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Query: [G] COG1023 Predicted 6-phosphogluconate dehydrogenase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDRTTGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAAPRTPGRDGEVAPSEQGYLHCGPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPLPNPECYQYDFDIPEVAEVWRRGSVIGSWLLDLTAIALRESPDLAEFSGRVSDSGEGRWTAIAAIDEGVPAPVLTTALQSRFASRDLDDFANKALSAMRKQFGGHAEKPANLast
1 -99.600[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali  100  1MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDRTTGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAAPRTPGRDGEVAPSEQGYLHCGPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPLPNPECYQYDFDIPEVAEVWRRGSVIGSWLLDLTAIALRESPDLAEFSGRVSDSGEGRWTAIAAIDEGVPAPVLTTALQSRFASRDLDDFANKALSAMRKQFGGHAEKPAN 340
2 -73.800[G] COG0362 6-phosphogluconate dehydrogenase  ali follow..  29  5GDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAIIGAYSLEDLAAKLEKPRKVMLMVRAGDVVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAEKGIRFIGSGVSGGEEGARHGPSIMPGGNQEAWQYVKPIFQAISAKTEQG-------------EPCCDWVGGEGAGHFVKMVHNGIEYGDMQLICEAYQFLKEGLGLSYEEMQAIFAEWKEASEQFGWDINYGATALLWREGCIIRSRFLGNIRDAYEANPNLVFLGILENALSDWRKVVAKSIEVGIPMPCMASAI-TFLDGYTSARLPANLLQAQRDYFGAHTYERTD 459
3 -72.900[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  30  3ADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANESIIGATSIEDFISKLKRPRKVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKGILFVGSGVSGGEEGARYGPSLMPGGSEEAWPHIKNIFQSISAKSDG--------------EPCCEWVGPAGAGHYVKMVHNGIEYGDMQLICEAYDIMKRLGGFTDKEISDVFAKWNEAAATYGWKLNNPAIALMWRGGCIIRSVFLGQITKAYREEPDLENLLAVTKAQSGWRKSIALATTYGIPTPAFSTALS-FYDGYRSERLPANLLQAQRDYFGAHTFRVLP 458
4 -56.700[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  21  3.TIGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLADLVAK----GLKTVSGHAAVAKAADIIITMVPDTPQVADVLNGVASGLTRGKLVIDMSSISPIETKVFAGKINELGCDYLDAPVSGGEVGAKAALTIMVGGEEKAFERAKPVFEKMGKN--------------------ITLVGPNGVGQTTKVANQIVVALTIEAVAEALVFASKAGADPARVRQALMGGLAASRILEVHGERMV-------KRTFAPGFRIELHQKDLNL-------------------ALEGAKALGVSLPNTSTTQQL-FNSCAANGGAREDHSALVRAL......... 285
5 -24.500[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  10  4MKVAVYGAGNQGSRMAIEFAEAGHDVVLAEPARDMLDDAHWKVVEAGVTVTDNDAEAASEAEIAVLFTPFGKKTFEIAKNITNHLPEGAVIANTCTVSPVVLYYVLERELRKDLGIASMHPAAVPGTPQHGHYVIGGHTDEQISRCVELAESCGKV---------------------AYVVPADVSSAVADMGSLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQILMTLQTIASLVETSGVNGMLKAMNPELLVRS------AKSMHLLEEQEELDAALNTLSDLDDEVNKWIEKGEIRHTDLVA-------------AQALAKEIKNLMGGKAAE... 332
6 -18.600[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  17  6PSIAILGAGRVGSSLARSAVAAGYEVKVAGSGAVDKIALTAEILMPGAV-PSTADQAVKDADIVFLAVP------HKFRSVNPATLEGKIVIDTMNDPRSTSEIIAEFFAGKSFNHIGYHEIEQDAGTGRAI-AYATDDVDAGAQVAQLIKSFG.......................................................................................................................................................................................... 170
7 -15.900[M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase  ali follow..  13  16ALIGIVGLGYVGLPLMLRYNAIGFDVLGIDIDDVKVDKLNAGQCYIEHIPQAKIASRVSECDALILCVPTPSFVINTTDALKPYLRVGQVVSLESTTYPGTTEEELLPRVQEG----DIYLVYSPEREDPGNPVIGGHTPQCLEVGIALYEQAIDRV--------------------VPVSSTKAAEMTKLLENIHRAVNIGLVNEMKIVADRMGIDIFEVVDAAAT................................................................................................................. 255
8 -15.000[E] COG0287 Prephenate dehydrogenase  ali follow..  21  9.RIALIGIGLIGSSIARDVRELGLHVVISTRSEDTLKRAEELALGT--DYTVSAAEAVKDADLVIVSVPVGA-SESVAQQIAPYLKPSAIVTDVGSTK-ASVIAQMAPHMPENVHFIPGPLAGGPDAGFAGLTPLPGTDAAALERLKDFWRALGSRV....................................................................................................................................................................................... 175
9 -14.800[M] COG1004 Predicted UDP-glucose 6-dehydrogenase  ali follow..  13  1MKVTVFGIGYVGLVQATVLAEVGHDVLCIDIDANKVADLKKGRIAIFEPGLAPLVAGVAHGVIQFIAVGTPKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKVHQVIQAILEQRIDFSVVSNPEFLKEGAAVIVIGIDTDDSGALELISEL---------------EPFNRNHDRMLVMDIRSAELTKYAANGMLATKISFMNEIANIAERLGADIEKVRQGIGSDS............................................................................................................... 251
10 -14.600[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  8  4MKLAILGAGVDEVVVADPVFDNQFTVIDDFAYEDVIAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDMQPGIIDKFIDDIKPGAIVTHACTIPTTKFYKIFEEKHGETLNVTSYHPGAVPEMKGQVYIAEGYASEEAINTLFELGQKARGNA....................................................................................................................................................................................... 243
