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Query: [G] COG0362 6-phosphogluconate dehydrogenase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSVKGDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKGTNIIGAYSLEDLAAKLEKPRKVMLMVRAGDVVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAEKGIRFIGSGVSGGEEGARHGPSIMPGGNQEAWQYVKPIFQAISAKTEQGEPCCDWVGGEGAGHFVKMVHNGIEYGDMQLICEAYQFLKEGLGLSYEEMQAIFAEWKNTELDSYLIDITTDILGYKDASGEPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKDQRVAANQLFGKTITPVEGDKKVWIEAVRKALLASKIISYAQGFMLIREASEQFGWDINYGATALLWREGCIIRSRFLGNIRDAYEANPNLVFLGSDSYFKGILENALSDWRKVVAKSIEVGIPMPCMASAITFLDGYTSARLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGNTASTTYDVLast
1 -125.000[G] COG0362 6-phosphogluconate dehydrogenase  ali  100  1MSVKGDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKGTNIIGAYSLEDLAAKLEKPRKVMLMVRAGDVVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAEKGIRFIGSGVSGGEEGARHGPSIMPGGNQEAWQYVKPIFQAISAKTEQGEPCCDWVGGEGAGHFVKMVHNGIEYGDMQLICEAYQFLKEGLGLSYEEMQAIFAEWKNTELDSYLIDITTDILGYKDASGEPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKDQRVAANQLFGKTITPVEGDKKVWIEAVRKALLASKIISYAQGFMLIREASEQFGWDINYGATALLWREGCIIRSRFLGNIRDAYEANPNLVFLGSDSYFKGILENALSDWRKVVAKSIEVGIPMPCMASAITFLDGYTSARLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGNTASTTYDV 484
2 -119.000[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  59  1..MSADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANEAKGKSIIGATSIEDFISKLKRPRKVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKGILFVGSGVSGGEEGARYGPSLMPGGSEEAWPHIKNIFQSISAKS-DGEPCCEWVGPAGAGHYVKMVHNGIEYGDMQLICEAYDIMKRLGGFTDKEISDVFAKWNNGVLDSFLVEITRDILKFDDVDGKPLVEKIMDTAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSALKNERIRASKVLPEVPKDAVKDREQFVDDLEQALYASKIISYAQGFMLIREAAATYGWKLNNPAIALMWRGGCIIRSVFLGQITKAYREEPDLENLLFNKFFADAVTKAQSGWRKSIALATTYGIPTPAFSTALSFYDGYRSERLPANLLQAQRDYFGAHTFRVLPEPVDKDIHINWTGHGGNVSSSTYQA 489
3 -73.800[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  29  1....MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGED----RTTGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAAEQGYLHCGPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPL----------------------------------------------------------------------------------------------------------------------PNPECYQYDFDIPEVAEVWRRGSVIGSWLLDLTAIALRESPDLAEFS-------GRVSDSGEGRWTAIAAIDEGVPAPVLTTALSRFASRDLDDFANKALSAMRKQFGGHAEKPAN......................... 340
4 -59.300[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  18  2....ETIGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLADLVAKGLK-----TVSGHAAVAKAADIIITMVPDTPQVADVLFGDNGVASGLTRGKLVIDMSSISPIETKVFAGKINELGCDYLDAPVSGGEVGAKAALTIMVGGEEKAFERAKPVFEKMGKN-------ITLVGPNGVGQTTKVANQIVVALTIEAVAEALVFASKAGADP----ARVRQALMGGLAASRILEVHGERMVKRTFAPGFRIELHQKDLNLALEGAKALGVSLPNTSTTQQLFNSCAANGGAREDHSAL......................................................................................................................................................................................... 281
5 -19.700[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  11  3...TMKVAVYGAGNQGSRMAIEFAEAGHDVVLAEPARDMLDDAHWKVVEDAGVTVTDNDAEAASEAEI---AVLFTPFGKKTFEIAKNITNHLPEGAVIANTCTVSPVVLYYVLERELRKDLGIASMHPAAVPGTPQHGHYVIGGHTDEQISRCVELAESCGKVA--------YVVPADVSSAVADMGSLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQIL--MTLQTIASLVETSGVNGMLKAMNPELLVRSAKS................................................................................................................................................................................................................................... 274
