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Query: [C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst TFQCKFWGFGSDGTVGANKAAIKIIGDNTDLYAQGYFSYDSKKSGGLTVSHLRFGENRIRSAYLIQQADFVSCSTSAYLRSYDLLKGLKPGGTFLLNTIWEGEQLERHLPAAMREYIAKNNIQFYTLNAMRIAGEAGLGRRINTVMQTAFFRVTDILPFEKALADLKASAIATYGKKDMAVAEKNILAMDQTVANLHKVEVPESWANPVLTAEASTATEKPAYVKNILEPVNRLEGDNLTVGDLISNGMVSGAYPPGTAAYEKRGIALEVPEWISENCTMCNECAFVCPHAAIRPILTNEEEMESAPEGFMTREMRGKDGLRYRIQVSPMDCTGCNLCAETCPAKDKALVMKPFEEVAAKENPNWSFAINVKPKKNPGKKNTVPGLast
1 -117.000[C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit  ali  100  1TFQCKFWGFGSDGTVGANKAAIKIIGDNTDLYAQGYFSYDSKKSGGLTVSHLRFGENRIRSAYLIQQADFVSCSTSAYLRSYDLLKGLKPGGTFLLNTIWEGEQLERHLPAAMREYIAKNNIQFYTLNAMRIAGEAGLGRRINTVMQTAFFRVTDILPFEKALADLKASAIATYGKKDMAVAEKNILAMDQTVANLHKVEVPESWANPVLTAEASTATEKPAYVKNILEPVNRLEGDNLTVGDLISNGMVSGAYPPGTAAYEKRGIALEVPEWISENCTMCNECAFVCPHAAIRPILTNEEEMESAPEGFMTREMRGKDGLRYRIQVSPMDCTGCNLCAETCPAKDKALVMKPFEEVAAKENPNWSFAINVKPKKNPGKKNTVPG 385
2 -27.900[C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit  ali follow..  25  26..........................................................................................................................................................................................................................................................APITLGTTLVNFTGDWRTFMPVIDESKCVKCYICWKFCPEPAIYIKEDG------------------------FVAIDYDYCKGCGICANECPTK--AITMVREEK............................. 105
3 -26.000[C] COG1146 Ferredoxin  ali follow..  13  38.............................................................................................................................................................................................................................................................................YPTIDYDKCVTCGICFVTCGRRVFDFDKKEGKVI---------------------VARPYNCMVACQTCMNLCPTG--AISFPDASYIKKLVAQNKIVKKAFEIIKPLLAEDHLS. 129
4 -25.400[C] KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit  ali follow..  22  107..........................................................................................................................................................................................................................................................................ALRRYPSGEERCIACKLCEAICPAQAITIEAEERADGSRRTTRYD---------------IDMTKCIYCGFCQEACPVD--AIVEGPNFEFSTETHEELLYNKE............... 193
5 -24.500[C] COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB  ali follow..  32  106..........................................................................................................................................................................................................................................................................ARMVAVIDENNCIGCTKCIQACPVDAIVGA------------------------TRAMHTVMSDLCTGCNLCVDPCPTH--CISLQPVAETPDSWK....................... 175
6 -24.200[C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)  ali follow..  29  58.................................................................................................................................................................................................................................................................................GEERCVACNLCAVACPVGCISLQKAETEDGRWYPEFF---------------RINFSRCIFCGLCEEACPTT--AIQLTPDFEMGEFKRQDLVY.................. 134
7 -22.000[C] COG1145 Ferredoxin  ali follow..  13  1................MHHSHHLEIYEKLREKLNKAPIGLPKTVSGVEKELLSFDEEEAKIAVHMTAEQLAERTGKSLEYVEKILNEMAKKGTVVIVGFAETPFWPGPGKDPRQEKLARLWSQYRKEGFLDEIGDREHPIMRALPERDTISEKSEILPYEDAVKLVKERDYIAVGY--RVMARLVGEGCRHSIENCIHMGSVGKYMVEHGLGRRISADEAIEILRQSNRELTERSKHVATICNCCSDCCVFFKAVHEAKHPNTIAHSSYLATVDTSRCIACGICMLRCPMKAIKAKINRE-----------------------PASVDAEKCLGCGVCVPTCPME--AIELVERDELLELPDGMTYVQELLADKGRD........ 363
8 -18.300[C] COG0348 Polyferredoxin  ali follow..  24  222.................................................................................................................................................................................................................................................................................HRQQCDNCMDCYNVCPEPQVLRDPLHAKKSESP-------------------LVLSKDCISCGRCIDVCPEKVFIFTTRFNHSVNHSGE....................... 291
9 -17.700[R] COG2768 Uncharacterized Fe-S center protein  ali follow..  11  6..................................................YTSTRAEVTDPAKWYQPDLSAVRKLEKLIDESGVLDVVSKGDVVAVKTHFGDRGTTRTLRSVFIRTVVEAGGRPFVTETTGLGMLRPRCTAVGRINIAEENGYTHQTLKAPIIIA-------------DGLLGFDYVEVPVEGKHLNSVKVAKAIAECDAVICCTHFKLHMQA---------------------VGGSIKNVGVGCVAKPSKFDIHMSDYPQIDEEKCTKCDECVKICPSNAIE-----------------------------DYQINREKCVKCLGCSEACDYGAVKTFWVFGRDVSERIVE...................... 260
