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Query: [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst HTGPTPLSHAQNRQWALAQLEPDSPLYNIPFALKIRGALDFEILSHALELTAQRQDTLRSRFVSVDGKPFVETDPEMIFKIVPEEIGDRELEAALLDCARRPFDLAVAPLLRIHAFRTGPQDHVLLFLLHHIIGDALSAEILLNDVATFYASLSKKEAPPNGALPLQYSDFAIWQREQDTTNEVDYWRRTLAGAPPLLELPTDFVRPAIQGFSGESIRFSLNADLLARLRQLCDQQGATLFMGMLTAFSTLLQRVSGMRDIVIGTPVSERFHPDLENVIGMFANTLAIRLQTQGGENFNEALKAARDTALSAFANQTAPFEKVVDALSLPRTWSHNPLFQAMLVSTVETRRGAISLAGMEWDRLALPDTSSRVDLTLFIHETAEELSCRLEYRSDLFRRATMESLGEALVALLEKIVERPELPLDRQSLVSGNHQKRLRQWNETDAEFQPQRRCLHDFVTASAETSPQAIAVTDQDRSLSYAELDWRADRLASGLVAAGIGRGKRVGIRLERSVELVVAILAVLRTGAAYVPLDPRYPADRIEFIAADADLALILVTTENDISTIGQNFRCMTPGMVENLAGGAVPTPVTSGADLAYLIYTSGSTGRPKGVAIEHRNAVAFMQWCMHAFTKDQLSGVLASTSICFDLSIFEIFATLAAGGRIFMVDDLFAFPSAPFAGEVTLVNTVPTPMSELLKLGPLPQNVKTVCLAGEPLPRELVARIYANDQVECLYNLYGPSEDTTYSTVAPVPPSGEWFGIGVPIANTRAYVLDGEMNEVPVGVPGELFLSGSGLARGYWNRPGQTAERFLPNPFADCSQHRVMYQTGDIVRRRDDGGLDYMGRADRQLKLNGFRIEPGEIEAVLLQQEGVHEAVAGLWRDAANHPRLAMWIAGDPALEITKLVATLRQRLPEHFIPVLATRLDALPRLPNGKLDRSALPDPAAYGERATETASLLNDQEDVLAQIWQGLLGCGDIRRNDNFFSLGGDSILAIQLVSQARQKGLKMTPRDVFLHPTLASLAEVTHVESTVTVGTGHADDEATLGAIQHWLLDQDLPDLAHWNQGLILKLTRSLDPDRLEKAISRLLEEHQSLRARFLRKNGQWQQKFAPLSAMPPMQQLAATDENDVTDFARKLHAGFDLGAGPLFGAILATLPDGSGRLILAAHHLIVDGVSWRMIVADIERHYLEASTIRSGAVAAGSWNSRLSRSALFDGEEEYWRGVCEEDVRALPLDNESGSNTQSDAVTYRQTIDAETTRQLLRDVPECFSIASNEVLVAALYLTLRQWSGQPRLRLEMESHGRLNLFEDIDVSETVGWLTALYPVLFDTPDDATPDRLLLDVKDTLRRIPNNGVGFGVLKYLRNKAEHLDYGKPQLRFNYLGQMDAMFAIDSLFAPSGITSGPMYGAANPRDTILEINAMVVRGELQLQWVYGAQLHSEDTIRTLADHFRDNLETLIQHCLTGSGAGFSPSDFPLMDLGQDELDNLLKSFLast
1 -309.000[Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins  ali  100  1HTGPTPLSHAQNRQWALAQLEPDSPLYNIPFALKIRGALDFEILSHALELTAQRQDTLRSRFVSVDGKPFVETDPEMIFKIVPEEIGDRELEAALLDCARRPFDLAVAPLLRIHAFRTGPQDHVLLFLLHHIIGDALSAEILLNDVATFYASLSKKEAPPNGALPLQYSDFAIWQREQDTTNEVDYWRRTLAGAPPLLELPTDFVRPAIQGFSGESIRFSLNADLLARLRQLCDQQGATLFMGMLTAFSTLLQRVSGMRDIVIGTPVSERFHPDLENVIGMFANTLAIRLQTQGGENFNEALKAARDTALSAFANQTAPFEKVVDALSLPRTWSHNPLFQAMLVSTVETRRGAISLAGMEWDRLALPDTSSRVDLTLFIHETAEELSCRLEYRSDLFRRATMESLGEALVALLEKIVERPELPLDRQSLVSGNHQKRLRQWNETDAEFQPQRRCLHDFVTASAETSPQAIAVTDQDRSLSYAELDWRADRLASGLVAAGIGRGKRVGIRLERSVELVVAILAVLRTGAAYVPLDPRYPADRIEFIAADADLALILVTTENDISTIGQNFRCMTPGMVENLAGGAVPTPVTSGADLAYLIYTSGSTGRPKGVAIEHRNAVAFMQWCMHAFTKDQLSGVLASTSICFDLSIFEIFATLAAGGRIFMVDDLFAFPSAPFAGEVTLVNTVPTPMSELLKLGPLPQNVKTVCLAGEPLPRELVARIYANDQVECLYNLYGPSEDTTYSTVAPVPPSGEWFGIGVPIANTRAYVLDGEMNEVPVGVPGELFLSGSGLARGYWNRPGQTAERFLPNPFADCSQHRVMYQTGDIVRRRDDGGLDYMGRADRQLKLNGFRIEPGEIEAVLLQQEGVHEAVAGLWRDAANHPRLAMWIAGDPALEITKLVATLRQRLPEHFIPVLATRLDALPRLPNGKLDRSALPDPAAYGERATETASLLNDQEDVLAQIWQGLLGCGDIRRNDNFFSLGGDSILAIQLVSQARQKGLKMTPRDVFLHPTLASLAEVTHVESTVTVGTGHADDEATLGAIQHWLLDQDLPDLAHWNQGLILKLTRSLDPDRLEKAISRLLEEHQSLRARFLRKNGQWQQKFAPLSAMPPMQQLAATDENDVTDFARKLHAGFDLGAGPLFGAILATLPDGSGRLILAAHHLIVDGVSWRMIVADIERHYLEASTIRSGAVAAGSWNSRLSRSALFDGEEEYWRGVCEEDVRALPLDNESGSNTQSDAVTYRQTIDAETTRQLLRDVPECFSIASNEVLVAALYLTLRQWSGQPRLRLEMESHGRLNLFEDIDVSETVGWLTALYPVLFDTPDDATPDRLLLDVKDTLRRIPNNGVGFGVLKYLRNKAEHLDYGKPQLRFNYLGQMDAMFAIDSLFAPSGITSGPMYGAANPRDTILEINAMVVRGELQLQWVYGAQLHSEDTIRTLADHFRDNLETLIQHCLTGSGAGFSPSDFPLMDLGQDELDNLLKSF 1483
2 -111.000[Q] KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes  ali follow..  12  1............................................................................................................................................................................................................................................................................................................................................................................................................................................MLCDSSES----VSFSSISKEED--TPIARLLKNAKETPDHRFISVYNEKYTYTELLRRVNTIAKFCDDLGLGK--TVGIHMGHELDFLCSIFALWATGRTCVIFNQIWSQQVVRVLVKRLNISDLLYHEYKPKFEV--DTLNATSLASLPLDIDAPCIRAGLEPEVALINHSSGSTGVPKSMPFLMKKYALGYDYGTPEFMNHLSTPMVM--ATSFALTTLSWINALYCNGNLLYPSSSAWNVYYALRAGCERLIILPNLLVLTLQKEECFPACKLVAAGGEMVPANMYHTCKRVLPNATIYPQYGTTESGLVSFLAYNGKDTLVYFPGKTVKKLMLVTEDNEAVPEKIGCEGFVCVVTDVQSEPYVGDDAETIQSRNSTFINYDGQ--PAVRFADLAVWKGKLGITIKGRLGRRVKRNGVFFDLKYFDQVVVGLKEVKDAFSFFI----FNRFVLVYVPAYNGVDPVTLKQKLNKELRDHHLFSSCFPLADIPRNAAGKVDLKSIETYASKSVEDQRLPVLLNPVAIEISKIASKILQNPSEGKDAPLYSCGLDSIHSVRFFHAIQSHHLEGPIRYNMNSNCTPNSIASIIQKKSYNVSSITYE-SILPTNGQYFLLTGATGYFGRRFLEYLVKLNISVSDEAAKERLISLVPSLRISSENIIVWAAHVEEIRFGLDDAKWEFLVENVSRIYHMAAEVHWMKSYQELRPANVLGTVLELSVMGPKAL---YFISGGGQQEVELDDDTQSAYAL-----------SKYVAELLCRKISDLG-------HPLIYVIRPGFIIANDGEILSRDFFWRFVATALRMGIWPQSDESQSLVFHISTTDALCMTLTQILEKEADAYAPLLAYDKFDGDEF-CESMKNVKLDFVT----------LEDWLKALEKDVDEKGEDHPLFALQHATKF.............................................................................................................................. 943
3 -62.200[Q] COG1021 Peptide arylation enzymes  ali follow..  21  23..................................................................................................................................................................................................................................................................................................................................................................................................................................................................QDVPLTDILTRHAD--SDKTAVIEGERAFSYRQLNQAADNLACSLRRQGIKPGETALVQLGNVPELYITFFALLKLGVAPVLALFSHQRTELNAYAMQIAPTLVIADRQHTLFAGEDFLNTFVADAAMRQAAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSNEICGFNEDTRFLCAIPAAHNYAMS-ALGVFLAKGTVVLATSATLCFPLIEKHQINATALVPPAVSLWLQAIQELASLRLLQVGGARLSATLAARIPAEIG-CQLQQVFGMAEGLVNYTRLDDSPERIINTQGRPMPDDEVWVADADGNPLPPGEIGRLMTRGPYTFRGYFNSPLHNASAFDANGF---------YCSGDLISIDQDGYITVHGREKDQINRGGEKIAAEEIENLLLRHPVVIHAALVSMEDELLGEKSCAYLVVKEPLRAVQVRRFLREQVAEFKLPDRVECVASLPLTPVGKVDKKQLRQ.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 528
