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Query: [M] COG0773 UDP-N-acetylmuramate-alanine ligase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MFFISIRYIFVRKLWRANGQPFKITPLRIENPPERNIMMKNRVTNIHFVGIGGVGMSGIAEVLHNLGFKVSGSDQARNAATEHLGSLGIQVYPGHTAEHVNGADVVVTSTAVKKENPEVVAALEQQIPVIPRALMLAELMRFRDGIAIAGTHGKTTTTSLTASILGAAGLDPTFVIGGKLNAAGTNARLGKGEYIVAEADESDASFLHLTPIMSVVTNIDEDHMDTYGHSVEKLHQAFIDFIHRMPFYGKAFLCIDSEHVRAILPKVSKPYATYGLDDTADIYATDIENVGAQMKFTVHVQMKGHEQGSFEVVLNMPGRHNVLNALAAIGVALEVGASVEAIQKGLLGFEGVGRRFQKYGDIKLPNGGTALLVDDYGHHPVEMAATLSAARGAYPEKRLVLAFQPHRYTRTRDLFEDFTKVLNTVDALVLTEVYAAGEEPIAAADSRALARAIRVLGKLEPIYCENVADLPEMLLNVLQDGDIVLNMGAGSINRVPAALLELSKQILast
1 -134.000[M] COG0773 UDP-N-acetylmuramate-alanine ligase  ali  100  1MFFISIRYIFVRKLWRANGQPFKITPLRIENPPERNIMMKNRVTNIHFVGIGGVGMSGIAEVLHNLGFKVSGSDQARNAATEHLGSLGIQVYPGHTAEHVNGADVVVTSTAVKKENPEVVAALEQQIPVIPRALMLAELMRFRDGIAIAGTHGKTTTTSLTASILGAAGLDPTFVIGGKLNAAGTNARLGKGEYIVAEADESDASFLHLTPIMSVVTNIDEDHMDTYGHSVEKLHQAFIDFIHRMPFYGKAFLCIDSEHVRAILPKVSKPYATYGLDDTADIYATDIENVGAQMKFTVHVQMKGHEQGSFEVVLNMPGRHNVLNALAAIGVALEVGASVEAIQKGLLGFEGVGRRFQKYGDIKLPNGGTALLVDDYGHHPVEMAATLSAARGAYPEKRLVLAFQPHRYTRTRDLFEDFTKVLNTVDALVLTEVYAAGEEPIAAADSRALARAIRVLGKLEPIYCENVADLPEMLLNVLQDGDIVLNMGAGSINRVPAALLELSKQI 506
2 -37.200[M] COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase  ali follow..  23  6...........................................KKILVAGLGGTGIS-MIAYLRKNGAEVAAYDAELKPERVSQIGKGLVFYTGLKDALDNGFDILALSPGISERQPDIEAFKQNGGRVLGDIELLADIVNRRDDIAITGSNGKTTVTSLVGYLCIKCGLDTVI-IGTPVLEAEWQREGKKADVWVLELSSFQENTESLRPTAATVLNISEDHLDRYDDLLDYAHTKAKIFRGD----GVQVLNADDAFCRAMKR-AGREVKWFSLEHEAD----------FWLERETGRLKQGNEDLIVTQDIPLQGLHNAANVMAAVALCEAIGLSREALLEHVKTFQGLPHRVEKIGEK-----NGVVFIDD--SKGTNVGATAAAIAGL--QNPLFVIL----MGKGQDFTPLRDALVGKAKGVFLI-----------GVDAPQIRRDLDGCG-LNMTDCATLGEAVQTAYAQAEAGDIVLLSPA-GYAHRSEVFIEAFKAL 445
3 -33.500[M] COG0769 UDP-N-acetylmuramyl tripeptide synthase  ali follow..  19  23................................................AEVKGIKTNSHACGAGDLFIGMPGTRVDGGEFWPSAIASGAIAAIVSPQAVEKNPPHDEAVVISSNNMTKACAAIA--------AAFYGYPGQKLKLVGVTGTNGKTTTTHLIEFFLTKAKL-STALMGTLLQQQLAQAVNAGCEFGVMEVSSHQGRVLGCPFEVGVFSNLTQDHLD-YHSDMEDYFAAKALLFSPEYLKGRAIINADDTYGQRLIKALSEKVWSYSVDSSADLWMSDLSYEPNGVTGTIHTPEGN-----VSFRSPLVGQYNLENLLAAVGAVLHLGLNLQLIANAIPEFPGVPGRME---RVQINPDQDISVIVDYAHTPDSLENLLKAARP-FIPGRMICVF--DRDRTKRPKMGKIVAEL--ADLAFVTSDNPRTEDP------DRILDDILAPDTVQPTVIGDRAIAIRTAILQAQPGDGVLLAGKGDDREHARAALTEREKL 496
