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Query: [R] COG0790 FOG: TPR repeat, SEL1 subfamily, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEIKFLSLCILAGVLFVSQVNASANNGKDDVKYAALTQKDLDALPVEKRASVLDELGFIHEYGLSVPMNRERALQYYKQACELGGNYGCYNVKYAYQYGDGVAKDSAQANKYAKKMNLDNLLIEQEYIDKFSQEIYMAKALADTDKSQRAAFISILIHALNNRPESDALFFSRIGFNQEKTFRLATLWSQDGDPQMDYQMGRLTLNDFSGRYADEPYQARPASLKWFRAAAEKGVVEAQSLLGGIYSGGEGDEWGIKPDIQEAQKWYGQAAKQGDSDAQIALGKIYYSGATGRTDYAKALALFTQVENDGTNSRSTMPLSWMYYNGLGTAPDCDKAWSYYKKASRYVGKKVEEKIFLSKCAADIQSRKNNADALPKVTLKKERIFSRGITAKPKECALIFQIGTDKIRNMANLHITLELKNADGMATEETLMIPPFGLNTLGIDMQNHDVDPLVTPYDLPLYTQDFCHGIGDIHFTLKSATATINGKNVDLLKADSVRFLDKELast
1 -134.000[R] COG0790 FOG: TPR repeat, SEL1 subfamily  ali  100  1MEIKFLSLCILAGVLFVSQVNASANNGKDDVKYAALTQKDLDALPVEKRASVLDELGFIHEYGLSVPMNRERALQYYKQACELGGNYGCYNVKYAYQYGDGVAKDSAQANKYAKKMNLDNLLIEQEYIDKFSQEIYMAKALADTDKSQRAAFISILIHALNNRPESDALFFSRIGFNQEKTFRLATLWSQDGDPQMDYQMGRLTLNDFSGRYADEPYQARPASLKWFRAAAEKGVVEAQSLLGGIYSGGEGDEWGIKPDIQEAQKWYGQAAKQGDSDAQIALGKIYYSGATGRTDYAKALALFTQVENDGTNSRSTMPLSWMYYNGLGTAPDCDKAWSYYKKASRYVGKKVEEKIFLSKCAADIQSRKNNADALPKVTLKKERIFSRGITAKPKECALIFQIGTDKIRNMANLHITLELKNADGMATEETLMIPPFGLNTLGIDMQNHDVDPLVTPYDLPLYTQDFCHGIGDIHFTLKSATATINGKNVDLLKADSVRFLDKE 503
2 -90.800[MOT] KOG1550 Extracellular protein SEL-1 and related proteins  ali follow..  14  80.SFNREKDCNNNNNNNNNNNGFISKSHLADGLDQKKPIILHWSSDSTNRLSWENCDLLLLRDGLDHIQNRENTVASETELDEKNHHGEEEESEDEEESQSQNDEDQLLDVITLRTMVKRERKRGDYMKKELEKEVAEQKQVYDQEVIQSLQWMLMKLDDDEDKIQINYGDDEEYGGGGEEAVDEIEAASSAGDPHAQSIMGFVYGIGM------MREKSKSKSFLHHNFAAAGGNMQSKMALAFTYLRQDMHDKAVQGEEDEDFQILEYQAQKGNANAMYKIGLFYYFGRGLRRDHTKALHWFLKAVDKG-EPRSMELLGEIYARGAGVERNYTKALEWLTLAAKEGLYSAFNGIGYLYAREYFEKAVDNEDPSGHYNLGVLYLKGIGVNRDVRQATKYFFVAANAGQPKAFYQLAKMFHTGVGLKKNLEMATSFYAALLIGDAYYYGRGTERDFVRAAEAYMHAKSQSNAQAMFNLGYMHEHGQGLPFDLHL--AKRYYDE. 863
3 -20.900[DO] KOG1155 Anaphase-promoting complex (APC), Cdc23 subunit  ali follow..  10  170.....LRRTGAIDSFGLYLYGVVLKE----KGNESLARASLVESVNNNHWMKEFFLGNAYQE-----RMHTESLAKYEYLQGSFSNYIQAQTAKAQYS----LREFDQVEIMFEELLRNDRVEDMDLYSNVLYAK--------EACAALSYLAHKVFLTDRPESCCIIGNYYSLKGQHEKAVMYFRRALNKKYLSAWTLMGHEYVE----------MKNTPAAIDAYRRAVDPTDYRAWYGLGQAYEM--------MGMPFYALHYFRKSIFPNDSRLWIAMAKCYQTEQ---YMLEEAIKCYKRAVNTDTEGIALNQLAKLHQK----LGRNEEAAYYFEKDLERMDAEGL---------------EGPNMFEALVFLATHFKN----HKKFEEAEVYCTRLLDYSGPEKEKAKSLLRGIRMAQTGFPSMDLEHFPI................................................................. 579
4 -20.800[T] KOG1130 Predicted G-alpha GTPase interaction protein, contains GoLoco domain  ali follow..  9  9.....VRYRMEASCLELALEGERLCK------DCRAGVSFFEAAVQKTLSAIYSQLGNAYFY------DYAKALEYHHHDLTLGEAKASGNLGNTLKV------NFDEAIVCCQRHLDVGEARALYNLGNVYHAK---------KSFGCPGPQDVGEFPEEVRDALQAAVDFY-----EENLSLVTALGDRAQGRAFGNLGNTHYL-----------GNFRDAVIAHEQRLLAAERRAYSNLGNAYIF----------EFETASEYYKKTLLAVEAQSCYSLGNTYTL------DYEKAIDYHLKHNDRIGEGRACWSLGNAYTA------NHDQAMHFAEKHLEISREVGD----------------KSGELTARLNLSDLQMV---LGLSYSTNNSIMSEN-------------TEIDSSLNGVLPKLGRR-----HSMENMELM------TPEKVQNWNSEILAPSAKLLFVNRLKGKKY.................... 448
