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Query: ACL93475.1, from C.crescentus

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTMKGGVASQDFSAAIATACEPAANVWSKVCVALKRELGDAAFGSWIAPAMLREAATGDVVLVTSTGIARDWIRRSAWRRIGELWAAHDATGRRIDLKSRLEFEAAAGAYVEATPKAVAAEPIEIVLPVSTDAPTVVAPSAKSPRTQGLQERFTFETFVPGPANEFAHAVARRIANWADGHFNPVLFHGPYGFGKTHLLNALAWEAMRNAPEKRVVYLTAERFLSTFVRAVMDRQTAAFKEELRAADLLIIDDVHFIAGKQSTQEELFHTLTALVGEGGRVVFSADRPPSAMTEMDAHLRSHLSAGLVCGLEPADRNLRLGILERKIQTLGAAHGFEPSIRPEVMQFLADRFTDSVRELEGALNTLSARAGEGLSRMTLDEVQAILRPHLRSGEKRITIDDIQKATAEHYGMKQADLLSERRNRAVARPRQAAMWLAKQLTTRSLPDIGRRFGGRDHTTVLHAVRRIEALRAEDSALSHDLETLTRKLRGLast
1 -117.000[L] COG0593 ATPase involved in DNA replication initiation  ali follow..  32  2.....................NLSNLWQSCLLQLQDQVSASDLSTWLRPLQADVVADNHIVLYASNMFVKGWVETHYLAQIQQICQTLAQNPELRISLKEGVKPAP----------KIVESTPNTSLRSESAVDFQAESSASVKFESHLNTKHLFDNFVEGKSNQLARAVGQKLAQAPGESANPFFLYGGTGLGKTHLLHAIGNGILADKPNARVLYIHANNFMQHMVKAVRDNKMDQFKKFYRSLDALLVDDIQFFAEKEKTQEEFFHIFNSLFETGRQIILTSDRYPKEIEKIEERLKSRFGWGLTTAIEPPDLETRVAILLKKAEEHNM------NLPEEVAFFIAQRLRTNVRELEGALNRVKAMQDFKGGDIDIDFVRDTLKDILALQERLVTIENIQKVVAEYYRIKVSDLKSKSRARSVTRPRQIAMALAKELTNRSLPEIGRAFD-RDHTTVLNACREVPKFREQDNSIQEDWANLIRTLSA 454
2 -22.500[L] COG1484 DNA replication protein  ali follow..  20  80.......................................................................................................................................................QLGFKEFRTEGKPQCTKEYVADYEQIKDCRKNSIALLGQPGSGKTHLLTAAANELMRTC-YVPVIYFPFVEGFTDLKNDFALLE--AKLNRMKQADVLFIDDL---NGKPRQLEQMYSVLNYRYLNHKPILLSSELTIEGLVRVDEALGTKIY-DYLVIIKGAAYELNHRLEGVR.................................................................................................................................................................... 266
3 -14.900[L] KOG2028 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  17  58...................................................................................................PKALAPAMGDDSSKRPNPKTQIHVAADDSNKRHKLSSSSHRQHQPLSERMRPR-TLDDVV-GQDHLLSPSSLLRSAVESNRLPS-IVFWGPPGTGKTSIAKSLINSSKDPSLYRFVSLSAVTSGVKDVRDAVESAKRLNLEGRKRT--VLFMDEVHRF---NKSQQDTF--LPVIEDGSILFIGATTENPS---HLITPLLSRCR---VLTLNPLKPNHVETLLRRAVDDSERGLPNSVEVDDSVIEFLANNCDGDARVALNALEISATMAT-TDAVVSIDDAKEALQ------CKHLAYDKAGEQHYNLISALHKSMRGGDANAAIYWLARMPLYIARRLIRFASEDIG......................................... 395
4 -13.800[O] KOG0730 AAA+-type ATPase  ali follow..  13  550........................................................................................................................................................................................VLFYGPPGCGKTLLAKAIANEC-----QANFISVKGPELLTMWFGESEANVREIFDKARQSAPVLFFDELDSIATQRGNSAQLLTEMDGMNAKKTVFIIGATNRPDII---DSALLRPGRLDQLIYIPLPDEDSRLNIFKACLRKSPVAKDVDVTLAKYTQGFSGADITEICQRACKYAIRENIEKDIENERRRSQNPEAMEEDMVDDEVSEIRAAHFEESMKYA-SVSDADIRKYQAFAQRGFGSEFRFDVGRTTGVAAADPFATSA...................................... 833