4 -29.000[M] COG0770 UDP-N-acetylmuramyl pentapeptide synthase  ali follow..  19  30..................................................SSGIQTDTRMIKPGEVFLAFRGEKFDGHEFISSAIARGAIAAIVDDDYENPGLPVLQVSNTL---------------------EAYQKLGRWWRDIGVTGSVGKTTTKELIAAVLTYGNYNNEIGVPKTLLELNAEHDYAVIEMAMRGRGQIAELAQIARPTIGVITNVGTAHIELLG-SEEAIAEAKCELLAEMPKDSVAILNHDNPLLMATAAKFSGEVLTYGLS-GGDVQGSLVD-------------NAIVEVAGLRLPLPLPGRHNATNYLAALAVAKVLGIEWSSLQAGVSVNMPTGRSQRFS------LPNDVLILDEYNAAPEAMLAALQLLADTPGKRKIAVL---ELGERSAQLHQRVGETVRNLKLDGLLVL----------VDGEDAEAIARSAEGIPSECFATHADLVARLTTFVQGGDRLLFKAA-GLDRVVSQLRAEFSN. 451
5 -20.900[H] COG0285 Folylpolyglutamate synthase  ali follow..  16  21...........................................................................................................................DMGLERTSEVKKRMKLEPQCPVVVVAGTNGKGSVCAYLTQIYKQAGYKIGTLTSPHLLRYNERIAINAEDVMILEGGRLDAVNA-FDGDCAVVTSVDLDHQAFLGDTVEQVGFEKAGVFRS----GKPAICGQNPAPKSLLSHAEAIGAKL-LMVQRDFEFHAMENIQWNYRFRPQHSDDPARNRNALPFPALRGTYQLSNAACALTVLECLNVDIGAIKRGLLLVE-NPGRFQVL-------PGRPLTVLDVGHNPHAARALRRSLINLAFAQKRTAVF----MLSDKDIDGVLETVKDQFDEWYIAPLDVPR-----GMTLESLQNKLHEHSIENIQTFAAVREAYRAAASKAGENDRIVVFGS................. 413
6 -15.800[H] KOG2525 Folylpolyglutamate synthase  ali follow..  13  36.......................................................................................................SLQSNAKVLEVLRKRGKIPNDQSMVWLRCIGYQPSDLNRLNVIHVAGTKGKGSTCAFTSSILQQIPKCIGMYTSPHLRSVCERIQLNGKDAAIIEGGEYDSTNLIEKPYATAVTSLGLDHTSLLGNTIAEIA----QKAGIYKESAIALTCEQAPEAMNVLKNRAAER-------------------------NTSLKVVIPPAELTPDMIGLSGVHQLGNTSLAVSLVQEFPYQDPAILDGL-------KYVKWPGRCQIEEINNIKWCFDGAHTKESLEATGLWLASKEDADARILLFNQQSRDDPIALLRSFLKGLESSTHVIFSSINTITDNKPVLHVQEDLCKWWKEGTTSEATVAPTIQEAIETVMSIKQKSRNTFVCVTGSLHLTGGVFVVLDQAV 504
