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Query: [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSKVEQMQATPARGEPDKLAIEARKTGFDEIYLPFRADQAQREASRCLKCGEHSVCEWTCPLHNHIPQWIELVKAGNIDAAVELSHLTNTLPEITGRVCPQDRLCEGACTIRDEHGAVTIGNIERYISDQALAKGWRPDLSHVTKVDKRVAIIGAGPAGLACADVLIRNGVAVTVYDRHPEIGGLLTFGIPSFKLDKSLLARRREIFSAMGIHFELNCEVGKDVSLDSLLEQYDAVFVGVGTYRSMKAGLPNEDAPGVYDALPFLIANTKQVMGLEELPEEPFINTAGLNVVVLGGGDTAMDCVRTALRHGASNVTCAYRRDEANMPGSKKEVKNAREEGANFEFNVQPVALELNEQGHVCGIRFLRTRLGEPDAQGRRRPVPVEGSEFVMPADAVIMAFGFNPHGMPWLESHGVTVDKWGRIIADVESQYRYQTTNPKIFAGGDAVRGADLVVTAMAEGRHAAQGIIDWLGVKSVKSHLast
1 -113.000[ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases  ali  100  1MSKVEQMQATPARGEPDKLAIEARKTGFDEIYLPFRADQAQREASRCLKCGEHSVCEWTCPLHNHIPQWIELVKAGNIDAAVELSHLTNTLPEITGRVCPQDRLCEGACTIRDEHGAVTIGNIERYISDQALAKGWRPDLSHVTKVDKRVAIIGAGPAGLACADVLIRNGVAVTVYDRHPEIGGLLTFGIPSFKLDKSLLARRREIFSAMGIHFELNCEVGKDVSLDSLLEQYDAVFVGVGTYRSMKAGLPNEDAPGVYDALPFLIANTKQVMGLEELPEEPFINTAGLNVVVLGGGDTAMDCVRTALRHGASNVTCAYRRDEANMPGSKKEVKNAREEGANFEFNVQPVALELNEQGHVCGIRFLRTRLGEPDAQGRRRPVPVEGSEFVMPADAVIMAFGFNPHGMPWLESHGVTVDKWGRIIADVESQYRYQTTNPKIFAGGDAVRGADLVVTAMAEGRHAAQGIIDWLGVKSVKSH 479
2 -54.200[F] KOG1800 Ferredoxin/adrenodoxin reductase  ali follow..  20  1.....................................................................................................................MGINCLNIFRRGLHTSSARLQV-IQSTTPTKRICIVGAGPAGFYAAQLILKQNCVVDVVEKLPVPFGLVRFGVPDHPEVKNVINTFTKTAEHPRLRYFGNISLGTDVSLRELRDRYHAVLLTYGADQDRQLELENEQLDNVISARKFVAWYNGLPGA-----ENLAPDLSGRDVTIVGQGNVAVDVARMLLSPLDERVHLVGRRGPLQAAFTIKELRELKLPNVDTRWRTEDFSGIDMEQGRISGSKQFLPIFLRAPKAIAPGEMEFSSSTERLPSHLILRSIGYKSSCVDFDTRRGRVHNINGRILKDDAT----GEVDPGLYVAGWLGTGPTGVITTMNGAFAVAKTICDDINTNALDTS 414
3 -40.500[H] COG1635 Flavoprotein involved in thiazole biosynthesis  ali follow..  13  2.........................................................................................................................ELDEVIITRAIFDEYSK--TFLDYTDIDVALVGGGPANLVAAKYLAEAGVKVALYEQKLSLGGGMWAG--GMMFPRIVVQEEATILDDFGIRYKEYESGYYVANSVESVGKLIAGATSAGAEVFNLVSFED-----MIRENDRVTGIVINWGPVTTQRLHVDPLMIRTKLVIDGTGHEAVVCNTILRKIPNAKIGELGLLGEKPMWS--EVGERLAVNATQEIYPGLIVA--GMAANAATRAPRMGPVFGGMLLSGEKAAKLALDRLKTI........................................................................................ 260
4 -29.100[O] COG0492 Thioredoxin reductase  ali follow..  18  10.....................................................................................................................................................ITIIGGGPTGLFAAFYGGMRQAKVKIIESMPQLGGQLAALYPEKYIYDDLVNDLKRQAEQFNPTIALEQSVQNTIKTDKETHYSKAIIITAGAGQPRRLEVEGAK-KNLQYFV-------------------DLNAYAGKNVLISGGGDSAVDWALMLEPV-AKNVTLIHRR--DKFRAHEHSVELLQKSSVNILTPFAISELSGDGE-KIHHVTIQEVK---------------GDAVETLDVDEVIVNFGFVSSLGPIKG---GLEIEKNSIVVNT----KMETNIPGIYAAGDICTYPKLIATGFGEAPTAVNNAKAFIDPTA.... 319
5 -28.300[O] COG3634 Alkyl hydroperoxide reductase, large subunit  ali follow..  18  214....................................................................................................................................................DVLIVGSGPAGAAAAVYSARKGIRTGLMGE--RFGGQVL-SVPKTE--QKLAGALKAHVSDYDVDVIDSQSASKLVPAATEGGLHRSIIIATGA-KWRNMNVPGED-KGVTYCPH------------------DGPLFKGKRVAVIGGGNSGVEAAIDLAGI-VEHVTLLEFA--PEMKADQVLQDKVRSKNVDIILNAQTTEVKGDGS-KVVGLEYRDRV---------------SGDIHSVALAGIFVQIGLLPNTHWLEGA--LERNRMGEIIIDAKC----ETSVKGVFAAGDCTTVPKQIIIATGEGAKASLSAFDYLIRTKIA.. 521
