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Query: ACL93479.1, from C.crescentus

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNAHATPTPAHEIDPTGATPVMAQFFEMKARQPDALIFFRMGDFYELFFDDAYKAAAALGISQTFRGTHNGQPIPMAGVPQHAAEAYLSKLIRLGFKVAVCEQMEDPAEAKKRGSKAVVRRDIVRVVTPGTLTEDGLLDARGANRLAAVALRAGQAAVASVELSTGEVEVLAVAKEGVAPILAALAPSETLVADRLLSDDSLSQTLRICGGLVQPMPSALSEPQASETRVKRLYGVETLDGFGGLSPAEIGALGLIAAHLEMTQAGRLPALRAPRRAADADVMAIDPATRSSLEIDRTQSGDRNGSLLAAIDRTVTAGGARMLASRLARPLLDVAAIDQRLDAVEWFVEHRQLRQRLREVLKGAGDMARALSRLALGRGGPRDLGCIRDTLKVGERLAGMAGGAPDPLSPPPFELEHAFKALTPALHEGLSQFLTTLEHGLGPDLPALARDGGFVAAGVRPELDQARGLRDDSRKVIAALESQLALESGVPLKIRHNGVLGYFVEATAGKADPLFQPPLNATFIHRQTLANQVRFTTVELADLDARIAQAAERALAMEVAAFEDWREQARLLADAIQIASEALARIDVASSLAEWAEDAGAVRPVVDASYAFDAKAARHPVVEAAVKRAGEPYTPNDCRLDASGETAARLSIVTGPNMAGKSTFLRQNALLAILAQSGCYVPAASFRLGVVDRLFSRVGAGDDLARGRSTFMMEMVETASILTQAGPRSLVILDEIGRGTATYDGLAIAWACAEALHDTNRCRALFATHYHELATLETRMAFVSNLSLRAKEWNGDLVFLHEAAPGPADRSYGVQVAKLAGVPAPVVVRAREVLDRLESKDQSPAKLDDLPLFAVSQAVAVTSAPAKAAPSAVETSLADLDVDGMSPREALEALYRLKGLLTALast
1 -209.000[L] COG0249 Mismatch repair ATPase (MutS family)  ali follow..  34  2..............AEKISPGMQQYLDIKQDYPDAFLLFRMGDFYELFYDDAVNAAQILELTLTSRNKNSENPIPMAGVPHHAAAEYIDKLVDLGYKVAVAEQMEDPKKA-----VGIVKRAVTQVITPGTTIDT--ANSVDNNFLVAIDFKDKHYALSYMDLSTGEFKVTELSESAVVGEIASLKAREIVAGFTLDESQL-------KVFERQMNLLISEQLEIPENLLIDLSGLTALENQ---------VASKLLAYVKETQMRDLSHLQEVEHYEIKDFLQMDFATKSSLELTANKENKKHGTLYWLLDETKTAMGTRMLRSWIDRPLISNSAIQKRMEIVQIFLDHFFERSDLIEALKGVYDLERLASRVSFGKAVPVDFLQLANSLSNVPAIKYILGMLNEA-----------PLEELKSQLDEIPELSGLINSAISENASRTITEGGIIKKGYNAQLDKYREALENGTSWIAKLEADEKAKTGITLRIDYNRKDGYYFHITQSQLNSV-----PEHFYRKATLKNSERFGSQELTEIEEIMLEAREKSSSLEYDLFMGLRTETEQYIGRLQALAKTIAEIDCLQSLSVVAEKQGYIRPTLTDGSIVEIKGGRHAVVEAVMG--AQEYVPNDIELPEQT----DIQLITGPNMSGKSTYMRQFALTVIMAQIGSFVPAETANLPIFDAIFTRIGASDNLISGESTFMVEMSEANHAIQKASSRSLIIFDELGRGTATYDGMALAQAIIEYVHDHIGAKTLFATHYHELTDLDEALDHLDNVHVATLEQNGNVTFLHKITEGPADKSYGIHVAKIAGLPQPLLERADLILQKLENKPLPAKKVAD-------EQEQLSLFDFTENSSEIIEKIKRQNVDNMTAREALNFLWELKDSL.. 840
