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Query: [E] COG0460 Homoserine dehydrogenase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst HENLFNSKHFLDVFVVGVGGVGGELVDQIQRQQAKLAEKGIMMRVCGLANSKGMLLDSQGLPLEQWRDRMINADQAFSLENLVALVQRNHIINPVLVDCTSSDEIANQYADFLAAGFHVVTPNKKANTASMSYYHQLRNVARHSRRKLMYETTVGAGLPVIENLQNLIAAGDELEKFSGILSGSLSFIFGKLDEGMTLSQATQLAKEKGFTEPDPRDDLSGMDVARKLLILAREAGYELELSDVDVEQALPAGFDASGSVEEFMARLAQADAAFAERVAQAKAEGKVLRYVAQIVDGQCQVRIVAVDENDPMFKVKEGENALAFYSRYYQPIPLVLRGYGAGSEVTAAGVFSDVMRTLGWKLGVLast
1 -98.700[E] COG0460 Homoserine dehydrogenase  ali  100  1HENLFNSKHFLDVFVVGVGGVGGELVDQIQRQQAKLAEKGIMMRVCGLANSKGMLLDSQGLPLEQWRDRMINADQAFSLENLVALVQRNHIINPVLVDCTSSDEIANQYADFLAAGFHVVTPNKKANTASMSYYHQLRNVARHSRRKLMYETTVGAGLPVIENLQNLIAAGDELEKFSGILSGSLSFIFGKLDEGMTLSQATQLAKEKGFTEPDPRDDLSGMDVARKLLILAREAGYELELSDVDVEQALPAGFDASGSVEEFMARLAQADAAFAERVAQAKAEGKVLRYVAQIVDGQCQVRIVAVDENDPMFKVKEGENALAFYSRYYQPIPLVLRGYGAGSEVTAAGVFSDVMRTLGWKLGV 364
2 -80.600[E] KOG0455 Homoserine dehydrogenase  ali follow..  32  1.....MSTKVVNVAVIGAGVVGSAFLDQLLAMKSTIT-----YNLVLLAEAERSLISKDFSPLNVGSDWKAALAASTTKTLPLDDLIATSPKPVILVDNTSSAYIAGFYTKFVENGISIATPNKKAFSSDLATWKALFS-NKPTNGFVYHEATVGAGLPIISFLREIIQTGDEVEKIEGIFSGTLSYIFNEFSNDVKFSDVVKVAKKLGYTEPDPRDDLNGLDVARKVTIVGRISGVEESPTSFPVQSLIPKPLESVKSADEFLEKLSDYDKDLTQLKKEAATENKVLRFIGKVDTKSVSVGIEKYDYSHPFASLKGSDNVISIKTKRYTN-PVVIQGAGAGAAVTAAGVLGDVIKIAQRL... 359
3 -27.900[E] COG4091 Predicted homoserine dehydrogenase  ali follow..  12  16......TGKPIRIGLIGAGEMGTDIVTQVARMQG--------IEVGALSARRFKAIRTAYGDEENARTRAIEAGKIAVTDDNDLIL--SNPLIDVIIDATGIPEVGAETGAAIRNGKHLVMMNVEADVT---IGPYLKAQADKQGVIYSLGAGDEPSS-CMELIEFVSALGYEVVSAGKGKNNPLNFDAT-------PDDYRQEADRRNMNVRLLVEFIDGSKTMVEMAAIANATGLVPDIAGMHGPRASIDQLSHTLIPQAEGGVLSKS---VVDYSIGKGVSPGVFVVAKMDHPRLNERLEDLKIGKGPYFTFHRPYHLTSLEVPL--TVARVVLHGKTDMVPLPKPVAEVCAVAKKDMQ.. 359
4 -13.900[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  12  1.........MLKIGIVGCGFIGGQICRAIDGGEV-------SAELYALCDS----------SESKALELAASLKTCKPSYMKIEELIRG---VDLIIESASQNAVRFIVPQALKAGCDVMILSVGALADE-ELRDTLFGLAKEHNCKLYFPSGAVVGIDGLNSVVEHGIELEKLEKKTVLFEGPASEAVKAFPANVNVAATISLAADPSLFRNVHEIIVEGEFGKFSTRVENLPSPENPKTSYLAALSAVS................................................................................................................. 258
5 -12.800[S] COG3804 Uncharacterized conserved protein related to dihydrodipicolinate reductase  ali follow..  12  2.........AIPVVQLGTGNVGVHSLRALIADPE--------FELTGVWVSSD---AKAGKDAAELAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAAGINIVGSGPVFLVIPDEIIKPLQDAARAGNSSL-YVNGIDPGFANDLLPMALAGTCESIEQIR----------CMEIVDYATYDSAVVMFDVMGFGKPM-QPGVLSLAWGSVVRQLAAGLGISLDGVEEMYVREPAPEAFNIASGH----------------IPKGSAAALRFEVLGLVDGVPAVV--ADLCPEWPQPAQPGGSYRIEISGEPCYAMDI--DHNHAGLVATAMRIVNAIPAVVAAEPGI 340
