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Query: [E] COG0287 Prephenate dehydrogenase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MMGDIMFERIALIGIGLIGSSIARDVRELGLARHVVISTRSEDTLKRAEELALGTDYTVSAAEAVKDADLVIVSVPVGASESVAQQIAPYLKPSAIVTDVGSTKASVIAQMAPHMPENVHFIPGHPLAGTEKSGPDAGFAGLFRERWCIFTPLPGTDAAALERLKDFWRALGSRVDEMDAEHHDKVLAIVSHLPHIIAYNIVGTADDLETVTESEVIKYSASGFRDFTRLAASDPTMWRDVCLHNKDAILEMLARFSEDLASLQRAIRWGEGDKLFELFSRTRSIRRSIIEAGQDVDTPDFGRHALDQKKLast
1 -98.300[E] COG0287 Prephenate dehydrogenase  ali  100  1MMGDIMFERIALIGIGLIGSSIARDVRELGLARHVVISTRSEDTLKRAEELALGTDYTVSAAEAVKDADLVIVSVPVGASESVAQQIAPYLKPSAIVTDVGSTKASVIAQMAPHMPENVHFIPGHPLAGTEKSGPDAGFAGLFRERWCIFTPLPGTDAAALERLKDFWRALGSRVDEMDAEHHDKVLAIVSHLPHIIAYNIVGTADDLETVTESEVIKYSASGFRDFTRLAASDPTMWRDVCLHNKDAILEMLARFSEDLASLQRAIRWGEGDKLFELFSRTRSIRRSIIEAGQDVDTPDFGRHALDQKK 310
2 -57.700[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  16  358SVNDGSRLKIGIVGFGNFGQFLGKTMVKQG--HTVLAYSRSDYT-DEAAKLGVSYFSDLD-DLFEEHPEVIILCTSILSTEKVLESLPQRLKRSTLFVDVLSVKEFPRNLFLQTLPQDFDILCTHPMFGPESGKNGWNNLAFVFDKVRIGMD--DRRKSRCNSFLDIFAREGCRMVEMSCAEHDWHAAGSQFITHTVGRLLEKLSLE----STPIDTKGYETLLKLVENTAGDSFDLYYGLFLYNPN-AMEQLERFHVAFESLKTQLFGRLHSQHSHELAKSSSPKTTKLLTS................. 640
3 -45.400[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  11  16LYVDQLNLPEKYGGEAPYGGS-RMAIEFAEAGHDVVLAEPARDMLDDAHWKVVEDTVTDNDAEAASEAEIAVLFTPFGKTFEIAKNITNHLPEGAVIANTCTVSPVVLYYVLERERKDLGIASMHPAAVPG-----TPQHGHYVIGGHSSSELDIATDEQISRCVELAESCGKVAYVVPADVSSAVADMGSLVTAVTLSGVLDYY--------YVGTQIIRAPKEMVEKQILMTLQTIASLVETSGVNGMLKAMNPELLVRSAKSMHLLEEQEELDAALNTLSDLDDEVNKWIEK............... 304
4 -36.500[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  16  75VIDDFAYEDVIEAHKEDPEKIMPQIREKNEVAKELPKPPEGAIHFTHPEDLGF--EITTDDREAVADADFIMTWFPKGDMQGIIDKFIDDIKPGAIVTHACTIPTTKFYKIFEEKPETLNVTSYHPGAVPEMKGQV-------------YIAEGYASEEAINTLFELGQKARGNAYRLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLGAPAQMMAKESLEQITALMEKVG-IDKMEEHLDPGALL-------GTADSMNFGASADILPTVFEILEKRKK.......................... 347
5 -17.000[S] COG5495 Uncharacterized conserved protein  ali follow..  14  13........NIAILSTGRVGVALERA-------QVVVACSAVSHASRQWVQFRLPETSVASPPEVASSAELLLLAVPDCEFAGLMSGVAVTRPGTIVAHTSWANGVGILAQLGK---DGCIPLAIHPAMMFSGSDEDLSQCQLRDTYFGI----TKTDDVGYAIAQSLVLEMGGEPFCVVEYAHSVSPHVGNHIVTVLADALVRRSALRGSELLGLGVPPACRGEVVDDQLDVIVERIVGSLARAACENTLQR--------AGLTKLVARGDLDALAGHLVALMRIGPELAQ................... 284
6 -16.300[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  19  1......METIGFIGLGIMGAPMAGHLLDAGY--KVIASDHRSKPLADLVAKGL--KTVSGHAAVAKAADIIITMVPDTPQVADVNGVASGLTRGKLVIDMSSISPIETKVFAGKINELGCDYLDAPVSGGEVGAKAAS-----------LTIMVGGEEKAFERAKPVFEKMGKNITLVGPNGVGQTTKVANQI-TIEAVAEALVFASKAGADPARVRQALMGGLAASRILEVHGERM......................................................................... 223
7 -15.000[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  21  2........QLGMIGLGRMGANIVRRLAKGGH--DCVVYDHDPDAVKAMAGEDRTTASLRELSQRLSAPRVVWVMVPAGNTTAVIEELANTLEAGDIVIDGGNTYRDDLRHEKLLFKKGIHLLDC-GTSG----GVWGRERGY--------CLMIGGDGDAFARAEPIFATVAPGV....................................................................................................................................... 157