5 -19.300[R] KOG1129 TPR repeat-containing protein  ali follow..  10  5.............................SDSTYVDELENEDMGLDQNVIAPNARPGTSFAR----PKTSAKGVNPILRPTNAGRPLSGVVRPQSSFK----SGSMDQAVRTARTAKTARAVSSTSARNMRLGTASMAAGADGEFVNLARLNIDKYAADPQVNRQLFEYVFYYLNDVAHQIAGTASKAAGFEDYYWKNQLAKCYLR----------LGMLQDATKQLQSSLEKKLIETFALLSKAYNR--------VDQPMAALKTYSAGLEPENVTMLTGMARVQEA----LGEYDESVKLYKRVLDESNNIEAIACVATTYYY----GGKPELAMRYYRRILQ----------------------MGVSSPELFLNIGLCCMAAQQFDFALSSILRAQSTMTDDVAADVWYNIGQILVD----IGDLVSAARSFRIVNLGILKHR----EGKIDEARSLYSSATSKNMFEGNYNLGLVSFTQGKYH------ECRELIEK. 433
6 -19.100[D] KOG1126 DNA-binding cell division cycle control protein  ali follow..  12  307...............................RSSKRGESTPQSFREEDELLKLFGKGVYLLA----QYKLREALNCFQSLPIQNTPFVLAKLGITYFE-----VDYEKSEEVFQKLRDPSRVKDMEVFSTALWHL--------QKSVPLSYLAHETLE------------------------------TNPYSPESWCILANCFSL----------QREHSQALKCINRAIDPTFEYAYTLQGHEHSA---------EEYEKSKTSFRKAIRVRHYNAWYGLGMVYLK----TGRNDQADFHFQRAAENPNNSVLITCIGMIYER-----KDYKKALDFYD.................................................................................................................................................................. 557
7 -18.800[DO] KOG1173 Anaphase-promoting complex (APC), Cdc16 subunit  ali follow..  9  373................................DYKQCLKILNELLKPFHNTALTIQIACLVE----NGDFNRLFYVAHKLVDRDKAISWYAVGCYYDM----IGKSDPARRYLSKATDRLYGPAWLAYGHSFAN--------ENEHEQAMAAYFKATQRGCHLPLLYIGVECGLTKNLELAEKFFLQAMNPLDVYVLHELGVIKYE----------YEFFDGAATIFQCTVDSRWEPLFINLGHSLRK---------HKYEEALYNFQYALLPQSPTTYTSIGFIHAL----LGNLDPAIEAFHKSLANRDCIVTSTILKSCIED-----MDDSATIDEICSAADVAKNITANSRRVLNSDKFNGMKLKFDEEEEFANSDSNMVVEMSFDT................................................................................................................ 718
8 -17.200[G] COG2956 Predicted N-acetylglucosaminyl transferase  ali follow..  9  27.........................................NKQDEANRLSRDYVAGVNFL----LSNQQDKAVDLFLDMLDTGTVEAHLTLGNLFRS----RGEVDRAIRIHQTLMEEQRLLAIQQLGRDYMA--------AGLYDRAEDMFNQLTDETRIGALQQLLQIYQATSEWQKAIDVAERLVKLGKDKQRVEIAHFYCELALQHMASD---DLDRAMTLLKKGADKNSARVSIMMGRVFMA--------KGEYAKAVESLQRVISQD-SETLEMLQTCYQQ----LGKTAEWAEFLQRAVEENTGADAELMLADIIEA----RDGSEAAQVYITRQLQR............................................................................................................................................................. 311
9 -16.700[U] KOG0547 Translocase of outer mitochondrial membrane complex, subunit TOM70/TOM72  ali follow..  8  112....IAQLKGLSPSQRQAYAVQLKNRGN-TAKNFNEAIKYYQYAIEPNEPVFYSNISACYIS----TGDLEKVIEFTTKALEIKHSKALLRRASANES-----GNFTDAMFDLSVLSLNSNTSLASFFGIFDSHLEVSSVNTSSNYDTAYALLSDALQRLYSATDEGYLVANDLLTKSTDMYHSLLSANTVNAALALCYTGIFHFL----------KNNLLDAQVLLQESINHPTPNSYIFLALTLAD--------KENSQEFFKFFQKAVDPEYPPTYYHRGQMYFI-----QDYKNAKEDFQKAQSNPENVYPYIQLACLLYK----QGKFTESEAFFNETKL----------------------KFPTLPEVPTFFAEILTD----RGDFDTAIKQYDIAKEEVQEKIHVGIGPLIGKATILARQSSQDPTQLDEEKF--------------NAAIKLLTKACEPRSEQAKIGLAQLKLQMEKID------EAIELFED. 589
