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Query: [E] COG0345 Pyrroline-5-carboxylate reductase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MENQKIGFIGAGKMGSALMQGTIKAGIVTPENIGASDVYEPFLKDLQAKLGIRVSTDNAVIVRESDILILAVKPQTLSSVLSNLKNEITSEKLVISIAAGVPLSTYEDALLEGTRVVRVMPNIAATVSEAASGIAPGKNATPEDLKAALEIFSAVGTAVQVPESLMDAVTGLSGSGPAFIFPVIEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETGMHPGELKDMVTSPAGTTIQGIHSLEEAGIRAAFMNAVIRASERSKELGKKLast
1 -101.000[E] COG0345 Pyrroline-5-carboxylate reductase  ali  100  1MENQKIGFIGAGKMGSALMQGTIKAGIVTPENIGASDVYEPFLKDLQAKLGIRVSTDNAVIVRESDILILAVKPQTLSSVLSNLKNEITSEKLVISIAAGVPLSTYEDALLEGTRVVRVMPNIAATVSEAASGIAPGKNATPEDLKAALEIFSAVGTAVQVPESLMDAVTGLSGSGPAFIFPVIEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETGMHPGELKDMVTSPAGTTIQGIHSLEEAGIRAAFMNAVIRASERSKELGKK 270
2 -91.800[E] KOG3124 Pyrroline-5-carboxylate reductase  ali follow..  40  1...MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNPTVSALRKMGVNLTRSNKETVKHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMPAPKVIRCMTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAYAFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSM 271
3 -33.000[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  11  35LKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEAIAEKRASFQRATENGFKVGTYEELIPTADLVVNLTPDKQHSKVVADVMPLMKKDSAFG-YSHGFNIVEVGEEIRKDITVVMVAPKCPGKRGFGVPAVHPENDPKGEGMAIAKAWAAATGGHSSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKLVADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELAEQIKES--LGFLYYKHMDDIISGH...... 311
4 -15.900[S] COG5495 Uncharacterized conserved protein  ali follow..  10  10.ARLNIAILSTGRVGVALERADQV--------VACSAVSHASRQWVQFRLPETSVASPPEVASSAELLLLAVPDCEFAGLMSGVAVTPRPGTIVAHTSWANGVGILAQLGKDGCIPLAIHPDEDLSQCQLRDTYFGITKTDDVGYAIAQSLVLEMGEPFCVVEYARILYHSVSPHVGNHIVTVLADALEVRRSALRGSELLGLGVPPACRGEVVDDQLDVIVERIVGSLARA----ACENTLQRGQAGLTKLVARGDLDALAGHLVALMR 277
5 -15.600[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  15  1MSTMKVAVYGAGNQGEAPYGGMAIEFAEAGHDVVLAEPARDMLDDAHWDAGVTVTDNDAEAASEAEIAVLFTPGKKTFEIAKNITNHLPEGAVIANTCT--VLERELRRDRKDLGIASMHPPQHGHYVIGGHSSSELDIATDEQISRCVELAESCGVAYVVPADVSSAVADMGSLVTAVTLSVLDYYYVGTQIIRAPKEMVEKQILMTLQTIASLVETSGVN---GMLKAMNPE-LLVRSAKSMHLLEEQEELDAALNTLSDLDDEVNK. 300
6 -13.200[E] COG0287 Prephenate dehydrogenase  ali follow..  14  5IMFERIALIGIGLIGSSIARDVRELGL--ARHVVISTRSEDTLKRAEELALGDYTVSAAEAVKDADLVIVSVPVGASESVAQQIAPYLKPSAIVTDVGSASVIAQMAPHMPENVHFIPGHPGFAGLFRERWCIFTPLPGTDAAALERLKDFWRALGRVDEMDAEHHDKVLAIVSHLPHII-----AYNIVGTADDLETVTESEVIKYSASGFRDFTRLAASDPTMWRDVCLHNKDAILEMLARFSEASLQRAIRDKLFELFSRTRSIRRS 288
7 -12.800[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  23  2...ETIGFIGLGIMGAPMAGHLLDAGY----KVIASDHRSKPLADLVAK-GLKTVSGHAAVAKAADIIITMVDTPQVADVLNGVASGLTRGKLVISSISPIETKVFAGKINELGCDYLDAPVSGGEVGAKAASLTIMVGGEEKAFERAKPVFEKMGKNI--------TLVGPNGVGQT-IEAVAEALV--ASKAGADPARVRQALMGGLAASRIL....................................................... 216