4 -56.300[IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II  ali follow..  17  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................ETLYESLLAAQYRYGAGKNCIEDFTPDTYRKLLTKTLFVGRILEKYSV-EGEKIGLMLPNAAISAAVIFGAVSRRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQIFAHLLAPRLAQVKQQPEDAAIILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTANDRFMSALPLFHSFGLTGLFTPLLTGAEVFLYPHYRIVPELVYDRNCTVLFGTSTFLGNYARFANPFYRLRYVVAGAEKLQESTKQLWQDKFG-LRILEGYGVTECAPVVSINV-PMAAKPGTVGRILPGMDARLLAVP----GIENGGRLQLKGPNIMNGYLRVEKPGVLEVPSAENSRGETERGWYDTGDIVRFDENGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSADKMHATAIKSDASKGEALVLFTTDSE-LTREKLQHYAREHIPELAVPRDIRYLKQLPLLGSGKPDFVTLKSWVDAPEQHHE........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 516
5 -54.300[I] KOG1179 Very long-chain acyl-CoA synthetase/fatty acid transporter  ali follow..  15  58....................................................................................................................................................................................................................................................................................................................................................................................................................................................VLLKVKAKVRQCLQERRTVPILFASTVRRHPDKTALIFTDTHWTFRQLDEYSSSVANFLQARGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGSEMASAICEVHASP-LDPLLKDAPKHLPSCPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGIVGIGQCLLHGMTVVIRKSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREHQVRMALGNA--SGSPSGPTFPAASTYPRWLSSTGPECNCSLGNFDSQVGACGFNSLVRVNEDTMELIRGPDGVPCQPGEPGQLVGRIIRRFDGYLNQGANNKK-IAKDVFKKGDQ---AYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVPTGNCDLERFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTELRKEAFDPAIVKTIYIEKGRYVPLDQEAYSRIQA................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 636
6 -49.400[I] KOG1176 Acyl-CoA synthetase  ali follow..  22  34.................................................................................................................................................................................................................................................................................................................................................................................................................................................................