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Query: [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MIVIKFRGRHRLIRRVSGQVYLWLAIFIFGASSAVTRKLTEIGARHFIDGRNPISLCNVLFVGNLCALMVMLLIYSRQWNKATLTQLSKKDWLGLTAVAILSGALAPGLIFHALSLTGVNNVILVGRLEPTLALALSVWLLKEQINFGEFIGAIAAFIGVILTIILQPPVSDMMNMGGWQLGLGEFFVAAGSVALAISTIIGKKYLTHIPLGIYSIFRTALGTVIFFFIALVLYGREHFADVFSPFLWQWMFLYGGVIVVVGQSFWLIGLKTSTVSTASLVASFTPIAGIVAAYFILSEVPTVAQYLGGGLIMLGIFLSQISKSRQTSHKSPIASTPAEQKVEMDMGFKGMLast
1 -107.000[GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily  ali  100  1MIVIKFRGRHRLIRRVSGQVYLWLAIFIFGASSAVTRKLTEIGARHFIDGRNPISLCNVLFVGNLCALMVMLLIYSRQWNKATLTQLSKKDWLGLTAVAILSGALAPGLIFHALSLTGVNNVILVGRLEPTLALALSVWLLKEQINFGEFIGAIAAFIGVILTIILQPPVSDMMNMGGWQLGLGEFFVAAGSVALAISTIIGKKYLTHIPLGIYSIFRTALGTVIFFFIALVLYGREHFADVFSPFLWQWMFLYGGVIVVVGQSFWLIGLKTSTVSTASLVASFTPIAGIVAAYFILSEVPTVAQYLGGGLIMLGIFLSQISKSRQTSHKSPIASTPAEQKVEMDMGFKGM 351
2 -73.800[R] COG5006 Predicted permease, DMT superfamily  ali follow..  11  1.....MPGSTRKLPVWLPILVLLIAMSSIQSGASLAKSL--------FPLVGAPGVTALRLALGTLILIAFF--------KPWRLRFAKEQRLPLLFYGLS-LGGMNYLFYLSIQTVPLGIAVALEFTGPLAVALFSSRRPVDFIWVVLAVLGLWFLLPL-------------GQDMSHVDLTGAALALGAGACWAVYILTGQRAGAEHGPATVAVGSLIAAIIFVPIGAVQAGDA-----LWHWSILPLGLAVAVLSTALPYSLEMIALTRLPTRTFGTLMSMEPALAAVSGMIFLGETLTGIQILALCAIIAASMGSTLTIRREPQIKQVDVK................ 295
3 -58.500[S] KOG2766 Predicted membrane protein  ali follow..  15  49...................LSLCICGTAITSQYLAERYKVNT----------PMLQSFINYCLLFLIYTVMLAF---RSGSDNLLVILKRKWWKYILLGLA-DVEANYVIVRAYQYTTLTSVQLLDCFGIPVLMALSWFILHARYRVIHFIAVAVCLLGVGTMVGADILAGR-EDNSGSDVLIGDILVLLGASLYAISNVCEEYIVKKLSRQEFLGMVGLFGTIISGIQLLIVE-YKDIASIHWDWKIALLFVAFALCMFCLYSFMPLVIKVTSATSVNLGILTADLYSLFVGLFLFGYKFSGLYILSFTVIMVGFILYCSTPTRTAEPAESSVPPVTSIGIDN....... 357
4 -52.500[S] KOG2765 Predicted membrane protein  ali follow..  12  4..........RTQRLLLGISILVLVDVVWVSSSELTKFLYN------ANFDKPFFCTYFKTSMFSIYLLVIGILAPWKESLRIRRQKTHHKTAKTALLFCLLWFAANYFFQLALEMDEAAMITLVSSTSSFFIICLAAVFPSDKLTITKVIAVAMNIGGVVAITMNDLHDT--------KMTRGVLLALFSAFFYAAYLVFVKRKSDTEEKVDIPLFFETFELP-------------------SQGQFALLFLNGLVGTVLSEALWLWGCFLTSSLIGTLAMSLQIPLAILFDVLLKNKPYSPMFYMGSIPIFVALVFVSLLMRNDDCRCHKPSIVRVNDDEQQES..... 420
