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Query: ACL93472.1, from C.crescentus

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAREIILDTETTGFDPKTGDRLVEIGCIEVVDFMPTGRSFHEYCDPLRDMPAEAEKVHGLSSAFLTGKPKFHEIADRFLDFVGDSVVVAHNAAFDRQFVNFELEKCGKAPIHEERWVDTLAMAKKRFPGMYNSLDALCKRFKISLESRDKHGALIDAHLLAEVYLELQGGKERALELTHSTGAMAVSTAIQGVYAARSRPLAPRSTDAEREIHAAWVRKNLKDKALWIQFGVVAAEALast
1 -58.300sp|Q9BQ50|TREX2_HUMAN Three prime repair exonuclease 2 OS=Homo sapiens GN=TREX2 PE=1 SV=1  ali follow..  23  50AETFVFLDLEATGLPSVE-PEIAELSLFAVHRSSLENDKLTLCMCPERPFTAKASEITGLSSEGLARCRKAGAVVRTLQAFLGPICLVAHNGDYDFPLLCAELRRLGARLPRDTVCLDTLPALRGLDRAQGYSLGSLFHRY-FRAEPSAAHSAEGDVHTLLLIFLHRAAELLA................................................................ 253
2 -56.600sp|Q9NSU2|TREX1_HUMAN Three prime repair exonuclease 1 OS=Homo sapiens GN=TREX1 PE=1 SV=1  ali follow..  16  66MQTLIFFDMEATGLPFSQ-PKVTELCLLAVHRCALESDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQDNLANLLLAFLRPWCLVAHNGRYDFPLLQAELAMLGLTSALDG-CVDSITALKALERAKSYSLGSIYTRL-YGQSPPDSHTAEGDVLALLSICQWRPQALLR---------VDAHARPFGTIRPMYGVTASARTKPRPSAVTTTAHLATTRNTSPSLGESRGTKD. 327
3 -46.400sp|Q9Y3B8|ORN_HUMAN Oligoribonuclease, mitochondrial OS=Homo sapiens GN=REXO2 PE=1 SV=3  ali follow..  16  41.QRMVWVDLEMTGLDIEK-DQIIEMACLITDSDNLIIKQPDELLDSMSDWCKEHHGKSGLTKAVKESTITLQQAEYEFLSFVRQCPLAGNSVHEDKKFLDKYMPQFMKH--LHYRIIDVSTVKELC-----RRWYPEEYEFAP--KKAASHRALDDISESIKELQFYRNNIFKKKIDEKKRKIIENGENEKTVS........................................... 237
4 -44.400sp|P29590|PML_HUMAN Probable transcription factor PML OS=Homo sapiens GN=PML PE=1 SV=3  ali   11  158.RPLVFFDLKIDNET----QKISQLAAVN------RESKFRVVIQPEAFFS------------IYSKAVSLEVGLQHFLSFLSRPILACYKLGPGLPNFFRALEDINRLWEFQEGFLAALPLIRERVPGSSFKLKNLAQTYLARNMSE--RSAMAAVLAM............................................................................. 300
5 -43.700sp|P29590|PML_HUMAN Probable transcription factor PML OS=Homo sapiens GN=PML PE=1 SV=3  ali   10  8.RPLVFFDLKIDNET----QKISQLAAVNRE------SKFRVVIQPEAFFS------------IYSKAVSLEVGLQHFLSFLSSPILACYKLGPGLPNFFRALEDINRLWEFQEGFLAALPLIRERVPGSSFKLKNLAQTYLA--RNMSERSAMAAVLAMRDLCRLLEVSPGP................................................................ 163
6 -43.000sp|O43414|ERI3_HUMAN ERI1 exoribonuclease 3 OS=Homo sapiens GN=ERI3 PE=1 SV=2  ali follow..  15  143YHYFLVLDFEATCDKPQI-QEIIEFPILKLRTMEIEST-FHMYVQPVVQLTPFCTELTGIIQAMVDGQPSLQQVLERVDEWMAKEGLLDPNVKSLKVMLPGQCQYLGLPADYFKQWINLKKAYSFAMGCPKNGLLDMNKGLSLQHIGR-PHSGIDDCKNIANIMKTLAYR................................................................... 326
7 -40.600sp|A8K979|ERI2_HUMAN ERI1 exoribonuclease 2 OS=Homo sapiens GN=ERI2 PE=2 SV=2  ali   14  34FDYLIVIDFESTDGKHHHSQEIIEFPAVLLNSTGQIDSEFQAYVQPQEILSEFCMELTGIKQAQVDEGVPLKICLSQFCKWIHKIQQQKNIIFATGICLEYECKRKQLLPVFLNSWIDLRATYKLFYRRKPKGLSGALQEVGIEFSGR-EHSGLDDSRNTALLAWKMIRD................................................................... 232
