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Query: [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid), from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDIWLADESQAERVRGELARFIENPGDPRYLAASWQSGQTNSGLRYRRFPFLATLRERAGPVTWIVMLACVLVYIAMSLIGDQTVMVWLAWPFDPVLKFEVWRYFTHIFMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITVISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALLWIVAGWFDWFGMSMANGAHIAGLIVGLAMAFVDTLNARKRTLast
1 -98.400[R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)  ali  100  1MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDIWLADESQAERVRGELARFIENPGDPRYLAASWQSGQTNSGLRYRRFPFLATLRERAGPVTWIVMLACVLVYIAMSLIGDQTVMVWLAWPFDPVLKFEVWRYFTHIFMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITVISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALLWIVAGWFDWFGMSMANGAHIAGLIVGLAMAFVDTLNARKRT 276
2 -48.800[T] KOG2980 Integral membrane protease of the rhomboid family involved in different forms of regulated intramembrane proteolysis  ali follow..  13  145...............................................................................................LVYALLGINVAVFGLWQLPKCWRFLQ--YMLLQKDYVTSKISIIGSAFSHQEFWHLGMNMLALWSFGTSLATMLGASNFFSLYMNSAIAGSLFSLWYPKGPSLGASGALFGVLGCFSYLFPHAKILLFVFPVPGGAWVAFLASVAWCALRWGSFDYAAHLGGSMMGVLYGWYISKAVEKQR 335
3 -48.600[T] KOG2289 Rhomboid family proteins  ali follow..  17  63...............................................................................................PNKECVARFLGRFSFQPLKENPLF---ALEWRKVVHEHQGWRLLSCMWLHAGIIHLLTNMLSLIFIGIRLEQQFGFIRVGLIYLISGLGGSILSSLFLQSISVGASGALFGLLGAMLSELLTNWTIYANKAAALITLLFIIAINLALGML-PRVDNFAHIGGFLTGFCLGFVLLVRPQYGW 251
4 -48.100[S] KOG2632 Rhomboid family proteins  ali follow..  21  20..........................................................................................NAIPFLTSSVVVVCGVIYLICLLTGYDTFYEVCFLPSAIISRFQVYRFYTAIIFHGSLLHVLFNMMALVPMGSELERIMGSVRLLYLTVLLATTNAVLHLLIANECAIGFSGILFSMIVIETSLSGVTSRS-VFGLFNVPAKLYPWILLIVFQLLMTNVSLLGHLCGILSGFSYSY.......... 209
5 -45.600[T] KOG2290 Rhomboid family proteins  ali follow..  16  609...............................................................................................ITSREYCDFMRGYFHEEATLCSQVHCMLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLL-PWIDNFAHISGFISGLFLSFAFLPYISFGK 794
6 -32.000[S] KOG4463 Uncharacterized conserved protein  ali follow..  12  9...........................................................................................SNMGITKFLLLTISTSSVVAGVFALKPFFHI-NFGLHLLSHYQYWRILLWQFIYWNSTEVFQALFIIYQAR-DVERLLGSHRFASFCVYMFILGMFVTPIFSDYIQPGPTFLIFAIL-YQYYYIVPSTVFVRLFNIKFTDKFQMVIPMIGLAFSHFPSTFINAFLGWTMGMFY............ 188
7 -28.500[S] KOG2890 Predicted membrane protein  ali follow..  13  14..................................................................................VERHSDVLRNNALPFRFLVVLRIIGYIISYL---HFARLLLWLHPYQIASIELWRIATSTFCGHNVLDVLWTVWCLHFGTNLVRLNNTNESLLKLYAITQGVTTFVIVVFAIEPLVGMTPICASVM---VLMKQFLPDTIVLA-AHLPFLAIFVSFILALTKFTYFVSFLQITIGVQVSWTY............ 210
8 -16.800[S] COG5291 Predicted membrane protein  ali follow..  13  1..........................................................................MPSIPQMNNTFLLGQMLRVPPITRYMTLLISAVALLVYV--DAVSPYSLYYSPLFLKRLEIWRVFTSFLYFGKPLDMFMHVVFLYRYSRMLEEGCVNTSEYFWLILVISSVLFAISNIYGISALGTS-----SATITYIWTKRNPRAIVQIFGFIFPAFYLPFILPGFMLLSRRSISIDDVLGIVVGHLFHYF......... 189
9 -13.300[S] KOG0858 Predicted membrane protein  ali follow..  18  9...........................................................................................SLPRFTRYWLTATVVLSMLCRF-DVIPLHWLHLDRSAVFSKLQLWRCMTSLFVFPISFHFLINCFFIVQYSSKLEKDQYSRSYLYLLIVSAVLANIGGMIFNVYF---LMDTLVLAITYIWCQLNKDVTVSFWFGTRFKAMYLPWVLAAFEFIFHFSL---ASLVGIFVGHVYYFF......... 184
10 -11.000[I] KOG3030 Lipid phosphate phosphatase and related enzymes of the PAP2 family  ali follow..  13  99...............................................................................................................................................IYKAIGTFLFGAAASQSLTDIAKYSIGRLRFLDVGYIEYYICRGNAERVKEGRLSFYSGSSFSMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHLTGLIQGALVAILV........ 243
11 -9.470[R] COG3907 PAP2 (acid phosphatase) superfamily protein  ali follow..  10  19............................................................SKTTRQASTGPSTLNNRSTVPTIKTISLYSLPLSFYFWQVFGLLLVGLLFLALSRSEQLDWLISNYWFDPVGQNF-NKWLDLLNHRLLKMALIATAIAALLWGIYRRNGRLVTTALLFGLGPLVIGILKATSAHS--GGHASSGFAVMALFFLFYPERPRLAMLC------WFAGIGLGMLMGF--GQIMRGAHLTHNLWAGWWVWLSQ....... 253
12 -9.230[S] COG5395 Predicted membrane protein  ali follow..  14  69.............................................................................................................................................VQVHLALTALAIGVVLMM--GTTLHKLLGW-----TWVLAMGSTAVSSLFIREINHGAFSF--IHLLSGWTIIGLKRGKVSAHRKAMTGMFVGGLLVAGVFTFLPGRL-----LWTVFLG............... 186
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;