6 -26.200[O] KOG0404 Thioredoxin reductase  ali follow..  20  28....................................................................................................................................................KVTIIGSGPAAHTAAIYLARAEMKPTLYEGMIAAGGQLTTGFPESLSGSELMERMRKQSAKFGTNIITETVSKVDLSSKPFR-TTDAIILATGA-SAKRMHLPGEE-QGISACAV----------------DGAVPIFRNKPLAVIGGGDSACEEAEFLTKY-ASKVYILVRKDHFRASVIMQR-RIEKNPNIIVLFNTVALEAKGDGK-LLNMLRIKNTK---------------SNVENDLEVNGLFYAIGHSPATDIVKGQ--VDEEETGYIKTVPGSS---LTSVPGFFAAGDVQDSRRQAVTSAGSGCIAALDAERYLSAQE.... 342
7 -23.700[C] COG1251 NAD(P)H-nitrite reductase  ali follow..  16  2.................................................................................................................................................SKVRLAIIGNGMVGHRFIEDLLDKSFDITVFCEEPRKA---RVHLSSYHTAEELSLVREGFYEKHGVKVLVGERAEKVIHSSA-TVYYDKLIMATGS-YPWIPPIKGSETQDCFVYRTI-----------EDLNAIEACARRSKRGAVVGGGLLGLEAAGALKNLGV-ETHVIEFAPM-DQMGGEQLRRKIESMGVRVHTSKNTQEIVQQGNEARKTMRF---------ADGS-----------ELEVDFIVFSTGIRPRDK-LATQCGLAVAQRGGIVIND----TCQTSDPDIYAIGECASWNNRVYGLVAPGYKMAQVAVDHILGSENA.. 313
8 -22.400[R] KOG2960 Protein involved in thiamine biosynthesis and DNA damage tolerance  ali follow..  11  1...................................................MAPATAVVTPQ-----------TAFKTDLPVEKTAHNTVVKSEMGALSKAY--PTYSLDESFSFAPIRESTVSRAMTRRYFSD-------LDKYAESDIVIVGAGSAGLTAAYYIGTRDLKIAIIEASVAPGGGAWLG-MVVRKPADLFLNEIGV-EGDYVVVKHAALFTSTVMARTLALPNVKLFNATAVE-----DLIVKEGKDGKQRIAGVVTNWTLVSLNHGLQSCMDPNTINAHLVVSATGHDGPFGAFCVKRLASAQLVSNLHDMRPLDMNRAEDLIVKGTREVFPGMIVGGMELSE-----FDGANRMGPTFGGMMFSGIKAAQEALADERKAVNEKYL.................................................................................. 328
9 -21.400[R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases  ali follow..  19  2...................................................................................................................................................TKIVIIGGVAGGASAAARARRLS-EIIMFERGPYVS-FANCGLPYHERSNLLLQTPESFLARFNVDVRTMNEVAKTITVRNLLDQYDFLLLSPGA-GPVIPPIPGIQNPLTH---------SLRNIPDMDKIIQTLQMNKPEHATVVGGGFIGLEMMEAFHHLGI-KTTLIEMADQ--MTPVDREMAEIRAKGIDLRLGAALKSVEYRPAATLPSAE-SGESLEHKHVEGELDLLLSNGDT--LTTDILIMAIGVRPETK-LAAEAGLQLGELGGIWVNE----QMQTSDPAIYAVGDAVEEKDFVTGANRQGRMAADNM............ 335
10 -20.400[Q] KOG0405 Pyridine nucleotide-disulphide oxidoreductase  ali follow..  20  1..........................................................................................................................MARKMLVDGEIDKVAADEANATHYDFDLFVIGAGSGGVRAARFSANHGAKVGICELIGGVGGTVIRGVPKKILVYGAYGGELEDAKNYGWEINEKVDFTKTDEILRLNNIYKHILIATGS-RAQKPNIPGHEL--AITSDEALS-----------------LEEFPKRAIVLGGGYIAVEFASIWRGMGA-TVDLFFRKEL--LRGFDDEMRNLEGRGVNLHPQTSLTQLTKTDQGIKVISS----------------------HGEEFVADVVLFATGRSPNTKRLLEAVGVELDQAGAVKVDE----YSRTNIPSIWAVGDATNRINLTPVALMEATCFANTA............ 360
