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Query: [F] COG0418 Dihydroorotase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEKLTITRPDDWHLHLRDGAALKAVLPHTVRQFARAIVMPNLKPPVRSVADAAAYRERILAAIPAGGQFEPLMTLYLTDNTNPEEIIAAKASQFVKAVKYYPAGATTNSDFGVTDIHRCDAVLAAMEQVDLPLLLHGEVTDSNIDIFDREKVFIEKYLIPLREKFPRLRVVLEHITTSDAVQFVLSANNIAATITPQHLLFSRNALFKGGICPHFYCLPILKREEHRLSLLHAATSGNPKFFLGTDSAPHARNSKESLCGCAGCYSALHAMELYAEAFESVNSLDKLEAFASFYGPDFYQLPRNTAQITLMKNPWRIPAELPFPESGLVPLRAGEEITWQMVLast
1 -126.000[F] COG0418 Dihydroorotase  ali  100  1MEKLTITRPDDWHLHLRDGAALKAVLPHTVRQFARAIVMPNLKPPVRSVADAAAYRERILAAIPAGGQFEPLMTLYLTDNTNPEEIIAAKASQFVKAVKYYPAGATTNSDFGVTDIHRCDAVLAAMEQVDLPLLLHGEVTDSNIDIFDREKVFIEKYLIPLREKFPRLRVVLEHITTSDAVQFVLSANNIAATITPQHLLFSRNALFKGGICPHFYCLPILKREEHRLSLLHAATSGNPKFFLGTDSAPHARNSKESLCGCAGCYSALHAMELYAEAFESVNSLDKLEAFASFYGPDFYQLPRNTAQITLMKNPWRIPAELPFPESGLVPLRAGEEITWQMV 342
2 -103.000[F] KOG2902 Dihydroorotase  ali follow..  36  2..SLKIPGLADMHVHLRQDNLKAVVPTVAEGGVSVAYVMPNLIPPITTVDACLQYKKEIEQL---DSKTTYLMSLYLSPETTPEVIYEAAKKG-IRGVKSYPKGATTNSESGVESYEPFYPTFAAMQETGMILNIHGEVPPSKDNTVFTAEPKFLPTLLDLHQRFPKLKIVLEHCTTADAVEAVKACGSVAGTITAHHLYLTQKDWQD---DPYCFCKPVAKTERDRRALIEAATSKNPKFFFGSDSAPHPRSSKLKTPPAAGVFTQPFAASYLAEVFDKEGRLDALKDFACIFGRKFYCIPFKESNIVLKKESFRVPES---VANDLVPFHPNEVLQWHC. 334
3 -58.100[F] KOG2584 Dihydroorotase and related enzymes  ali follow..  11  62.GLMVLPGGVDVHTRLQMPDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYERWRER----ADSAACCDYSLHVDITRWHESEELEALVKEKGVNSFLVF----MAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRVFGEPITASLGTDGSHYWSKNWAAFVTSPPVNPDPTTADHLTCLLSSGDLQ-VTGSAHCTFTTAQKNFALIPEGTNGIEERMSMVWEVASGKMDENEFVAVTSTNAAKIFNFSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVECSQGRVA 453
4 -57.100[F] COG0044 Dihydroorotase and related cyclic amidohydrolases  ali follow..  50.GCYVMPGGIDPHTHLQMPDFDTGTAAALAGGTTMVVDFVLPDSEGNLLDALQEWFQKAGKAR-----TDYSFHIAITNERTFNEMVEVVKRG-INTFKHF----MAYKGALMVNDDEMFASFQRCAELGAMPLVHAENGDIHAYSRPPEVEGEATNRAIMIADQAGVPLYVVHVSCEQSHEAIRRARQVFGEPLIQHLTLDESEYHNRDYAARRVMSPPFRDKLNQDSLWAGLAAGSLQ-CVATDHCAFTTEQKNFTKIPNGTGGLEERMPVLWTVRTGRLTPNEFVAVTSTNIAKILNIADADLVIWDPEATKKISAKTQHSSIDYNVFEGFELSRGRIA 438