6 -16.300[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  14  1MSTKPSIAILGAGRVGSSLARSAVAAGYEVKVAGSGAV--DKIALTAEILMPGAVPSTADQAVKDADIVFLAVPLHK--------FRSVNPATLEGKIVIDTMNTSEIIAEFFAGSTMVKSFNHIGYHEIEQDAGTGRAIAY-ATDDVDAGAQVAQLIKSFGFVPLN-------IGALENGRILE........................................................................................................................................................................................................................................................................................................... 186
7 -14.500[M] COG1004 Predicted UDP-glucose 6-dehydrogenase  ali follow..  11  1....MKVTVFGIGYVGLVQATVLAEVGHDVLCIDIDANKVAPLVKENYEAGRLQFSTDAQAGVAHGVIQFIAVGTPADLKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKVHQVIQAILEQRIDFSVVSNPEFLKEGAAVIVIGIDTDDSGALELISELYEPFNRNHDRMLVMDIRSA-ELTKYAANGMLATKISFMNEIANIAERLGADIEKVRQGIQALIRTAEDKGYKPQLLQAVEQINNQQKYKLTEFIKSHFNSQLAGKTFAVWGLAFKPNTDDMREAPSRVVM----ESLWEAGATIQAYDPEAMDETQRIYGARDDLRLMGTKESALQGADALIICTEWQSFAPDFDMIKSRLKHPVIFDGR................................................................................................................. 421
8 -12.900[M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase  ali follow..  16  13.SRQALIGIVGLGYVGLPLMLRYNAIGFDVLGIDIDDVKVDKLNAG-KARASGFEATTDFSRVSECDALILCVPTPPDMSFVINTTDALKPYLRVGQVVSLESTTYPGTTEEELLPRVQEG----DIYLVYSPEREDPGNPVIGGHTPQCLEVGIALYEQAIDRV-------VPVSSTKAAEMTKLLENIHRAVNIGLVNEMKIVADRMGIDIFEVVDAA........................................................................................................................................................................................................................................................................ 253
9 -12.400[E] COG0287 Prephenate dehydrogenase  ali follow..  12  8....ERIALIGIGLIGSSIARDVRELGLHVVISTRSEDTLKRAEELALGTD---YTVSAAEAVKDAD----LVIVSVPVGASESVAQQIAPYLKPSAIVTDVGSTK-ASVIAQMAPHMPENVHFIPGPLAGTEKGPDAGFAGLFREDAAALERLKDFWRALGSRVDEMDAEHHDKVLAIVSHLPHII--------------AYNIVGTADDLETVTESEVIKYSASGFRDFTRLAASDPTM................................................................................................................................................................................................................................................... 237
10 -12.300[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  11  34FLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEAIAEKRASFQRATENGFKVGTYEELIPTADLVVNLTPDKQHSKVV----ADVMPLMKKDSAFGYSHGFNRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHK------VLESSFVAEVKSDLMGEQTILCGMLQAGSIVYDKLVADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELAEQIKESLGFLYYKHMDDIISGHFSATMMAD-WANGDKDLFAWREATGKTAFENAPKYDGKISEQEYFDNGVLMIAMVKAGVEAFDAMVASGIYEESAYELPLIANIARKR-------LYEMNVVISDTAEYGNYLFSNVATPILAKE-------IIPNLQKG----------DLGEPTPAVEVDNITLRDVNDAIRNHPVELIGQELRGYM.................. 482
11 -11.300[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  13  362.GSRLKIGIVGFGNFGQFLGKTMVKQGHTVLAYSRSDYTDE------AAKLGVSYFSDLDDLFEEHPEVIILCTSILSTEKVLESLP--FQRLKRSTLFVDVLSVKEFPRNLFLQTL-PQDFDILCTPMFGPESGKNNNLAFVFD-RKSRCNSFLDIFAREGCRMVEMSC-----------AGSQFITHTVGRLLEKLSLESTPIDTKGYETLLKLVENTAGD..................................................................................................................................................................................................................................................................... 581
