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Query: [R] COG0385 Predicted Na+-dependent transporter, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRFLPDKFTTMLIATILFASVLPVRGEFAVWFALATKIAVGLLFFLHGARLSREAVIAGITHWKLHVTVLASTFVLFPILGLAAGWAIPGLSQSPFYTGILYLCVLPSTVQSSIAFTSMARGNVSAAVVSASASNIFGMFLTPLLVGLLFAIKGGGGISMDALESILLQLLAPFVLGQVLQPFIGNFVRRKARVLAVVDRGSILMVVYLAFSEAIVEGLWRTVSWDDLGMMVGVNILLLAVVLLATWYGSKWLGFSRPDRITIMFCGSKKSLASGALMANAIFAGANVGNIVLPLMLFHQIQLMACAIIARKLAERHEIRPLast
1 -105.000[R] COG0385 Predicted Na+-dependent transporter  ali  100  1MRFLPDKFTTMLIATILFASVLPVRGEFAVWFALATKIAVGLLFFLHGARLSREAVIAGITHWKLHVTVLASTFVLFPILGLAAGWAIPGLSQSPFYTGILYLCVLPSTVQSSIAFTSMARGNVSAAVVSASASNIFGMFLTPLLVGLLFAIKGGGGISMDALESILLQLLAPFVLGQVLQPFIGNFVRRKARVLAVVDRGSILMVVYLAFSEAIVEGLWRTVSWDDLGMMVGVNILLLAVVLLATWYGSKWLGFSRPDRITIMFCGSKKSLASGALMANAIFAGANVGNIVLPLMLFHQIQLMACAIIARKLAERHEIRP 321
2 -77.000[R] KOG4821 Predicted Na+-dependent cotransporter  ali follow..  20  20..LKSQWFFICLAILIVIARFAPNFARDGGLIKSIGYGCVAWIFLQSGLGMKSRSLMANMLNWRAHATILVLSFLITSSIVYGFCCAVKAAIDDWVLIGLILTATCPTTVASNVIMTTNAGGNSLLCVCEVFIGNLLGAFITPALVQMFTNGNGIGALYGRVMKQVGLSVFVPLFVGQVIQNCFPKGTAYYKKYHIKIGSYMLLLIMFSSFSTAFYQDAFTSVSHVCIIFLCFFNLGIYIFFTGLSYLCARPFYYSKEDAICIMFCGPAKTAALGVSLITSQYGDEHLGKLLVPLVLYQVEQVMTANFFVSLFKRWIQKDA 391
3 -66.700[P] KOG2718 Na+-bile acid cotransporter  ali follow..  17  95.EAVSTAFPIWVSLGCLLGLMRPSTFNWV--TPNWTIVGLTITMLGMGMTLTLDDLRGALSMPKELFAGFLLQYSVMPLSAFFVSKLL--NLPPHYAAGLILVGCCPGGTASNI-VTYIARGNVALSVLMTAASTVSAVIMTPLLTAKLAK-QYITVDALGLLMSTLQVVLLPVLAGAFLNQYFKKLVKFVSPVMPPIAVGTVAILCGYAIGQNASAIL------MSGKQVVLASCLLHISGFLFGYLFSRILGIDVASSRTISIEVGMQNSVLGVVLATQHFGNP---LTAVPCAVSSVCHSILGSVLAGIWRRSAPKQ. 398
4 -48.700[P] COG0798 Arsenite efflux pump ACR3 and related permeases  ali follow..  12  16.KYLTLWVFLCIFVGIALGRLFPELAVKLDAVSIPIAVCLFFMMYPIMVKIDFTQAMNALRTPKPVILTLVVNWLIKPFTMVAFSQFFLGWLANSYIAGTILLGIAPCT-AMVLMWGYLSYGNQGHTLVMVAVNSLAMLFLYAPLGRWLLAANDLTVPWQTIVLSVLIYVGLPLIAGIYSRYWIFKFESRFLKYLSPIAITALLLTLILLFAFKGELIVKN---PLHILLIAVPLFIQTNFIFLISYVAALKLNLAYEDAAPAALIGASNHFEVAIATAVMLFGLN--SGAALATVVGVLIEVPVMLMLVELCKRTASW.. 356
