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Query: [H] COG0285 Folylpolyglutamate synthase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKTLQDWLSHLETAHSGGLIDMGLERTSEVKKRMKLEPQCPVVVVAGTNGKGSVCAYLTQIYKQAGYKIGTLTSPHLLRYNERIAINAEPVSDDTIIASFERIEAARGEISLTYFEFNALAAVDIFMREQVDVMILEVGLGGRLDAVNAFDGDCAVVTSVDLDHQAFLGDTVEQVGFEKAGVFRSGKPAICGQNPAPKSLLSHAEAIGAKLLMVQRDFEFHAMENIQWNYRFRPQHSDDPARNRNALPFPALRGTYQLSNAACALTVLECLNDKLPVDIGAIKRGLLLVENPGRFQVLPGRPLTVLDVGHNPHAARALRRSLINLAFAQKRTAVFSMLSDKDIDGVLETVKDQFDEWYIAPLDVPRGMTLESLQNKLHEHSIENIQTFAAVREAYRAAASKAGENDRIVVFGSFHTVADVMSVLLast
1 -116.000[H] COG0285 Folylpolyglutamate synthase  ali  100  1MKTLQDWLSHLETAHSGGLIDMGLERTSEVKKRMKLEPQCPVVVVAGTNGKGSVCAYLTQIYKQAGYKIGTLTSPHLLRYNERIAINAEPVSDDTIIASFERIEAARGEISLTYFEFNALAAVDIFMREQVDVMILEVGLGGRLDAVNAFDGDCAVVTSVDLDHQAFLGDTVEQVGFEKAGVFRSGKPAICGQNPAPKSLLSHAEAIGAKLLMVQRDFEFHAMENIQWNYRFRPQHSDDPARNRNALPFPALRGTYQLSNAACALTVLECLNDKLPVDIGAIKRGLLLVENPGRFQVLPGRPLTVLDVGHNPHAARALRRSLINLAFAQKRTAVFSMLSDKDIDGVLETVKDQFDEWYIAPLDVPRGMTLESLQNKLHEHSIENIQTFAAVREAYRAAASKAGENDRIVVFGSFHTVADVMSVL 424
2 -76.700[H] KOG2525 Folylpolyglutamate synthase  ali follow..  25  25.KTFEGAINRLNSLQSNAKVDQSMVEMRHWLRCIGDLNRLNVIHVAGTKGKGSTCAFTSSILQQIPKCIGMYTSPHLRSVCERIQLNGKPISQELFTKYFFDVWERLENAVPMYFRFLTLMAWHVFISENVDAAIIEVGIGGEYDSTNLIEPYATAVTSLGLDHTSLLGNTIAEIAWQKAGIYKESAIALTCAPEAMNVLKNRAAERNTSLKVVIPPAELTPDM-------------------------IGLSGVHQLGNTSLAVSLVQEFYERDPYQDPAILDGLKYVKWPGRCQIEEINNKWCFDGAHTKESLEATGLWLASYEDADARILLFNQQSRDDPIALLRSFLKGLESINTITDNKPVLHVQEDLCKWWKESKTSEATVAPTIQEAIETVMSIKSRNTFVCVTGSLHLTGGVFVVL 500
3 -26.300[M] COG0769 UDP-N-acetylmuramyl tripeptide synthase  ali follow..  14  105...................................PGQKLKLVGVTGTNGKTTTTHLIEFFLTKAKLSTALMGTLYTRWPGFEQTATHTTPFAVELQQQLAQA-----------------------VNAGCEFGVMEVS--GRVLGCPF---EVGVFSNLTQDHLDYHS-DMEDYFAAKALLFSKGRAIINADDTYGQRLIKALSPEKVWSYSVNDDLWMSDLSYEPNGVTGTIHTPEGNVS-----FRSPLVGQYNLENLLAAVGAVLHLG----LNLQLIANAIPEFPVPGRMERVDQDISVIVDYAHTPDSLENLLKAARPF-IPGRMICVFGCGGDRDRTKKMGKIVAELADLAFVTSDNPRTEDPDRILDDILAPDTVQPTVIGDRAIAIRTAILQAQPGDGVLLAGK........... 465
4 -20.900[M] COG0773 UDP-N-acetylmuramate-alanine ligase  ali follow..  16  124....................EQQIPVIPRALMLAELMRFRDGIAIAGTHGKTTTTSLTASILGAAGLDPTFVIGGKLNAAGTNARLGKG------------------------------------------EYIVAE---ADESDASFLLTPIMSVVTNIDEDHMDTYGHSVEKLHQAFIDFIHRGKAFLCIDSEHVRAILPKVSKPYATYLDDTADIYATDIENVGAQMKFTVHVQMKGHEQGSFEVVLNMPGRHNVLNALAAIGVALEVG----ASVEAIQKGLLGFEVGRRFQKYGGTALLVDDYGHHPVEMAATLSAARGAYPEKRLVLAF-YTRTRDLFEDFTKVLNTVDALVLTEVYAAGAADSRALARAIRVLGKLEPIYCENVADLPEMLLNVLQDGDIVLNMGA........... 489
5 -20.500[M] COG0770 UDP-N-acetylmuramyl pentapeptide synthase  ali follow..  15  87...................VSNTLEAYQKLGRWWRDRFDIPVIGVTGSVGKTTTKELIAAVLGTKGNVLKTYGN-----YNNEI------------------------GVPKTLLEL----------NAEHDYAVIEMAMRGQIAEAQIARPTIGVITNVGTAHIELLG-SEEAIAEAKCELLADSVAILNHDNPLLMATAAKFWSGEV--------LTYGLSGGDVQGSLVDNAIVEVAGLRLP----LPLPGRHNATNYLAALAVAKVLG----IEWSSLQAGVSVNMPTGSQRFSLPNDVLILDETYNPEAMLAALQLLADTPGKRKIAVLLGERSAQLHQRVGETVRNLKLDGLLVLVDGEDA------EAIARSAEGIPSECFATHADLVARLTTFVQGGDRLLFKAA........... 433