11 -20.200[C] KOG1335 Dihydrolipoamide dehydrogenase  ali follow..  20  44.....................................................................................................................................................VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTLNVGIPSKALSHYYHMAHGTDFASRGIEMSDKMMEQKSTAVKALTGGTKNILIATGS-EVTPFPGITIDEDTIVSSTGALS-----------------LKKVPEKMVVIGAGVIGVELGSVWQRLGA-DVTAVEFLGHVGGVGIDMEISKNQKQGFKFKLNTKVTGATKKSDGKID-------------------EAASGGKAEVITCDVLLVCIGRRPFTKNLLEELGIELDPRGRIPVNT----RFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGM............ 377
12 -20.000[R] KOG1336 Monodehydroascorbate/ferredoxin reductase  ali follow..  17  2................................................................................................................................................GRAFVYVILGGGVAAGYAALEFTRRG-ELCIISEEPV----APYERPA--LSKGFLLPEAKWYKDHGIELVLGTRVRKTLLSST---SYKFLIIATGARALKEFGVEGSDAENVCY---------LRDLADANRLATVIQSSSNGNAVVIGGGYIGMECAASLVINKI-NVTMVFPEAHCMARLFTPKIASLRAKGVKFIKGTVLTSFEFDSNKKVTAVNL---------KDGS-----------HLPADLVVVGIGIRPNTS-LFEGQLTIEK--GGIKVNS----RMQSSDSSVYAIGDVATGEMRRLEHVDSARKSARHAVSAIMDPI.... 332
13 -19.900[C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes  ali follow..  16  7.....................................................................................................................................................YIAIGGGSGGIASINRAAMYGQKCALIEAKELGGTCVNVGVPKKVM-DRIHTSYDNVLGKNNVDVIKGFA-AKTIEVNGETITADHILIATGG-RPSHPEIPGVEY--GIDSDGFFA-----------------LSALPERVAVVGAGYIAVELAGVINALGA-KTHLFVRKHA--LRSFDPMIEVMNAEGPQLHTHAVPKAVVKNADGSL---------------------TLELEDGRSETVDCLIWAIGREPSTDNILAAAGVKTNEKGYIIVDKF----QNTNVEGIYAVGDNTGAVELTPVAVAAGRRLSERL............ 325
14 -19.200[O] KOG4716 Thioredoxin reductase  ali follow..  21  12.....................................................................................................................................................LIVIGGGSAGLACAKEAVLNGARVACLDTKWGVGGTVNVGIPKKLMQASLLGEAVHEAAAYGWNVDEKIKPDVQNHIKSVNWVTRVDLRDKKVEDSHTLLAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDGKTLVVGAGYIGLECAGFLKGLGY-EPTVMVRSI---LRGFDQQMASMEERGIPFLRKTVPLSVEKQDDGKLL-----------------KYKNVETGEEAEDVYDTVLWAIGRKGLVDDLLPNAGVTVQK-DKIPVDS----QEATNVANIYAVGDIIYGKPELTPAVLAGRLLARRL............ 349
15 -18.300[C] KOG3851 Sulfide:quinone oxidoreductase/flavo-binding protein  ali follow..  10  29....................................................................................................................................TRFLSTSRVNRERQECQVLVVGGGTGGCAMAAKLSSRSDKVVVLEPEDK----MFTLIGGGMKRLDQSHRQMADVLPTKAKWVKEKALEFDPDNNTVS-KYDFLIIATGLQLNYG-KIPGLV-----ALETPDSNVCSIYSPKYVDHVYECLRRTNKGNAIFTFPNCPIKCAGAPQKIGRRDNVNIIYNTSLPVIFGVKHYAEALMK------LIKRRNITLNVQRNLVEVRHKDNIAVFEDLAK-------PGVHYEETYSMLHVTPPMSTPD--VVANCKKLVTPTGFVDVDQLTLQ--HNKYSNVFAIGDSAS-SKTAAAAAAQSPVVFKNVMAAIEGKAPTDI 375
16 -18.100[Q] KOG1399 Flavin-containing monooxygenase  ali follow..  17  1.........................................................................................................................................MAPAPSPINSQHVAVIGAGAAGLVAARELRREGHTVVVLDREKQVGGLWVYDSRRYPSHREVLAYLQDFATEFNIEIRFETEV-KTGGGFSNDEIYDAVVMCCG-AEPNIAQIPGKISKFSYTLFQK----------------------KLLVVVVIGNFASGADISRDISKV-AKEVHIASRASKSNTFEKRPVPNNNLWMHSEIDTAHEDGTIVFKNG-------------------------------KVVHADTIVHCTGYKYYFPFLETNNYMRVDDNRVEPLYKHIFP--PALAPGLSFIGYMFEVQSKWVAAVLSGRVTLPSVDEMMDDLKLSYE 361