2 -174.000[L] KOG0220 Mismatch repair ATPase MSH4 (MutS family)  ali follow..  19  8.STSPSAPAVSPVVGETRSPQGPRYNFGLQETPQSRPSVQVVSAPGTSGAAGDRSSSSSSLPCPAPN-----SRPAQGSYFGNAENTVASNFTFGASSSSARDTNYPQTLKTPLSTGNPQRSGYKSWTPQSASSSSAISAHSPSVIVAVVEGRGEIGMASIDLKNPQIILSQFADNKVITKLKILSPLEIIMSNTACAVGNSTKLFTLINVNFTTIQRKYFNETKGLEYIEQLCIAESTVLMEVQSKYCLAAVAALLKYVEFIQNSVYAPKSKICFQGSEQTAMIDSSSAQNLELLINNDYRNNHTLFGVLNYTKTPGGSRRLRSNILEPLVDIETINMRLDCVQELLQDEELFFGLQSVISRFLDTEQLLSVLNAAESKITNLIYLKHTLELVDPLKIAMKNCNTPLLRAYYGSLED---------KRFGIILEKIKTVINDDANMRTQKCYAVRSNINEFLDIARRTYTEIVDDIAGMISQLGEKYSLPLRTSLSSVRGFFIQMTTDCIA-LPSDQLPSEFIKISKVKNSYSFTSADLIKMNERCQESLREIYHMTYMIVCKLLSEIYEHIHCLYKLSDTVSMLDMLLSFAHACTLSDYVRPEFTDT--LAIKQGWHPILEKIS---AEKPIANNTYVTEG----SNFLIITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYSSFRIAKQIFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGICYAVCEYLLS-LKAFTLFATHFLELCHIDALYPNVENMHFEVQHVKNAILYTYKLSKGTEEKNYGLKAAEVSSLPPSIVLDAKEITTQITRQILQNQRSTPEMERQ------------RAVYHLATRLVQTARNSQLDPDSLRIYLSNLKKKYK. 921
3 -170.000[L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)  ali follow..  22  4KATDSRQEPTLNMDTNARRNFIKFHAKLGEKPATTVRFFDHTDRYTVHGDDCELVAKIVYKSTAFIGADKKETLQFVSMSKGNFELAVRELLVRNYRVEVYVKNSSD-------------WEIEYRGSPGNLLQEDILFSNKEVLVGNSIIGQRRVGVASVEQNDCKFQLLEFLDDDLEATVVLLGPKECLLPSIEGEYSAVKTLLDRNGVMITPKKSGDNDLLQDLNRLLRFAKGQQEDATGLKEQLASNALKTAIKYLDLVNDAGNLGHYEIKQLDLNRFVHLDSAAVAALNIMPKMPSYRWQSVLGVLDHCRTPQGHRLMGQWVKQPLRSRNIL--------------------------------------------NDRHNIVQCLLESPDTMETLSLDYLKRLKQM--------------------------VEQVVDFEAIERGEYLVKASFDSRLMELQQMMTELYSKMEELQSQELNLDGKQVKLESVAKLGHHFRITVKDDSVL---RKNKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARPTPYVRPKMLEEGALVLEDVRHPCLELQE---HVNFIANSVDFKKEE---CNMFIITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAETLSTVKNCHMAAVADADDFTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFEDEHVDKQKKEDKALLEKIQVAIQQLSTAGNNVDINVEDLTQLVTQFTKDIEQLDSDYFKSVLATS 852
4 -52.500[L] COG1193 Mismatch repair ATPase (MutS family)  ali follow..  18  1............................................................................................................................................................................................................................................................................................MNKKILETLEFDKVKA--------LFEPHLLTEQGLEQLRQ--LAPTAKADKIKQAFAEMKEMQALFVEQPHFT--ILSTKEIAGVCKRLEMGADNIEEFLLLKRVLLASRELQNFYTNLENVSL--------EELALWFEKLHDFPQLQGNLQ---------AFNDAGFIENFASEELARIRRKIHDSESQVRDVLQDLLKQKAQLLTEGIVASRNQVLPVKNTYRNKI------AGVVHDISASGNTVYIEPEVVKLSEEIASLRADERYEMLRILQEISERVRPHAAEIANDAWIIGHLDLIRAKVRFIQERQAVVPQLSENQEIQLLHVCHPLVKNA--------VANDVYFGQD----LTAIVITGPNTGGKTIMLKTLGLTQVMAQSGLPILADKSRVGIFEEIFADIGDEQSIEQSLSTFSSHMTNIVDILGKVNQHSLLLLDELGAGTDPQEGAALAMAILEDLRLR-QIKTMATTHYPELKAYGIETAFVQNASMEFDTATLRPTY--RFMQGVPGRSNAFEIAKRLGLSEVIVGDASQQIDQIEQLEEQTLESRKRLDNIREVEQENLKMNRALKKLYNELNREKETELNKAREQAAEIVDMALSESDQ 581