8 -12.500[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  11  51.PPLRIAIIGFGNYGQFLAETLISQG-----HILFAHSRSDHSSAARRLGVSYFTDLHDLCERHPDVVLLCTSILSIENILKTLPFQRLRRNTLFVDVLSVKKTLLLQYLPEDFDILCTHP----MFGPQSVSSIGEERLRVSRCESFLEIFVREGEMVEMSVTDHDKFAAESQFITHTLGRLLGMLK----------LISTPINTKGYEALLDLAENICGDSFDLYYGLFVYNNNSLEVLERIDLEALRKELFSRLHGVVRKQSFEGEA 321
9 -12.400[H] COG1893 Ketopantoate reductase  ali follow..  15  1MEKPRVAVIGSGSIGLLLYAYLKLAN----WPALLVTNRPEQADHLNKEISVTATPLSSFSAEEAEVGFITVKSFAVKALLPQLQRKK--WDGLVFFQNGMTHLEILRQIPARAICCGIVDVRVQHTGDGAIWIGDMVG-DSKNFDPMWACLHNAGLKAQKVTNWINPLTGLFRENQLFSLLLKELVKEACVTLGREREVDEHLAY-----TRAICDKTANNLSSMYMDLTHHRRTEIESIKEAAKKGIEIPNTSFVYHAVMGMDEEGRK 304
10 -12.200[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  16  1...MQLGMIGLGRMGANIVRRLAKGGH----DCVVYDHDPDAVKAMAGETGVASLRELSQRLSAPRVVWVMVPGNITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLL---DCGTSGGVWGRERGYCLDGDAFARAEPIFATVAPGVVAPSEQGYLHCGPCGSG-------FVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPLPNPECYQYDFDIPEVAEVWRRGIGSWLLDLTAIALRESPDLAE. 275
11 -12.100[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  19  4.TKPSIAILGAGRVGSSLARSAVAAG----EVKVAGSGAVDKIALTAEILMPGAPSTADQAVKDADIVFLAVPLHKFRSVNPAT-----EGKIVIDTMDPRSTSEIIAEFFAGSTMVKSFNHIGYHEIEQDAGTGRAIAYATDDGAQVAQLIKSFG----LNIGALENGRILEPGQEAF........................................................................................... 192
12 -12.100[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  15  2..KQHIGYLGMGIWGFCLASLLANKG----YPVVAWSRNPDLIKQLQEE-NLSFTTDMKEAIHNAFMIVEGVTSAGIRPVAEQLKQITDLSVPFVITSKGIEQNTMLEVLGDSVTPYLGYLSGPSIAKEVLNGSPCSVVVSAYDSQTLKQIHEAFSLPTFRVYPNTDIKGAALGGALKNVIAIACGIAEG---LSFGNNAKAGLVTRGLHEMRKLAAIMDCKPE------------TLNGLAGLGD------LCVTCFSESSRNLRFGHL 263
13 -10.900[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  15  1MIDMKLAILGAGCYAGVDEVVVADPVFDNQFTVIDDFAYEDVIETHPEDLGFEITTDDREAVADADFIMTWFPGDMQPGIIDKFIDDIKPGAIVTHACT-IPTTKFYKIFEEKHGDLVTKPETLNVTSMKGQVYIAEGYASEEAINTLFELGQKARNAYRLPAELLGPVCDMCSALTAITYAILSYRDSVTQVLGAPAGFAQMMAKESLEQITALMEKVGLDPGALLGTADS...................................... 325
14 -10.800[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali follow..  13  23...NNVTIIGAGLMGSGIAQVSANAKL----NVTVVDSNQSALEKAQQGIAIKMSTNVSDSVKDADLVIEAINIDIKRKLFAEVEVAAKPTTLITTNTSSLRLADIGLNLKDKSRFGGLHFFNPVPMMK-LLEVVRHTETSDATFNQLVDYGKTVGKTTVACKDT-----------PGFI--------------------VNRLLVPYMFEALRLYERGDASMEDIDVAMKLGAGYPMGPFELSDYVGLDTCK................. 266