10 -16.200[DO] KOG1174 Anaphase-promoting complex (APC), subunit 7  ali follow..  7  57...............................KEYRNAVSKYTMALQPSEIEVKYKMAECYTM-----KQDKDAIAILDGPSRQRTPKINMMLANLYKK----AGRERPSVTSYKEVLRQCPLALDAILGLLSLSV-------GAEVASMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNSRAISTICSLEKRDNVDLLGSLADLYFR----------AGDNKNSVLKFEQALDLYLIKGMDVYGYLLAR--------EGRLEDVENLGCRLFNDQHAEPWVVSGCHSFY----SKRYSRALYLGAKAIQNSNSVQALLLKGAALRN----MGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAANAQTLTLLATVCLEDPV---TQEKAKTLLDKAQRPDYIKAVVKKAELLSR----EQKYEDGIALLRNAILGDFLVA----VNEYQEAMDQYSIALDPNDQKSLEGMQKMEKEESPTDATQSDSEAAQWADQE 559
11 -16.200[S] KOG4340 Uncharacterized conserved protein  ali follow..  10  91................................DLPGSRSLVEQLLSDNETDGQVNLGCLLYK----EGQYEAACSKFSATLQASQPDLSYNLALAYYS----SRQYASALKHIAEIIERGHQTALVEAFNLKAAIEYQLRNYEVAQETLTDMPPRAEEELDPVTLHNQALMNMDA-RPTEGFEKLQFLLQQNPPETFGNLLLLYCK----------YEYFDLAADVLAENAH--TPYLYDFLDALITCQTAPEEAFIKAIKKAVNEYDETMEK-YIPVLMAQAKIYWN----LENYPMVEKVFRKSVECNDHDVWKLNVAHVLFMQEN---KYKEAIGFYEPIVKKHYDNILNV-----------------SAIVLANLCVSYIM----TSQNEEAEELMRKIEKE-LCIVNLVIGTLYCA----KGNYEFGISRV-------------------IKSLEPYNKKLGTDTKRCFLSLLENMSKHMIVIHDSVIQECVQFLGH. 581
12 -15.900[R] KOG1125 TPR repeat-containing protein  ali follow..  13  341................................DLPVTILFMEAAILQDDAEAWQFLGITQAE----NENEQAAIVALQRCLELNNLKALMALAVSYTN----TGHQQDACDALKNW-------------------------IKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAH-GDMIDPDLQTGLGVLFHL----------SGEFNRAIDAFNAALT-EDYSLWNRLGATLAN--------GDRSEEAVEAYTRALE-GFIRSRYNLGISCIN-----GAYREAVSNFLTALSQRKSRNQQQVPHPAISG---FQAANLGDLDVLLRAFN.............................................................................................................................................................. 623
13 -15.200[Z] KOG1840 Kinesin light chain  ali follow..  10  148.............RFLLNQARNLVSSGDSTHK-THRAAKLFEASAENGKIMCLHVTAAVHCK------EYNEAIPVLQRSVELAKFAGLMQLGDTYAM-VG---QLESSISCYTEGLNENDPRVGETCRYLAEALVQAL-----RFDEAQQVCETALSIAEAADRRLMGLICETKGDHENALEHLVLASESEVAFVDTSIGDSYLS----------LSRFDEAICAYQKSLTPAVGSVYIRLADLYNR--------TGKVREAKSYCENALREEIASGLTDISVICES----MNEVEQAITLLQKAGQKIMIAGIEAQMGVLYYM------KYMESYNTFKSAIS--------------KLRATGKKQSTFFGIALNQMGLACIQ----LDAIEEAVELFEEAKC------------ILEQECGPYHPETLG----LYSNLAGAYDA------RLDDAIKLLGHVVGPVTEDEKRRLAQLLKEGNVTGRKAKSLKTLIDSDL. 643
14 -14.300[T] KOG4162 Predicted calmodulin-binding protein  ali follow..  9  523.ALDALERAVQNDHLAEYYLSLQYAL----LGQLAEALVHIRFALAMEHAPCLHLFALLLTS----SRRPREALGVVEDALHEDNLQLLHVKAHLQLH-----EDAETALGTVQHMLA---------VWRDVYEAQLAGEEEKHSDTKSGVHLAHSSQMSDKDSNSVYAASLAAVSRVEQALSEAASSLSS-QIEIWLLLADVYLR----------IDQPNEALNCIHEASQPLSHQIMFMRGQVHVY--------LEQWFDAKQCFLNAANPNHTEALRALGEAHLV----LGEPRLAEKMLKDAAKDPSCPKIWFALGKVMEI----LGDFHASADCFATSLQ.............................................................................................................................................................. 843