5 -10.100[O] KOG0743 AAA+-type ATPase  ali follow..  11  200..............................................................................INLEHPSTFDTLAMDPNAKKKIIDDLERFLKRKE-KRVGK-KRGYLLYGPPGT---------GKSSLIAAMANY--KFDVFDLELSS------IYDNGELKRVLLSTTNRSILVIEDIDCNAEVRDREAENQEDEQIKGKVTLS-------------LNFIDGLWS------SFGDERIIVFTTNHKERLDPA--LRPGRMDVHINMSYCTGLGFRTLDGLNHPLCEEIEALVDSTEVTPAE--LAEELMQDDDTDVVLRGVISFVEKRKVERSKTKKEVSICKATDDDEKQNGSLGCVKKKKKGGKQKGKGKARSKEIPQDNCGFRLTEMFPSISNISLSPSSLFTAYASLTGFLMLFRSLFNDEVPERLRS--------------TDLLNRFFTPKSKNLTMVIDEIIGFKRNQVFDAAEVYLRNKIGPETARLRVGKLPKQKHFTIYIEKGEEILDTSQKEKRYYELTFEKKLRDKVMNSYLSHVVAESEETKRDLRAVKLYSRDVRASKDDDGMAGAGWGCINLEHPSTFETLA--DPGAKKKIIDDMERFLKRREFYKRVGKAWKRGYLLYGPPGTGKSSLI--AAM------------ANYLKFDVFDLELSSIYENAQLKS--------------ILLSTTNRSILVIEDIYYGRVTLSGL----NFVDGLWSSFGDERIFTTNHKERLDPALLRPGRMDMHINMTGLGFRTLVSNYLGLGGLNHPL-VTPAELAEETDVVLRGVVSFVENRKVEISKTKELEGSTCRKLDGDDKHNVSSTNDLKKTKKKK........................... 986
6 -9.770[S] KOG4508 Uncharacterized conserved protein  ali follow..  6  502..........RTCEGDRTVRLVAMLVKLRERVLNV-IAADVKPFTLKYNRECTALYQSMINMQNGGGGGGQENMTTSTTTTTTTTK---------------SSSPNSLSTTTTTTSHNPGASATTTTTTVVKTCGPATFKQTSRKVVLQVWEVCGFLADCGQNFQFFWNFSNIHSSQTSKIRLKMHACRIIVSSSSLFSNLLRKSIAKNGKWFSSTSNKFFNEKSEKNPFFGKKWKKVV-----QAFFQKNNSKNILFFSRKKWKKVIFQ--ICSFVNSAAAPIIASGPSSNFSIISSKSDTHT-QAFESSKDVKKGVFQRFFVPENAEKGEN----RKKIDKFDE............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 855
7 -9.520[J] KOG0066 eIF2-interacting protein ABC50 (ABC superfamily)  ali follow..  14  372..........................................................................................................................................................................................................................................................................................LLIAHGRRYGL----GPNGHGKTTLLRHIATRAFAIPPN-----IDVLLCEQEVVATDKTAINTILEADVRRTEMLKKADELEK--------QFVAGDLTVQEELNDTFAELKAIGAYSAEARARRILAGLGFSKEMQDRPTNKFSGGWRMRVSLARALYLEPTLLMLD--------TNHLD----------NAVIWLDNYLQGWKKTLLIVSHDQ---SFLDNVCNEIIHLDQKKL-SMFKKMYVQKRREMIKEYEKQEKRLRELKAHQSKKAAEKKQKESLTRKQEKNKSKQQKQDEDEGPQELLARPKEYIVKFRFPEPSQLQPPILGVHN-----VTFAFPSQKPLFIKVDFGIDLTSRVA-----IVGPNGVGKSTFLKLLL---LEPQEGEQRKNHRLHVGRFDQALGSFGLVSHLSGGQKARVA----LAELC--LSAPDVLILDE----TNNLDIESIDA-LAEAINEYEGGVIIVSHDERLIRETGCTLYVIEDQTIN.................................................................................................................. 867
