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Query: [F] COG0015 Adenylosuccinate lyase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MIERYTLPEMGKIWTDTYKLQTWLDVEIAVCEAQAELGYIPQAAVDEIKAKAKFDPQRVLEIEAEVRHDVIAFLTNVNEYVGDAGRYIHLGLTSSDVLDTALALQLVASLDLILEQLEKLIQAIRYQAQQHRYTVMVGRSHGIHAEPITFGFKLAGWLAEVLRNRDRLVRVAQSIAVGKISGAVGTYANIDPKVEAIACQKLGLEPDTASTQVISRDRHAEYVQQLALLAASLERFAVEIRNLQRTDVLEVEEYFSKGQKGSSAMPHKRNPIRSERLTGMARLVRGHAVAALENVALWHERDISHSSVERVAFPDCCILTHFMLKETTDLVKNLLVYPENMKRNMNVYGGVIFSQKVLLALVEKGMNREDAYRVVQGSAHQAWNTEGGNFEELVRADAQVTALLSAEEIDQCFDPQQHLTNLAEIYSRLDILast
1 -128.000[F] COG0015 Adenylosuccinate lyase  ali  100  1MIERYTLPEMGKIWTDTYKLQTWLDVEIAVCEAQAELGYIPQAAVDEIKAKAKFDPQRVLEIEAEVRHDVIAFLTNVNEYVGDAGRYIHLGLTSSDVLDTALALQLVASLDLILEQLEKLIQAIRYQAQQHRYTVMVGRSHGIHAEPITFGFKLAGWLAEVLRNRDRLVRVAQSIAVGKISGAVGTYANIDPKVEAIACQKLGLEPDTASTQVISRDRHAEYVQQLALLAASLERFAVEIRNLQRTDVLEVEEYFSKGQKGSSAMPHKRNPIRSERLTGMARLVRGHAVAALENVALWHERDISHSSVERVAFPDCCILTHFMLKETTDLVKNLLVYPENMKRNMNVYGGVIFSQKVLLALVEKGMNREDAYRVVQGSAHQAWNTEGGNFEELVRADAQVTALLSAEEIDQCFDPQQHLTNLAEIYSRLDI 431
2 -111.000[F] KOG2700 Adenylosuccinate lyase  ali follow..  25  11LTARYASAEMSHLFSREMRINTWRQLWLNLAIAEKQLGLITDEAIEQLKAHVKPEFEIAAKEEKRQRHDVMAHIYTYGLAAPAASGIIHLGATSCFVTDNADLIFLRSAMDLLIPKLVNVINRLSQWSLRYKDIPTLGFTHYQPAQLTTVGKRATLWIQELLWDLRNFVRARNDIGFRGVKGTTGTQASFLALFEGDHAKVEELDVYPVTGQTYDRKIDIDVLQPLASFGATAHKIATDIRLLANLK--EVEEPFEAGQIGSSAMAYKRNPMRCERICSQARYIMNLIPNALNTASQWFERTLDDSSNRRSLLPEAFLFTDSVLKILLNVISGMVIYPKVIQKHIRAELPFMATENIIMAMTKHGASRHECHEQIRVLSHQAGRVGDNDLIERIKNTPYFA--PIYDELDSLLDASTFVGRAPEQTESF.. 457
3 -91.400[E] KOG1316 Argininosuccinate lyase  ali follow..  18  23ALHSL----NNSLPYDSRLYADDLDASKAYAEALHRAGLINSAEADKLVKNLELLRFDWIEGTLPGDEDVHTVNERLVEITGELGQRLHTGRSRNDQVVTDMKLWLRKAIRETLGRLSGIIETATRQAELHLGVLMPGYTHLQRAQTVQFSHWLLSHAGALAGNPLGIDRLWLAERLGFSGVTANSM-----------------------HAVGDRDFVVDFIYCCSMVSLHLSRLAEDLIIYSTKEFDFIKLA-DGFSSGSSLMPQKRNPDSLELIRGMAGVITANLTGIMMTIKGTPSTYNKDLQYDKQFCFQSFDKLSQVLEVTDGVLQTIQVKQESMEAALS---TDMLATDWAYYLVKKGVPFRQAHHIIGRVVSEAEK-RGVDITDLPLGDLQKFSPLFGSDIVAVADYSNNVGTASSSIVEQ.. 430
4 -90.800[E] COG0165 Argininosuccinate lyase  ali follow..  20  8..DRFEGT-NASIGFDIELIEYDLDGSIAHGKMLAKTGIISPGEAEQLVQGLEQIRQEYRAGNGVDQEDVHFAVERLTELVGDVGKKLHTARSRNDQVGTDVRLYLRAQIDDIRQRLRDFQAVLLQLAETNVETLIPGYTHLQRAQPVSLAHHLLAYFQMAQRDWQRLGEIRARTNVSPLGSGALAGTTFPID-RHYSAELLGFAGVYANDGVSDRDFAIEFLNAASLIMVHLSRLSEEMILWASQEFSFISLT-DSCATGSSIMPQKKNPDVPELIRGKAGRVMGHLQGMLVLMKGLPLAYNKDLQEDKEALFDAVKTVQVSLEAMTILLDEGIVFRQERLAEAVAE-DFSNATDVADYLAAKGVPFREAYNLVGKVVKTSLA-AGKLLKDLTLAEWQALHPAFEEDIYQAITPQQVVGTGFEQVKMA.. 450
5 -76.700[C] COG0114 Fumarase  ali follow..  16  83...GIVKQAAARANMALAGLDPKVGDAIIAAAQEVIDGKLTEHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGGEMGTKKPHPNDHVNMSQSSNDTYPTAMHIACEEIVHHLLPALKHLHTALEAKVKQFEKIIKIGRTHTQDATPLTLGQEFSGYAAQVASAIANIELTLPALSKLAQGTAVGTGLNAPVGFAEKVAEEIS-TAPNKFEALASHDSMVFSHGAINAAAAALFKIANDIRFLGSGPRAGLGELSPENEPGSSIMPGKVNPTQSEALTQVCAHIFGNNAALSFAGSQGHELNVYNPMMAYNFLQSVQLLGDAAVSFTDNCVVGIEAREDNIRKGVENSLMLVTA-----------LNGKLGYDICAKIAKTAHK-NGTTLREEAVGG----GYLTNEEFDQYVRPENMIG........... 495