10 -17.500[C] COG1150 Heterodisulfide reductase, subunit C  ali follow..  21  37.................................................................................................................................................................................................................................................................................SVQACYQCGTCTGSCP-SGRRTSYRTRLIMRKLQLGLVDEVIKSDE-----------MCTTCYTCYERCPRGVKIVDAVKAARNLAAKK....................... 115
11 -17.100[C] COG1142 Fe-S-cluster-containing hydrogenase components 2  ali follow..  16  62............................................................................................................................................................................................................................................................VCPVNAITRVDG-----AVQLNESLCVSCKLCGIACPFGAIEFSGSRPLDIKAPPAPPAPARISTLLDWVPGIRAIAVKCDLCSACVRMCPTKALHLVDNTDIARVSKRKRELTFNTDFGDLTL......... 193
12 -16.500[C] COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain  ali follow..  9  25..................KAVVMAQERIGANRQKMVEELGHWEEWREHAKEIRLDAYLYQLSEKVIQNGGHVYFAATAEDATNYIKNVAKQKKIVKSKSMVTEEI------GMNHVLEAEGIKVVETDLGEYILQVAEDKPSHIVVPAIHKDRHQIRKVEEMTLFIRETIRNDFLEADIGVSGCNFAVAETG-----SVCLVTNEGNLRLATSLPKTHIAVMGMERLAPTFKEVDVLITLLARSAVGARLTGYNTWLTGPRLAGETDGPEEF-EVLRCIRCGACLNTCPAYRQIGGHGYGSIYPGPIGSVISPILGGYEEFKDLPSA----CSLCTACNQVCPVKIPLANLLLKHRRHIAESGMNPLAERL.............. 401
13 -16.400[C] COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit  ali follow..  15  166.................................................................................................................................................................................................................................................................................GLYECILCACCSTSCPSYWWNGDRYLGPAVLLQAYRWLIDSRDEATGERLDNLEDPFRCHTIMNCAQACPKGLNPAKAIAEIKKMMVERR...................... 258
14 -15.800[C] COG1141 Ferredoxin  ali follow..  16  43..........................................................................................................................................................................................................................................................................RQKGVYVDEITCIGCKHCAHVARNT----------------------YIEPDYGRSRVIRQDGDAEEVIQEAIDTCPVD--CIHWVDYTELKNLEED...................... 116
15 -15.600[C] KOG3049 Succinate dehydrogenase, Fe-S protein subunit  ali follow..  18  182.................................................................................................................................................................................................................................................................................GLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFRCHTIMNCTRTCPKGGKAIAEIKKMMATYKEKK...................... 277
16 -14.800[C] COG2440 Ferredoxin-like protein  ali follow..  15  29...............................................................................................................................................................................................................................................................................KVRPHERPSANLLTHICPAKCYELNDKG------------------------QVETTSDGCMECGTCRVLCEASG....................................... 81
17 -13.900[C] COG0437 Fe-S-cluster-containing hydrogenase components 1  ali follow..  25  61...............................................................................................................................................................................................................................................................................YYLSISCNHCDDCTKVCPSGAMH------------------------KREDGFVVVDEDVCIGCRYCHMACPYGAPQYNAEK................................ 120
18 -13.200[C] COG1035 Coenzyme F420-reducing hydrogenase, beta subunit  ali follow..  16  8...............................................................................................................................................................................................................................................................................VIDYDVCAACGACEAVCPIGAVTVKKAAGIRDPNDLSLYEK-------------GGGYQVCEGCLTCSRVCPV------------VDGFIQDELTNVRKFFGARSKDNVGSQDG 96