8 -39.900sp|Q8IV48|ERI1_HUMAN 3`-5` exoribonuclease 1 OS=Homo sapiens GN=ERI1 PE=1 SV=3  ali follow..  14  127YDYICIIDFEATGNPPEFVHEIIEFPVVLLNHTLEIEDTFQQYVRPEIQLSDFCISLTGITQDQVDRADTFPQVLKKVIDWMKLKELGTKYKSWDMSFLNIQCQLSRLKPPFAKKWINIRKSYGNFYKVSQTKLTIMLEKLGMDYDGR-PHCGLDDSKNIARIAVRMLQD................................................................... 312
9 -31.500sp|Q96AZ6|ISG20_HUMAN Interferon-stimulated gene 20 kDa protein OS=Homo sapiens GN=ISG20 PE=1 SV=2  ali follow..  19  5.REVVAMDCEMVGLGPHRESGLARCSLVNVHGAVL----YDKFIRPEGEITDYRTRVSGVTPQHMVGATPFAVARLEILQLLKGKLVVGHDLKHDFQALKEDMSG---YTIYDTSTDRLLWREAKLDHCRRVSLRVLSERL----NSLLGHSSVEDARATMELYQISQRIRAR................................................................ 171
10 -27.100sp|Q8WTP8|AEN_HUMAN Apoptosis-enhancing nuclease OS=Homo sapiens GN=AEN PE=1 SV=2  ali follow..  16  108.SKCVAIDCEMVGTGPRRVSELARCSIVSYHGNVL----YDKYIRPEMPIADYRTRWSGITRQHMRKAVPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPR--------SQTRDTTYVEPGLHTRARVSLKDLALQL----VGQHGHSSVEDATTAMELYRLVEVQWEQ................................................................ 275
11 -25.200sp|Q9GZR2|REXO4_HUMAN RNA exonuclease 4 OS=Homo sapiens GN=REXO4 PE=1 SV=2  ali follow..  16  241.TRALALDCEMVGVGPKEESMAARVSIVNQYGKCV----YDKYVKPTEPVTDYRTAVSGIRPENLKQGEELEVVQKEVAEMLKGRILVGHALHNDLKVLFLDHPK--------KKIRDTQKYKKSQVKSGRPSLRLLSEKILGLQVQQAEHCSIQDAQAAMRLYVMVKKEWES................................................................ 403
12 -24.500sp|Q9H6T0|ESRP2_HUMAN Epithelial splicing regulatory protein 2 OS=Homo sapiens GN=ESRP2 PE=1 SV=1  ali   10  26WPGSLVVLFGAT---GSDETDLILLVWQVVPRSRQVGTLHKSLVRAEAALSTQCREASGLSADSLARAEPLDKVLQQFSQLVNGDVALLGGGPYLLRVLHPEASRKNLVPDMFFSFYDLRREFHMQHPSRDLTVATMAQGLGLETDATEDDFGVWEVKTMVAVILHLLKE................................................................... 216
13 -23.900sp|Q9H9L3|I20L2_HUMAN Interferon-stimulated 20 kDa exonuclease-like 2 OS=Homo sapiens GN=ISG20L2 PE=1 SV=1  ali follow..  17  177.RKMVAIDCEMVGTGP--KGHVSSLARCSIVNGDVL---YDEYILPPCHIVDYRTRWSGIRKQHMVNATPFKIARGQILKILTGKIVVGHAIHNDFKALQYFHPKS---------TRDTSHIKADCPENATMSLKHLTKKLDIQ-VGKSGHSSVEDAQATMELYKLVEVEWEEHLA............................................................. 347
14 -23.400sp|Q96IC2|REXON_HUMAN Putative RNA exonuclease NEF-sp OS=Homo sapiens GN=44M2.3 PE=2 SV=1  ali   18  76.SPLFGLDCEMC---TSKGRELTRISLVAEGGCCV----MDELVKPENKILDYLTSFSGITKKILNPVTKLKDVQRQLKALLPDAVLVGHSLDLDLRALK----------MIHPYVIDTSLLYVR---GRRFKLKFLAKVIDIQCPDRLGHDATEDARTILELARYFLKH................................................................... 232
15 -22.700sp|Q504Q3|PAN2_HUMAN PAB-dependent poly(A)-specific ribonuclease subunit 2 OS=Homo sapiens GN=PAN2 PE=1 SV=3  ali   13  72.GDLVGLDAEFVTLNEEEAESVARITCVRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTKLRFLIDGVKFVGHGLQKDFRVINLMVPK--------DQVLDTVYLFHM---KRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKN................................................................ 256