6 -67.700[C] KOG1317 Fumarase  ali follow..  17  18.......................................VPADKYYGAQTMRSQINFPIGGATEPAMGILKKAAAEVNKEFGLDSKVSEAISKAADDVISGKLYDDHFPLVIWQTGSGTQSNMNVNESEEFKDIIKIGRTHTMDAVPLTLGQEFSGYAQQLAYAQERIDACLPRVYELALGGTAVGTGGFAEKCAAKIAELTSLPFVTAPEALAARDAMVEVHGVLNTIAVSLMKIANDIRFLGSGPRCGLGELLPENEPGSSIMPGKVNPTQCESLTMLSAQVMGNQVAVTIGGSNHFELNVFKPLIVSNVLRSIRLLSDGSRTFTANCVNGIQANRENIAKIMNESLMLVTA-----------LNPHIGYDKAAKIAKTAHK-NGTTLKEEAINL----GYLTEQQFNDWVRPEQMLGP.......... 395
7 -51.900[E] COG1027 Aspartate ammonia-lyase  ali follow..  14  39..........SKISDVPEFVRGMVMVKKAAAMANKELHTIPRKIADIIIQACDEVLDKMNTNEVLANIGLELMGHQGEYQYLNPNDHLNKCQSTNDAYPTGFRIAVYASILKLIDAINQLGEGFGRKSKEFEKILKMGRTQLQDAVPMTLGQEFRAFQVLLNEETKNLQRTAELLLEVNLGATANTPEGYSQLAVQKLAEISGLACVPAEDATSDCGAYVMVHSALKRLAVKMSKICNDLRLLSSGPRTGLNEILPELQAGSSIMPAKVNPVIPEVVNQVCFKVIGNDTCITMAAEAGQLQLNLMEPVIGQAMFESIHILTNACYNLLECINGITANKEVCERYVF--NSIGIVTYLNPFIGHNGDIVGKICAETGKNVREVVLERGL---------------LTEAELDDIFSVENLMH........... 464
8 -4.820[D] COG4477 Negative regulator of septation ring formation  ali follow..  5  106.....ARESVADSEAQIELMEGDVEGIRQGVAQLVEQEKRNSNKIQESLDLYDNLRSDIADNADLYGTVITELEKHLANIETEFSQFVTLNSTGDPIEAAEVLETAEEHTIALRAITEQI-KRLEELQEASDKFVAEEYILPDNVNIKE--------MDDLHDHLVESSSLLEQFELDRVEAELGLIQEKVEELYAIFEREYSARRNVEKRSSVLKEYIEHIRANNKNLLLEIDHVTQAYIL-YQEHLESLDSDVDEGNIQAKTMPYSILSRRVNSVVNALEDIEKNQIKISDTLTGLRDEERAAQEIEKCNLPDLFFTTGDRVQNLFKELGRVRINIDTINHLVEATTNLTDHAVLAEQLIQYANRYKAANEQVAQGISRALQENSRDYDGSFDEISKTLELVEPGAASRISG................. 564
9 -4.170[T] KOG2607 CDK5 activator-binding protein  ali follow..  7  70VFGTYGSQRMKD---------------QEISRLYEKNATYLAETAQIFVRNVNYEIPGVRKQMARLEQQADETQKRLNKPESQILADHSALLEQLGVKGDNLHAEFVQVLSGLPELYDKSLVGIANIQPGNKQVLPILNHLVEFGNTTVYQYIHKEAPLAVEEPPIRLNLSEGNASKDDNAVAEIDFGTDDNGGTSSTVSAEIIDYGDFGSGDLPESDGGNIDWGIESAPTDAVEINFDIPVEEYGIVVEGTGMDGGTAKGDQAYTLLDSPNYRDRFLDEIYELESFLRMRIYELKQLESSSDIMFSLMDNIATHDGESIWKILVSVEKIIQQTS--DKQTQHLFQLKHSPKYANMLATKLQQMTKAVEKLRATREALKQLTIELREQPVLEELIAQTRTLQSHIEKDISKRYK-----NRVVNLMGGVN. 495
10 -4.060[DZ] KOG4302 Microtubule-associated protein essential for anaphase spindle elongation  ali follow..  9  25.............................LQKIWVEIGETETEMLMELERECLQIYQRKVDEAANSKAKLHQSVASIEAEVASLMAALGVLNINSPIKLDKGSKSLKEKLAAVTPLVEELRIQKEERMKQ---------------------------FSDIKAQIEKISGEISGYSDHLNKAMNISLTLEEQDLTLRNLNEYQTHLRTLQKEKSDR------LNKVLGYVNEVHALCGVLGVDFSQTVSAVHPSLHRTDQEQSTNISDSTLEGLEHMIQKLKTERKSRFQKLKDV----------------------------VASLFELWNLMDTPQEDRTKFGKVTYVVRSSEANI-----------TEPGILSTETIEQVSTEVDSLSKLKASRMKELVMKRRSELEDLCR................. 340
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24