5 -13.500[R] COG1223 Predicted ATPase (AAA+ superfamily)  ali follow..  17  99.....................................................................................................................................................VRDITLDD-VVGQEE-----AKRKAKVILEYLRNPVLFYGPPGTGKTMMAKALSNEA-----KTPFLSVKSTKLIGEHVGDGARRVHELYERARQLAPIVFLDEFDAIALDSEIVNALLTELDGTNSNEGICTIAATNRV---ELLDASIRSRFEEEIEFRL--PSYEERLEILRRNLEEFPVPVKARLEVAAASEGFSGRDLVEKVIK-----ASLHKAIAEGKDKIETEDLLTAAEKVKMPSRQPPKQMFV........................................................................................ 352
6 -13.300[L] COG2255 Holliday junction resolvasome, helicase subunit  ali follow..  16  9......................................................................................................................................SAAVINDEESIDRAIRPK-LLTEYV-GQPHVRE-EIFIQAAKQRGDALDHVLIFGPPGLGKTTLANIIANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPH------------DVLFIDEIHRL--SPVVEEILY----PAMEDYQLDIMIGEGPAARSIKLDSPLRDRFG--IVQRLEFYQVADLEHIVSRSAKCLGL------ELTPEGAHQLARRSRGTPRITNRLLRRVRDFAEVRADGAINGEVAMKALDMLNVDAEGFDFMDRLDNLAAAIGEERETIEDVLEPYLIQQGFIQRTPRGRIATNHAYKHFG......................................... 329
7 -13.000[O] KOG0741 AAA+-type ATPase  ali follow..  13  256........................................................................................................................................................................................ILLYGPPGCGKTLLARQIGKMLNARE----PKVVNGPEILNKYVGESEANIRKLFADAEEGLHIIIFDEIDAICKQDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLR--GRLE--VKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVD-------IKELAVETKNFSGALEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERL...... 608
8 -12.500[O] KOG0737 AAA+-type ATPase  ali follow..  13  408.....................................................................................................................................................EIGVTFAD--IGSLDETKESLQELVM--KGGLLKPILLFGPPGTGKTMMAKAIANEA-----GASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPIIFVDEVDSMLGQRKIKNEFMTHWDGLMSNAGDLVLAATNRPFDL---DEAIIRRFERRIMVGL--PSVESREKILRTLLSKEKTENLDFQELAQMTDGYSGSDLKNFCT--TAAYRPVRELIKQECLKDQERRKREEAEK--SEEGSEAKEEVSEERGITLRPLSMEDMKVAKSQVAASFAAEGA......................................................... 699
9 -12.400[O] COG1222 ATP-dependent 26S proteasome regulatory subunit  ali follow..  14  185........................................................................................................................................................................................VLMYGPPGTGKTLMARACASKT-----NATFLKLAGPQLVQMYIGDGARLVRDAFALAKERKPIIFIDEIDAIGAKQRTMLELLNQLDGFSSSEEVKIIAATNRVDILDPALLR--GRLD----IEFPLPNTLGRKRILQIHARKMSVRDDVNFDLARSTEGFNGAQCKAVCV--EAGMAAL----RKEKTEISQNDFMDGIQEVLSRKKSKLLY........................................................................................... 399
10 -12.400[O] KOG0728 26S proteasome regulatory complex, ATPase RPT6  ali follow..  16  185........................................................................................................................................................................................VLLYGPPGTGKTLLARAVAHHT-----ECTFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPIIFMDEIDSIGSSQRTMLELLNQLDGFEATKNIKVIMATNRIDILDPALLR--GRID----IEFPPPNEEARLDILKIHSRKMNLTRGINLRIAELMPGASGAEVKGVCT--EAGMYAL----RERRVHVTQEDFEMAVAKVMQKDSEKNMSI.......................................................................................... 400
