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Query: [G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVSSVVEKTSVAHKETALILWFEEVGTHDVGLVGGKNSSLGEMIQQLTNKGVNVPSGFATTAYAYRYFIQEAGLEQKLRDLFTDLDVNDMANLQERGHLARQLILDTPFPQNLQTAIAEAYGAMCERYGQKMGRTGVDVAVRSSATAEDLPEASFAGQQETYLNVHSLSCVLESCHKCFASLFTDRAISYRHHNGFDHFAVALSVGVQKMVRSDLATSGVMFSIDTETGFKNAALITAAYGLGENVVQGAVNPDEYFVFKPTLKEGFKPILEKRLGSKAIKMVYDVGGSKLTKNVEVAEPEREKYCINDEEILQLARWACIIEDHYSGVRGVYTPMDIEWAKDGQTGELFIVQARPETVQSQKSANVIKTYELKDHSQVLATGRSVGAAIGQGKAQVIRNVSQINQFRPGEVLITNRTDPDWEPIMKQASAIVTNQGGKTCHAAIIAREMGIPAIVGCGDATDTIKTGEDVTICCSEGDEGSVYSGILNYEVHETELSNLPRTKTQILMNVGNPEQAFGFASYPADGVGLARLEFIIANHIKAHPLALMKFDELEDPLAKAEIAELTKLYAGDRPRFFVDKLAHGIAMIAAAFYPKPVVVRMSDFKSNEYANLLGGRQFEPKEENPMIGWRGASRYYDPNYREAYALECQALKRVRDEMGLTNVIPMIPFCRTPDEGRKVIAEMAKHGLKQGKNGLEIYVMCELPSNVILADEFSEVFDGFSIGSNDLTQLTLGLDRDSSLVAHLFDERNLGVKRMVKMAIETAKANGRKIGICGQAPSDYPEFAEFLVELGIDSISLNPDSVLKTVLRIAEVEKALGLast
1 -263.000[G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase  ali  100  1MVSSVVEKTSVAHKETALILWFEEVGTHDVGLVGGKNSSLGEMIQQLTNKGVNVPSGFATTAYAYRYFIQEAGLEQKLRDLFTDLDVNDMANLQERGHLARQLILDTPFPQNLQTAIAEAYGAMCERYGQKMGRTGVDVAVRSSATAEDLPEASFAGQQETYLNVHSLSCVLESCHKCFASLFTDRAISYRHHNGFDHFAVALSVGVQKMVRSDLATSGVMFSIDTETGFKNAALITAAYGLGENVVQGAVNPDEYFVFKPTLKEGFKPILEKRLGSKAIKMVYDVGGSKLTKNVEVAEPEREKYCINDEEILQLARWACIIEDHYSGVRGVYTPMDIEWAKDGQTGELFIVQARPETVQSQKSANVIKTYELKDHSQVLATGRSVGAAIGQGKAQVIRNVSQINQFRPGEVLITNRTDPDWEPIMKQASAIVTNQGGKTCHAAIIAREMGIPAIVGCGDATDTIKTGEDVTICCSEGDEGSVYSGILNYEVHETELSNLPRTKTQILMNVGNPEQAFGFASYPADGVGLARLEFIIANHIKAHPLALMKFDELEDPLAKAEIAELTKLYAGDRPRFFVDKLAHGIAMIAAAFYPKPVVVRMSDFKSNEYANLLGGRQFEPKEENPMIGWRGASRYYDPNYREAYALECQALKRVRDEMGLTNVIPMIPFCRTPDEGRKVIAEMAKHGLKQGKNGLEIYVMCELPSNVILADEFSEVFDGFSIGSNDLTQLTLGLDRDSSLVAHLFDERNLGVKRMVKMAIETAKANGRKIGICGQAPSDYPEFAEFLVELGIDSISLNPDSVLKTVLRIAEVEKALG 818
2 -86.600[G] COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria)  ali follow..  18  4..................................................................................................................................................................................................................................................GILASPGIAFGKALLLKEDEIVIDRKKI----------------------SADKVDQEVERFLSGRAKASAQLEAIKTKAGETFGEEKEAIFEGHIMLLEDEEIALIKDKHMTADAAAHEVIEGQATALEELDDEYLKERAADVRDIGKRLLRNILGAIIDLSAIQEEVILVAADLTPSETAQLNKVLGFITDAGGRTSHTSIMARSLELPAIVGTGSVTAQVKNGDYLILDAVNNQVYVNPT-----------NDVIEQLRAVQEQVATEKAELAKLKDLPAITLDGHQVEVCANIGTVRDVEGAERNGAEGVGLYRTEFLFMDR-----DALPTEEEQFAAYKAVAEACGSQAVIVRTMDIGGDKELPYMN----FPKEENPFLGWRAVRIAM--DRKEILRDQVRAILRASAFGKLRIMFPMIISVEEVRALRKEIEIYKQELRDEGDESIEIGVMVETPAAATIARHLAKEVDFFSIGTNDLTQYTLAVDRGNDMISHLYQPMSPSVLNLIKQVIDASHAEGKWTGMCGELAGD-ERATLLLLGMGLDEFSMSAISIPRIKKIIRNTNFEDA 545