PSKESLDITTFISSQTYRGKTAFIDADHRISFSDLWMAVDRVADCLLHDGIRRGDVVLVLSPNTISIPIVCLSVMSLGAVLTTANPLNTASEILRQIADSNPKLAFTTPELAPKIASSGISIVLEEMMKKEPSGQAVRNQVHKDDTAMLLYSSGTTGRSKGVNSSHGNLIAHVARYIAEPFEQPQQTFICTVPLFHTFGLL-VLATLALGTTVVILPDLGEMMAAVEKYRATTLILVPPVLVTMINKADQVSFLRTVRCGGAPLSKEVTQGFMKKYPTVDVYQGYALTESNGAGASIESVEESRRYAVGLLSCGVEARIVDNTGQVMGLNQTGELWLKGPSIAKGYFRNEEEIITS------------EGWLKTGDLCYIDNDGFLFIVDRLKELIKYKGYQVPPAELEALLLNHPDILDAAVI.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 478
7 -49.000[I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases  ali follow..  19  18........................................................................................................................................................................................................................................................................................................................................................................................................PTEFSERAYVRSGRE-YEQLYSRAASNPEGELAEQELHWFKKWDQVLDWQPPFAKWFVGGQLSHNCLDRHLTTRRNKAAIIWEGEIITYAQLHREVCQFANALKSLGVQKGDRVAIYLPMIPEAAITMLACSRIGAPHSVVFGGFSAEALRDRLVDAEAKLVITDKALEHGAPSVENVIVVQHELQPQQSAHCPAEPIDSEDMLFILYTSGSTGKPKGVVHTTGGNLYTHMTTKWIFDLKDTDVYWCTADVGWITGHSYVYGPLSNGATTVMYENPGCFWDVIERYGVNIFYTAPTAIRAFIRMGEALSSLRLLGTVGEPINPEAWMWYHRVIGKCPIVDTWWQTETGIMLTPLPGAIPTKPGSCTKPFPGIVAEIVDLDGNPVESDQGGFLVIK-PSMIRDVYGDTDRFRHTYWEH---QPKEGQYLYFAGDGARRDKDGYFWVMGRVDDVINVSGHRLGTMEIESALVSHPLVAEAAVVGRPDELTGEAIFAFVSLEGNAEPSDLVKHVTEEIGAIARPAEIRFTDVLPKTRSGKIMRRLLRSLASGQEISGDTSTLEDR................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 644
8 -47.700[I] KOG1175 Acyl-CoA synthetase  ali follow..  19  117......................................................................................................................................................................................................................................................................................................................................................................................................................................................................CYNCLDKNVEALGDKTAIHWEGNSLTYSELLQRVCQLANYLKDNGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSADSLAQRIVDCKPNVILTCNTTRENTKWQNGRDVWWQDVISQYPTSCEVEWVDAEDPLFLLYTSGSTGKPKGVLHTTGGMIYTATTFKYAFDYKSTDVYWCTADCGWITGHSYTYGPMLNGATVVVYPDPGRCWDIVDKYKVSIFYTAPTLVRSLMRDDDKRKSLRVLGSVGEPINPSAWRWFFNVVGDSRISDTWWQTETGFMITPLPGAWPQKPGSATFPFFGVQPVIVDEKGNEIEGECSGYLCVKGSGAFRTLFGDHERYETTYFKP--------AGYYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVLHPQCAEAAVVGIEHEVKGQGIYAFVTLLEGVPYSSLVLMVRNQIGAFAAPDRIHWAPGLPKTRSGKIMRRILRK--IASRQLEELGDTSTLADPSVVDQLIALADV.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 693
