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Query: [M] COG0836 Mannose-1-phosphate guanylyltransferase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNEQSRKITPVLLAGGAGSRLWPVSRDQLPKQFQPLVGNLSTYQQTLKRVGDKSLYSEPLVITNEDFRFFARRQAEEIDLPATVVLEPARRDSAAAMAAAAVLAERREPGCLVLALAADHVVLDVDKFSEAVKLGAKAADQGNIVVFGLVPTEPRTSYGYIKPGDAIDGEKDLSTVDAFVEKPDVTTAISYLEKGYLWNSGNFLFRSDVMIAELKAFAPEILAAVTQAVEQYESDLGFVRLHQASFEASPKNSIDYAVIEKTKRMAVVHGHFRWSDIGSWDAIWEIADKHDNDNALEGDGVFIDSEGCLIHSTQLLTTVVGAKDLVVVATKDAVLVVPKNRVQDVKGLVDTLKLast
1 -113.000[M] COG0836 Mannose-1-phosphate guanylyltransferase  ali  100  1MNEQSRKITPVLLAGGAGSRLWPVSRDQLPKQFQPLVGNLSTYQQTLKRVGDKSLYSEPLVITNEDFRFFARRQAEEIDLPATVVLEPARRDSAAAMAAAAVLAERREPGCLVLALAADHVVLDVDKFSEAVKLGAKAADQGNIVVFGLVPTEPRTSYGYIKPGDAIDGEKDLSTVDAFVEKPDVTTAISYLEKGYLWNSGNFLFRSDVMIAELKAFAPEILAAVTQAVEQYESDLGFVRLHQASFEASPKNSIDYAVIEKTKRMAVVHGHFRWSDIGSWDAIWEIADKHDNDNALEGDGVFIDSEGCLIHSTQLLTTVVGAKDLVVVATKDAVLVVPKNRVQDVKGLVDTLK 353
2 -22.600[M] COG1209 dTDP-glucose pyrophosphorylase  ali follow..  14  4.......RKGIILAGGSGTRLYPVTMA-VSKQLLPIYD-KPMIYYPLSTLML-AGIRDILIISTPQDTPRFQQLLSQWGLNLQYKVQPSPDGLAQAFIIGEEFIGGDD----CALVLGDNIFYGHD----LPKLMEAAVNKESGATVFAYHVNDPERYGVVEFDKN--------TAISLEEKPLEPKSN-------YAVTGLYFYD------------NDVVQMAKNLKPSARGELEITDI------------NRIYLEQGRLSVAMMGRGYAWLDTGTHQSLIEASNFIATIEERQGLKVSCPEEIAFRKGFIDVEQVRKLAVPLIK......................... 278
3 -19.800[GMO] KOG1460 GDP-mannose pyrophosphorylase  ali follow..  13  3.SSMEEKVVAVIMVGGKGTRFRPLSLN-IPKPLFPIAG-QPMVHHPISACKRIPNLAQIYLVGFREFALYVSAISNELKVPVRYLREDKPHGSAGGLYHFRNLIMEDSPSH-IFLLNCDVCCS---PLPKMLEAHRGYGGIGTLLVIKVSPESA-SQFGELVADPVTN------ELLHYTEKPETFVSDRI-------NCGVYVFTPEIFTQRKDRATLKRVSSFEALQPATRIPTDFVRLDQDILS----------PLAGKKRLYTYETMDFWEQIKSPGMSLRCSGDGTRSAIVIGDVYI--HPSAKVHPTAKIGPNVSISANARVGPGVRLIILDDVEIMENAVVTNAI. 354
4 -19.600[M] COG1210 UDP-glucose pyrophosphorylase  ali follow..  15  1MRKKVRK--AVIPAAGLGTRFLPATK-AQPKEMLPIV-DKPAIQYIVEEAAE-SGIEDILIITGRNKRSITLKEMQQIADLANIIRQKEPLGLGHAVLCAEHFI----GDEPFAVLLGDDIMVSETPALRQLMDVYD-VYGTEVVGVQSVLPEDVSKYGIINTSGS---QGHVYEVNDLVEKPSPEEAPSEIA-----VMGRYVLN------------SSIFSVLKTIGRGAGNEIQLTDALRE--------------VCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEMRSQLLAYLEDVIKRETKEML.................................... 296
5 -17.900[G] COG0448 ADP-glucose pyrophosphorylase  ali follow..  16  15KYELVKDTLVLILAGGRGSRLYELTDK-RAKPALYFGGNRRIIDFALSNCLN-SGLNRIGVVTQYAAHSLLREFIDMLPARQQIDDSTWYRGTADAVYQNMAIIRDHYCPKYILILAGDHIYK---DYSQMLLDHIHSGAKCTVGCIEV-EREKATEFGVMAVNEN--------KVKSFVEKPKDPPAMVGKPNTSLASMGIYVFDADYLYDVLER--------------EVSSPYTSHDFGKDILPKALEEGVLYAHFSRSCMGRNTEGEIYWRDVGTLDSFWQSNNARPVDNSLISGGCVITDSYSVLFDRIKINEGSQIDHCVVLPQ------VTIGKNCKLKRCI.... 385
6 -17.000[MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)  ali follow..  17  1.......MRAVLMAGGSGTRLRPLT-CDLPKPMVPILN-RPIAEHIINLLKRHHITE--VIATLHYLPDVLRDYFQD----TYAVEEDQPLGTAGCVKNIAELL-----DETFLVISGDSITD-----FDLGEAIAFHKQKQSKATLILTRVPNPIEFGVVITDEA--------KIKRFLEKPSTSEIFSDT------NTGTYILE------------PEVLEYL--------PSNTECDFSKDLFPL---------LLAKDEPMYGYVAEGYWCDVGHLDAYREAQYDGLDRKVKLDFAYRENSPGLWIGQNTYIDPSAHIEAPAVIGNNCRI................... 276