11 -12.200[O] COG0464 ATPases of the AAA+ class  ali follow..  16  253........................................................................................................................................................................................VLLQGPPGTGKTMLAKAVANES-----DAYFISINGPEIMSKYYGESERAIREIFEDAEKNAPIIFLDEIDSIAPKRRVVAQLLSLMDGLKARKNVIVIGATNRPEAL---DIALRRPGRFDREIELRVPDTEGRLEIFQIHTRGMPLADNVNLMFAQITYGFVGADIAALCREAMSALRRILPKINLNEPEISKEILDALLERVKELLKEVVEWPLKNPESYRDIGVEAPKLYGPPGTGKTLLAKAIAHESDANFITAKGSDLLSKWYGESEKRIAEVFTRARQVAPS---FLDELDSLAPI... 597
12 -12.100[O] KOG0727 26S proteasome regulatory complex, ATPase RPT3  ali follow..  13  192........................................................................................................................................................................................VLLYGPPGTGKTMLAKAVANHT-----TAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPIIFIDEVDAIATAQRILMELLNQMDGFDQTVNVKVIMATNRADTLDPALLR--GRLD----IEFPLPDRRQKRLVFQVCTSKMNLSDEVDLEYVSRPDKISAAEIAAICQ--EAGMHAV----RKNRYVILPKDFEKGYRANVKKPDTDFEF........................................................................................... 406
13 -12.000[LD] KOG2227 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase  ali follow..  9  126..............................................................................................................................................................ILCREDEQIRIFEFVKGCIDQQKAGSLYICGCPGTGKSLSMEKVVQQVGDWSPPVDTLSVNCTSLSKKILGEIKPGKSQKQESSSSRMMLIIADEMDYLITKD--RGVLYDLFMLTTLPFSRCILIGVANAIDLDRFLPKLKSLNCKPMVITFRAYSKDQILRILQERLRV------SYVAFQPKALELCARKVAAASGDMRKALCVCRSALEILEIETRGSTGPE--SQGPTPDDSVVRMDHMAAALSKTFKSPVVETI-----QSLPQHQQIIICAAAKAFRGSKKDA---------GELNKLYLEICKSWMISPAGITEFTNMCTVLND 464
14 -12.000[O] KOG0733 Nuclear AAA ATPase (VCP subfamily)  ali follow..  15  529........................................................................................................................................................................................VLLWGPPGCGKTLLAKAVANES-----KANFISIRGPELLNKYVGESERAVRQVFLRARASSPVIFFDELDAMVPRRDDSLTLLTELDGLSDRSGVYVIAATNRPDIIDPAMLR--GRLD----LLVDLPDAHERVEILKTLTKQTPLHEEVNLDRDERCSNFSGADLAALVREAAVTALRSAVFADIASNEPEITQHSALEPIRVTNADFELAFKNIKPSVS................................................................................... 756
15 -12.000[O] KOG0726 26S proteasome regulatory complex, ATPase RPT2  ali follow..  15  221........................................................................................................................................................................................VILYGPPGTGKTLLAKAVANQT-----SATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPIVFIDEIDAVGTKQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIR--GRID----IEFPLPDEKTKRRIFTIHTSRMTLAEDVNLS-----------ELIMAKDDLSGAIKAICTEAGLRRMKVTNEDFKKSKESVLYRKKEGTPEG.......................................................................................... 436