5 -49.200[R] KOG4510 Permease of the drug/metabolite transporter (DMT) superfamily  ali follow..  14  1..MTLQRISKDYLKPNYGLILLIVSYFFNSSMVVSTKVLENDPLETSQSRINPLQILLVRMSITYCCTLVYMHW--NKQSVPDIPWGPAPCRKWLILRGIMG-FFGVFGMYFSLMYLSISDAVLITFMSPTLTIFLSFLLLGEPFSKLEALGSLISFSGVVLIIQQSPQDDIVETQNPKLRLIAIGVSLLGVCGLSSVYIIIRYIGNKAHAIMSVSYFSLVTTVVAALGVLLI-PSMSLQLPHSWKQWGLFLNLGIS-GFIHQILLTMGIQRERAGRGSLMTYTQVIYAVFWDVVLFHHWPNIWTWCGMAVIVSSTIWVINMRASKQNVVATAELLSTSDFELDDL..... 351
6 -44.800[R] COG2962 Predicted permeases  ali follow..  12  1.........MDAKQTRQGVLLALAAYFIWGIAPAYFK---------LIYYVPADEILTHRVIWSFFFMVALLSVSRQWRQVKRL--LKTPKKIFLLALSAVLVGGNWLLFIWAVNNHHMLEASLGYFINPLVNILLGMIFLGERFRRMQWLAVILAVCGVLVQLWTFGS-------------IALGLAFSFAFYGLVRKKIAVEAQTGMLVETLWLLPVAAIYLFGIADSPTSH------GQNALSLNLLLMAAGVV-TTIPLLCFTGAATRLRLSTLGFFQYIGPTLMFLLAVTFYGEVPGADKMVTFAFIWVALAIFVMDAIYTQRKK..................... 294
7 -37.400[S] COG2510 Predicted membrane protein  ali follow..  15  1..................................................................................................................................................................................MMMASWQFWALMSAVFAALTAIFAKVGIQGINSDFATLVRTFVIIGALCLFLTVTGQWQKPG-EISARSWLFLVLSGLA-TGASWLAYFRALQIGDASRVAPIDKLSVVLVALFGAAFLGERMSTINWIGILLIGCGVVLVALR............................. 142
8 -35.900[GOU] KOG1444 Nucleotide-sugar transporter VRG4/SQV-7  ali follow..  11  3...........................................................................................................YTSSKSLQYLAVPIYTIFKNLTIILIAYGEVLFFGGKVTSMELTSFIMMVLSSVVATWGDQQAIAIKASSLEDLDQGYLWMFTNCISSALFVLIMRKRIRNFKDYDTMFYNNVLALPLLLVFSFIMEDWSTKNLSLSADSLAAMVISGLMSVGISYCSG-WCVRVTSSTTYSMVGALNKLPIALAGLVFFDAPKNFLSFFSIFLGFLSGLLYAVAKQKKIQQQKVLAATLEK............ 249
9 -34.800[GE] KOG1441 Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter  ali follow..  11  56...................LFISSLIILW----YTSNIGVLLLNKFLLSNYGPIFLTMCHMSACAILSYVSIVFLKLVPLQYLKSRSQFLKVATLSIVFCASVVGGNI----SLRYLPVSFNQAVGATTPFFTALFAYIMTFKREAWVTYGALVPVVTGVVIASGGEPG-------------FGFIMCISATAARAFKSVLQGILLSRLNSMNLMLYMSPIAVIALLPVTIFMEPDVMSVTLTLGRQHKYMYILLLVNSVMAYSANLLNTKHTSALTLQVLGNAKGAVAVVISILLFRNPVTVMGIGGYSITVLGVVAYGETKRRFR........................ 355
10 -34.600[R] KOG3912 Predicted integral membrane protein  ali follow..  13  5...................VFLSLIFVLSGTFNVLVVKWANQQQVIGSDG-HPVVFTLLMFLGEFLCFAVFKVIRLISNRRILSQDSSEFRPVSMLLPTLLDA-AASILLFTGLYLTYATSFQMIRGAALIFVGIFSTMFLNHTLTGRHWLAIFTISCGLLDIISLDVHRVEYDLVTLPYTDTGDLLIIIAEILHGLQYVCEEKQLKTVAPLQAAGWQGIFGLGITSMLAIFDDWGDLFAALQGSISLIMTLIAFTISCAMYNFIGLYIAMYSSSANRLLADGLRVYFIWVFVIIMEWEYMNLVTIMGFLILQMGIILYRQALFLDWYRAAVARWYRARYVDLGTE..... 368