5 -32.700[E] COG0804 Urea amidohydrolase (urease) alpha subunit  ali follow..  12  125.GKILTAGGFDAHIHFICPALMSGITTMLGGGTGPAHGTLATTCTPGP-----------HMARMIQSFDAFPMNIGLSGKGNASLPAALEELGGACSLKLHEDWGTTPA--------AIDCCLSVADDYDVQVMIHTDTLNEGRTIHAFHTEGAGGGHAPDIIKVCGLPNVIPSSTNPTR----PYTVNTLAEHLDMLMVCHHLSPSIPE-DIAFAESRIRKETIAAEDILHD--IGAFS-IISSDSQAMGRVGEVIRTWQTADKMKRQRGALPQEGDNDNFRVRRYIAKYTINPAIAHGLKRADLVLWNPAFFGVKPDMVLVGGMIAAAPMG......... 461
6 -25.900[P] COG3454 Metal-dependent hydrolase involved in phosphonate metabolism  ali follow..  46.GDYLLPGLVELHTDHLEAAIQAHDAQVVTSGITTVFDCLRLGSDEDSGFPKGEMRSMADALAQAKQEGRLRADHLIHLRCEVSTADVLEHYEDFRNDPQVRLVSLMDHAPGQRQFQTMDQYTLYYKTK---RGLTDDAFAAFIERQQALSARYATPHRNALAKACAERGITVASHDDATVEHVEESIGYGIRLAEFPTSFEAAEASHRAGLSVLMGAPNIKSHSGNIAARDLAKRGVLD-VLSSDYVPFSLIHA----------------PFILADEVESIGLPEAIAMVTATPARTVGLEDADIARVRRPEGIPVVRTV---------WREGRRVA.... 379
7 -19.100[C] COG1229 Formylmethanofuran dehydrogenase subunit A  ali follow..  11  52.GMTVMPGGVDSHSHVAGAKVNKTALTHSGSGYTVPSVFKQFEAAVPPLEARHTHEEMRATPLLDMGGYLVLGNNFFLMRYIRNGVAWMMKTHKTYGIKCVNPAGVENIHFEITPREVIKGLTEINETLGMPMPVHLHANNLGPDGVKTRQNMDVEWAETKIDPLRDRSVYLTHLMFKDIADYINNRDHVVIDSGCEATVMTGDGPAIHDLCGSGVLPFNYLKSNPVHSLQWAMINDPWKTIMTTDSPPEVMT-MSEAFRKQTFGECHKWANDRSAL-NRELSLYDLAILTRANPAKTIGMAHGDVTVYNLNPQQLKGGEIVAVKGEIVSLPEKRTY..... 533
8 -16.400[R] COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold  ali follow..  11  2........YFDSHLHSEGLGF-SELVKLKENGIKEVCSLAFFPVKPKYPQTMIDVFRKLTEFEPEAAGVKMHPAVGIHPRCIPPDYEFVLGY--LEEGEWVAFGEIGLELVTDEEIEVLKSQLELAKRMDVPCIIHTPRGNKLK-------------------------------ATRKTLEILESLDFPADLAVIDH---TLDMVLETEYWIGLTVQPGKLSAEDAARIVAEH--GPERFMLNSD-AGYRDVE-------------ITTVAEAAVKIEEAVGREEMEKVARENARKFLRVLE....................................... 250
9 -15.100[R] COG3964 Predicted amidohydrolase  ali follow..  94.GAFISPGWVDLHVHIWHGGTDISIRPGAERGVTTLVDAGSA-----GEANFHGFREYIIEPSRERIKAFLNLGSI-IKDIDLDRILECYAEEHIVGLKV----RASHVITGSWGVTPVKLGKKIAKILKVPMMVHVGEPPALYD---------------EVLEILGPGDVVTHCFNGKSGSSIMEDEDLFNLAERCAGEGIRLDIGHG------------GASFSFKVAEAAIARGLLPFSISTDLHGHSMNFPVWD-----------LATTMSKLLSVDMPFENVVEAVTRNPASVIRLDMADFTVFDLVD--DSNGDVSRLKRLFEPVIGAEAI..... 415