15 -10.600[C] KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase  ali follow..  18  23.KLISVGIIGSGNWGTAIAKICGENAKAHPEVFNTTHENVKYLKGIKCPSNVFANPDIRDVGSRSDILVWVLPHQFVVRICNQLKGCLKKDAVAISCIKGVSVTKIEENTGMYCGVLS--ANIASEVAQECETTIGYLPNSSVNPRYTPKTIQALFNRPYFRVNIVEDVPGVALGGALKNIVAVAAGIIDGLELGDNTKSAV-----MRIGLLEMQK..................................................... 269
16 -10.200[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  18  2...LKIGIVGCGFIGGQICRAI-DGGEVSAELYALCDSSESKALELAASLKTCSYMKIEELIRGVDLIIESASQNAVRFIVPQALK--AGCDVMILSVGALADEELRDTLFGLAK........................................................................................................................................................... 112
17 -10.100[Q] COG5310 Homospermidine synthase  ali follow..  10  17..TGPVVMIGFGSIGRGTLPLIERHFKFDKSRMTVLDPRDTDRKLLDER--------------GIAFVQEAVTENNYKKLLTPLLTNGGGQGFCVNLSVDTG----------SVDLMRLCRKLGVLYIDTVVEPWLGFYFDAKADNASRTNYALREAMIKEKHDKPGGATVVSTCGPGMVSWFVKQALV................................................................................. 181
18 -10.000[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  16  3...KTVGIIGAGQMGCGIAHVSAAAGY----KVQLYDIAADRIEAGLATINGNLGSGDINDLAQADLVIEAVDETVKRKIYGQVCPVMRPDAILATNTSSLSITRLASATDRPERFMGIHFMNPVPVMK-LVELVRGIATEEETFKAAKEFVAHLDKTVTVAEDFPAFIVN------ILLPMINEATLYEGVGTVDAIDTAMKLGANHPMGPLQLADFIG.................................................. 235
19 -9.810[G] COG0362 6-phosphogluconate dehydrogenase  ali follow..  14  3.VKGDIGVIGLAVMGQNLILNMNDHGF----KVVAYNRTTSKVDEFLQG-NIIGAYSLEDLAAKLEVMLMVRAGDVVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAEKGIRFI---GSGVSGGEEGARHGPSINQEAWQYVKPIFQAISAKTEQGEPCCDWV-GGEGAG-GDMQLICEAYQFLKEGLGLSYEEMQAIFAEWKNTETDILGYKDASGEPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESV......... 286
20 -9.760[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  10  2..SADFGLIGLAVMGQNLILNAADHGF----TVCAYNRTQSKVDHFLAN-SIIGATSIEDFISKLKVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKGILFV---GSGVSGGEEGARYGPSLSEEAWPHIKNIFQSISA----KSDGEPCCEWVGPAGAGHYVKMVHNGIEYGDMQLICE-------------AYDIMKRLGGFTDKEISDVFAKWNNGVLDSFLVE......................... 232
21 -9.690[Q] COG4569 Acetaldehyde dehydrogenase (acetylating)  ali follow..  14  1MSKRKVAIIGSGNIGTDLMIKILRHGQHLEMAVMVGIDPQSDGLARARRMGVATTHEGVIGLADIDIVFDAT------------SAGAHVKNDAALREAKPDIRLIDLTPAAIGPYCVPVVNLEANVDQLNVNMVTCGG------QATIPMVAAVSRVARVHYAEIIASIASKSAGPG............................................................................................ 166
22 -9.390[S] COG4408 Uncharacterized protein conserved in bacteria  ali follow..  9  2...SKLLMIGTGPVAIQLANICYLKS----YEIDMVGRASTSEKSKRLYQAYKLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKHVILISPMIVEQFMSKFSQDIEVIKEAPNHVLTTGVKKKLYMGSTHSNSTMCQRISALAEQLKIQLEVVESPLH--AETRNSSLYV------------------------------------------HPPLF-KAIFEGTDVPVYVYKLFPEGPITMTLIREMRLMWKEMMAILQA 269
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;