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Query: ACL93473.1, from C.crescentus

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAQFQTLIVEAPESAPGVTLIRLNRPEALNALNTALLGELAQALAAAQADDSVGCIVLTGSAKAFAAGADIKEMSDKTYAQMFKADFFTAGARAIEQCRKPIIAAVAGYALGGGCELAMMCDFILAADTAKFGQPEINLGVAPGIGGTQRLTRFVGKSKAMDMILTGRMMGAEEAERSGLVSRIFPADSLVDETLAIAAKIAGQSPLAVAMNKELVEAAYETTLTTGVALERRLFHSLFAFEDQKEGMTAFVEKRKPLFKGALast
1 -100.000[I] KOG1680 Enoyl-CoA hydratase  ali follow..  49  8............GAAENVALITLNRPSALNALCRELMLELSENLLKVEKDQSYHVIVLTGSEKAFAAGADIKEMAKLEFADVF-ENDYFTNWDTLSHITKPVIAAVNGFALGGGTELALMCDIVYAGENAIFGQPEITIGTIPGLGGTQRWPRYVSKSVAMEICLSGDRLGAQEAKEDGLVSKVFPVQQLVGEAVLLADRIAKNSPLIVKTVKRSLNSAYQTSLNQGLEMEKQLFQSTFATNDRREGMSAFAEKRAPKWTSS 256
2 -95.900[I] COG1024 Enoyl-CoA hydratase/carnithine racemase  ali follow..  31  3.EEFKDIIYEEK---GQVAWVTLNRPATYNAFTPVMNREVTVALKKANQSDAIRAIVLTGTGRAFCSGEDLDGVTVDTDHGAILRARYHPMMQGMKQVEKPIIAAVNGTAAGAGMSLALAADFRLVHENAKFVSAFLGVGLIPDSGFLYQLPRMIGYAKALELAVLGKPLSAEDAQRCGLVTEVFAADEWEDGVASFSMKLAALPTKAIGLIKRLMIDGMNEGFLEVLEKEAQAQRIAGQSADHREGLEAFKQSRPPMFTG. 259
3 -92.400[H] COG0447 Dihydroxynaphthoic acid synthase  ali follow..  32  21..GYSDIRYHKST--DGIAKITINRPEVRNAFRPQTVKEMMTAFSDARFDENIGVIVLTGEGKAFCSGGDQKVRGDYGGYKDDSHLNVLDFQRDIRSCPKPVVAMVAGYAIGGGHVLHMLCDLTIAAENAIFGQTGPKVGSFDGGWGASYMARLVGQKKAREIWFLCRQYNAQEALDMGLVNTVVPYADLEKETVRWCREMLRNSPIAIRCLKAALNADCDGQA-GLQELAGNATMLFYMTEEGQEGRNAFNEKRAPDFSK. 280
4 -87.700[I] KOG1679 Enoyl-CoA hydratase  ali follow..  34  1...................................MVETFNDVLEDIKKDNGSRVVVLRSLSGIFCAGADLKERKGMTPEEATEVKELRGLLIAIEQLPMPVIAAVDGAALGGGLEMALACDIRTAASDTKMGLVETRLAIIPGAGGTQRLPRILSPALAKELIFTARVFNGAEAKDLGLVNHVVKQNETYQQALKLAEEILPNGPVGVRMAKLAIDKGMQVDLATGYSIEEICYSQVIPTKDRLEGLAAFAEKRKPVYKG. 232
5 -79.500[I] KOG0016 Enoyl-CoA hydratase/isomerase  ali follow..  24  54ASTYRDIVVKKED---GFTQIVLSRSTEKNALNTEVIKEIVNALNSAAAD-DSKLVLFSAAGSVFCCGLDFGYFVKHLRNNLEMVDTIKNFVNTFIQFKKPIVVSVNGPAIGLGASILPLCDLVWANEKAWFQTPYTTFGQSPDGCSSITFPKMMGKASANEMLIAGRKLTAREACAKGLVSQVFLTGTFTQEVMIQIKELASYNPIVLEECKALVRCNIKLELEQANERECEVLRKIWSSAQGIESMKAAFPPRKTQNDQ. 324
6 -48.000[I] KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase  ali follow..  29  36............EKQGDVAVMKIDLPTTENVLNKALFAEMNETLDRLQSDQSVKAIVVMGKPNSFVAGADIQMFKAEKTAAGVSLREGQKQLLTIELSQKPIVAAIMGSCMGGGLEIALACHYRIAVNDTLLGLPEVTLGIMPGDGGTQRLPKLTTVQNVLDLTLTGKRIKANKAMKIGIVDRVIQPLGDGICTSTETTH-KYLEEIAVQSARELANRTAYLDPKNGYEAEAKAFGELSQTFQSKALFGLFEGSTN...... 340
7 -44.700[I] KOG1684 Enoyl-CoA hydratase  ali follow..  25  15............TESSNKGMIILNRPKALNAINLEMVRKIYKHLKKCEKSKSL-VIIKGTGDKAFCAGGDVRALVEAGPTDESKSFFREETNALIGNYKIPYIAIIDGITMGGGVGLSVHGKYRVASDRTLFAMPETAIGLFPDVGGSYFLPRLQG-KLGLYLGLTGYRLRGADVYYSGIATHYCESSKIPD-AKKTLETLSKMSPTSMKVTFRQLELGSQLSLAQCLIMEYRLAVRHLERSDFKEGVRALLKDQKPQWQ.. 324
8 -10.600[OU] COG0616 Periplasmic serine proteases (ClpP class)  ali follow..  20  350.....................................DTTASQIRDARLDPKVKAIVLSPGGSVNAS------------------EVIRAELAAARAAGKPVVVSMGGMAASGGYWISTPANYIVASPSTLTG----SIGIFGVINTVENSLSSIGVHEQIDKIAQGHVWTGEDAKANGLVDSLGDFDDAVAKAAELAK............................................................... 541
9 -9.380[I] COG0777 Acetyl-CoA carboxylase beta subunit  ali follow..  17  112....EAVVTGTALIKGQTVALGIMDSNFIMASMGTVVGEKITRLFEYATVEKLPVVLFTASG-----GARMQE----GIMSLMQMAKISAAVKRHSNAGLFYLTILTDPTTGGVTSFAMEGDIILAEPQSLVGF-----------AGRRVIENTVRESLPEDF-------KAEFLLEHGFVDAIVKRRDLPDTIASLVRLHGGSP......................................................... 287
10 -7.350[O] KOG0840 ATP-dependent Clp protease, proteolytic subunit  ali follow..  13  111.............................QPINAQVAQRVISQLVTLASIDDKSDIYLNCPGGSTYSVLAI--------------------YDCMSWIKPKVGTVAFGVAASQGALLLAG-----GEKGMRYAMPNTRVMIHQPQTGVNEAIEARQKIDRMYAAFTGQPLSASEALEFGLIDGLLETE.......................................................................... 270
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.