16 -12.000[R] COG2607 Predicted ATPase (AAA+ superfamily)  ali follow..  15  60..............................................................................................................................................................LAGVGRQTELLVRNTEQFIVGRPANNVLMSGARGTGKSSLVKALLHEY--ADKGLRLIEVDKSDLIGYLLTLLKECPEK----------IVFCDDLSFESGDETYKALVYATSNRRHENAGTTGMRGEIHQKEAVEEKISLSDRF--GLWLSFYPFDQNDYLAAVQNWLEDFGV--PYDETAQMAALQWAQTRGSRSGRSAWQFACDWAGRLPKQRA................................................................................................................... 286
17 -11.800[O] KOG0739 AAA+-type ATPase  ali follow..  15  163........................................................................................................................................................................................ILLFGPPGTGKSYLAKAVATEA----NNSTFFSVSSSDLMSKWLGESEKLVKNLFEARQHKPSIIFIDEVDSLCGSRNENEEFLVQMQGVGNNNDGTVLGATNIPWVL---DSAIRRRFEKRIYIPL--PEEAARAQMFRTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSATTRPTVNADDLLKV....................................................... 426
18 -11.700[O] KOG0652 26S proteasome regulatory complex, ATPase RPT5  ali follow..  15  208........................................................................................................................................................................................VLLYGPPGTGKTLMARACAAQT-----NATFLKLAGPQLVQMFIGDGAKLVRDAFQLAKEKAPIIFIDEIDAIGTKQRTMLELLNQLDGFSSDERIKVIAATNRADILDPALMR--GRLD----IEFPHPTEEARARILQIHSRKMNVHPDVNFELARSTDDFNGAQLKAVCV--EAGMLAL----RRDATEVNHEDFNEGIIQVQAKKKASLN............................................................................................ 421
19 -11.500[L] KOG0990 Replication factor C, subunit RFC5  ali follow..  11  13........................................................................................................................DEIQPRKPINKGKDVVGFGPPPQSKATPWVEKYRPQSLVAAH-RDIIDTIDRLTNEN---KLPHLLLYGPPGTGKTSTILAVARKLYGPKYRNMILELNASD--DRGIDVVRQASTQSFSLGKSSVKLVLLDEADAMT--KDAQFALRRVIEKYTKSTRFALIGN-----HVNKIIPALQSRCTRFRFAPLDGVHMSQRLKHVIEA---------ERLVVSDCGLAALVRLSNGDMRKALNILQSTHMASKEITEEESKQITEEDVYLCTGNPLPKDIEQISHWLLNKPFDECYKDVSEIKTRKGLA-IVDIVKEITLFIFKIKMPSAVR-------VQLINDLADIEYRLSFGCNDKLQLGAIISTF.. 357
20 -11.500[O] KOG0651 26S proteasome regulatory complex, ATPase RPT4  ali follow..  15  187........................................................................................................................................................................................CLLFGPPGTGKTLLARAVASQL-----DCNFLKVVSSAIVDKYIGESARMIREMFNYARDHQPIVFMDEIDAIGGRQRTLMELLNQLDGFDSLGKVKVIMATNRPDTLDPALLR--GRLD----IEIGLPNEQSRLEILKIHSNKITKHGEIDFEVVKLSDGFSAADLRNVCT--EAGMFAI----RAEREFVIDEDFMKAVRKVGDAKRLETKLD.......................................................................................... 402