17 -17.700[C] COG1252 NADH dehydrogenase, FAD-containing subunit  ali follow..  17  4............................................................................................................................................SLENHQPHEVVIVGGGFGGLYAAKALAKTNVNVTLIDKRNF----LLYQVATGTLSPADISAPLRSVKSKNTKVLLGEVNDIDPNLQQII-PYDTLIVATGA-KHSYFGKDNWQLKTVEDAIE-MRRRIFGAFEAAEKETDLEKRKALLTFVIVGGGPTGVELAGAIAELAYKTLQEDFRNINTS------ETRILLLQGGDRILPHIAPELSQAATTSLREFGVVQTKTRVTSIENDIVTFKQGDELQTITSKTILWAAGVKASPKVLAERTGVECDRAGRAIVEPDLS---IKGHQNIFVVGDLAN-PSVAPVAIQEGEYVAKLIKKRLQGKTLPA. 354
18 -17.200[C] KOG2495 NADH-dehydrogenase (ubiquinone)  ali follow..  12  1....................................................................................MSFHSFYQRASSLFKAYPSTSKILLLSTFSGGGGVLVYSDSNPLKRILHADATLDSDGNPIRKKKVVVLGSGWSGYSFLSYLNNPNYDVQVVSPRNF----LLPSVTNGTVEARSIVEPIGLMRKKGFEYKEAECVKIDASNKKIH-DYDILILAVGA-KPNTFNTPGVELKEAEDALNIRHSVIDCFERASLPNLTEEERKKILHFVVVGGGPTGVEFSAELHDFLVQDVAKIY-------PKVQEFTKITLLEAGDHILNMFDKRITAFAEEKFQGIDLTGSMVVGVTADEISTKERETGKIVSEPYGMVVWSTGIGSRPVIKDFMQQIGQGQRRVLATDEWLR---VEGCDGVYALGDTATDIAAIFNKADKGNTGTLKKKDFNSVVKDIC. 417
19 -14.400[R] COG3380 Predicted NAD/FAD-dependent oxidoreductase  ali follow..  14  2..................................................................................................................................................SVPIAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRMALGAQYFTARDRRFLDALQHWREEGWVDEWKPALYQYRDGQLSPSP---------DEQPRWVGIPRMSTRALLTDLQVITEVFRGKQHWHLQDSEGQNHGPFNQVLIAIPAPQATPLLASVPKLAATAASVVMEPTWAVALGFREVLDTPVQGCFVHGSPIAWLACNRSKPGRDTTLDTWVLHATSQWSRQHIDMAKEDVVEHLRCAFAEVIGCA-------VPEAAFSIAHRWLYARPAEAHQWGALGDPDGIYACGDWCSSGR-VEGAWLSGQEAARRLLEHL........ 327
20 -14.100[E] COG3075 Anaerobic glycerol-3-phosphate dehydrogenase  ali follow..  13  5.....................................................................................................................................................TIIMGGGLAGLLCGLQLQKHGLRCAIVTRGQSASGSL-YSLLGPQRVLDLACQAQALIAESGAQLQGSVELPHQRGLMDFQAHLAAASLRELDLAVETAEIELPELDVLRNNATEFRAVNIARFLDNEENWPLLLDALIPVAMILMPACFGLADDKLWRWLNEKLPCSLMLLPTLPPSVLGIRLQNQVRQGGVWMPGDEVKKVTC-KNGVVNEIWTR------------------NHADIPLRPRFAVLASGSFFSGGLVAERNGIREPQQFGVTTDQTRPSQAGQTIENLFTIGSVLGGFDPIAQCAVSALHAAQQIAQRAGGQQ.... 419
21 -13.900[Q] COG3486 Lysine/ornithine N-monooxygenase  ali follow..  17  4.........................................................................................................................................TACTTPAGEILDVVGIGIGPFNLSLAALLAEAGYDRTVFERKPYFSGMLRFSFLNYQLPSLRFGSEVTRVDVVDGCYRVTARAGNSESIHYAHN----LVLGTGTQPACLHTLAQRFPEKVMHTADYARHFDIAG---------------KQRVLVLGSGQSAAEVIQALLNRQCDELDWVTRAPDRVVPKQGLFYKGISSKTISAIYDCLYHRSVGDAPLPVHLRALSELRHVEPTANGRLDAR-QTGHTFSIVVDAIISGSGYRYTLPSFLDGLGVHYDDMKRLKIDAGYRVEH-RGPGQIFMQNGELHTHGIGAPDLGLGAWRAAHIANRIAGHELYR. 427
22 -13.800[S] COG3349 Uncharacterized conserved protein  ali follow..  17  2....................................................................................................................................................RVAIAGAGLAGLSCAKYLTDAGHTPIVLERRDVLGGLVA----GLHAFFGAYPNMLQLLKELGIEDRLQWKIASILRNNDMLTWEQKIRFAIGLLPAIVRGQKYVEEMDKYSFSDWLKRQGVGERVASDVFIAASKALTFINPDEVSSTILLTALNRFLQERYGSKIAFLDGSPTERLCQ----VDYITERGGEVRLNAPLKEILLNPDGTVKGFLLRGLNGE---------------PDEVITADFYVSAMAVDPLKVMLPQKSHVVKTPRSVYKATPGRQQAQKTPIANFFLSGSYTM-LGSMEGAVLSGKLTAQAICESLPEDN.... 461