16 -22.200sp|Q8N1G1|REXO1_HUMAN RNA exonuclease 1 homolog OS=Homo sapiens GN=REXO1 PE=1 SV=3  ali   15  8.PGIYALDCEMS---TTYGLELTRVTVVDTDVHVV----YDTFVKPDNEIVDYNTRFSGVTEADLADTSTLRDVQAVLLSMFADTILIGHSLESDLLALK----------VIHSTVVDTVLFPHRLGLPYKRSLRNLMADYQIIQDNVDGHSSSEDAGACMHLVIWKVRE................................................................... 165
17 -21.100sp|Q8IX06|GOR_HUMAN Exonuclease GOR OS=Homo sapiens GN=REXO1L1 PE=2 SV=2  ali   15  49.PGIYALDCEMC---TTHGLELTRVTVVDADMRVV----YDTFVKPDNEIVDYNTRFSGVTEADVAKTITLPQVQAILLSFFSQTILIGHSLESDLLALK----------LIHSTVVDTVLFPHYLGFPYKRSLRNLAADYQIIQDSQDGHNSSEDASACLQLVMWKVRQ................................................................... 206
18 -18.800sp|A0PJM3|GORL_HUMAN Putative exonuclease GOR-like protein OS=Homo sapiens GN=REXO1L2P PE=5 SV=2  ali follow..  17  407.PGIYALDCETT-----HGLELTRVTVVDADMRVV----YDTFVKPDNEIVDYNTRFSGVTEADVAKTITLPQVQAILLSFFSQTILIGHSLESDLLALK----------LIHSTVVDTAVL----FPHYKRSLRNLAADYQIIQDSQDGHNSSEDANACLQLVMWKVRQ................................................................... 564
19 -17.200sp|Q8N1G1|REXO1_HUMAN RNA exonuclease 1 homolog OS=Homo sapiens GN=REXO1 PE=1 SV=3  ali   15  158.PGIYALDCEMS---TTYGLELTRVTVVDTDVHVV----YDTFVKPDNEIVDYNTRFSGVTEADLADTVTLRDVQAVLLSMFSDTILIGHSLESDLLALK----------VIHSTVVDTVLFPHRLGLPYKRSLRNLMADYQIIQDNVDGHSSS................................................................................... 299
20 -16.400sp|Q8IX06|GOR_HUMAN Exonuclease GOR OS=Homo sapiens GN=REXO1L1 PE=2 SV=2  ali   12  199.PGIYALDCEMC---TTHGLELTRVTVVDADMRVV----YDTFVKPDNEIVDYNTRFSGVTEADVAKTITLPQVQAILLSFFSQTILIGHSLESDLLALK......................................................................................................................................... 293
21 -15.000sp|Q504Q3|PAN2_HUMAN PAB-dependent poly(A)-specific ribonuclease subunit 2 OS=Homo sapiens GN=PAN2 PE=1 SV=3  ali   15  11.....................................................................TLKSTYLKLRFLIDGVKFVGHGLQKDFRVINLMVPK--------DQVLDTVYLFHM---KRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKN................................................................ 106
22 -14.200sp|Q96IC2|REXON_HUMAN Putative RNA exonuclease NEF-sp OS=Homo sapiens GN=44M2.3 PE=2 SV=1  ali   22  3..................................................................................PDAVLVGHSLDLDLRALK----------MIHPYVIDTSLLYVR---GRRFKLKFLAKVIDIQCPDRLGHDATEDARTILELARYFLKH................................................................... 82
23 -13.800sp|Q9UFF9|CNOT8_HUMAN CCR4-NOT transcription complex subunit 8 OS=Homo sapiens GN=CNOT8 PE=1 SV=1  ali follow..  12  35..SYIAMDTEFPGVVVRPIGKIIQLGLFNLTEDMYSQDSIDLLANSGLQFQKHEEE--GIDTLHFAELLMTSGVVLC-----DNVKWLSFHSGYDFGYMVKLLTDSRLPEEEHESIYDVKYLMKSC-KNLKGGLQEVADQLDLQRIGRQ-HQAGSDSLLTGMAFFRMKE.................................................................... 243
24 -13.800sp|Q6NXG1|ESRP1_HUMAN(removed signalp:1-20) Epithelial splicing regulatory protein 1 OS=Homo sapiens GN=ESRP1 PE=1 SV=2  ali   11  4...............GSDEKELILLFWKVVLANKKVGQLHEVLVRPDLELTEDCKEETKIDVESLSSASQLDQALRQFNQSVSNELNIGVGTSFCLQILHPEASKKNVL................................................................................................................................ 108
