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Query: [M] COG0769 UDP-N-acetylmuramyl tripeptide synthase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKLRELLATVDSVENLPPVLADAEVKGIKTNSHACGAGDLFIGMPGTRVDGGEFWPSAIASGAIAAIVSPQAVEKNPPHDEAVVISSNNMTKACAAIAAAFYGYPGQKLKLVGVTGTNGKTTTTHLIEFFLTKAKLSTALMGTLYTRWPGFEQTATHTTPFAVELQQQLAQAVNAGCEFGVMEVSSHALAQGRVLGCPFEVGVFSNLTQDHLDYHSDMEDYFAAKALLFSPEYLKGRAIINADDTYGQRLIKALSPEKVWSYSVNDSSADLWMSDLSYEPNGVTGTIHTPEGNVSFRSPLVGQYNLENLLAAVGAVLHLGLNLQLIANAIPEFPGVPGRMERVQINPDQDISVIVDYAHTPDSLENLLKAARPFIPGRMICVFGCGGDRDRTKRPKMGKIVAELADLAFVTSDNPRTEDPDRILDDILAGIPDTVQPTVIGDRAIAIRTAILQAQPGDGVLLAGKGHEDYQILGTEKIHFDDREHARAALTEREKLLast
1 -134.000[M] COG0769 UDP-N-acetylmuramyl tripeptide synthase  ali  100  1MKLRELLATVDSVENLPPVLADAEVKGIKTNSHACGAGDLFIGMPGTRVDGGEFWPSAIASGAIAAIVSPQAVEKNPPHDEAVVISSNNMTKACAAIAAAFYGYPGQKLKLVGVTGTNGKTTTTHLIEFFLTKAKLSTALMGTLYTRWPGFEQTATHTTPFAVELQQQLAQAVNAGCEFGVMEVSSHALAQGRVLGCPFEVGVFSNLTQDHLDYHSDMEDYFAAKALLFSPEYLKGRAIINADDTYGQRLIKALSPEKVWSYSVNDSSADLWMSDLSYEPNGVTGTIHTPEGNVSFRSPLVGQYNLENLLAAVGAVLHLGLNLQLIANAIPEFPGVPGRMERVQINPDQDISVIVDYAHTPDSLENLLKAARPFIPGRMICVFGCGGDRDRTKRPKMGKIVAELADLAFVTSDNPRTEDPDRILDDILAGIPDTVQPTVIGDRAIAIRTAILQAQPGDGVLLAGKGHEDYQILGTEKIHFDDREHARAALTEREKL 496
2 -48.200[M] COG0770 UDP-N-acetylmuramyl pentapeptide synthase  ali follow..  21  5VTLNQLIEVLLARPVISEAALTQVSSGIQTDTRMIKPGEVFLAFRGEKFDGHEFISSAIARGAIAAIVDDDYE-----NPGLPVLQVSNTLEAYQKLGRWWRDR---DIPVIGVTGSVGKTTTKELIAAVLGTKGNVLKTYGNYNNEIG------------PKTLLEL-----NAEHDYAVIEMARGRGQIAELAQIA-TIGVITNVGTAHIELLGSEEAIAEAKCELLAEMPKDSVAILNHDNPLLMATAAKFWSGEVLTYGLSG--GDVQGSLV--------DNAIVEVAGLRLPLPLPGRHNATNYLAALAVAKVLGIEWSSLQAGVSVNMPTGRSQRFSLPND---VLILDEYNAAPEAMLAALQLLADTPGKRKIAVLG--GERSAQLHQRVGETVRNLKDGLLVLVDGEDAEA--------IARSAEGIPSECFATHADLVARLTTFVQGGDRLLFKAHSVGLDRVVSQLRAEFSN.............. 451
3 -34.800[M] COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase  ali follow..  19  8.........................................ILVAGLGGTGISMIAYLRKNGAEVAAYDAELKPERSERQPDIEAFKQNGGRVLGDIELLADIVNRRDDKVIAITGSNGKTTVTSLVGYLCIKCGLDTVIAGNIG-----------------TPVLEAEWQREGKKADVWVLELSSFQLE--NTESLRPTAATVLNISEDHLDRYDDLLDYAHTKAKIFRG---DGVQVLNADDAFCRAMKR--AGREVKWFSLEHEADFWLERETGRLKQGNEDLIVTQ------DIPLQGLHNAANVMAAVALCEAIGLSREALLEHVKTFQGLPHRVEKIGEKNGVVFI---SKGTNVGATAAAIAGL----QNPLFVILG-GMGKGQDFTPLRDALVGKAKGVFLIGVDAPQIRRDLD---------GCGLNMTDCATLGEAVQTAYAQAEAGDIVLLACASFDMFKGYAHRSEVFIE.............. 440
4 -33.500[M] COG0773 UDP-N-acetylmuramate-alanine ligase  ali follow..  19  49......................VGIGGVGMSGIAEVLHNLGFKVSGSDQARNAATEHLGSLGIQVYPGHTAEHVNGADVVVTSTAVKKENPEVVAALEALMLAELMRFRDGIAIAGTHGKTTTTSLTASILGAAGLPTFVIGGK--------------------LNAAGTNARLGKGEYIVAEADES---DASFLHLTPIMSVVTNIDEDHMDYGHSVEKLHQAFIDFIHRMPFYGKAFLCIDSEHVRAILPKVS-KPYATYGL-DDTADIYATDIENVGAQMKFTVHVQMKGFEVVLNMPGRHNVLNALAAIGVALEVGASVEAIQKGLLGFEGVGRRFQDIKLPNGGTALLVDDYGHHPVEMAATLSAARGYPEKRLVLAF----HRYTRTRDLFEDFTKVLVDALVLTEVYAAGEEPRALARAIRV--LGKLEPIYCENVADLPEMLLNVLQDGDIVLNMGAG--------------SINRVPAALLELSKQI 506