11 -34.300[S] KOG1443 Predicted integral membrane protein  ali follow..  12  4...................TVFLAFVFGW----YFCSIALSIYNRWMFDPKDPVLVTTFHQATLWLLSGIYIKLKPVKNVLRKNNGFNWSFFLKFLLPTAVASAGDIGLSNVSFQYVPLTIYTIIKSSSIAFVLLFGCIFKLEKFHWKLALSVIIMFVGVALMVFKPSDSTSTKNDQALVI-FGSFLVLASSCLSGLRWVYTQLMLRNPHPIHTIHQLAPIMGITLLLTSLLVEKPFPGIFSSIVRGIVLLILPGFAVFLLTICEFSI-LEQTPVLTVSIVGIVKELLTVIFGIIILSERLSFYNWLGMLIIMADVCYYNYFRYKQDLLQKYHSVSTQDNRNELKG..... 400
12 -33.800[GOU] KOG1442 GDP-fucose transporter  ali follow..  15  3......KNLEEHNRLVNKYLKIFFVVSLY----WCTSILTVFVNKHLLSSDTPLFMSWFQCVVSTVICFVASRLSRKYPSVFTFPELDIDTFRKILPLSVL-YTLMIGANNLSLSYVTVAFYYIGRSLTTVFSVVLTYVILRQRTSFKCLLCCGAIVVGFWLGVDQESLTEVFS--------RGTIFGVLSSLALAMFSIQTKKSLGNQEVWLLSYYNNLYSTLLFLPLIIINGELESIITY-ASWFWAAMTLSGLCGFAIGFVTALE-IKVTSALTHNISGTAKACAQTVIATQYYHDVRSALWWTSNVVVLVASAAYTRVKQLEMMRQHQQRSTATQKA.......... 337
13 -33.700[GOU] COG5070 Nucleotide-sugar transporter  ali follow..  10  1.....MSELKTGHAGHNPWASVANSGPISILSYCGSSILMTVTNKFVVNLKDNFVMLFVQSLVCTITLIILRIL--------KFRSLNKTDAKNWFPISFL-LVLMIYTSSKALQYLAVPIYTIFKNLTIILIAYGEVLFFGGSVTSMELSSFLLMVLSSVVATWGDQQAVAAKAASLAEGAPGYFWMFTNCITSALFVLIMRKRIKNFKDFDTMFYNNVLALPILLLFSFCVEDWSSVNLTFSNDSLTAMIISGVASVGISYCSG-WCVRVTSSTTYSMVGALNKLPIALSGLIFFDAPRNFLSILSIFIGFLSGIIYAVAKQKKQQAQPLRK................. 337
14 -33.300[G] KOG1581 UDP-galactose transporter related protein  ali follow..  10  19....................GVFAVSGIMSTLVIYGVLQEKIMRVPYGVNKEFFKHSLFLVFCNRLTTSAVSAGALLASKKVLDPVAPVYKYCLISVTNILTTTCQYE----ALKYVSFPVQTLAKCAKMIPVMVWGTLIMQKKYKGFDYLVAFLVTLGCSVFILFPAGDDVSPYNKGRENTWGVSLMAGYLGFDGFTSTFQDKLFKGYEIHNQIFYTTLCSCVLSFTGLILQGHLLPAVDFVSLHDCLLDIALLSTVATASQFFISYTIRTFGALTFAAIMTTRQLASIMLSCIWFSHPLSWEQCIGSVIVFGSLYAKNLLNNKKNSQTQPPPPELPQYEKVESS..... 344
15 -33.000[G] KOG1583 UDP-N-acetylglucosamine transporter  ali follow..  10  1...........MALNLKALLGMLFVFIGCCSNVVFLELIIQIDPGA------GNLITFAQFLFIALEGLVFTSKFFTVRPKIALKD---------VILVALFFGANVCNNYAFNFNIPMPLHMIFRSGSLMANMIMGIVLLKKRYNLRQYSSVAMITAGIILCTLVSSGDVKDNTHHSLKVDVGIGLLTIALLVTAYMGIYQEVIYKKYHPSEALFFTHMLPLPGFLIMAGNIVQHGAIGLEWKFPLMLFYLLCNVVTQYVCISAVYVLTTECASLTVTLVVTLRKFVSLLFSIIYFRNPFTLNHWVGTILVFFGTILFANVINQVRDAYRARSSRKTHFDTAPLAK.... 349
16 -21.100[G] KOG2234 Predicted UDP-galactose transporter  ali follow..  9  27......YDDHKIRVSSKQRVLNVLLVVGDCMLVGLQPVLVYMSKVDGKFNFSPISVNFLTEIAKVIFAIVMLLIQARHQKVGEKPLLSNNYLKFTMQKLWLYGKSMSCGVLSVPLYFNPATVKMLSNLKVLVIAVLLKMVMKRRFSIIQALALLLIGISVNQLRSLPEGATAIGIPLAT---GAYVCTVIFVTVPSMASVFNEYALKSQYDTSIILGTVIYKGLQYALLRNFVMILTGPGSFDILQGHSRATMFLILNNAAQGILSSFFFKYADTILKKYSSTVATIFTGIASAALFGHVITMNFLLGISIVFISMHQFFSPLAKARDEQQQNGNLELGNTKDTHRA.... 428