3 -86.400[T] COG3605 Signal transduction protein containing GAF and PtsI domains  ali follow..  15  1.................MLTRLREI-VEKVASAPRLNEALNILVTDICLA---------MDTEVCSVYLADHDRRCYYLMATRGLKKPRGRTVAAFDEGIVGLVGRLAEPINLADAQKHPSFKYIPS------------------VKEE--------RFRAFLGV--------------RQLLGVLVVQQRELRQYDESEESFLVTLATQMAAILSQSQVTALFGQYRQTR-----------ALPAAPGVAIATGWQDATMPLMEQVYEA----------------------STLDTSLERERLTGALEEAANEFRRYSKRFAAGAQKETAAIFDLYSHLLSDRELFAEVDKGAVAEWAVKKIIEKFAEQFAALTDNYLKERAGDLRTLGQRLLFHLDDSVQGPNAWPERFILVADELSATTLAELDRLAGVVVRDGAANSHAAIMVRALGIPTVMGA-DIQPSVLHRRTLVVDGYRGELLVDPE-----------PVLIQEYQRLISEEIELSRLAEDDVNLPAQLKSGERVKVMLNAGLSPEHEEKLGSRIDGIGLYRTEIPFMLQ-----SGFPSEEEQVAQYQGMLQMFNDKPVTLRTLDVGADKQLPYMP------SEENPCLGWRGIRITL--DQPEIFLIQVRAMLRANATGNLSILLPMVTSIDEVDEARRLIERAGREVEEMIIPKPRIGIMLEVPSMVFMLPHLANRIDFISVGTNDLTQYILAVDRNNTRVASIYDSLHPAMLRALSMIAQEAEKHGLDLRLCGEMAGD-PMCVAILIGLGYRHLSMNGRSVARVKYLLRHIDFEDA 711
4 -38.000[T] COG3848 Phosphohistidine swiveling domain  ali follow..  35  1..........................................................................................................................................................................................................................................................................................................................................................................................IIAKGQGIGRKSAYGPVVVAQNAKEAQKMTDGAVLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQDITVDASRGAV.................................................................................................................................................................................................................................................................................................................................................. 103
5 -15.900[S] COG1786 Uncharacterized conserved protein  ali follow..  19  1..........................................................................................................................................................................................................................................................................................................................................................................................MEVDCRVISRGKGRGPVLVSTEPPLHGRSIRGKVLLIPGGKGSTVGSYAPAAIICLNAEPIIATGAIMA---GIPMVDRPSDLLGLLEDSMEVEVDADEGKIRF................................................................................................................................................................................................................................................................................................................................................ 131