15 -14.100[R] KOG1124 FOG: TPR repeat  ali follow..  10  156.AARAQERPLAVNLDLSLYKAKVLAR----NFRYKDAEKILEKCIAPEDGRPYVALGKILSK----QSKLAEARILYEKGCQSENSYIWQCWAVLENR----LGNVRRARELFDAAADKKHVAAWHGWANLEIK--------QGNISKARNLLAKGLKGRNEYIYQTLALLEAKAGRYEQARYLFKQATISRSCASWLAWAQLEIQ----------QERYPAARKLFEKAVQAKNRFAWHVWGVFEAG--------VGNVERGRKLLKIGHAPRDPVLLQSLGLLEYK----HSSANLARALLRRASEDPRHQPVWIAWGWMEWK----EGNTTTARELYQRALSIDANTESASRCLQAWGVLEQRAGNLSAARRLFR--------SSLNINSQSYVTWMTWAQ--------------LEEDQGDTERAEEIRNLYFQQRTEVVDDASTGFLDIIDPALDTVKRLLNFGQNNDNNRLTTTLRN.................... 587
16 -14.000[NU] COG3063 Tfp pilus assembly protein PilF  ali follow..  12  32.............................................................................................................................................................................................ANQVSNIKTQLAMEYMR----------GQDYRQATASIEDASDPKNELAWLVRAEIYQY--------LKVNDKAQESFRQALSPDSAEINNNYGWFLCGRLN---RPAESMAYFDKALAD-TPYIANLNKGICSAK----QGQFGLAEAYLKRSLA----------------------AQPQFPPAFKELARTKML----AGQLGDADYYFKKYQSEVLQADDLLLGWKIAKALGNAQ............................................................................ 227
17 -13.900[B] KOG1156 N-terminal acetyltransferase  ali follow..  9  23..............................HKQYRNGLKFCKQILSAEHGETLAMKGLTLNC-----GKKEEAYELVRRGLRNDSHVCWHVYGLLQRS----DKKYDEAIKCYRNALKKDNLQILRDLSLLQIQM--------RDLEGYRETRYQLLQ------------------------------LRPAQRASWIGYAIAYHL-------LEDYEMAAKILEEFRKTQQTSPDKVDYEYSELLLY-QNQVLREAGLYREALEHLCTYEKQDKLAVEETKGELLLQ-----CRLEDAADVYRGLQENPENWAYYKGLEKALKPA-----NMLERLKIYEEAWTKYPRGLVPR--FKECLDKFLRMNFSKGCPPVFNTLRSLYKDKEKVAIIEELVVGYETSLKSCRLFNPND-----------GKEEPPTTLLWVQYYLAQHYDK------QPSIALEYINTAIEPTLIELFLVKAKIYKHAGNIK------EAARWMDE. 433
18 -13.500[O] KOG0548 Molecular co-chaperone STI1  ali follow..  10  21.AINHFTEAIATNHVLFSNRSAAHAS----LHQYAEALSDAKETIKPYWPKGYSRLGAAHLG-----NQFELAVTAYKKGLDVDNEALKSGLADAEAS-----ARSRAAPNPFGDAFQGPEMWTKLTSDPSTRGFLQQPDFVNMMQEIQKNPSSLNLYLKDQRVMQSLGVLLNVKFRPPPPQGDEAEVSDMGQSSSNEPEVEKKRE----------PEPEPEPEVTEEKEKKERKEKAK-------EKELGNAAYKKKDFETAIQHYSTAIEDEDISYLTNRAAVYLE-----GKYNECIEDCNKAVEGRELRSDYKMVARALTRKGTALTKMAKCSKDYEPAIEAFQKALTEH--AERAKKEWEQKQDPKLGDEEREKGNDFFK----EQKYPEAIKHYTEAINPNDHKAYSNRAASYTK-PEGLKDAEKCIE--GYSRKAAVQFF----LKEYDNAMETYQAGLDPSNQELLDGVKRCVQQINKANRGDLTEELKERQAK. 517
19 -13.200[R] KOG1128 Uncharacterized conserved protein, contains TPR repeats  ali follow..  12  360..............................IKDRLLRTSYILASGLTPFWQSSVLLAGILNSGC-----TSEALLILEKL------EMWDGVIDCYKQ-----GQMDKAETLIRRLIEPNDSMLHVYLGDITRNL--------------------------------------------EYFTKAIELSDDRNARAHRSLGHLLLM----------DKKFEEAYKHLRRSLELQQLGTWFNAGYCAWK--------LENFKESTQCYHRCVQPDHFEAWNNLSAAYIR----HGQKPKAWKLLQEALKNYEHPNVWENYMLLSVD----VGEFSQAIQAYHRLLDMNKRGADDEVLELIAQTLLRREAEISMDES................................................................................................................................ 627
