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Query: [H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVIISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQRRTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRISVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRDLast
1 -95.300[H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A  ali  100  1MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVIISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQRRTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRISVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD 199
2 -52.100[H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase  ali follow..  16  1..MLTLLMCGGKGTRLGREKPLFEVCGMKLIDHSLLQYKDDVIAITSPHTPATESYLAEKGVEVYRA--AGKGYIEDYSEACRELANEPVIVASADIVYIRDIAFDIVDAYMKTIKPALTVVMEGEPVGVNIIDSLLINTWQEEEI-----------------------YSIEKDSVVNVNTVADVERAERLWTTMRKE 175
3 -31.000[R] COG2068 Uncharacterized MobA-related protein  ali follow..  15  9LKVGIVLLAAGRSSRMGGPNKLLLFDGKPLVRRTAERAASGTIVVTGHQRERVRAALSGLDVTFADNPDFANGLSTSLKAGIAYLDTAGAMIVLGDMPGVVSGDLDRLIDAFAGGNSVVRASHQGKRNPV--LLPRALFPAIAHL--EGDTGARHLVEAEGLDVV---DVEIGEGASVDVDTREALEGAGGVLQD.... 206
4 -19.600[M] COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog  ali follow..  10  3.DILFIIQARMGSTRL--GKVLRPLGSNRLLDILVHRVRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRLTGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQYQEHV-ALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGER 215
5 -19.400[I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase  ali follow..  10  11.RIVAVVPAAGIGSRMQMDKQYLHIHGKTILEHTLSVLLGEKIILAVAANDPYISTCPLLTHPKIQLVEGGSSRADSVLNGLNAVEDFWVMVHDAARPCLTHQDLDKLVQVEDQNGAILAIPATDTIKRALHFFPIATLAQALEQALAQGLQVTDEASAMEFAGFRPHLVAGRSDNI-KVTRPEDFALAEFYLSRTK.. 238
6 -18.700[M] COG1213 Predicted sugar nucleotidyltransferases  ali follow..  19  1..MEAVILAAGFGSRLGIPKALLKIGKRPLIYYTVQTLMRDVVVVTGYVLREYLSQFDLNFKFVHNSLYKKTNNIYSLYLAMDHVSKG-FYILNSDV-LFHPGIFRELHSSTKEEEEMKVKIEDGVVKRIIARVEENIIDDLYNHVSRRRVFYEEAFQSMMDDGIAVYYETTKGLPWIEIDTPADLMKARYEI...... 235
7 -16.800[M] COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes  ali follow..  16  1..MKAIILAAGLGTRLNTPKALVQVNQKPLIEYQIEFLKEKIIIVGYLKEQFDYLKEKYGVRLVFNDKYADYNNFYSLYLVKEELANS--YVIDADNYLFKNMFRNDLTRSTCTNEWFLVYGDDYKVQDIVSFWDAPTAEKIVSFIDKAYVSVKDNIKELDVYVEELEG-----NSIYEIDSVQDYRKLEEILKNEN.. 229
8 -16.800[M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase  ali follow..  13  3.NFTVIIPARYASTRL-PGKPLAEIAGKPMIAHVFEKAKRVIVATDHEQVATVARGFGAEVCMTSETHQSGTERLAEVVEKLGIAEDEIIVNIQGDEPLIPPAIVRQVAENLAKNPNAVKVLTDHAGYVLY-AYRAGFIKQYIQ-WQPSVLEQIESLEQLRVLWEKIHVELAREVPPVGVDTAEDLEKVRSILEK.... 258
9 -15.900[M] COG1209 dTDP-glucose pyrophosphorylase  ali follow..  13  4..RKGIILAGGSGTRLAVSKQLLPIYDKPMIYYPLSTLMRDILIISTPQDTPRFQQL--LNLQYKVQPSP-DGLAQAFIIGEEFIGGDDCALVLGDNIFYGHDLPKLMEAAVNKESGATVPLEPKSNYAVTGLYDNDVVQMAKNL-ARGELEITDINRIYLEQGRLSVAMMGRGYAWLDTGTHQSLIEASNFIATIEER 246
10 -15.100[S] COG1920 Uncharacterized conserved protein  ali follow..  13  1MKTCAIIPV----SRFTHAKTRLS---KAMLMDVSGALARRVLVISADEDVLEYAYSLGLKILEEEGERDLNGALEQAMDFCAP-EFDRVIITPSDIPLIGKADVSNLLDHASRADVVIAPANGGGTNTL-------ILRPSAMSLRFGDCSFFEHIHEARERGLSVSVYDSFYLSL-DVNTAEDLGEIILHGEGTH.. 196
11 -14.100[M] COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)  ali follow..  15  5.TLNIVILAAGKGTRMYSKKVLHEIGGETMLGRVIDTAAQNICVVVGHGKEQVLDTVKRDVVWVEQTEQLGTG---AVKTALPHLAAE-TLVLYGDVPLIDVETLETLLEAAGNEVGLIIRDSSGSVTAIVGIL-EAWLNSLSSNNAQGEYYLTDLIAKAVADGIKIHPVQRSSHLAAGVNNKLQLAELERIFQTEQAQ 244
12 -13.600[M] COG1083 CMP-N-acetylneuraminic acid synthetase  ali follow..  13  5MTRIAIIPARAGSKGI-KDKNLQLVGGVSLVGRAILAMFDQIVVTSDGENILKEATKYGAKPVARPESLAQTRTIDAILHCLETLNIGTAALLQPTSPLRNALDIRNAMEIFGGKYKSVVSACECEHHPYKSFTLEG-----LTDFESPRQKLPKSYRANGAIYINDIQSLFEEKRFFDIDSTLDLQLAESLISKE... 227
13 -12.000[S] COG3222 Uncharacterized protein conserved in bacteria  ali follow..  12  4LPVSVLVVAGRVKTRLGDKVAADIA--AAALLDTLDAVAARAVALTGDLDSAADSAEIRRRLKSFTVFRQRGDAFA-LANAHVDADGYPVLQIGMDTPQVTAELLADCARLLLQIPAVLGLAFDGGWW-VLGIRTPTAAECLRAVPMSQPDTGELTLKALRDNGIDVTLVQ----RLGDFDIVDDIALVRDCCAPGSR. 210
14 -10.200[MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)  ali follow..  14  1..MRAVLMAGGSGTRLDLPKPMVPILNRPIAEHIINLLKRH-VIATLHYLPDVLRDY--VQMTYAVEEDQPLGTAGCVKNIAELLDETF-LVISGDS-ITDFDLGEAIAFHKQKQSKATLILTRVPNPIEFGVVITDEAGKIKRFLEKPST------SEIFSDTVNTGTYILEPEVLEYLPSNTECDFSKDLFPLLLAK 203
15 -9.360[GMO] KOG1460 GDP-mannose pyrophosphorylase  ali follow..  13  7EKVVAVIMVGGKGTRFNIPKPLFPIAGQPMVHHPISACKRAQIYLVGFYEEREFALY-PVRYLREDKPHGSAGGLYHFRNLIMEDSPSHIFLLNCDV-CCSFPLPKMLEAHRGYGGIGTLL--------VIKVSPESASQFGELVADPVTNELLHYTEK........................................ 176
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 3 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.