23 -13.600[C] COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins  ali follow..  15  30...........................................................CHCGVNIGGVVDIEAVRDYAAKLPNVVVSKDYKYYCSRVVVAA--CSPRLHEPTFRRCVEEAGLNQFLFEFAKARLLEPLEASKVSVDDKALVIGGGVAGIQTALDLADMGFKTYMVEKRPSISGRMG--FPTLDCSMCILAPKMVDVGK-NIELITYAEVKEDQEPEEIEIEVGTIIVATGYDATEKLEYGYGRHTNVITGLELERMINASGSDGEKPKRVAFIHCVGSRDEQIGKPYCSRVCCMYIMKNADTEVTLYYMDIRAFGKGFEEFYKRSQEKYGIKFIRGRPAEILENPDLTLT-----------------RSEDTLLGKVTEYDYDMVVLGVGLVPPEGSLRQTIGLSKSADGFLMEAHPKLRPVDTLTDGVYLAG-VAQGPKDIPDAVAQASGAAARAAIPMVKGEVEIE 591
24 -13.000[S] COG4529 Uncharacterized protein conserved in bacteria  ali follow..  15  2...................................................................................................................................................KSFIIIGGGASGVIIAAQLLRRA-TVRIFEKSGRLGAGIAYSAPRRLYRDYLAGLLQPYHLEAHPRLFVEKVEAADIVLED-RFSADAIILATGNEASIATPGKHVAEYWSSNGYFNIPI--------------------DAPVAIFGTGLSMIDSVLSLLDNGHKEIFAISRRGPSLVQHIRALMRKVEQKGGNWRDVMDGLRPHTQKSGQLKVMAGRLVSVRQDGEDIAVCYSP-KGGEQMLRVAAIIDCRGGNQHFSTTRNPALIRLMEQGLARPDAQVVNARGEPSGPFFALGPVTKGMFWEVTAVPDIRVQAEKLAQRLLQE..... 442
25 -12.500[C] COG1150 Heterodisulfide reductase, subunit C  ali follow..  15  1MVEPRDTVIREEDLNP------DFLEELSELVEPVFEEEEVLSVQACYQCGT---CTGSCPSGRRTSYRTRLIMRKLQLGLVDEVIKSDEL------MCTTCYTCYERCPRGVKIVDA-VKAARNLAAKK-----------------------GYMAKAHMVAMFVIKTGHAVPINDEIREVR--KNIGLDEVPPTTHRYEEALEEVQKLVKINEFDKLIGYDWEEGDLVD........................................................................................................................................................................................................................................................ 192
26 -12.400[S] COG4716 Myosin-crossreactive antigen  ali follow..  11  9.....................................................................................................................................EAFATPRKPEGVDQKSAYIVGTGLAGLAAAVFLIRAGERIHLFEELPLAGGSLDLKFNKYNQYDSMVKPIIAYLESHDVDIQFDTKV-TDIQVEQ-LTPDDLVFVTNGSITESST------YGSHHEVAKPTKALGGSWNLWENLAAQSDDFGHPKVFYQDLPAESWFVSATATIKHPAPYIERLTHRDLHDGKVNTGGIITITDSNWMMSFAIHRQPHFKEQKENETTVWIYGLYSNSEGNYVHKKIEECTGQEITEEWLYHLGVPVDKIKDLASQDYINTYITSYFMPRVKGDRPKVIPDGSVNLAFIGNFAESPFTTEYSIRTAMEAVYSF............ 523
27 -11.700[C] KOG2415 Electron transfer flavoprotein ubiquinone oxidoreductase  ali follow..  13  71.....................................................................................................................................................VVIVGAGPAGLSAAVRLKQLDIRVCLVEKAAQIGAHTLSG-------ACLDPGAFKELFPDWKEKGAPLN-----------------------------------------------------------------PVTEDRFGILTEKYRIPVPILPGLPMNNHGNYIVRLGHLVSW------GEQAEALGVEVYPGYAAAEVLFHDDGSVKGIAT-----NDVGIQKDGAPKATFERGLELHAKVTIFAEGCHGDLRANCEPQTYGIGLKELWVIDEKNWKP-KLTFPGGLLIGCSPKG---THTAMKSGILAAESIFNQLTSENLQSK 426