20 -12.900[U] KOG3081 Vesicle coat complex COPI, epsilon subunit  ali follow..  10  2...........................................SAMGAGPDHLFNLRNNFYLG-----AYQTAINNSEIASPENAVERDCLVFRSYIA----LGSYQLVISEIDESAATPLQAVKLLAMYLST---------PQNKESTISSLKEWLADSTIGNNDTLRLIAGIIFMHEEDYNETLKHTHAGTMDLYALNVQIFIK----------MHRAEYAEKQLRVMQQEDHTLTQLASAWLNLA--------GSKIQEAYLIFEDFSEKMTCLILNGKAVCCMQ----MGNFDEAETLLLEALNDAKDPETLANLVVCSLHGKSSSRRVSSAEDNFERAVQL............................................................................................................................................................. 291
21 -12.200[U] COG5010 Flp pilus assembly protein TadD, contains TPR repeats  ali follow..  12  58................................................................................................................................................ELAAAAERIGQAYERKDREAGLNYANLLRMTGRNEQALAVMQQVAHPADREVLGAYGKAQAA----------AGQLEQALATISRAQDRPDWKLKSAEGAILDQ--------LGRSAEARLRYREALD-NEPSVLSNLGMSYL----LTKDLRTAETYLKSAASPDAGSSVRQNLALAV----GLQGRFQEAETIAGQELTSEQAEAN....................................................................................................................................................... 248
22 -12.000[S] KOG4814 Uncharacterized conserved protein  ali follow..  8  173................................DFQRASMCVLQCKDMRLPQMTSSLHLCYNFGVETNNKYEESSFWLSQSYDIGKMDKKRLLATNYLD-WDDTKYYDKALNAVNLANKEHLSSPGLFL---KMKILLKGETSNEELLEAVMEILHLDMPLDFCLNIAKLLMDHERESVGFHFLTIIHERFKSSENIGKVLILHTDMLLQRKEELLAKEKIEEIFLAHQTGRQLTAESMNWLHNILWRQAA------VQNYTDALQWYYYSLDLDFTKLQRNMACCYLN----LQQLDKAKEAVAEAERDPRNVFTQFYIFKIAVI----EGNSERALQAIITLENILTDEESEDNDLV---------AERGSPTMLLSLAAQFALENGQQIVAEKALEYLAQHSEDQEQVLTLRFLLPKIAEMPESEDKKKEMDRLAFVKLSQPFGEEALSLESRANEAQWFRKTA--------WNLAVQCDK.................... 628
23 -11.500[S] KOG3060 Uncharacterized conserved protein  ali follow..  10  9........................................................................................................SWSDVRDQFRTWREETGRHSEEVVQLWVAVLEDKVHKTGNERHLILEQVIIAALDTAR---------------FDIATKCTKQLSLEGSLRVMKFKAMRYEA----------LEQYDEADEVLDAIIAKDNAAPRKRKIAILKA--------RGRRLEAIKELNEYLKMSDQEAWHELCNMYLA----EGEFGKAAFCMEEVLLNPHSHLIHQRLAEIRYT-MGGVENMESARTYYSQALKLNPHNLRALYGIYLCCNHLDNSRAVSSKRKEL.............................................................................................................................. 250