5 -13.600[R] COG0679 Predicted permeases  ali follow..  15  168ISAAKEPVVWAPVLATILVLVVKIPAAWDPTFNLIAKANSGVAVFAAGLTLAAHKFEFSAE----IAYNTFLKLILMPLALLLVGMAC--HLNSEHLQMMVLAGALPPAFSG-IIIASRFNVYTRTGTASLAVSVLGFVVTAPLWIYVS............................................................................................................................................................................ 310
6 -13.500[P] KOG4505 Na+/H+ antiporter  ali follow..  12  35.KLFLGEATMATATGLIFGFVPTSWGNTDYITEELARVLLVVEVFAAGAELPRAYMLRHWRSMVMLLPVMIFGWLVSTGFMYAL--IPRLSFLESLAIAACITATDP-VLASSIVGKGKFARRVPGHLAESGCNDGMAIPFLYLAIYLIIEKPARHAGRDWVCIIILYECTFGCVLGAIIGVIARKMIKFSERRGLMDRESFLVFYFVLAL------------------FCGGIGTIIGVDDLLVSFCAGAAFSWDSWFSKKTEESHVSNVIDVGAIMPWPQFHMPHMDLSVWRLVVLAICILIARRIPA........... 344
7 -12.100[R] COG3180 Putative ammonia monooxygenase  ali follow..  10  43IGIPAGLLMGPMIAGALVGMN----GGTIRLPRQLFFCVQVVLAMMIAASMSPDLLVTFSGNWLLFLAIILSVIGVSTLCGWTITRM------GILPGTTAIWGSSAGAASTMLLMADAYGADARLVAFMQYLRVVFVASTATIVSHLWVSGVEAEIAGLPFFMTLAVGIAVPAFLVPFAIGSALNITGTLTIELPQWLLALSFAMLGWNIGLGFTRAILAHAR-RALMPTIVSIVVLISFSGLLALLLIKVAGIDPLTAYLATSPGGLDSIAV----------AASSNVDLPFVMALQTARLLIITLIGPALARFVADR. 361
8 -11.700[P] KOG3826 Na+/H+ antiporter  ali follow..  10  93...........LFGCLALGIIIKNITFPPFVETMIRKVALVMIIVRWGLATDIHFLYENALM--PVTIGLVTAIGEIIAVTIASYFILNISFVMSIFCALILVTVSPAVTVPAMI-LGSLKRIPENILAICCVDNLFCVILFMVLSSIIFTDAPIATTILLNAGSIVFGCIGGIVLGWILWRFPRSDAPHTQFARITLLGTICIAVVIGTYLIKYMKFDCSTLTWEIVFLCIAVIAIGLLVRTILVMLVTLSSHINFKEQIVVALSLLPRA-TFQADLAPTLLLMA-LKAAILSVLITAPIFDILLNLVGSKCLSQYNPQD 474
9 -10.000[P] COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain  ali follow..  11  20................................YMVSNLALAIILLDGGMRTQASSFRVALGP--ALSLATLGVLITSGLTGMMAAWLFNLDLIEGLLIGAIVGSTDAAAVFSGSTLEIESGSNDPMAVFLTITGIVIGLGGGYLLLQMINRIALPAGLYPLLALSGGILILAVYLCGFLLGNRPIRNRYGILQNFDGLAWL-AQIAMFLVLGLLVNPSDLLPIAIPALILSAWMIFFARPLSVFAGLLPFR--GFNLRERVFISWVGLRGAVPIILAVFPMMAGLENARLFFNVAFFVVLVSLLLQGTSLSWAAKK..... 347
10 -9.190[S] COG3216 Uncharacterized protein conserved in bacteria  ali follow..  13  50...........................................................................................VAAGVAAGV-FASFFP-FAIAAIVCWLISGNMVAAGLGTFVFGNLPFVVGATWETGKIMLHGHMQSDERPAISQLWAPVLKPMLCGAVP............................................................................................................................................. 153
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;