10 -13.900[Q] COG1228 Imidazolonepropionase and related amidohydrolases  ali follow..  10  69.GKLVTPGLVDPHTHLKQQGVPYLEILKNGGGILAT--VEATRAASEEELITKAICHLNRMLSYGVTTIEAKSGYGLDRETEWKQLRAAKAVGTFLGAHAIPTSHRNDPDRFLDEMADMLGEIKEQNLAEFVDIFTETGV-----------TVEQSRTFLQKAKERGFGLKL-HADEIDPLGGAELAGELGAISADHLVGASDQGIQKAAAGTIACLLP-FYLGKDTYARARDMIDQGLAVTISTDFNPGSSPTENLQLI------------MSIAALRLKMTPEEIWHAVTVNGAHAIGRGDADVVVWDAKNYYYVPYHYGVNHVHSV-WKKGEVVRRRAF 419
11 -13.500[R] COG1831 Predicted metal-dependent hydrolase (urease superfamily)  ali follow..  10  3........ILDNHFHVDNGLFLEAVKQFHRAGGTHLVVVGFGGMKGEDFMRAMDFHVELVEIINKETPVKAYAVVGVHPAKALEHAQRLCLDGKAIGIEVGRPHYPVPEEIWEASIEIMKYAMALAKEADCAVQLHTES---------FDEEKFRELGRYVREVGIKPYRVVKHFSPPLVKVAEEVGIFPSIIASRKNI--------------------------------EEAIKQGTRFLMETD-YIDDKRRPGAVLGPKTVPRRTKEL-----LQKGILTEDDVYRIHVENPEKVYGIE........................................ 278
12 -13.400[R] COG2159 Predicted metal-dependent hydrolase of the TIM-barrel fold  ali follow..  12  1MGRENILFIVDSDCHNYWCSAIMKEKHLDKYNIDVAILTGDLANAHYANALCRAYNDYMIDLPKDSRFWGSIIVAPQDPKLAAEEIRRLGSHPRIVQV------LVSHGAQRPYGDPFYHPIYEACAEMGLPFAMHLGGQGGVNSTQSAMTHMASLIAQGVFEKWPSLKVVIIECGVAWVPSVLWRLKRLPSEYFKTNIRMSTQ---------------PLEQPENVQHLWATLEAGENTLLFASDY-PHWDYD---------------------DVTKLHIPPAWREKVLGLNALDVYRRIPRPAAIA................................. 364
13 -13.100[L] COG0084 Mg-dependent DNase  ali follow..  10  3........IFDTHAHIDPVERLRVVQEARRASVTRIMSICNSLHDFAAVYETLQFSPSVYHAVGVSPS------VMAPGKDWIDTIQKSLQLPQVVALGETGLDYCKKYGDKRSQIGLFITQLDIASKAKKPVIIHNRG------------------------------------AGQDILDILSERIPDQGGVF--HCYSEDAEYARMALDLPVYFS--NLTYRNARNLHETVLALPLDRILVESESPFMSPAT-------NKRNRPAHTVETVEFMAEDMDMLELADQLWKNSCACFHLPE....................................... 257
14 -12.600[L] KOG3020 TatD-related DNase  ali follow..  12  140.......PYIDSHCHTDLLDWIEKYPRAFPKCFFGLIAN-FIKPDLFVDVKGNSSYDVEWIVKELASPLYLGTTWGCHPHFAQEYILSDAEEWKVLAVGECGIDLHRCESELEVQKDVFEKHVALAFKFKLPLVIHCRNGSKG----RAEEECLQILKKKMDVNHKFLKIHR-HCNWEVAQMWLKQCPDVHFGFTP-----------------------FTMGAPQIQAIRNIPLD---RILLETD-GPYFKPKC-------GVAPPKVCLPGMAIATASKIAIEEVLRATFNNTRRVYQLP........................................ 435
15 -12.400[R] KOG4245 Predicted metal-dependent hydrolase of the TIM-barrel fold  ali follow..  12  15.........IDVHAHVLPKNIPDFQEKFGRANVNVQCLSTVPAKPADTEIVARFVNDDLLAECQKFDRLVPLGTLPMNDQRAVEEVKRCVSMG------IKGFEVGSHVAEKSLDHRDFWPLYKICEELSVVLFVHPWDMHMWDG-SETAQAICSVLMGNILVLFPKLKLCFAHGGGA--RGRVSHGWNVRPDLCAGKCKVAPNKLDG-----LLWTDSLVHDPKALELLINTV--GKEHIVLGTDY-PFPLGELEVGRVVEEYKPFSA---------------KDREDLLWKNAVKMLDIDENLLF................................... 348