9 -44.700[I] COG1022 Long-chain acyl-CoA synthetases (AMP-forming)  ali follow..  16  13................................................................................................................................................................................................................................................................................................................................................................................................................................................................PCALPPPNEMLLRWAKERPNEVYLKQIIVEFTYAEVADKALRLVSALRALGADPGDKVALISKNCAEWFICDLAMMLGDYISVPIFPTAGSETIDYCLEHSESKILIVGKLDDNKAPSAAKCQYEFQTLIKQHQPSEERPTHFDEKLMSIVYTSGTSGQPKGAMLTYGAFTWSAQQLINHIGIEENDRLFSYLPLAHITEVYIFGSSIIGGVLTAFPESLDTFIEDVKMHRPTLFISVPRLWTLFLADGLGLDQARVLGCGSAPVSPALLEWYRSV--GLNITEAWGMTESFAYSTLNYPFRADKIGTVGNAGPGIELKIAED----------EEILVRSKGLFAGYYKNDTATAESFNDDGW---------LHTGDIGSLDSEGYLTIQGRKKDTFKTKGKFVAPVPIEKKLFEYSRVEMMCLI----GSGLPAPILLAVPHNFFDRARYERTTQEQIKGVLMIKDPWSIDNGILTPTLKIKRHVL---------EKKYHDVGQNWPKGQLVVWEE...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 563
10 -41.100[I] KOG1180 Acyl-CoA synthetase  ali follow..  19  78.........................................................................................................................................................................................................................................................................................................................................................................................................................................................DGLMNSSFEGIHDLGTQWEECVRRYGNQPCMGTREHWRSYAQVDKRVNMIASGLTSLGQQEKEPIILFAETREEWMTTALACMKMNFPIATMYATLGDEAVQFAINEVGAKTIFTSEALISKVKKDQLLSRGEREYCMLLGAYPVPTRSKKDDLAFIMYTSGTTGNPKGVMISHQNIVAVTAGQAFNIVLGPDDRYIGYLPLAHILEVCAEMVVFTKGVRIGYSSAQTGEHGDCWVLQPTLMACVPAVMDRIFKGKLLGGKVRQILSGGAPLSPE-TQRFMNICFCCPVVQGYGLTETCGGGTIAD-IHDLSTGTVGPPLTCCEILLQEAGYSPKNDPPQGEILISGPNVALGYFKNDEKTKEEFVK-------NGKTFFATGDIGEFREDGSLKIIDRKKDLLKLHGEYISLGKVETNLLTNPNVDNVCVY---GDSNKSFLVALVVPNQKN-QKELAQYGASKLQRVEIPQKIFICHE--LTEALKLKRKNI----------------EKAFRKELDELYK....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 726
11 -40.200[I] KOG1256 Long-chain acyl-CoA synthetases (AMP-forming)  ali follow..  17  60..............................................................................................................................................................................................................................................................................................................................................................................................................................................DGGRKAAWLGDGPLQHGWFEGVLTTYSGIR-RGPTVGGKEMLGKRVEWISYDQAFETSDHASQAIRKLGIEIGEKIGIYSNNRPEWILSEMAIHNFSNVSVPLYDTITNDDMHYITNLCEISLMFVDAEIKTKQLIRDKSIVQFNECSDDIKEHRPHVPPTPETLATISFTSGTTGRPKGVMLTHLNMCSATMSCEEFENAGVQDAYLSYLPLAHIYERLCLLSNFMIGSRIFSRGDPKLLVDDVQALAPRSFATVPRVIDKIHKQMLLGPNIRQLILGAAKSDVS-AMRFARGAFGVEVLEGYGQTETSGPTTL-QLVGDTRIGCVGPPMACAMIKLIDPELGYSVDKNGGEVLVKGHNVTSGYYKNPEATASSFTEDGY---------MKTGDIGRFTAEGSLQIIDRRKNVFKMQGKFVAPDLTESLYTSSSFVQQIYVH---GDMEKPWLVAIVVPDPECNIPILADDVLRQFVELTEEDKRPRYEGVYTTPTLKNKRNAI----------------AQFFKAEIDGMYKKI..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 690
12 -37.400[R] COG4908 Uncharacterized protein containing a NRPS condensation (elongation) domain  ali follow..  13  3KITSYPAEPSDIKHYISG--EKMKNDHHLHTVLTFDNHLNIDVLKKAVMQSTKKLRLLLCHFKETNKGAFWQESVFSAEDLVFLI-KTTEPEAEVNRALVRKLSTENGPQIRLTVVR-TESADKLVIILNHMLADGAGFKEYLYLLSELYSKLLENPNYQANL-SLGSRNLKQVFDQFSRKEIKTIFTEKTNRKTVPFPLKGDPKNPKI-------IWTKLPKEVFDGIVHYAKENDATVNDVFFAAMVRIVQQTTHQNELSIDCPVDLRKYLPGKASQGITNLTANITCQINANTSFESTLQAVKNS-LNPQKNSLTPLRIYYLLELIFKKKSYSFA-KTSFTNIGIIDEEKLIFEGSTLTDCFICGSLKY-FFQVAATTFRGELTLSTNLHGTTRDHDWQKHFLDQLAREFTLLVQDE....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 426
13 -25.400[Q] COG3433 Aryl carrier domain  ali follow..  15  1............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AALRALILPLLDEDEPLDDENLIDYGLDSVRMMGLAARWRKVHGDIDFVMLAKNPTIDAWWALLSRGVE.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 70
14 -17.600[H] COG1541 Coenzyme F390 synthetase  ali follow..  16  17.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EIQERKLKALVSTVYQYSPFYRQRFREKSLNDLPKLPFTKKQDLRDTYPFGMFCVPLSQVVRFHASSGTTGKPTVVGYTANDIRNWVESLCRALGVSSDDIMQIAYGYGLFTGGLGFHYAAERLGATVLAGNTARQIELMKDLGSTVMACTPSYMIYLAEYASQMGNLRAGIFGAEPWSEETRKRIEDKT-GITAYDVYGTSELSGPLFTECTERQ------GLHIWADMFLIIDPKTEQVGEGEKGELVV---------------TTLTKEALPLIR-------WRTGDITYMETDGR-RILGRADDMLIIRGVNVFPSQIEHVLMQIPEVGEHMIIVDRREDGLDELTVQVELSDKAEIDTLEKKIADKLKSVLAKVEVVNPGTLQRF-EGKIDRRKI.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 433
15 -11.900[E] COG2902 NAD-specific glutamate dehydrogenase  ali follow..  10  95.......................................NMPFLYDSVMGEVTSSYRGLYLAVH----PILVRDDEAQGYRLAEPEDDPAENISL-------IQLHIAPLTPQAASALEERLRFVLTQVQSAYRD---WRPMLTKLDEALDELSKRGSSRRKTERTEAVEFLNWLRNDNFT--LGMRDYTYSGKGKNAKIERGDGVGLGSLSDPDVRVLRLGKNAVTTTPEILALDGPDFLIVTKANVKSIVHRRAYMDYIGIKRFDEDGNVIGELRIVGLFTATAYTRSVKQIPLLRAKVADVERHFGFDPNSHSGRILQNTLEAY---------PRDDLFQIETDLLIRFIEQIMELS--------DRPRVRVLARIDRFDRFVSAIIFVPREEYNSYVREKIGDYLSRVYDGHISAYYPAFPEGAVARVHFIVGRTEGKTPRIAQDKLEDAVSDIAARWIDHFVALSEPGAPVLDVDYQEAFTPEEAIGDMPDILAAANGEPVRIEFYQQEGPLSRRVPLLENLGFNVDIGVVSEGEKRDIVLHDMELSVAAGTTLDLPHYGPKLEEAFLA------------SGKVDNDNFNRLILACGLNVREVSVL---RAYARYLRQTGIVYSQEHISETLYKYP---------------------ISRNIFALFKAGFDPSIEEKKRVKKLAEIHKAIEAALSGVPNL-------