21 -11.400[H] COG1239 Mg-chelatase subunit ChlI  ali follow..  12  58..............................................................................................................................................................VVGYDDTVIPQLVNALLARQN-----FILLGLRGQAKSRILRAITELLLPRADRYVEKLATPDVTVADLIGDVDPIKAARLGTSLGD-GIFAVNELADLSPKNILQEGDVQIKGYPIRLELDVMLVFSANPEDYTAIVTPLKDRI--GSEIRTHYPDVQLGMDITAQEAVKEE-----GVVVPPFIAELIED-IAFQAREDGRIDKLSGVSQRLPISLMELACANAERRSLVSGDAPVVRVTDVYAGLPA--------ITGKMELEYEGELKGADNVAKDLIRKAAGAAYARSYGSADTRELEKWFDQGNVFRFPQGGDASAALKATGEVPG 430
22 -11.400[LO] COG1474 Cdc6-related protein, AAA superfamily ATPase  ali follow..  12  33....................................................................................................................................................LRPSYTPDL-LLHRNEQINSLATILVSALRGETPSNVLIYGKTGTGKTYVGKELERVSEDKSLFCSVVYITQYRLLANLARHFEEMKFKEAIDARDQVIIIILDEIDKLIKKGDDVLYNLSRINTDLRKAKVSMIGVSNDLKFTEFLDPRVKSSLGEEELI-FPPYDAEQISDILKQRAKMA-----NDGVLGEMVIPLCAAFAAQEHGDARRAL----------------DLLRVSGEIAERENQPQVLEEHVRRAQEKIEIDRVVEVV-----RTLPTQSKLVLYSIILLRSRGREGKNVTTG-----EMYNVYRQLCHHIDVDILTQRRVTDLMSELDM 365
23 -11.100[O] KOG0740 AAA+-type ATPase  ali follow..  16  395.....................................................................................................................................................GPPVNWED-IAG---EFAKATIKEIVVWP--MLRPILLFGPPGTGKTLIGKCIASQS-----GATFFSISASSLTSKWVGEGEKMVRALFAARCQQPAVIFIDEIDSLLSQRGDGEEFLVQLDGATTSSEDLVVGATNRPQEI---DEAARRRLVKRLYIPL--PEASARKQIVINLMSKE------QCCLSEEEIEQIVQQS-------DA-------FSGADMTQLCRGASLGPIRSLQTADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDL----------------ELYENWNKTFGC.................................... 672
24 -11.000[QK] COG3284 Transcriptional activator of acetoin/glycerol metabolism  ali follow..  16  324.....................................................................................................................................................QIPPALRR-LGGDAPVI--AALQAKAAKLARTRLPILIQGETGTGKEHLARAIHEGSGLEGPFVAI-LIESELF-GAFTGASAKGRKGLIEQA--DGGTLFLDEIGDMP---ALQSRLLRVLAE-RKVRIRIVSASHRPLQTLGAFREDLYYRLN---AATLTLPALRDRPDFDWVLEQLLKRHGDGELILSPAALSALKAH-PGNIRELDNVIGVAAALAE--NGVVELGDLPDQLLANADTVGGNEASATLSLTLARRLGLDRSTVHRQIKRYRLKPHRH........................................................... 627
25 -10.900[L] COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  18  25.........................................................................................................................................................TVEQYI-GQQHILGPGKPLRRALEAGHIHS-MILWGPPGTGKTTLAEVAANYA-----NAEVERVSA---VTSGVKEIRA-EKARENKLSGRRTILFVDEVHRF---NKSQQDAF--LPHIEDGTVTFIGATTENPS---ELNNALLSRAR---VYKLTSLNQQEILQALHQAIADTERLGKVAAVFADNVLDRLAELVNGDARMSLNYLELLYDMAR-GRKQIDLPLLAEVAG------EKVSRFDNKGDIWYDLISAVHKSIRGSDPDAALYWAARMPLYIARRLLAIASEDVG......................................... 305