16 -11.900[R] COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold  ali follow..  11  2........IIDTHLHLRDFLYATYAAEAKRVGVAASLHMEVDVDPAEIELETREVARLAGE--PGSLLKGAIAACRPEDEGFAAYLERQEENAFVKGFR----RVLHVVTDDLSEQPLFRENVKRLSGTRFTFDLCVLPHQIP-------------KAIALADLAPDVQFILDHCGVRDHMTEIARHPNVVAKISGVVAYAEEDWALDS-------IRPYVEHTISV---------GWDRVVWGSD--P--------------VCTLGGNLSTWVAATQALIE-QERRKLLSGNAQRIWNL......................................... 277
17 -11.300[FQ] KOG3968 Atrazine chlorohydrolase/guanine deaminase  ali follow..  11  71.HEFFMPGLVDTHIHASQ-VYTRVVRRTLKNGTTTACYFATIHTDSS---------LLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSR-SCSETLMGELGNIAKTRDLHIQSHSENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCSAEELNVFHERGASIAHCPNSNLSLSSG------------------------LNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSN---ILLINKVNEKSLTLKEVFRLATLGGSQALGLDGFDAILINPKAS............................ 405
18 -10.300[FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases  ali follow..  52.GKIVMPGFVDTHRHVWESANLWGALEAIDAGVTTVLDWSMLETPEHADASIKGLQAAGIRAVFAHGTPGYETYWSRDSEVRHPKDAKRVKKEYFQSDDQLLTMALAIRGPEFSSWEVTLDDIQLARELDAIASMHIGFG--------TWGPHDRSITRMREAGLLDSDLNLVHVNQPHEYEYIAESGASLSVTPEVEMMMGHG------------------------PATGYLHKHRGLVTLGVDVVVATAAQMKFALQAERAWQNEQRLDRGEMPEQLKMTTNDVLTFATLNGAKALKLDDADLLLINPSSFNLFP........................ 387
19 -9.240[F] COG1001 Adenine deaminase  ali follow..  13  75.GKIVVPGFIDTHLHIESSLVTPHEFDVLPYGVTTAICDPHEIANVLGAEGLQFFLDSAMETIMDIRVQLSSCVPATHLETSGADLPIEKLLPFRNHPKVIGLAEFMNFPGVIHKDPVCMAKLEAFQ--GQHIDGHAPLLSGAA-----------------LNGYLAAGIRTEHTSAAEALEKIRKG----------HILVREGSV-----------------SKDLHALMPIITERLSPLALCTDDR-----------NPLDIAEQGHLDYMIRTAIASGVEPLAIYRAASISAAKAFGLRDADLVVIDTLQNCKASMVLSGGR................. 356

FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 6 0 7   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Pio F, Pawlowski K, Godzik A. Saturated BLAST: an automated multiple intermediate sequence search used to detect distant homology. Bioinformatics. 2000 Dec;16(12):1105-10.