EDRTLRRYVNAIDATLRTNYFQKNADGTPRDLLAFKFDPKHLDLPDPRPFREIFVYGTEVE-------G-VHLRFGKVARGWSDRGQDYRTEVLGLVKAQQVKNAVIVPVGAKGGFFPKNLPAGGSR--DEVFNAGREAYKTYIRTLLSITDNIVDDAIVPPADTLRLDGDDPYFVVAADKGTATFSDTANGLAHEA-----FWLDDAFASGGSAGYDHKKM-----GITARGAWETVKRHFREMDTDIQTTPFTVAGVGDMSG--DVFGNGM----LLSEKIRLIAAFDHRDIFIDPDPDTDKSFAERKRLFELPRSSWQDYDRSTLSAGAMIISRSEKSVTLTPEAVAAIGLDKSVATPFEIMTAILKAPTDLL-TYIKAAVETNAEVGDRAN-------DPIRVNATELRAKVIGEGANLGITQKGRIAYVNSSDVEVNIKIALASAVNSGRLTMPKRNQLLASMTPDVAQLVLRNNYQQSLAISLTERLGLANREELGRLMGALEATGQLNRKVETLPNNAEFSERYASGKPLTRPEIGVLLSYAKLTLFDALVAS-AKMQKNYANDREIVGGPGFVQKLADASGLLAADVVKAAVIVEDG-------------LKRLWTEVDALDGKVGGQVQNGLYATITRIFSDASRLYLQTGSAGAAAGDMATEIERLKTAIKTLSPAATKYRRELGVTEIDGVPSGLLEELDTLSLLVYVPEIMRIAESAGTTLARAAE................................ 1478
16 -10.300[R] COG1204 Superfamily II helicase  ali follow..  520......LNRIQSHLY--------PIAFGTDENILLTGAGKTNVAMLCILNELQKHLREDLSFNLQNFKIVYIAPLKALVQEMVNNFSKRTPYNIRVAELTGDSQLTKQQISETQIIVTTPEKWLVIIDEVHLLHDGPVLESIVARIFRHQEETLEQRLVGLSATLPNYTDVASFLHVDPKKGLFYF--------STYRPCPLKQEFIGITEKTPFKRMQTTNEACYEKVMQHAGKNQVLIFVTAKTARFIRDKALEEETI--FAIHHAGMRREDRQTSEDLFIQVLVSTATLAWGVNLPAIIKGTQVYSPEKGIWTELSPQDVLQMLGRAGRPQFDTYGEGIIITAHSELQLSLMNQQLPIESQFMRRLADCLNAEVSLGTVRSILYVRMLRSPALYSVGPEYDDDKYLVQKRADLLHSAAILLEKCKLLVYNRQSGTLELGKVAASYYVTHNSMAIYNRLLMQTTSFIELFRVFSFSDEFKHIPVREEELQSYISRQRLDGFALVAYVTQSAGRIMRAIFEISLRRGWSSVA-PNCPSEVIRFDLDPAELGELVGVPKEGRRVYNMVQSFPRLSVEAHVQPITRSLVRVELVINSQFNWDDHLSGTSEAFWILVEDVDGDRLLHYEQFFLLKKYKDDEHINFTVPLLEPLPPCYFIKIVSDRWLHSITKVPLSFQRLIMPEKFPAPTPLQNAPVSSLNNPSFISLYPN-NKIQTQVFNSVYKTNDSVFIGAPNGSGKTVCAALLHHWSQEDYGTAV-QEIVDRRYEEWYGKFSDLGDGKTGERSQDLKLIQVADL----CTPSQW--DSLSKRWRSMRSIQK-DELQLLGGGPLIVISRIRYMAVQLEKNIRVVGLSVSVANARDLGEWLGTSPQCI--TIHLQSFSITHFPSLMLAMSKPIYRSLKNFISQRVFTPDRKVAKQLAFDLVTFSMADEDEYLFSLMENEAFNKVEDAALQQSLKHGIAYISEITSQYLYRHGLIKVL---IASRDVIYSLKAKSNAVIVMGTISELLQMLGFTASIGSSE-LSQVILMTVTTKKEYYKKFLNEPLPMESHLQVWLHDAFVSEISTQTIESKQDAVDWLTWSY---------MYRRLVANPAYYGLQDITHESVSEFLSDLVET---TMNDLSEARLITVDDEDDSCIASHYGITYITMQTFALSLSERTKMKGLLEIVTSAAEYEQLPIRKYEDIVLER------------------------------------IHSRLPVRLSNPNYEDPHTKSFILLAAHFSRFELPPGLVIDQKFILTRVHN-----------LLGACVDTLSSEGHLIACIRPMEMSQMVTQAL................................................................................................................................................ 1989
17 -10.100[TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family  ali follow..  