8 -14.300[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  19  7........SIAILGAGRVGSSLARSAVAAGYEV-KVAGSGAVDKIALTAEILMPGAVPSTADQAVKDADIVFLAVPLHKFRSVNPATL----EGKIVIDTMNHPRSTSEIIAEFFAGSTMVKSFNHIGYHEIEQDAGTGRAIA---------YATDDVDAGAQVAQLIKSFGFVPLNIGALENGRILEPGQEA..................................................................................................................... 191
9 -13.200[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  14  1....MENQKIGFIGAGKMGSALMQGTIKAGIPENIGASDVYEPFLKDLQAKLGI-RVSTDNAVIVRESDILILAVKPQTLSSVLSNLKNEITSEKLVISIAA--GVPLSTYEDALLEGTRVVRVMP-----------NIAATVSEAASGIAPGKNATPEDLKAALEIFSAVG-TAVQVPESLMDAVTGLSGSGPAFIAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETGMHPGELKDMVTSPAGTTIQGIHSLEE--AGIRAAFM----NAVIRASERSKELGKK...................... 270
10 -13.100[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  12  32.ANFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISY-AIAEKRASFQRATENGF---KVGTYEELIPTADLVVNLTPDKQHSKVVADVMPLMKKDSAFGYSHGFN---IVEVGEEIRKDITVVMVAPKCPGTEVREEYKRGF---PTLIAVHPENDPKGEGMAIAKAWAAATGGHKAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYD------KLVADGK---------DPAYAGKLIQYGWETITEALKQITLMMDRLSNSAKLRAFELAEQIKESLGFLYYKHMDD.................. 306
11 -12.800[E] KOG3124 Pyrroline-5-carboxylate reductase  ali follow..  14  2........SVGFIGAGQLAYALARGFTAAGIAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETVKHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAGVTISSVEKKLMAFQPAPKVIRCMT-----------NTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVG-FCTEVEEDLIDAVTGLSGSGPAYAALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIHALHFLES--GGFRSLLI----NAVEASCIRTRELQSMADQEKIS............... 278
12 -12.800[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  12  1.....MSADFGLIGLAVMGQNLILNAADHGF--TVCAYNRTQSKVDHFLANEAKGKGATSIEDFISKLKVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHPDSNRRYEELKKKGILFVGS-GVSGGEE-GARYGPSLMPGG-----------SEEAWPHIKNIFQSISAKCEWVGPAGAGHYVKMVHNG----AYDIMKRLGGFTDKEISDVFAKWNNGVLDSFLV-----EITRDILKFDDVDGKPLVEKIMDTAGQ................................................ 258
13 -12.400[G] COG0362 6-phosphogluconate dehydrogenase  ali follow..  12  5.......GDIGVIGLAVMGQNLILNMNDHGF--KVVAYNRTTSKVDEFLQGAAKGTGAYSLEDLAAKLEVMLMVRAGDVVDQFIEALLPHLEEGDIIIDGGNSNPDTNRRVKALAEKGIRFIGS-GVSGGEE-GARHGPSIMPGG-----------NQEAWQYVKPIFQAISAKTEQGEPCCDWVGGEGAGHFVKMVAYQFLKEGLGLSYEEMQAIFAEWKNTELDSYLIDITTDIL......................................................................... 241
14 -11.900[S] COG4408 Uncharacterized protein conserved in bacteria  ali follow..  8  1......MSKLLMIGTGPVAIQLANICYLKS-DYEIDMVGRASTSEKSKRLYQAINRLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKHVILISPTFGSQMIVEQFMSKEVISFSTYLGDTRIVDKEAPNHVLTTGVKKKLYMGSTHSNSTMCQRISALAEQLKIQLEVVESPLHAETSSLYVHPPLFMNDFSLKAIFEGTDVPVYVYKLFPEGPI---------------------TMTLIREMRLMWKEMMAILQAFRVPSVNLLQFMVKENYPVRPE...................... 291
15 -10.900[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali follow..  20  22......INNVTIIGAGLMGSGIAQVSANAKLNVTVVAQQGIANSLKRVAKKKHADDMSTNVSDSVKDADLVIEAIVIDIKRKLFAEVEVAAKPTTLI--TTNTSSLRLADIGLNLKDKSRFGGLHPVP-----------------KLLEVVRHTETSDATFNQLVDYGKTVGKTTVACK................................................................................................................................... 207