6 -10.300[R] KOG2742 Predicted oxidoreductase  ali follow..  11  2.........LPGVGVFGTGEIANVLVPLLREK---------GFEVRAIWGR----------TLKEAKETATTQNVQFHTNVIDDVLLRKDV--DLVFIVCQPFLHAEISVKALGIGKHVVC--DKPAGLHQQDALKMVRASQYYPTLISLVNHPLRFLPAFTHMRRCLQEEGSIGDVVLMFPEKYNWMCDAQMGGGALNLVGSVVDLVTFLLQQQAIRVHGV.............................................................................................................................................. 202
7 -10.100[Q] COG4569 Acetaldehyde dehydrogenase (acetylating)  ali follow..  11  2........SKRKVAIIGSGNIGTDLMIKILRHGQ-------HLEMAVMVGID---------PQSDGLARARRMGVATTHEGVIGLMNMPEFAIDIVFDATSAGAHVKNDAALREAKPDIRLIDLTPAAIGPYCVPVVNLEANVDQLNVMVTCGGQATIPMVAAVSRVARV-------------HYAEIIASIASKSAGPGTRANIDEFTETTSRAIEVVGGAAKGKAIIVLNPAEPPLMMRDTVYVLSDEASQDDIEASINEMAEAVQAYVPGYRLKQRVQQDKPVNLPGVGQFSGLKTAVWLEVEGAAHYLPAYAGNLDIMTSSALATAEKMAQSLARKAGEAA................... 316
8 -9.540[GQ] KOG2741 Dimeric dihydrodiol dehydrogenase  ali follow..  1....MSGDNQIRIGLLSCTNKVRKLSRAINLSPNA--------TISAIATTSSI-------EAKSFAKSNNFPPNTKLHSSYESLLE--DPDVDAVYFPIPTRLHVEWATLAAIKGKHILL--DKPVALNVAEFDQIVEACEVNGVQFM-DGTQWMHSPRTDKIKEFVNDLESFGQIKSV---YSCFSFAASDDFLKHDIRVKPGLDGLGA------DAGWYTIQAILLVNNFK.................................................................................................................................. 204
9 -8.150[R] COG0673 Predicted dehydrogenases and related proteins  ali follow..  14  2........KTVNIGLIGAGRIGQLHASNIISSP--------YMELKAVSD----------VQLDHLKGTEIERSVEIMTTNPDELFSNRDIDAIFI--CSSTDTHAAFIKAAALAGKHIFC--EKPISFHVTETKGALNIVNEAGVKFQVAGAIGGGMFMDMTIHDF-LSGSEVTEVSVKAANLVDIITLMLENGAIAVIDNSRQAAYGY---DQRVEVFGSLGSVSA........................................................................................................................................ 253
10 -8.030[S] COG1810 Uncharacterized protein conserved in archaea  ali follow..  11  1.....MFQSDLKLIVFQHGFFGERFVANLMNYPNSCP---YGACGIDGCTQCKEGLYNFSKNIIAVFSMPDPTTMPDFIENAEDFLPKVIPEADIAVAINLHPDVLAVMPEKLKGKKALIVPVEEPRWCSPGLAKQIREKCDELGLEFAAPKPFCNGYPEF----EIELLEDGKAYVRISRSGCAYYIGVKLR-GFDFSEVKEGKMRE............................................................................................................................................................ 219

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.