19 -12.500[C] COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit  ali follow..  11  88.........GKKGAIDAATQQARTVLLACLIGTAAHAGHARHLVDHLIERLGEDYKIDLGSNVDIEAPRTVMGKRPATLGDLREVDYAEEQMSHLLSACHTGQEGD--------KDFESKAFHAGLMDDVELGFGTIDTEKPVVLCIGPGADIVDYLDENEMEDQVEDVTRYNEAAKVVGPLSKQLRFIRSGVADVDVLEEALKNRSAVIATTDKMCLGLPDMTDEDPDKIVNDLINGNIEGALILDPEKVGEVAVKTAMKLAPIRKSLKKLPDIDECTDCGWCQRVCPNSLPVMDAVKK--------------AADGDLSKLEEMAIEELCYTCGRCEQECERNIPIVSMVTKAGERRVKDEK..................... 481
20 -11.800[C] COG1600 Uncharacterized Fe-S protein  ali follow..  19  195..................................................................................................................................................................................................................................................................................EEGCGKCVACMTICPTGAI---VEPYTVDARRCISYLTIELEGAIPEAFRPLIG-NRIYGCDDCQLICPWNRYSQLTDEADFSPRKALHNPDLLELFSWSEAQFLK..... 296
21 -11.700[C] COG1036 Archaeal flavoproteins  ali follow..  15  1..............................................................................MSFKSIAWGITGAGHFLDRS----------------------------YQVFKELKQRDPELSVNTYISRAAEEVLRMYGLEQKLVKISGGLEEIFRESEQGSSSPKVGRFLLDRYDALFV---------------------TPATSNTVSKIAYGIADSLVTNAVAQAVKGKVPVYVVPVDIEGSIISEMPYNIDRKQCRHCETPRENCPHGAIT------------------------EKNGVTDQIELLKCKGCGICKELCPYNAIKGGPVE................................ 206
22 -11.200[R] COG1453 Predicted oxidoreductases of the aldo/keto reductase family  ali follow..  11  59.........MGESEPFLGRALAD--GYREKVKLATKLPSWMVKSREDMDKFLNAQLEKLKTDYLIHNLSGETWDRIEALNVIDFFEKAKSDGRI---SFHGLANDFKRIVDAYPWTFCQIQYNFMDEEGLKYAASKGLGVMIMEPLRGGNLARTVPLAIENIWSEADVERTPVEWALRWVWNHPEVTVVLSGMNEEVHIKENLKIASEAYPNSLTEAELQLV-----------------------------------------SKVEQKYRQIMKVGCTGCQYCM--CPSGVCFSIYNHLSTFGNAEDANLLYIGLLSGAVSGGKPGMASQCVQCGQCLEKCPQHIDIPTILESVAEELEGSD...................... 384
23 -10.500[O] KOG1100 Predicted E3 ubiquitin ligase  ali follow..  11  115.................................................................................................IQKNPTDPLMFLGQDLSSNVQQHHFDIISNHVERMRMEIEEKRKTQG---------------RRIVEAVEQGLMKTLRAKDDEINHIGKLNLFLE-EKVKSLCVENQIWRDVAQSNEATVNALRSNLQQVLAAVERNPTVADDAQSCCGSNDEGDSEEERWKLAGEAQDTKKMCRVGMSMCRSCGVLLLPCRHMCL--------------------------------------CSVCGSSLNTCPPKTASLHV.................................. 331
24 -10.400[C] COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC  ali follow..  11  52.......GPEGELRVRAGEQVLK------GQPLTVGRGRTVPVHAPTSGMITAIAPHTTAHPSGLAELCVHITPD-RQRDKMALLDRIHQAGIAGLGG--------AGFPTASKLQGGLNGIITLIINAAETADDRLMQEHADEVITGIHI-LRHLLQPQQVLIGIEDNKPEAIAALNVGTVVAIKRAVIDDEPLIERVVTLTGDALSSPGNFWARIGTPVLYLLKLAGFKPQNPPMVIMGGPLMGFTLPSLDVPIISNCILAPAETEMGLSEPEQSCIRCGLCVDACPAGLLPQQLYWFSR---------------GEEHEKARNHNLFDCIECGACAYVCPSNIPLVQYYRQEKAEIRALDQ..................... 448
25 -10.300[C] COG1140 Nitrate reductase beta subunit  ali follow..  24  181..................................................................................................................................................................................................................................................................................PRLCEHCLNCVATCPSGAIYKREED------------------------IVLIDQDKCRGWRMCITGCPYKKIYFNWKS................................ 238
26 -9.860[C] COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins  ali follow..  20  565................................................................................................................................................................................................................................................IPDAVAQASGAAARAAIPMVKGEVEIEPIVAVTDSDVCGGCEVCIELCPFGAISIE-------------------------EGHANVNVALCKGCGTCVAACPSGAMDQQHFRTEQIMAQIEAALN................... 665
27 -9.070[C] COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits  ali follow..  14  378...........................................PGCPHSASFYAIRRVVDELGDAALPSDIGCYTLGINKPLEGVDITICMGASV---------------GVSNGLAHVLNNKIIATIGDSTFIHAGIPPLINAVYNHADFVLVILDNSTTGMTGHQPHPGTGFRGCGEAGKAVRIEDIVRGVEFVEVVNPYNVRKMVDVLRRALNHDGVAVVIARQP---------------------------AILWSRARRREGKIVTYKVTEDCTLCMECVFACP---------------------------ALIFDGEKVSIDQSLCVGCAVCAKICPNR--AIKPAKSN.............................. 623
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Veeramalai M, Ye Y, Godzik A. TOPS++FATCAT: fast flexible structural alignment using constraints derived from TOPS+ Strings Model. BMC Bioinformatics. 2008 Aug 31;9(1):35