5 -26.300[H] COG0285 Folylpolyglutamate synthase  ali follow..  14  36........................................................................................................LEPQCPVVVVAGTNGKGSVCAYLTQIYKQAGYKIGTLTSPHLLRYNERIAINAEPVSDDTIIASFERIMREQVDVMILEVG------GRLDAVNADCAVVTSVDLDHQAFLGTVEQVGFEKAGVFR----SGKPAICGQNPAPKSLLSHAEAIGAKLLMVQR---DFEFHAMENIQWNYRFRPQHSDDPARPFPALRGTYQLSNAACALTVLECLNVDIGAIKRGLLLVE-NPGRFQVL----PGRPLTVLDVGHNPHAARALRRSLINLFAQKRTAVFSMLSDKDIDG--VLETVKDQFDEWYIAPLDVPRGMTLESLQNKLHE--HSIENIQTFAAVREAYRAAASKAGENDRIVVFGS............................... 413
6 -20.700[H] KOG2525 Folylpolyglutamate synthase  ali follow..  16  28.......................................................EGAINRLNSLQSNAKVLEVLRKRGKIPNDQSMVEMRHWLRCIG--YQPSDLNRLNVIHVAGTKGKGSTCAFTSSILQQIPKCIGMYTS--WERLENAVGSDSEKPMYFRFLTLMA-FISENVDAAIIEVG------GEYDSTNL-ATAVTSLGLDHTSLLGTIAEIAWQKAGIY---KESAIALTCEQAPEAMNVLKNRAAERNTSLKVVIPPAELT----------------------PDMIGLSGVHQLGNTSLAVSLVQEFPYQDPAILDGLKYVK--PGRCQIE---EINNIKWCFDGAHTKESLEATGLWLASKKNDARILLFNQQSRDDTNVTWKDAGYNPELLSINTITDNKPVLHVQEDLCKWWKESKGTTSEATVAPTIQEAIETVIKQKSRNTFVCVTGSLH............................. 491
7 -20.000[S] COG3367 Uncharacterized conserved protein  ali follow..  14  44..VVAEHEGKMASDFVKPVRYDVPVVSSVEKAKEMGAEVLIIGVGYLEEQIATLVKKALSLGMDVISGLHFKISQQTEFLKIA-TRIIDIRIPPLELDVLRGGIYRKKIKVVGVFGTDGKRTTAVQLWERALEKGIKAGFLATGQTGIAGYVIDAVPADFVSGVVEKAVLKLEKTGKEIVFVEGQGAQVTLGLLYGSNPDVVFLHDPSRDHFESFPEIPKKPDFEEERLSNAKVIGGVSLNGGFETDLPVYDPFNTDDL............................................................................................................................................................................................................................................. 328
8 -7.260[M] KOG1371 UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase  ali follow..  14  95..........................................................................................................THVLVTGGAGYIGSHAALRLLRD-----SYRVTIVDNLSRGNLGAVKTLQQLFPQTGRLQFIYADLGDPLAVEKIFSENAHFAAVAYVESTLYPLKYYHNITSNTLGVLEAMARH-KVKKLIYS----STCATYG--EPEKMPITEDTPQVPINPYGKAKKMAEDMILDFSKNSD--------------MAVMILRYFNVIGSDPGGRLGEAPRPELREQGRISGACDAARGFIPGLQVKGTDDGTCIRDYIDVTDLVDAHVKALEKAQPRK---IYNVGTGKGRSVKEFVEACKKATGVEIKVDFLPRRPGDYAEVYSDPTKILKDLNWTARFTNLQDSLQVAWRWQKIHP------HGYNSY.......................... 436
9 -6.270[R] COG0433 Predicted ATPase  ali follow..  9  195.........................................................................................................ERSNGVFGKSGT-GKSFLTRLLISGIIHKQAAVNLMFDMHSEYGWEAMREGKTVSTVKGLRQLFPGEVE------IFTLDAESTKRRGVRGAQELYLSFDQIEIEDIRLVGFELGLSEAALDNANILFSEFGRLLVMSNEEIKVFCEEKQGHPGSIMSLQRKLKRLENLKYLKQVSTHNYIDQLLQCLEAGKHVVI---EFGSQSNLLSYMLATNMITRRIHSIYVKKAEKFLQTKH-VGDRPRQLVITIEEAHHQTIFGTIAREMRKYFVTLLVV----------DQRPIDNEVMSQIGTRITCLLNDE--KDIEAIFTGVAGGQNLRSVLAKLDSKQQALVLGHAVPMPVVVRTRPYDQQFYSEIGCQDWPNKTDAEVLAEAAIAREDL 577
10 -6.090[G] KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase  ali follow..  8  41............................................................................................................IVMIGLPA-RGKTYVSKKLTRYLNWIGVPTKVLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEEN-----------QIAVFTNTTRER-------------RDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPERNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVYYLMNIHVQPRTIYLCRHGESE-----SGLSVRGKQFAQALRKFLEEQEITDLKVWTSHVKRTIQTAESLGVPYEQWKIL--MTYAEIEKRYPEEF-EKYLYRYPGGESYQDLVQLLEPVIMELE--RQGNVLVISHQA.............................. 393
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.