQVGDWSTQTLSVNCTSLSK---TTDIFSKILGEIKPGKNANTNSSPLQH--LIIADEMDYLITKDRGVLYDLFM---------TTLPFSRCILIGVANADLADRFLPKLKSL----NCKPMVITFRAYS--KDQILRILQERLRVLSYVA------FQPKALELCAR---SGDMRKALCVCRSALEILEIETRGSTGPESQGPTPDDSVVRMDHMAAALSKTFKSPVVETIQSLPQHQQIIICAA................. 418
45 -9.020[R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain  ali follow..  12  135..................................................................................................................................TKSTQENLNRITPYLVQKRPILLAGPEGIGKKFLITQI---AAKLGQQIIRIHLSDSTDP---KMLIGTYTSPKPGEFEWQPGVLTQATGKWILFTNIEHAPSEVLSVLLPLLEKRQIPSRGETIYAKGSFQMFATSS-------MKTKILGQRLWQILDLTYQPDECVEVVSTLYPVLSIICPTLYSVYKDIFDLFSQRSFLATSKIYRRLCLRDFYKFIKRVA............................................................................. 350
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Awobuluyi M, Yang J, Ye Y, Chatterton JE, Godzik A, Lipton SA, Zhang D. Subunit-specific roles of glycine-binding domains in activation of NR1/NR3N-methyl-D-aspartate receptors. Mol Pharmacol. 2007 Jan;71(1):112-22. Epub 2006 Oct 17.