28 -11.500[P] COG2072 Predicted flavoprotein involved in K+ transport  ali follow..  15  6....................................................................................................................................................DVLIIGAGLSGIGTACHVTAEFKTIALLERRERLGGIRQY-ATEFGVDEKIYGLKVNTAEWSSRQCRWTVAGVHEATGETRTYTCDYLISCTGYDAGYLPDFPGHRFGGCVHPQHWPEDLDYS----------------GKKVVVIGSGATAVTLVPAMAGSNAAHVTMLQRSPSYIFSLPAVDKRSVDMSNFTPNYLPWDERLCAVPNGDLGAASVVTDQIETFTEKG------LCKSGREIEADIIVTATGLNIQ.......................................................................... 351
29 -11.100[R] COG2509 Uncharacterized FAD-dependent dehydrogenases  ali follow..  17  2................................................................................................................................................EQKFDVVIIGAGPAGLFAAYELVERNLKVLIIDEGGDVGGLLRHEAPRNLYKPKVIKSIKNYLESKGVKFLLWTKA-LEFNKGWVK-EAKYIIVAPGRGGAEWFHEVAKKIGRVEVPAIIMEPITSINHDPKFHIYTDTYDDFVRTFCTNPYGFVVEERYDSYVGVNGHSMREKKSNNTNFALLTRIELTEPVEDTTAYGRSIAQLATT-IGGGKPIIQRLGDLRKGRRSTWSRIRKSDVEPTLKHVTPGDIAMALPHRVVTNIIEGLERLDKVIPGVASDHTEVNELLETSIENVFAAGDGAGLSRDIVNAAATGIMAARGILVKEGLYNLKDF 467
30 -11.000[E] COG1231 Monoamine oxidase  ali follow..  13  28...............................................................................................................AKVGGTAALYQAMTSLGHAAETRFPGPPNLQGARPGASVIVLGAGLAGLLAAFELRKAGYKVQILEFQNRPGGRNWFNPGPWRIPHH--RTLLHYCKQFGVALESQAFGGKPVRFNAAAADFEGNIVNAKALDDAVTLEDRERLLEALKGWGMLDKDYRYAASLRTSSHRGFKRPGGGGVDPVGGMDMIGKAVEGLITYNAKVSKIAQDDKGVVVTYADTVTGKVTEAKGDWCVCTIPLGILGQMDLAVTDEMMAAIK-GHSFTDQEIGLISYPNNNLFQDGPAVLLGAFARDLGAFRLAGMTPEQRIEVALAQVPWTLGCCARWNEEIVLAGEHAS-GCWMEGALLSSLDAITRLHKRALSA..... 541
31 -10.700[C] KOG2403 Succinate dehydrogenase, flavoprotein subunit  ali follow..  17  49.....................................................................................................................................................CVVVGAGGAGLRAAFGLAEAGYKTACLSKLFAQGGINAAWLGDQDAIHYMTRESVIELEHYGMPFSRT----EDGRIYQRAFGGQSKDFGKGGQAYRTCAVADRTGHAMLHTLDLLTHNGEVVGVIAYNQEDGTIHRFRAHKTVIATGGYGRDGNAMVSRAGFPLEDLEFVQ-----PSGIYGSGCLITEGAR-----GEGGFLLNSEGEMERYAPTAKDLASRDVVSRAITMEIAGRGVGKNKDHILLQLSHLPPEETAAVFAGVDVTQEGGIPTKIDEETGEDKVIPGLMACGEAACGANSLLDLVVFGRAVANTIADTLQPGLPHK. 469
32 -10.600[Q] KOG0029 Amine oxidase  ali follow..  15  22............................................................................................................................................KMKKKRSPSVIVIGGGMAGISAARTLQDASFQVVVLESRDRIGGPVDLG-PLAAVIGRLVGENFEHILEEICKVRDEQDEDMSIAAHNVLQWYLCRMEGWFAADAETISAPGGHG--MVRGYRPVINTLSKGLDIRLSHRITKISRRYSGVKVTKGDTFVADAAVIALPLGVLKSGMI--TFEPKLPQWKQEAINDLGVGIENKIILN-LGVVAETSYGCSYFLNLHKATSHPGQLARDIEKKSDEAAANFAFSQLQKILPDASSPNYLVSRWGSDINSLGSYSKPHDLYERLRVPLDNLFFAGEATS-PGSVHGAYSTGVLAAEDCRMRVLER..... 465
33 -10.600[I] KOG1298 Squalene monooxygenase  ali follow..  11  37..........................................................................................................................................VAEDQKDGAADVIIVGAGVGGSALAYALAKDGRRVHVIERDMRE--------PERMMGEFMQPGGRLMLSKLGL-------------QDCLED--------IDAQKATGLAV------------------------------------------YKDGKEADAPFPVDNNNFSYEPSARSFHNGRFV-------RRKAFSLSNVRLEEGTVKSLL-EEKGVVKGVTYKN-----------------EGEETTALAPLTVVCDGCYSNLRRSLEKLHLILSKPSFTMVYQISSTDVRCGFKGVIVLGDAFNVASGMMVLLSDILILRRLLQPLSNLGDANK. 374