26 -10.800[L] COG2812 DNA polymerase III, gamma/tau subunits  ali follow..  15  6....................................................................................................................................................LYRVWRPQKLVVGQEH-ITKTLQNALVQ--EKFSHAYLFSGPRGTGKTSAAKIIAKAIKGITSGSIVDVMEIDAASNNGVDEIRDRDHVKFAPSEVRYKVYIIDEVHMLTTG---------AFNALLK-------TLEEPPSHAHKIPLTIISRCQRFDFKRISNDALVGRMKEILTH---------EGIEAEDEALVLVARAAEGGMRDSLSLLDQAISFA---DERVTVEDVLAITGESAQKGETAEALQLVNQLLANGKDPLVEDLIYYYRDLMLFKAPEASQLLERAQINDSFKTLAGEINDASLFAAIEILNDCQQRMRWSSHPRVALELGVVTL.. 357
27 -10.700[O] COG0465 ATP-dependent Zn proteases  ali follow..  18  146.....................................................................................................................................................QIKTSFAD-VAG-----CDEAKEEVSELVDYLREPVLMVGPPGTGKTLLAKAIAGEA-----KVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPIIFIDEIDAVGRQRGAHDEREQTLNQMLGNEGIIVIAATNRPDVLDPALLR--GRFDRQVVVGL--PDVRGREQILKVHMRRVPLDTDIDANLVNEAALFAARGNKRVVVEFEKAKDKIMMGAERRSMVMT------------EAQKESTAYHEAGHAIIGRLVPEHDPVH-----KVTIIPRGRALGVTFFLPEGDESQISTLYGGRLAEEIIYGPEKVSTGASNDIKVATSI......... 499
28 -10.700[L] KOG0991 Replication factor C, subunit RFC2  ali follow..  11  9.......................................................................................................................GAGEVEAQDSDPAPAFSKAPGSAGHYELPWVEKYRPVKLIVGN-EDTVSRLEVFAREG---NVPNIIIAGPPGTGKTTSILCLARALLGPALKDAMLELNASN-VRNKIKMFAQQKVTLPKGRHK---IIILDEADSMT--DGAQQALRRTMEIYSKTTRFALACN-----ASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEK---------ERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYS----------PEDIIGNIFRVCKTFQMAEYLK-------LEFIKEIGYTHMKIAEGVNSLLQMAGLLARL.. 344
29 -10.600[S] COG4916 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain  ali follow..  12  9...........................................................................................................................................................DVFKTVGLPPYTYVKPKHFGEVRADISQVLLIEGPSGIGKTCVVFKVFEELQWSQGRDFTYVGCRDQNAEQIIDDFLKNAAAGNALS-----VLVIDDFHLL--SQAKRMEIGSTLKRLSDRAKVILIGIPTAGVSLLSDAYDLGPRLG---SYALTRASDVEIDKLISEGEQA--------LAVLFEDRDVLLAESAGNFWLAQYVCNKVCAIEEVYETQDDAKILTFDILGIR---------GRLMAELTQRYLPIARTFAKGKRWRP................................................................. 263
30 -10.500[R] KOG2383 Predicted ATPase  ali follow..  14  132........................................................................................................................................................................................LYVYGDVGTGKTMVMDMFYAYV-EMKRKKRVHF---HGFMLDVHKRIHRLKQSLPKRK-EEACLLCFDEFQVTDIADAM---LKQLFENLFKNGVVVVATSNRPPEDL----------YKNGLQRANFVP-----IAVLKEYCNTVQLDSGIDYELPAAGKLYYLTSEADVEAVMDKLFDELAQKQNDLTRPRILKVQGRELRTFEELCERPLGASDYLELSKNFDTIFLRNIPQFTLANRTQGRRFINFYDLKRIICSASTPISSLFLHQHHDSELEQSRILMDDLGLSQAFQRTISRLTEM... 467
31 -10.500[L] KOG1514 Origin recognition complex, subunit 1, and related proteins  ali follow..  11  396..............................................................................................................................................................LPCRSKEMETAFIKGSISDDQCLGRCMYIHGVPGTGKTISVLSVMKNLKAEVSPYCFVEINGLKLASVIYEGLSGHRVERFAEGKKIGKILLIDELDVLVTRN--QSVLYNILDWPTKPNSKLVVLG----ANTMDLPEKLLPRISSRMRLCFGPYNHRQLQEIISTRLEGINA-------FEKTAIEFASRKVAAISGDARRALEICRRAAEVAD--------YRLKKSNISAKSQLVIMADVEVAIQEMFQAPHIQMKSVSKLSRIFLTAMVHELYKTGMAETSFDRVATTVHRLQKLQLNFPSDDVAFALKDNKDLPWLANYL...... 771