12 -9.960[H] COG1893 Ketopantoate reductase  ali follow..  11  2..EKPRVAVIGSGSIGLLLYAYLKLANWPALLVTNRPEQADHLNKEGLTFVAKSGEHQPISVTATPLSSFSVGFITVKSFAVKALLPQLQRKKWDGLVFFQNGMTHLEILRQIPARAICCGIVEIGAKRESDVRVQHTGDGIWIGGDSKNFDPMWACLHNAGLKAQKVTNWQDKM-------ERKLIANAAISLLLKELVKEACVTLGREREVDEHLAYTRAICDKTANNSMYMDLTHHRRTEIESITGYLIKE-----------AAKKGIEIPNTSFVYHAVMGMDEEG.................................................................................................................................................................................................. 302
13 -9.820[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  14  2..ENQKIGFIGAGKMGSALMQGTIKAGINIGASDVYEPFLKDLQAK-----GIRVSTDNAVIVRESD----ILILAVKPQTLSSVLSNLKNEITSEKLVISIAAGVPLSTYEDALLEGTRVVRVMAATVSEAASGIAPGKNA----TPEDLKAALEIFSAVGTAVQVPESLMDAVGLSGSG------------AFIFPVIEAMADGAVLEGMDRKSALTLAAQTVLGA---------AKMALETGMHPGELKDMVTSPAGTTIQGIHSLEEAGIRAAFMNAVIRAS...................................................................................................................................................................................................... 261
14 -9.720[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  10  1..MKQHIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERRHPPNLSFTTDMKEAIHNAFMIVEGVTS----AGIRPVAEQLKQITDLSVPFVITSKGIEQNTGLLLSEIMLEVLG--YLGYLSGPSIAKECSVVVSAYDSQTLKQIHEAFDIKGAALGGALKNVIAIA-CGIAEGLSFGNNAKAGLVTRGLHEMRKLAAIMDCKPET-LGDLCVTCFSESSRNLRFGHL---------AQGLTFEQAKAKIGMVVEGAYTALSAYQVA................................................................................................................................................................................................................ 294
15 -9.680[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  9  55.........ELAGVDEVVVADPVFDNQFTVIDDFAYEDVIGAIHFTHPEDLGFEITTDDREAVADADF---IMTWFPKGDMQPGIIDKFIDDIKPGAIVTHACTIPTTKFYKIFEEKHGETLNVTSYHPGAVPEMKGQVYIAEGYASEEAINTLFELGQKARGN-------AYRLPAELLGPVCDMC-SALTAITYAGILSYRDSVTQ.................................................................................................................................................................................................................................................................................... 278
16 -9.120[E] KOG3124 Pyrroline-5-carboxylate reductase  ali follow..  10  1....MSVGFIGAGQLAYALARGFTAAGIKIIASSPEMNLPTVSAL---RKMGVNLTRSNKETVKHSD----VLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC-MTNTPVVVQEGATVYATGLVEDGQLLEQLMSSVGFCTEVEEDLIDAVGLSGSG--------AYAFMALDALADG---GVKMGLPRRLAIQLGAQALLGA----------AKMLLDSEQHPCQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASC...................................................................................................................................................................................................... 262
17 -9.070[S] COG5495 Uncharacterized conserved protein  ali follow..  10  9.SARLNIAILSTGRVGVALE----RADQVVVCSAVSHASRQWV----QFRLPETSVASPPEVASSAELLLLAVPD----CEFAGLMSGVAVTPRPGTIVAHTSWA---NGVGILAQLGKDGCMFSGSDEDLSQCQLRDTYFGITKTDDVGYAIAQSLVLEMGGEVVEYARILYHSVSPHVGNHI-----------VTVLADALEVRRSALRGSELLGLGVPPACRGEVVDDQLDVIVERIV................................................................................................................................................................................................................................................... 237
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;