24 -11.100[U] KOG1586 Protein required for fusion of vesicles in vesicular transport, alpha-SNAP  ali follow..  10  6....................................................................KEAEAMALLAEAERK--KNSQSFFSGLFGG----SSKIEEACEIYARAAN----------------MFK----MAKNWSAAGNAFCQAAQLHLQLQS------------------------KHDAATCFVDAGNAFKKA-----------DPQEAINCLMRAIETIAAKHHISIAEIYETELV-------DIEKAIAHYEQSADSSANKCLLKVAGYAAL----LEQYQKAIDIYEQVGTNAMDTPLLKYSAKDYFF---FCIDMLNAKLAVQKYEE.............................................................................................................................................................. 230
25 -11.100[S] KOG2796 Uncharacterized conserved protein  ali follow..  9  18..............................ADSVEQSFVGLKQLISCRNWRAAVDLCG--KSGLLTSHTTDSLQLWFVRLALLVKLGLFQNAEMEFEPFGNLDQPDLYYEYYPHVYPGRRGSMVPFSMRILHAELQQY-LGNPQESLDRLHKVKTVCSKILANLEQGLAEDGGMSSVTQEGRQASIRLWRSRLGRVMYSMANCLLL----------MKDYVLAVDAYHSVIKEQEPQLLSGIGRISLQG---------DIKTAEKYFQDVEKQGKIMVLMNSAFLHLG----QNNFAEAHRFFTEILRDPRNAVANNNAAVCLLY----LGKLKDSLRQLEAMVQQDPRHYLHESVLFNLTTMYELESSRSMQKKQALLEAV......................................................................................................................... 363
26 -10.900[S] COG3898 Uncharacterized membrane-bound protein  ali follow..  11  70...................................YTISRYFRVRRRDRGYQALSTGMIAGAG-----DGALARKKTKEAAKLIRSDQEPLIHLLEAQASLLEGDHEGARQKFESMLDDPEMRLLGLRGLYLEAE------RLGDRNAARHYAGRAAAVALAWAAESTLEELTARGDWDGALKLVDAQKSTRERDAANRRRAVLLTAKAQSLADS---DPNAARTAALEANKPDFAPAAVAAAAALFK--------QNDVRKGSKILETAMKKNHAESSMTVARAALD----AQDFSTARSEAEAAIRMDRREGAYLLLADIEEAETG---DQGKVRQLLSKAVR.............................................................................................................................................................. 391
27 -10.300[S] COG4700 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats  ali follow..  11  40....................................................................................................................................................AYFVIVMLPETGADRHGHTLLMRLQDKLNPERHLRKLTEELAAETNQNHYALANELAR----------LGRYHEAVPHYQQALSAHEAAMMLSLAQAQFA--------IQEFAACQQTLEDVMRYNSADGHLLFARTLAA----QEKYADAESEFEVLISYYPGPQARIYYAEMLAK----MSRLREANEQYVAVVDTAKRSRPH...................................................................................................................................................... 226
28 -10.200[R] COG4785 Lipoprotein NlpI, contains TPR repeats  ali follow..  15  54.........................................RALTDDERAQLLYERGVLYDS------LRALARNDFSQALAIDMPEVFNYLGIYLTQ----AGNFDAAYEAFDSVLE--------------------------------------LDPTYNYAHLNRGIALYYGGRDKLAQDDLLAFYQDDPNDPFRSLWLYL-----AEQKLDEKQAKEVLKQHFEKSDKEGWNIVEFYLGNISEQTL----RLKADATDNTSLAEHLSE-----TNFYLGKYYLS----LGDLDSATALFKLAVANNVHNFVEHRYALLELSLLG---QDQDDLAESDQQ................................................................................................................................................................ 294