16 -10.400[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  17  1......MLKIGIVGCGFIGGQICRAIDGGEVSAELYALDSSESKALEAASLKTCKPSYMKIEELIRGVDLIIESASQNAVRFIVPQALKAGCDVMILSVGALADEELRDTLFGLAKEH................................................................................................................................................................................................ 114
17 -10.400[M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase  ali follow..  12  17........LIGIVGLGYVGLPLMLRYNAIGF--DVLGIDIDDVKVDKIAKARASGFEATTDFSRVSECDALILCVPMSFVINTTDALKPYLRVGQVVSLESTTYPGTTEEELLPRVQEGGYLVYSP----EREDPGNPNFETRTIPKVI----GGHTPQCLEVGIALYEQAIDRVVPVSSTKAAEMTKLLENIHRAVNIGLVNEMKIVADRMGIDIFEVVDGGLTWKAREYGLHTRFIELSGEVNQAMPEYVLGKLMDGLNEAGRALKGSRVLVLGIAYKNVDDMRES...................... 346
18 -10.300[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  19  1.....MIKTVGIIGAGQMGCGIAHVSAAAGYKVQLYGLATINGNLARQVSSGKMSDEDRKRANDLAQADLVIEAVTETVKRKIYGQVCPVMRPDAIL--ATNTSSLSITRLASATDRPERFMGIHPVP-----------------KLVELVRGIATEEETFKAAKEFVAHLDKTVTVAE................................................................................................................................... 181
19 -10.200[M] COG1004 Predicted UDP-glucose 6-dehydrogenase  ali follow..  10  2........KVTVFGIGYVGLVQATVLAEVG--HDVLCIDIDANKVADLKKGRI--QFSTDAQAGVAHGVIQFIAVGLKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKVHQVIQAILESVVSNPEFLKEGAAVAD-----CKRPERIVIGIDTDDSGALELISELYEPFNHDRMLVMDIRSAELTKYAANGMLATKISFMNEIANIAERLGADIEKVRQGIGSD-SRIGYHGCGYGGSCFPKDIQALIRTAEDKGYKPQLLQAVEQINNQQKYKLTEFIKSHFNSQLAGKTFAVWGLAFKPNTDDMRE 337
20 -9.780[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  14  1.....MKQHIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERRH---SFTTDMKEAIHNAFMIVEGVTSAGIRPVAEQLKQITDLSVPFVITSGIEQNTGLLLSEIMLEVLGDSVTPYLG----SGPSIAK-EVLNGSPCSVV-VSAYDSQTLKQIHEAFSLPTFRVYPNTDIKGAALGGALKNV-----IAIACGIAEGLSFGNNAKAGLVTRGLHEMRKLAAI............................................................................. 229
21 -9.480[C] KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase  ali follow..  12  25.......ISVGIIGSGNWGTAIAKICGENAFHPQVHMWMYEEKIQHEGKECNLTEFANPDIRDVGSRSDILVWVLPHQFVVRICNQLKGCLKKDAVA--ISCIKGLFSDIIEENTGMYCGVLSGANIASEVAQEKFCE---------TTIGYLPNSSVNPRYTPKTIQALFNRPYFRVNIVEDVPGVALGGALKNIVA--VAAGIIDGLELGDNTKSAVMRIGLLEMQKFGRM............................................................................. 273
22 -9.390[C] COG0039 Malate/lactate dehydrogenases  ali follow..  11  1.MNKFKGNKVVLIGNGAVGSSYAFSLVNQSIVDELVIIDLDTEKVRVSKNLKIFKSIVGEVMASKFDGIFLVATNPVDILAYATWKFSGLPKERVIILDSARFRLLLSEAFDVAPRSDAQIIGEH----GDTELPVWSHANIAGQPLKTLLEQRPEGKAQIEQIFVQTRDAAYDIIQAKGATYYGVAMGLARITEAI----------FRNEDAVLTVSALLEGEYDEEDVYIGVPAV-------NRNGIRNVVE----PLNDEEQSKFAHSAKTLKDIMAEAEELK........................ 317
23 -9.290[S] COG1255 Uncharacterized protein conserved in archaea  ali follow..  18  15.......GKVIEVGIG--YTRIAKRLKELGF--DVLAIDINKDAVVNAKNSGLVDDIFNPNISLYMGAKAIYSIRPTPEMMNYILKISKAVKVPAYIVPLTG................................................................................................................................................................................................................ 109
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;