25 -13.700sp|Q07864|DPOE1_HUMAN DNA polymerase epsilon catalytic subunit A OS=Homo sapiens GN=POLE PE=1 SV=5  ali   18  120..VVLAFDIETTKFPDAETDQIMMISYMIDGQGYLI--TNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETIMVTYNGFFDWPFVEARAAVHGLSKAPQCIHMDCLRWVKRYLPVGSHNLKAAAKAK................................................................................................ 281
26 -13.300sp|Q96IC2|REXON_HUMAN Putative RNA exonuclease NEF-sp OS=Homo sapiens GN=44M2.3 PE=2 SV=1  ali   14  226.SPLFGLDCEMC---TSKGRELTRISLVAEGGCCV----MDELVKPENKILDYLTSFSGITKKILNPVTKLKDVQRQLKAL............................................................................................................................................................ 300
27 -12.500sp|Q9UIV1|CNOT7_HUMAN CCR4-NOT transcription complex subunit 7 OS=Homo sapiens GN=CNOT7 PE=1 SV=3  ali follow..  10  35..NYVAMDTEFPGVVARP--KIIQLGLFNLTEDMYAQDSIELLTTSGIQFKKHEEE--GIETQYFAELLMTSGVVLC-----EGVKWLSFHSGYDFGYLIKILTNFEILRLFFPVIYDVKYLMKSC-KNLKGGLQEVAEQLELERIGPQ-HQAGSDSLLTGMAFFKMRE.................................................................... 243
28 -11.900sp|O95453|PARN_HUMAN Poly(A)-specific ribonuclease PARN OS=Homo sapiens GN=PARN PE=1 SV=1  ali   20  110............................................................EQEELNDAVGFSRVIHAIAN--SGKLVIGHNMLLDVMHTVHQFYC--------PRLLDTKLMASTQ---NNTSLAELEKRLKYDTASEQLHEAGYDAYITGLCFISMAN.................................................................... 245
29 -10.900sp|A8K979|ERI2_HUMAN ERI1 exoribonuclease 2 OS=Homo sapiens GN=ERI2 PE=2 SV=2  ali   17  3...........................................................................................SDWDLGCLEYECKRKQLLPVFLNSWIDLRATYKLFYRRKPKGLSGALQEVGIEFSGR-EHSGLDDSRNTALLAWKMIRD................................................................... 82
30 -10.500sp|P28340|DPOD1_HUMAN DNA polymerase delta catalytic subunit OS=Homo sapiens GN=POLD1 PE=1 SV=2  ali   15  11..RVLSFDIECAGFPEPERDPVIQICSLGLRWGEPEPFLRLALT---------LRPCAPILGAKVQSYEKEEDLLQAWSTFIRIDVITGYNINFDLPYLISRAQTLKVQSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFNDQTRRRLAVYCLKDAYLPLRLLERL...................................................................... 226
31 -10.300sp|Q8NA58|PNDC1_HUMAN(removed signalp:1-18) Poly(A)-specific ribonuclease PARN-like domain-containing protein 1 OS=Homo sapiens GN=PNLDC1 PE=2 SV=2  ali follow..  15  204......................................................DRESCWKENILLSARGFSVFFQMLVK--AQKPLVGHNMMMDLLHLHEKF-KQNIHSLF-PVLIDTKSVTKDI---RVSNLSEVYEVLN-YVETKCPHEAAYDAFLCGSVLLKVAHLLLQ................................................................ 353
32 -10.300sp|P09884|DPOLA_HUMAN DNA polymerase alpha catalytic subunit OS=Homo sapiens GN=POLA1 PE=1 SV=2  ali   10  88..VVMAFSMKTMQNAKNHQNEIIAMAALAAPKPPFQSHFCVVSKPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKDIIVGHNIGFELEVLLQRINVCKAPHWSKRMICDVEISAKELIRCKSYHLSELVQQIRVVIPMENIQNMYSESSQLLYLLEHTWKDAK................................................................. 300