34 -10.500[H] COG1232 Protoporphyrinogen oxidase  ali follow..  12  5..............................................................................................................................................RMGQHVETLVIGAGPAGLTTAYTLAKAGRGVTVLEMDEYVGGISR----TVDYKGFKFDIGGHRFFSKSQEI---VDLWNEILPDDFIDRPRLSRI---YYREKFYAYPLKAFEALANL---FGWAKLTPIAAPTTFHQWVRNQFGEKLFVWGMSCDEISADWASQRIKGLDLGAAIIKAAEGGPKTLIESFRYPRKGPGMMWEACADKVMALGGDVRMGRKVDGLHFDKIAKLWTVAVTCADGRKEIYTADNVVSSAPIRELMQSISPTPI-KELPDNWIYIHDPSVKVGRVQNFRSWSPEMIPDGVSTCLGLCFEGDGLWVTSDEELVAQAKRE. 385
35 -10.300[C] COG0644 Dehydrogenases (flavoproteins)  ali follow..  12  7.....................................................................................................................................................VVVAGAGTAGAYASYLLAKAGLKVALLESKSGDDGLGLHHVERMSPNPKVFQNKIEGVELISPD-QKTTLIVRGEGYVLDRFAWGKWLVEEAVRAGAVL-YEGHTATAPIVENGSVVGVKAVERISGVAKE------FRARVVIDSTGSAAV----LRSKLIGWLV----------------------SEPLHPEDVSHAYREIIYSEEPLENPQYIKIYLDMVVAPG--------GYWWIFPRNATMLNVGLGIWGILKQNPRINYEKFILPKFKVRGKYHIGGGFIPGIVALGDAIHGGG-IGQALLTAELSSKVITKAFEKGDFSEK 322
36 -10.300[C] KOG2404 Fumarate reductase, flavoprotein subunit  ali follow..  15  6.....................................................................................................................................................VVVIGTGLAGLAAANELVNKNIPVTILEKASSIGGNSIKASSGINGACTETQRHFHIEDSPRLFEDDTIKSAKGKGVQELMAKLDLLAQLGGHSVARTHRSSGKLPPGFSKVVDIHEKDGSISAVVYEDKNGEKHMVSANDVVFCSGGFGFSDGQRLLQKLGADLIDMDQIQVHPTGFIDPNDRSSSWKFLAAESLRGLGGILLNPITGRLTTRDVVTAAIQKVCPQEDNRALLVMGEKMY-TLSQVVSEYNLPITVAQLCEELGARINVKAQVIGKND-----ERLLKGLYAAGEVSGGGSSLLECVVFGRTAAESIANDRK....... 470
37 -10.100[H] KOG1276 Protoporphyrinogen oxidase  ali follow..  12  52..............................................................................................................................................GTTITTDCVIVGGGISGLCIAQALATAAPNLIVTEAKDRVGGNII----TREENGFLWEEGPNSFQPSDPMLTMVVDSGLKDDLVLGDPTAPRFVLWNGKLRPVPSKLTDLPFFDLMSIGGKIRAGFGALGIRPSPPGREESVELGDEVF-FCSGVYAGDPSKLSMKAAFGKVWKLEQNGGS-FKAIQERKNAPKAERDPRLPKPQGQTVGSFRKGLRMLPEAISARLGSKESGGYNLTYETPDGLVSVQSKSVVMTISYPKEAIRTECLIDGELKGFGQLHPRTQGVETLSSGYEGLFLGGNYVAGVA-LGRCVEGAYETAIEVNNFMSRYAYK.. 537
38 -9.870[R] COG2907 Predicted NAD/FAD-binding protein  ali follow..  12  14.............................................................................................................................................ANVVPRQSIAVIGAGVSGLSAAWLLSH-RHDVTLYEADNRLGGANTIIAEGVAVDEPNYPNLTALFRHIGVETTADLEQGGLCRLDDYLRRQGAALLRFFDNHGLMLPIDKRPVGGSARYVEKLAAGVSGPILTGRPVKAIHRGPDGVRIEDATGETRAFDHVVIGAHADQALSML-----AAPSAEERELLGAFRYSRNRAVLHSDPALMPRRRGA-----ASWNHVGRRGEDGEGGVTYWMNILQPLGVERPYFLSLNPMQDPAGLMHDQVYEHPLFDGPAMLAQRRLWSLQGRRRTWFCG-AYFGSGFHEDGLQAGLAVAEQL............ 423
39 -9.820[C] COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit  ali follow..  14  10.....................................................................................................................................................AVVIGAGGAGMRAALQISQSGQTCALLSKVFAQGGITVAYIGDQDAIEYMCKTAILELEHMGLPF------SRLDDGRIYQRPFGGQSKNFGGEQAARTDRTGHALLHTLYALDLVKNQDGAVVGCTCIETGEVVYFKARATVLATGGAGRIDGVGMAIRAGVPVQDMEMWQ-----PTGIAGAGVLVTXGCR-----GEGGYLLNKHGEMERYAPNAKDLAGRDVVARSIMIEIREGRGC-WGPHAKLKLDHLGKEELSRTFAHVDPVKEGGIPTKTVNEKGEDVVVPGLFAVGEIACGGNSLLDLVVFGRAAGLHLQESIAEQGALRD 431