32 -10.500[O] KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain  ali follow..  10  541...............LIASAESTEGISPTIRRCFSHEIRSEMLSQSLQGVSQFLNISSDEFMKGLVGQTSGFLPRDLQALVADAGANLYISQESETKKINSLSDDLHGVDIHQASQIDNSTEKLTAKEDFTKALDRSKKRNASALGAPKVPNVKWDD--VGGLEDVKTSILDTVQSSGLRKRSGVLLYGPPGTGKTLLAKAVATEC-----SLNFLSVKGPELINMYIGESEKNVRDIFEKARSARPVIFFDELDSLAPADRVVSQMLAEIDGLSDSSQDLIIGASNRPDLIDPALLR--GRFDKLLYVGV-NADASYRERVLKALTR--------KFKLSEDVLYSVAKKCPST---FTGAMYALCADAWFQAAKRKVSKSDSGDMPTEEDDPDSVVVEY------VDFIKAMDQLSPSLSITELKKYEMLRDQFQGRSS................................................. 973
33 -10.400[O] KOG0729 26S proteasome regulatory complex, ATPase RPT1  ali follow..  17  212........................................................................................................................................................................................VLLFGPPGTGKTLCARAVANRT-----DACFIRVIGSELVQKYVGEGARMVRELFEMRTKKACLIFFDEIDAIGGAQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMR--GRLD---KIEFSLPDLEGRTHIFKIHARSMSVERDIRF---ELLARLCPNSTGAEIRSVEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFS................................................................................................. 424
34 -10.200[L] COG0470 ATPase involved in DNA replication  ali follow..  15  23.........................................................................................................................................................TLDEVY--GQNEVITTVRKFVDEG---KLPHLLFYGPPGTGKTSTIVALAREIYGKNYSNMVLELNASD---DVVRNQIKDFASTRQIFSKGFKLIILDEADAMT--NAAQNALRRVIERYTKNTRFCVLAN-----YAHKLTPALLSRCTRFRFQPLPQEAIERRIANVLVH---------EKLKLSPNAEKALIELSNGDMRR---VLNVLQSCKATLDNPDEDEISDDVIYECCGAPRPSDLKAVLKSILEDDWGTAHYTLNKVRSAKGLA-LIDLIEGIVKILEDYELQNEETR------VHLLTKLADIEYSISKGGNDQIQGSAVIGAIK. 328
35 -10.100[DL] KOG2035 Replication factor C, subunit RFC3  ali follow..  10  6......................................................................................................................................................DKYRPKDLLGKDGVDYHIEQANHLKFLSADCMPHLLFCGPSGAGKKTRIKCLLRELSPSNKKLEIQTVSSNYHIEMTPSDVGIYDRVVVQDLVKEMKVVVLCEADSLT--RDAQHGLRRTMEK-YANNCKIVLSCESLSRIIEPLQSRC-------IIINVPAPTDEDVTKVLRKVIERESF------LLPENVLQKIVEKSEGNLRR---AILMTEALRMENESGVAESVVEIYIQETARLILQKQSSDMLLKVRERLYELLSRCIPPTV--------KKLLEHLLPKCPPQIAREVVSEAAKFEH--------RLVLGQKAIFHLEGFVAAFMDIYLT 348
36 -9.700[O] KOG0734 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  20  276.....................................................................................................................................................MKNVTFEH-VKG-----VEEAKQELQEVVEFLKNPILLVGPPGTGKTLLARAVAGEA-----DVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPVIFIDELDSVGGKRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIR--GRFDMQVTVPR--PDVKGRTEILKWYLN--------KIKFDQSVPEIIARGTVGSGAELENLVNQAALKAAVDGKEVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIA---NKATIMPRGPTLGHVSLLPENDLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKI......... 627