7 -16.700[M] KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase  ali follow..  13  78QNADPKNVASIILGGGAGTRLFPLTSK-RAKPAVPIGGCYRLIDIPMSNCIN-SGIRKIFILTQFNSFSLNGVNFGDGFVEVLAATQTSGQGTADAVFIWVFEDAKTKNVEHVLILSGDHLYR---DYMNFVQKHIESNADITVSCLPM-DESRASDFGLLKIDQS--------KIIQFSEKPKGDDLKAMQVDTSI-SMGVYVFRKEVLLKLLRSSYPTSNDFGSEIIPLAVGEHNVQAFLFNDY---------------------------WEDIGTIGSFFDANCRILDSIVSHGCFLRECSQHSIVGIRSRLESGVELQDTMMMGA....................... 436
8 -14.400[M] COG1213 Predicted sugar nucleotidyltransferases  ali follow..  12  1.......MEAVILAAGFGSRLGHHT-REIPKALLKI-GKRPLIYYTVQTLME-NGIRDVVVVTG--KGYVLREYLSQFDLNFKFVHNSLYKKTN---NIYSLYLAMDHVSKGFYILNSDVLFHP-----GIFRELHSSTKENLILSVDTFKELGEEEMKVKIEDG---------VVKRISKQLNPSEADG--------YIGIARVEENII--------DDLYNHVSRVMERKGRRVFYEEAFQS-------------MMDDGIAVYYETTKLPWIEIDTPADLMKARY................................................................. 233
9 -13.400[M] COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes  ali follow..  10  1.......MKAIILAAGLGTRLRPMT-ENTPKALVQV-NQKPLIEYQIEFLKE-KGINDIIIIVG--LKEQFDYLKEKYGVRLVFNDKYADYNNFYSLYLVKEELANS------YVIDADNYLFKNMFRNDLTRSTYFSVYREDCTNEWFLVYGDDY------------------KVQDIIVDSKAGRI----------LSGVSFWDAPTA--------EKIVSFIDKAYVSGEFVDLYWD------------NMVKDNIKELDVYVEELEGNSIYEIDSVQDYRKLEEILKNEN........................................................... 229
10 -12.300[M] COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)  ali follow..  14  2...PQNTLNIVILAAGKGTRM----YSKMPKVLHEIGG-ETMLGRVIDTAAALNPQNICVVVGHGK-----EQVLDTVKRDVVWVEQTEQLGTGHAVKTALPHLAAEGR---TLVLYGDVPLIDVETLETLLE-----AAGNEVGLLTDVPADP-SGLGRIIRDSS--------SVTAIVEEKDADAAQKAVKE----NTGILVLPNAKLEAWLNSLSSN------------NAQGEYYLTDLIAKAVADGIKIHPVQVRSSHLAAGV------NNKLQLAELERIFQTEQAQELLKAGVTLRDPARFDLRGRLKHGQDVVIDVNCIFEGKIEL................... 285
11 -12.300[I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase  ali follow..  14  5IAKSTRRIVAVVPAAGIGSRM----QMDKPKQYLHIHG-KTILEHTLSVLLGYPLIEKIILAVAANDPYISTCPLLTHP-KIQLVEGGSSRADSVLNGLNAVKSAVQNSEDFWVMV---HDAARPCLTHQDLDKLVQVEDQNGAIL--------------IPATDTIKRALHNQQIHYTEDRSQLWLAQT-------------FFPIATLAQALEQALAQGLQVTDEASAMEFAGFRPHLVAGRSDNIKVTRPEDFALAE............................................................................................. 231
12 -9.920[H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase  ali follow..  16  1.......MLTLLMCGGKGTRL-----GRGEKPLFEVCG-MKLIDHSLLQYKDF---DVIAITSPHT-----PATESYLAEKGVEVYRAAGKGYIEDYSEACRELAINEP---VIVASADIAFDIVDAYMKTIKPALTVVMEGEPV--GVNIIDSLLINTWQEEEIYSIEKDSVVNVNT---VADVERAERLWTT............................................................................................................................................................... 171
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 3 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.