6 -19.500[M] COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase  ali follow..  16  99............................ELLADIVNRRDDKVIAITGSNGKTTVTSLVGYLCIKCGLDTGNIGTPVLEAEWQR-------------------------------------------EGKKADVWVLELS---QLENTESLRPTAATVLNISEDHLDRYD-DLLDYAHTKAKIFRGDGVQVLNADDAFCRAMKRAGR---------EVKWFSLEHEADFWLERETGRLKQGNEDLIVTQDIPLQGLHNAANVMAAVALCEAIG----LSREALLEHVKTFQLPHRVEKIGEKNGVVFSKGTNVGATAAAIAGLQ-----NPLFVILG--KGQDFTPLRDALVGKAKGVFLI------GVDAPQIRRDLDGCGL-NMTDCATLGEAVQTAYAQAEAGDIVLLSPA........... 421
7 -8.530[H] COG0132 Dethiobiotin synthetase  ali follow..  20  2.......................................LTRLFVTGTDGKTVVSRALLQALSQNGRTAVGYKP---VATESKETSEGLRNQDALILQASSSIELNYQEVNPTLINYEKMTEGLQCLSAKADTVIVE-GCGG-SDWVVQEQLPVILVVGIKLNHALLTAQAIINDGLPLLGWV................................................................................................................................................................................................................................................. 170
8 -8.520[E] COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family  ali follow..  15  20.ATLAQAMTLVESRHPRHQ-----ALSTQLLDAIMPYCNTLRLGVTGT-GKSTFLEAFGMLLIREGLKVAVISSPV---LGDKTRMNDLARAEAAF------IRPVPSSGHLGGASQRARELMLLCEAAGYDVVIVEVGVGSETEVARMVDCFISLQIA--------GGDDLQGI---KKGLMEVADLIVINKDD..................................................................................................................................................................................................................................... 203
9 -7.230[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  14  1....................................MKRPLIIGVGGPVGAGKTMLILTRYLSTKGYSMAAITNDIYTKEDARILLNTSVLPADRIAGVETGGCPHTAIREDASMNFAAIEEMCD-KHPDLQLLFLEGGDN-ATFSPDLVDFSIYIIDVAQGE----------KIPRKGGQGMIKSDLFIINKVDLAPYVGANVEVMKADTLKSRGNKDF............................................................................................................................................................................................................ 177
10 -7.100[F] COG1618 Predicted nucleotide kinase  ali follow..  13  1..............................MRIEGKEKTMLRIAVTGSPGVGKSTKTAEKLAEKPGFKIGGIRTAEIRKEGHREGFSIRDLATGKTGILSHVKGSGPRLGKYHVNLLERIGANAVRNALACDLVVIEIGLESDKPVLAVLHHSSFEVLTVDKGNRDELPEKITNRFLRKLG................................................................................................................................................................................................................................................... 184
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 4 1   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.