29 -10.200[S] KOG4648 Uncharacterized conserved protein, contains LRR repeats  ali follow..  11  113...............................ESLSQESESEEDGVDSQKALVLKEKGNKYFK----QGKYDEAIDCYTKGMDADNPVLPTNRASAYFRNLAVALNRSYTKAYSRRGA------ARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQKQQAISEKDRGNGFFK----------EGKYERAIECYTRGIAADNALLPANRAMAYLK---------QKYEEAEKDCTQAIDGSYSKAFARRGTARTF-----GKLNEAKQDFETVLLEPGNKQAVTELSKIKKE.................................................................................................................................................................................. 396
30 -10.100[S] KOG4555 TPR repeat-containing protein  ali follow..  12  68..........................................................................................................................................................................................................................ELDGALELFQQSLNAQRASVLNNRAQTLRL-AKRDEEALDDLNKALELANDQQTRTKCHAHCQRGVLYRK----LDNLEAARADFEAAAQLGSKAREQLVEINPYAA----NQMLRQAFDQLK.................................................................................................................................................................. 185
31 -10.000[R] COG0457 FOG: TPR repeat  ali follow..  14  475.............LKWFISVSDPFNR-QLITPMYEEMLQILEAKHGPEHKDTLNILDVLYYKG-----EYKKALQFSERALAIGEATSLDNLAGLYES-MG---NYKQALQLSERALEPQHRDVAITLDNLAGLYESMG-----EYEKALIFYQRTIE------------IKEKVLGPQ----------HSNFATSLDNLAVLYRQ----------MGEYEKALQLSQRALEPDIATTLNNIALLYDS-MGDYQKTLPLYQRALEINEKVFGPQYATTLNNLAGFYRR----VGDYEKALSLSQRSLE-GSQARTLNSLALIYEN-IG---DYEKALAFYQRSLD-----REKVLG----------PQHPDVGRTLNNLARLYEI----MGDHEKALTLYQRTIE------------IKEKALGPQHPDVAT----ILNNLAGLHYR------EYKKALPLYQRALDPNSVVIKNNYNRLLSK.................... 907
32 -9.740[O] KOG0550 Molecular chaperone (DnaJ superfamily)  ali follow..  9  1.............................MTEVETTHMNAGTESQQAELAEKQKAIGNAFYK----EKKYAEAIKAYTEAIDLGSDSALSNRAATYMQ-----GEFELALCDAKQSDKPDVPKTQSRIRQAYEGLSILNEAENKQAGLALNALDRLQRRIDSTTQPPMSWMYLKAQDMDRAQKIAHDVLRPKNVEALVLRGKVMYY----------SGENAKAITHFQEALDPDCTTAKTLFKQV-TKNQGNDLFRQGNYQDAYEKYSEALQIDPDNKETVAKLYMNRATVLLRRPEEALSDSDNALADSSYLKGLKVRAKAHEA----LEKWEEAVRDVQSAIELDASDANLRQELRRLQLELKKSKRK----------HYKILGVSKEATDIEIKKAYRKLALVYHPDKNAG----NLEAEARFKEVGEAYTILSDPESRRRFDSGVDLEPGMEGG............................................. 423
33 -9.640[A] KOG2047 mRNA splicing factor  ali follow..  10  396..............................EGNAAKQILTYTEAVRT-AVGKPHTLWVAFAKLYENHKDLVNTRVIFDKAVQV-TVDHLASVWCEWAEMELRHKNFKGALELMRRATAVPTVEVRRRVAADGNEFYVDLEESLGTLESTRAVYEKILDLRIATPQMNYAFLLEENKYFEDAFKVYERGVKIFKYPHVKDIWVTYLTKFVKRYGKT---KLERARELFEHAVSMAPSDAVRTLYLQYAK--------YGLAKRAMKVYEEATKKVPEGQKLEMYEIYISRAAEIFGVPRTREIYEQAIESGLPHKDVKIMCIKFAELERSLGEIDRARALYKYSSQFADPRSDPEFWNKWH----EFEVQHGNEDTYREM---LRIKRSVSASYSQTHFILPENMMQKDKLLDVEDAKGELKRAGLPEDEMAALE--QLLSTTTPTEPAKDGGRRVGFVSAGVISQSGENEGKPVTGNGEDIELPDESDDESDGDDHVEISQK. 874