575.........................................SLREFIMKALASTSRCLRVVAAKV---PIFIKGPNNLDIVEFHKESKALIFNTLKILAVENTAILETVILSWISLSRVVEEEELHFVLLEVISSVINSGIFYQGIGSALQQIASTRHISVWQLLSPYWPTVS----VAIVQGMGKKPNIASLFAQLMNISEGD----LIRTQAYTLPFLVLTKNKALIVRIAELSQSDVATLCLTNMHKILASLLTTDH-LLSLATSDFEKVDLTSLL-ITVELLQLYQNDVPHEKIENALRKVAMIVSQVVNDEDLSNKELLYDFFNNHILGILAEFSNILNDLKGKTSINEKIKTISLCGGAVKLGLPQILSNLQSAFQNEHLFYAIKAWFSLILATKEPEYSSIAGLSLVILPQEAELVIQIFDFISSDTHKCLQGLKWAIPTSLACFSLKAKEIFCSLQNEDFYSELQSIIKCLTNENEPVCYLGLQKLELFFQAKVDELHDTLNLDISNEVLDQLCLLDC-GELGAIDPS----RAKAQHIIKETVVL--------------------DNFENGEESLKFILDFMQSQLIPAFLVTTDTKAQGFLAYALQEFLKLGGFKSAVINKKKGLTVVTEHWMSLPDLSKRVLIPFLTSKYHLTPIPKIDIRYPIYKENVTIHTWMQLFSLKLMEYAHSQNAEKIFGICSKVVKDQEVNIPCFLLPFLVLNVILTESELLVINQPGPDGLNSVGQQRYTSFVDVFFKIVDKRNWDRRSAIARKENRYMSVEDATSRESSISKVESFLSR-FPSKTLGIVSLNCGFHARALFYWEQHIRNATAPYAALESDYRVLQEIYAGIDDPDEI-EAVSLNFHDYSFDQQLLLHENSGTWDSALSCYEIIIQKDPE--KKAKIGLLNSM----------LQSGHYESLVLSLDSFIINDNHEYSKMLNLIDSLKKCLSKSNLESFEAKLGSIFYQ------------------YLRKDSFAELTERLQPLYVDAAT--------AIANTGAHSAYDCYDILSKLHAINDFSRIAETDGIVSDNLDIVLRRRLSQVAPYGKFK--HQILSTHLVGYEKFENTKKTAEIYLEIARISRKNGQFQRAFNAILKAMWWWHQGQHRKAISELNFSLNNNMFDLVDEHEERPKNRKETLGNPLKGKLTKWLGKAGQLGLKDLETYYCENYLGHHRVLMYEEEQKLPVNEQSERFLSGELVTRIINEFGRSLYYGTNHIYESMLLTLWGAEELRLSKDDGEKYFREHIISSRKKSLELMNSNVCRLSMKIPQYF----------FLVALSQMISRVCHPN-----------------NKVYKILEHIIANVVASYPGETLWQLMATIKSTSQKRSLRGKSILNVLH-----------SRKLSMSSKVDIKALSQSAILITEKLINLCNTRINSKSV..................... 1999
18 -9.510[O] COG4934 Predicted protease  ali follow..  64.................................................................................................................................................................................................................................................................................................................................................................................................................................VNGSMEMNVIIGIIPNNLNEL-------------ENYATEI------SMPGSPLY---RHWLTTQQINSMVETVSSYFSKLGFSVQVK--VAISGNASMMESVFHT-KNGQVLF--SIELPGSVARYVLSVDGLSNFQMTTNPVYPTLSDYTSSGLIKNFENVTGYTPPFQALFPSDLP--IYTPGANGTGTTIAIVMGTGYINATLAYPAWNYNDMLKYGKEVEFTLDT---QYSATVAPDAHLDIMAIPSL--------------------------------------STVALDNAYITLYELPNTPQVITNSWSGSEDSWWNMYGPYWQSADLM--------NLLFE--------------LLSMKGSTI----------------------------VAATGD------SGSGEFPGTSPWVTGVGGDQVTMFN--ANYSSLPPYYWSNLRLNIVNIGLKHNNGFTQTYWDNNQYVVVNGAPEVISTGAGSAALSIFFKQPWWQHGYTGRMSEVEVSAEAGFNQTEL----------------------VDGMWGSWFFGGTSEATAGMIADVISYNATIHVNYLDINPLLYEIGNEYMQNPGKMPDPALMVNDSYTLDGPQNYPSNYYTTDNGYSMLTGW---GTINVGNFKIDLEQFLTQ............................................................................................................................................................................................................................................................................................................................................................................................................... 740

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24