7 -9.510[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  12  33.......................HLSVTDTIPLPNSNSNATPPLRIAIIGFGNYG-QFLAETLISQGHILFAHSRSDH--SSAARRLGVSYFTDLHDLCERHPDVVLLCTSILSIENIL---KTLPFQRLRRNTLFVDVLSVKEFAKILCTHGPQSVSS-LRFVYDKVRIGEERLRVSRCESFLEIFVREGCEMVEMSVTDHDKFAAEYEALLDLAENICGDSFDLYYG--NNSLEVLERIDLAFEALRKELFSRLHGVVRKQSFEGEAKKVHVPNCGENDASLDMMRSEDVVVKYEYNSQVSGSVNDGSRLKIGIVGFGNFGQFLGKTPEVIILCTSILSTEKVLESLPFQRKRSTLFVDVLSVKEFPRNLFLQTCTHPPESGKNGWNNLAFVFDKVRIGM-RKSRCNSFLDIFAREGCRMVEMSC----DWHAAGSQFITHTVGRLLEKLSLESTPIDTKGYETLLKLVENTAGDSFDLYYGLFLYNPNAMEQLERFHVAFESL 610
8 -8.370[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  20  1......................................MSHTKPSIAILGAGRVG-SSLARSAVAAGYEVKAGSGAVDKIALTAEILMPGAVPSTADQAVKDADIVFLAVVIDTMNHEIIAEFFAGSTMVKSYHEIEQDAGTGRAIAYATDD--VDAGAQVAQLIKSFGFVP-LNIGALENG.................................................................................................................................................................................................................................................................................................................................... 182
9 -7.960[M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase  ali follow..  12  13........................................SRQALIGIVGLGYVGLP-LMLRYNAIGFDVLGIDIDDVKVDKIAKARASGFEATTDFSRVSECDALILTPLNKYREPDMSF-------VINTTDALKPYLRVGQVVSLESTTYPGTTEEELLPRVQEGGLVV------------------GRDIYLVYSPERGNPNFETRTIPKVIGGHTP-------QCLEVGIALYEQAIDRV-------VPVSSTKAAEMTKLLENIHRAVNIGLVNEMKIVADRMGIDIFEVVDAAATKPFGFTPYYPGPGLGGHCIPIDPFYLTWKAREYGLHTRFIELSGEVNQAMPEYVGLNEAGRALKGSRVLVLDDMRESP-----SVEIMELIEAKGGMVAYSDPHVPVFPKSSEPLTAENLARFDAVVLATDHDKFDYELIKAEAKLVVD....................................................... 421
10 -6.880[R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase  ali follow..  11  55.....................................FSIEPGKTLCVVGESGSGKSVTARSILQIGYITSGSIILNKADGSSVDLAKLDPRGRAIRAVRGADIAMIFQEPMSSLSPVHTVGDQITEVLMSKAQARAEAIELLRQVEIP-SGGMRQRAMIAMALA----CKPQLLIADETTALDVTTQAEILDLISRLQKAHGMAVLFITHDMGVVAQIADDVLVMHHGVVKEYGTVEQIFHKPQDPYTRMLIGSVLKLEQKAEIRLARPPLDQTAAPILEVKDLSMHFGEMKALDGVSIKLLPGE------TLGIVGESGSGKTTMGRSIMRLYDPTAGEMLYRRADGSVVDLSKIEGKELKAARRELRMVFQDVAQVIGEPLLVNGIAKGKELEERVCSLMEPHAFSGGQRQRIGIARAITLRPRIIVADEATSALDVSVRFQVLDLLMKLQDELGLAYIFISHDIGVIRYMC------DRVGVMYRGKLVEVGE......... 542
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;