8 -8.460[O] KOG2004 Mitochondrial ATP-dependent protease PIM1/LON  ali follow..  12  278................................................................................................................................................................................................................................................................................................................................................................................................................................KATMMAIVQTIRDVVQFNQLFGQQILHPSQNVIDNPVYLCDLVATLVQSAE--TKDLQEMMDEIDVSKRLKIALLLIQKEKAVAKLKYDINKDVEKKVQDHH--RKYLLNEQLKVIKKELGIEKDEKTTIIEKIDERIKTLAVP--EYALKVINEEKTKLQFLDPHSSEFSVTRNYLEWLTSVPWSPENRRLSVAKKALDEGHYGMKDV----KERIMEFIAVNLLRKSIGGKILCFHGPPGVGKTSIAKSIA--------------------ALNREYFRFGMTDEIKGHRRTYVGAM--IQCMKKVKTENPLVLIDEVDKGGAGFHG---ASALLELLDPEQNAN--FNDHFLDVPDLSRVLDRMEMIDVSGYLAEEKVEIAHQHLIPQLRKDTSLATEQLSGLQQHIERIFRKAALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFV............ 771
9 -8.130[N] COG1419 Flagellar GTP-binding protein  ali follow..  12  2................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KIKKYVAESIREAMIMIRRELGENAVILSSRRIKKGGFFGIGGKTYFEVTAAVEEERKKEENTSYRLQEILVKNRQSSNDNIKGEFDEIKRTINEIKQMLVTEKRQTLPEGLSKILYGMEKQEILPEIRYKLIDFLKMKFGDLDPNSNETFKILSEQFVNLVKT-------------NAPDFKNAKVLFVGTTGVGKTTSLAKLAARFKIDE--------KKRVAILTLDTYRIAAAEQLKIYADIMDIPMKEAEYEMMALKDYDIVLVDTAGRSHQNDLQMSELRALSEAVKPNITFLVLSMNKLDDMKRIVERFSAVKPTHIILTKMDE-------------TSVYGVNISEITGLPIAFVTNGQRVPDDIFEANPVE........................................................... 356
10 -8.070[F] COG1618 Predicted nucleotide kinase  ali follow..  20  4.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EGKEKTMLRIAVTGSPGVGKSTVVAKTARTAEIRKEGHREGFSIRDLATGKTGILSHVKGSGPRLGKYHVNLDDLERANAVRNALACDLVVIDEIGP---ELISQSFVSAVEEVLES--DKPVLAVLHHSSRHPLAQRFRKGFEVLTVDKGNRDEL.......................................................................................................... 171
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.