37 -9.470[R] KOG2170 ATPase of the AAA+ superfamily  ali follow..  10  70.......................................................................................................................................................DADIANLLFGQHDVVVNSIKSHWYNENPRKPLVLSFHGYTGSGKNYVAEIIANNTFRLGLRSTFVIVATNDFPDNKLEEYQVELRNRILTTVQKCSIFIFDEA------DKLPEQLLGAIKPFLDYYSTFILLSNKGGGEI---ARITKEQYESGYP-QLRLEAFE---RELMNFSYNEKGGLQMSELISNHLIDHFVPFLPLQREHVRSCVGAYLRKRGRGDLVSNVDFVERVLNSL--------------------YFPESSKAFSSSGCKRVD--AKTDLEMAKIRPLLSSVHFDDEL...................................... 356
38 -9.450[R] COG1485 Predicted ATPase  ali follow..  13  75........................................................................................................................................................................................LYFYGGVGRGKSFLMDAFFGCL----PYRRKRRVHFHAFMAEIHQRLKTLKSES-AEIAKETRVLCFDEFHVSDIADAM---LGRLLENLLNEGVVLVATSNYAPSEL----------YPQGQNRSSFLP-----IALIESSLTVLNVDGGEDYRLRRPAEIFFTPANEENEAKLAKLFKEMTGITDLNPGISTIHGREIPHKAESGR-FGPRSQSDYLYLAEHYEMVFISGLEQLSPQEKAEARRLTWLI-VKLCATGAVDVNHIYTEGDFAEEFTRTASRMVEMQSEV................ 367
39 -9.360[KE] COG3283 Transcriptional regulator of aromatic amino acids metabolism  ali follow..  12  198.....................................................................................................................................................QDLSAFSQ-IIAVSAKM--KHVVEQARKLAMLSAPLLITGDTGTGKDLFAYACHQASPRSAKALNCASIPEDAVESELFGHAPEGKKGFFE--QANGGSVLLDEIGEMS---RMQAKLLRFLND-IHVDVRVICATQKNLVELGLFREDLYYRLN---VLTLNLPPLRDCPQFVARFADEQGVPRP---KLSADLSTVLTRY-PGNVRQLKNAIYRALTQLE----------------------GYELRPQDILLPDYDAATVAVGEDAMEGSLDDITSRFERSVLTQLYRSYPSTRKLAKRLG--SHTAIANKLREYGLSQKKGEE.............. 513
40 -9.210[R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain  ali follow..  11  130...........................................................................................................................................................CSLVLTKSTENLNRITPYLVQK-----RPILLAGPEGIGKKFLITQIAAKL---GQQIIRIHLSDSTDPKMLIGTYTSPKPGEFEQAVITGKWILFTNIEH------APSEVLSVLLPLLEKRQLVIPSRGETIYAKGSFQKILGQRLWQILDLTYQPDEC---VEVVSTLYPVLSIICPTLYSVYKDIFDLFSQRSFLCLRDFYKFIKRVAFMIPSDHVVISQELQDAVFKEAIDMFGAFIPSRDGFDLVVRNVALKKLSTIRSCSTNSYAFTSSSLGLLEQLAAGVQTNEVGETGTGK--TTTIQLLAGLLGQKVTVINMSQQTE........ 505
41 -9.000[O] KOG0731 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  17  314.....................................................................................................................................................KNKIYFKD-VAG-----CDEAKQEIMEFVHFLKNPALLVGPPGTGKTLLAKATAGES-----GVPFLSISGSDFMEMFVGVGPSRVRHLFQEARQAAPIIFIDEIDAIGRARGRNDERESTLNQLLTTAGVVVLAGTNRPDILDKALLR--GRFDRQITIDK--PDIKGRDQIFKIYLKKIKLDHEPSYYSQR-----LAALTPGAGADIANVCNEAALIAARHEGAVTMAHFESAIDRVIGGLEKKNRVISKLERRTVAYHESGHAVVG---LKVTIVPRGTAALGFAQYVPNEFDMTCMTLGGRAAEQVLIG--KISTGAQNDLEKVTKM......... 667
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.