40 -9.810[HC] COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases  ali follow..  12  4....................................................................................................................................................QVAIIGAGPAGLLLGQLLQRSGIDAVILETRSRQ-------VEERIRAGVLEQGTVDTLNEAGVGERMRRE--HRLDLTALSGGRSITVYGQHEVVKDLIAARIGQGAPLLFEVSEVSLHDLESATPSVRFVHEGVPQTLHCDYIAG-----CDGFHGICR-----------------PAIPAQRQAVFERVYPFAWLGILAEAAPAADELIYASHARGFALFSMRSPKITRQCKPDENLAEWSDARIWDELHTRLENNDGWHLKEGPILQKSVTPMRSFVCETMRHG--RLFLAGDAAHGAKGMNLAVADVRVLAQALTARYRQND.... 321
41 -9.370[R] COG3573 Predicted oxidoreductase  ali follow..  18  7.....................................................................................................................................................VIIVGAGLAGLVAAAELAEAGKKVIIVDQEPELGG--------------------QAFWSFGGLFLVDSPEQRRMRIRDSHDLALEDWMGTAAFDRPEDFWPRKWAEAYVEKRSWLIERGLKFFPVVGWAERGGGNAI--------GHGNSVPRFHITWGTGPGVLEPFVQRVR----------EAQKRGLISFKFRHRVNELT-RAGDVVTGVRGDVLEPSTVERGHK--SSRDISGDFELHAQAVIVASG------------GIGGNHR---LVRENWPKRLGTAPKRMITGVPDHVDGRMLAITEQAGGSII............... 272
42 -9.370[Q] COG1233 Phytoene dehydrogenase and related proteins  ali follow..  15  2..............................................................................................................................................AVTQTRDAVIIGGGHNGLVCAFYLAKAGLKVTVCEARGVVGGAAV--HPGFRNSNPRVIADMG-LRELGLTF-----LERPISNFLPISDDKYIKLGGGLERTQE-KYSRRDAEVLPAYYAMLDEISARDVLDGWFESEPVKAAFGFDAVVGNFASPDTPGSAYVLLHHTFGEVNGKKGAWGHAVGGMGAITQAEAAGVEILLDAPVEAVHI-DGGKAAGVQL---------VDGR-----------QIMAPIVSANVNPALLYKKLVPPSALTPDFRKAVDGYKNGSGTFRMNV.......................................... 336
43 -9.220[H] COG0029 Aspartate oxidase  ali follow..  17  17.....................................................................................................................................................VLVVGEGLAALTLLLHLPP-SLKIGVISRNKAQGGISAVGLCDEAAVRQIVCEVLRWLIDQGVPF--TREDGEIHLTREGGHSERRVA-MTGRGIMRALQAKVAQLPNVYEAVELLSDGQAVSGVIAESLADGEVTVFSAPTVVLAAGGLT-----------------LYQYATNPHASKGEAIAMAWRAGATIEVQFHPTAFQIEGRVISLITEAVRGEGGL-NVANERFMPGYSSQQELAPRDVVARAIYSEPNLVEITRAHGCDLSQHGGIGADVAG----RTNIEGLYAIGEVANASNSLLECVVMGKACAQSVTDTAGSAS.... 408
44 -9.210[H] KOG4254 Phytoene desaturase  ali follow..  15  3........................................................................................................................................RRSFSTLPKKKWDAVVIGGGHNGLTAAAYLARGGLSVAVLERRHVIGGAAV--VPGFKFSRRPCIIRELELGRHGLKL-----LKRSPSSFTPCLDGRYLLLGPDQDLNHS-KFSKHDADAYPRYEKQLERFCGFMDPLLDSTPPESLQSASSFNDKLSNK-FWARCLRQAVSLGHKDMVAFMDLLLAPASKVLNNWFESDV---------------------------LKASLATDAVIGSTASVHTPGSGYVLLHHVMGETDGEKGGMGSVSMAIANAAKEAGAEIFTNAEVSEILTEDSSIVKGVLLADGTRVESSAILSNATPYRTYVELVPTNVLPEN 336
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Bourne PE, Allerston CK, Krebs W, Li W, Shindyalov IN, Godzik A.,Friedberg I, Liu T, Wild D, Hwang S, Ghahramani Z, Chen L, Westbrook J. The status of structural genomics defined through the analysis of current targets and structures. Pac Symp Biocomput. 2004;:375-86.