6 -12.400[G] COG3836 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase  ali follow..  17  34..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IAATSGY-LLIDGEHAPNTIQDLYHQLQAVAPYASQPVILLIPMVDTAEQARQVVSATRENYMAQVNDSLCLLVQVESKTALDNLDEILEGIDGVFIGPADLSA----------SLGYPDNAGHPEVQRIIETSIRRIRAAGKAAGF-----AVAPDMAQQCLAWGANFVAVGVDTSDALDQRLAMFKSGKN 259
7 -7.980[L] COG0587 DNA polymerase III, alpha subunit  ali follow..  11  1.MIQSTHFWYLDMAEPRFV----HLRVHSDYSMIDGLAKIGPLVKRAAALGMPTDFTNLCGLVKFYGSAHGAGIKPIIGADFYVQSEILGDELAHLTVLARNNEGYQNLTLLISEAYQRGYGAAGPIIDRDWLIKHKEGLILLSG--------GRMGDVGKFLLRGNQVQVDQCLAF-YQEHFPDCYYLELIRTGRPDEENAAVALATERGLPVVATNDVRFIDESDFDAHEIRVIHDGFTLVDPKRPKNYSPQQFMRDEEQMCELFADILINSVEIAKRCNVTIRLGEYFLPQFPTGEMS------TEDFLVEKAKQGLEERLEFLFPDPEVRLQKRPEYDERLDIELKVINQMGFPGYFLIVMEFIQ--------WSKDNGVPVGPGRGSGAGSLVAYALKITDIDP-DLLFERFLNPERVSM-DAVSQIIT--GTMAAKAVIVGRVLGHP-YGFVDRISKLIPLDPGMTLEKA---------AAEPQLAEIYEADEEVRALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDAEGNNPVTQFDKEYAGLVKFDFLGLRTLT-------IINWALEMINARRAKTGLEPIDIASIPLEDKKSFDMLQRSETT------QLESRGMKDLIKRLKPDCFE-DMIALVALFRPGPLQS-----GMVDNFIDRKHGREAISYPDIEWQHESLK--VLEPTYGIILYQEQIAQVLSGYSLGGADMLRRAMG------------KKNPAEMAKQRSVFEDGAKNQGIDGELAIKI-----DLVEKFAGYGFNKSHSAAYALVSYQTLWLKAH.... 788
8 -7.690[G] COG2301 Citrate lyase beta subunit  ali follow..  13  67............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................INPLNTPFGLADLEAVVRGGADI------VRLPKTDSKNDVLELEAQVERIERECGRESTRLMAAIESAKGVVNAVDIATRMVAIALAAFDYVM--MGTSRGDGT----------ELFYARCAVLHAARVAGIALGFNGKSL--NPRQIELL-----QAYSPTRKEVEHAYEVIAAAEEAES 255
9 -6.890[C] COG2225 Malate synthase  ali follow..  16  209.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FYLPKMESHLEARLWNDVFNEDTIQIPRGSIRATVLIETIVAAFEMDEILEHSAGLNCGRWDYIF-RVLPDRAKVTMAV------PMMQNYSKLAIQTCHKRGAPAGMSAFIPVKGDEEKNA-ATNGHDTWVAHPGMVQLATEVFDRIMPQPN 386
10 -6.750[G] COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB)  ali follow..  11  6........TITLNAAYDLVGRLNRIQLGEVNTVAGKGINVAKVLKDLGVNVAVG--GFL-NSADFEQMFNQHGLEDKFHRVDGKTRIN-VTDSLAYCLNYDIVAVCGSLPRGVSPELFADWLNQLHQAGVKVVLDSSNAALTAGLKAKPWLVKPNHRELEAWVGLNSLEEIIAAAQQVIISMGAKGSLWINNEGVLKAEPAQCENVVSTVGAGDSMVAGLIYGFEKGLSKTETLAFATAVSAFAVSQSNVGVSDLSLLDP.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 301
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24