17 -20.000[S] COG3238 Uncharacterized protein conserved in bacteria  ali follow..  12  1...........MNKNKYSTPLLMLATILAGMLSPMQSAVNGQLGHWL----DGNACAVISFASGLVVMFFIIIARKETRQASIPTLIKKRKIPLWNWFAGLCGAMVVFSEGASASALGVATFQTALISALLLSGLL-----KKYFTPWRITGALFAVIATIFVVSPQWHSTSFILLAILPFLAGLLAGWQPAGNAKVAEATG-------SMLVSITWNFIVGFCVLGAALAIRIALGHVTIQLPDTWW---MYLGGPLGLLSIGLMAILVRGLGLLMLGVASTAGQLLGSVLIDELIPNTVYLVTIIGTLFALVGAIVTTIPEYRASKMAQRIEVSE.............. 323
18 -16.200[G] COG4975 Putative glucose uptake permease  ali follow..  12  2..............QFLDFLIALLPALFWGSVVLINVFVGGGPYNQIRG-----------TTLGALIVGLGLLITGF--------KFNNPTVIIVGLISGALWAFGQANQLKSISLIGVSNTMVSTGMQLVGTTLFSVIFLGEWSSMTQLIAMILLVTGVALTSLKAKNERQSD---NPEFKKAMGILIVSTVGYVGFVVLGDIFGVGGTDALFFQSVGMAIGGFILSMNHKTSLKSTALNLLPGVIW-----------GIGNLFMFYSQPKVGVATSFSLSQLLVIVSTLGGIFILGERKDRRQWAGIIIIVIAAIILGNLK............................ 287
19 -15.400[R] KOG4314 Predicted carbohydrate/phosphate translocator  ali follow..  16  378.....................................................................................GLTLKLFLKRTAPFSILWTLTNYLYLLALKKLTATDVSALFCCNKAFVFLLSWIVLKDRFMGVRIVAAIMAITGIVMMAYADNFHADSI--------IGVAFAVGSASTSALYKVLFKMFLGSANFGEAAHFVSTLGFFNLIFISVILYFTKVEHWSSFAALPWGCLCGMAGLWLAFNILVNVGVVLTYPILISIGTVLSVPGNAAVDLLKQEVIFNVVRLAATIIICIGFLLMLLPEEWDEITLRFINSLKEKKSEEHVDD.... 634
20 -15.000[X] KOG4831 Unnamed protein  ali follow..  13  1...........MAASLGQVLALVLVAALWGGTQPLLKRASAGLQRVHEPTWAQQLLQEMKTLFL-------------------------------YLMPFLLNQCGSLLYYLTLASTDLTLAVICNSLAIIFTLIVGKALGEDIGGKRAVAGMVLTVIGISLCITSS........................................................................................................................................................................................ 129
21 -12.200[P] COG2076 Membrane transporters of cations and cationic drugs  ali follow..  15  33...............................................................................................................................................................................................................................................................FILIAVSFILLIRSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKESKSQPGGEK................. 111
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;