34 -9.430[V] KOG0624 dsRNA-activated protein kinase inhibitor P58, contains TPR and DnaJ domains  ali follow..  9  41................................QFADALTQYHAAIEPKSYQAIYRRATTYLA-----GRGKAAIVDLERVLELDFYGARIQRGNILLK----QGELEAAEADFNIVLNSSNNDVQEKTALIEQHRQLRHQIKSGDCATVEEYINHIIEIQVWDASRMRAKCLEERGELKKAIHDMRIVSKTDSTDTMFETSKLLYT----------VGDLEESLNVIRECLNPDHKSCYPFYKKLRKLESMKKKVENSDWMACLEEGQKTMK--QLNVFRITNRCQRE----AGHISEAIAECNEILNDPSDADILCERAEAHIL----DEDYDSAIEDYQKATEVNPDHREAKEGLEHAKRLKTQAGKRDYYKI-------------LGVKRNASKREITKAYRKLAQKWHPDNFSDEEEKKKAEKKFIDIAAAKEV................................................................. 433
35 -9.300[O] COG4235 Cytochrome c biogenesis factor  ali follow..  13  72........................................................................................................................................................................................................................EEEMSRLALGMRTQLQKGDIEGWIMLGRVGMA---------GNASIATDAYATAYRPKNSDAALGYAEALTR-SSDPNDNRLGGELLRQLVRDHSNIRVLSMYAFNAFE----QQRFGEAVAAWEMMLKLLPANDTRRAVIERSIAQAMQHLSPQESK................................................................................................................................. 221
36 -9.220[O] KOG4642 Chaperone-dependent E3 ubiquitin protein ligase (contains TPR repeats)  ali follow..  14  2.....................................................................................................................................................................................................................KGKEEKEGGARLGAGGGSPEKSPSAQE------LKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYNRALCYLK-----QQHEQALADCRRALEDGQSVKAHFFLGQCQLE-----ESYDEAIANLQRAYSLAKEQRLNFGDDIPSALRIAKKKRWNSIEER............................................................................................................................... 153
37 -9.080[S] COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA  ali follow..  7  46...........NSIIALYISGIISSKQLLDDSCLVTLLTIFGDNHKGESKLALRALGECYK-----TSGNEQLYDVWERLVRIDEAEITRVLADKYEQ----EGNKEKATEFYKKALYR-----------------------RRQNAAIKEVWTKLVALIPDDVEFFYREQ-----------KISEKLGEGRGSVLMQDVYVYYKE----------NEDWTTCINILKHILEEKDVWARKEIIENFRCKYRGHSQLEENVFEAINDFEKHIDEGSFVFHRTWGV----GRIAKVCNDELLIDFAKRRAH------TMLLKMAISALQTLGKEHIWVLKSVLKRQDLAAKIRQDPEWALKVI------TSFDNNCNLKKVKQELVPSLLSVGEWTS---WSTKARKILKESTGFAANTVRSCPVSLEEKLAVEFK--RIDILNTFMDKADTDSDAFREMFDYFNTFLRAFSVVDGNVIAAYL...................... 493
38 -9.060[S] KOG4507 Uncharacterized conserved protein, contains TPR repeats  ali follow..  9  245.VVECAMRARHNKDIALVNLANVLHR----AHFSADAAVVVHAALDSDFFTSYYTLGNIYA----MLGEYNHSVLCYDHAARPGFEQAIKRKHAVL-----CQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQNKGLRIHELSSDDYSTEEEAQTDLKAKMPDDHARKILLSRINNYTIPEEEIGSFLFHAINKPNAPIILNEAGLYWRAVG-------NSTFAIACLQRALLQYQDVPLVNLANLLIH----YGLHLDATKLLLQALANSSEPLTFLSLGNAYLA----LKNISGALEAFRQALK-KCPECENSLKLIRCMQFYPFLYNITSSVCSGNCHEKTLDNSRDKQKYFDNSQSLDAAEEEPSERGTEEDPVFSVENSGRDSDALRLESTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGG----ALEMKGRRLDLQGIRVLK..... 868
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.