33 -9.900sp|Q01780|EXOSX_HUMAN Exosome component 10 OS=Homo sapiens GN=EXOSC10 PE=1 SV=2  ali   16  1..................NEKLLNCQEFAVDLEHHSYRSFLGLT---------LMQISTRTEDFIIDTLELRSDMYILNESLTDPAIVFHGADSDIEWLQKDFG------LYVVNMFDT-HQAARLLNLGRHSLDHLLKLY--PLPEEMLSYARDDTHYLLYIYDKMRLEMWE................................................................ 157
34 -9.830sp|Q8N9H8|MUT7_HUMAN Probable exonuclease mut-7 homolog OS=Homo sapiens GN=EXD3 PE=1 SV=3  ali   13  93.HQVVGVDVEWTPVFVAGGRP--RPSLLQVAVEGHV----------------FLLDVLALSQ--PPTGQGAQAFSRLVAQLLSDPSILGYGMVGDLQKLGTSCPALAHVEKQILGGMDLLLVHRQM-ARELRGLSLLVQQV--PLCEEQVIYAAADAYCLLEVHQALCREPAR................................................................ 272
35 -9.680sp|P54098|DPOG1_HUMAN DNA polymerase subunit gamma-1 OS=Homo sapiens GN=POLG PE=1 SV=1  ali   18  192.ERALVFDVEV----------CLAEGTCPTLAVAISPSAWYSWCSQR--VEERYSWTSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIREQYLIQGSRMRF----LDTMSM................................................................................................................... 297
36 -9.460sp|Q01780|EXOSX_HUMAN Exosome component 10 OS=Homo sapiens GN=EXOSC10 PE=1 SV=2  ali   15  141........ISSLDELVELNEKLLNCQEFAVDLEHHSYRSFLGLT---------LMQISTRTEDFIIDTLELRSDMYILNESLTDPAIVFHGADSDIEWLQKDFG------LYVVNMFDT-HQAARLLNLGRHSLDHLLKLY--PLPEEMLSYARDDTHYLLYIYDK....................................................................... 300
37 -9.280sp|P46020|KPB1_HUMAN Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform OS=Homo sapiens GN=PHKA1 PE=1 SV=2  ali   14  5........LKDKGIYVET---IAEVYPIRVQPARILSHIYSSL-RPYRHM--GTSKLYDIRKTIFTFTPQFIDQQQFYLAL--DNKMIVEMLRTDLSYLCSRWRMTGQPTI-------TFPISHSMLDEDGTSLNSSI----LAALRKMQDGYFGGARVQTGKLSEFLT.................................................................... 159
38 -9.180sp|Q14191|WRN_HUMAN Werner syndrome ATP-dependent helicase OS=Homo sapiens GN=WRN PE=1 SV=1  ali   13  76.GDVVGFDMEWPPLYNRGKLG--KVALIQLCVSESK---------------------------YLFHVSSMSVFPQGLKMLLENKAVAGVGIEGDQWKLLRDFD------IKLKNFVELTDVANKKLKCTETSLNSLVKHL--PLTEDQKLYAATDAYAGFIIYRNLEILDDT................................................................ 233
39 -9.010sp|Q8N9H8|MUT7_HUMAN Probable exonuclease mut-7 homolog OS=Homo sapiens GN=EXD3 PE=1 SV=3  ali   17  1...............................................................................QLLSDPSILGYGMVGDLQKLGTSCPALAHVEKQILGGMDLLLVHRQM-ARELRGLSLLVQQV--PLCEEQVIYAAADAYCLLEVHQALCREPAR................................................................ 122
FFAS is supported by the NIH grant R01-GM087218-01
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Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. VISSA: a program to visualize structural features from structure sequence alignment. Bioinformatics. 2006 Apr 1;22(7):887-8. Epub 2006 Jan 24.