11 -14.000[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  11  365LKIGIVGFGNFGQFLGKTMVKQGHTVLAYSRSDYTDEAAKLG-----SYFSDLDDLFEEHPEVIILCTSILSTEKVLESLPFQRLKRSTLFVDVLSVK-EFPRNLFLQTLPQDFDILCTPMFGPESGKNNNLAFVFD-RKSRCNSFLDIFAREGCRM-----SCAEHDWHAAGSQFITHT----VGRLLEKLSLESTPIDTKGYETLLKLVENAGDSFDLYYGLFLYNPNAMEQLERFHVAFESLKTQLFGRL....................................................................................... 618
12 -13.300[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  10  38KKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEAIAEKRASFQRATNGFKVGTYEELIPTADLVVNLTPD-KQHSKVVADVMPLMKKDSAFGYSHGF----NIVEVGEEIRKDITVVMV-KRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHKAGVLESSFVAEVKSD----------------LMGEQTILCGMLQAGSIVCYDKLVADGKDPAYAGKLIQYG................................................................................................................ 257
13 -12.700[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  13  4.HIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERR-PNLSFTTDMKEAIHNAFMIVEGVTS-AGIRPVAEQLKQITDLSVPFVITSKGIEQNTGLLLSEIMLEVLG--YLGYLSGPSIAKECSVVVSAYDSQTLKQIHEAFSLPTFRVYPNTDIKGAALGGALKNVIAIACG-EGLS----FGNNAKAGLVTRGLHEMRKLAAIMDCKPETLNGLAG---------------LGDLCVTCFSESSRNLRFGHLLAQGLTFEQAKAKIGMVVEGAYTALSAYQVAKHHKIDMPITTGIYRVLYENLDLKEGIALLLQ............... 326
14 -12.700[S] COG5495 Uncharacterized conserved protein  ali follow..  14  12LNIAILSTGRVGVALE----RADQVVVCSAVSHASRQWVQF---RLPETSVASPPEVASSAELLLLAVPDCE-FAGLMSGVAVTPRPGTIVAHTSWA----GVGILAQLGKDGCMFSGSDEDLSQCQLRDTYFGITKTDDVGYAIAQSLVLEMGGEP-----------CVVEYARILYHSVSPHVGNHI-----------VTVLADALEVRRSALRGSELLGLGV................................................................................................................... 216
15 -12.200[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  16  4QKIGFIGAGKMGSALMQGTIKAGINIGASDVYEPFLKDLQAK---LGIRVSTDNAVIVRESDILILAVK-PQTLSSVLSNLKNEITSEKLVISIAAGVPLSTYEDALLEGTRVVRVMAATVSEAASGIAPGKNA----TPEDLKAALEIFSAVGTAV------------QVPESLMDAVTGLSGSG-IEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETGMHPGELKDMVTSPAGTTIQGIHSLEEAG--IRAAFMNAVIRASERSKELGK................................................................. 269
16 -12.100[H] COG1893 Ketopantoate reductase  ali follow..  12  4PRVAVIGSGSIGLLLYAYLKLANWPALLVTNRPEQADHLNKEGQPISVTATPLSSFSAEEAEVGFITVKS--AVKALLPQLQRKKWDGLVFFQNGMTHLEILRQIPARAICCGIVEIGAKRESDVRVQHTGDAIWIGDMVGDSKNFDPMWACLHNAGLKAQKVTNWQDK------------------ERKLIANAAINPLTGLFRVKNGALIENQLFSLLLKELVKEACVTLGREREVDEHLAYTRAICDKTANNLSSMYMDLTH--HRRTEIESITGYL---------IKEAAKKGIEIPNTSFVYHA............................... 294
17 -12.000[E] KOG3124 Pyrroline-5-carboxylate reductase  ali follow..  14  1MSVGFIGAGQLAYALARGFTAAGIKIIASSPEMNLPTVSALRK--MGVNLTRSNKETVKHSDVLFLAVK-PHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC-MTNTPVVVQEGATVYATGLVEDGQLLEQLMSSVGFCT------------EVEEDLIDAVTGLSGSG-LDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIHALHFLESGG--FRSLLINAVEASCIRTRELQSMADQ............................................................. 274
18 -11.700[K] KOG0067 Transcription factor CtBP  ali follow..  17  183..LGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQD-----GIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINFTIKQMRQGAFLVNAARGGLVDEKALAQALKE---------------GRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSAPWSVIDQQAI............................................................................................................................. 376
19 -11.200[S] COG1255 Uncharacterized protein conserved in archaea  ali follow..  13  16.KVIEVGIGF-YTRIAKRLKELGFDVLAIDINKDAVVNAKNSGLNAEVDDIFNPNISLYMGAKAIYSIRPTPEMMNYILKISKAVKVPAYIVPLTGDPVPQGMKLIT......................................................................................................................................................................................................................................... 120
20 -10.800[CHR] COG1052 Lactate dehydrogenase and related dehydrogenases  ali follow..  18  147SRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPNDAAKEWLT--------YVSMDELLSTSDVISLHMPATKDSHHLINKTIAQMKDGVYLVNTARGAVIDSQALLDSLDKGKIAGAALDA........................................................................................................................................................................................................................... 260
21 -10.600[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  14  2LKIGIVGCGFIGGQICRAIDGVSAELYLCDSSESKALELAASLKTC-KPSYMKIEELIRGVDLIIESASQNAVRFIVPQ----ALKAGDVMILGALADEELRDTLFGLAKEHNCKLY-------PSGAVVGIDGLNSASAAGISSVT................................................................................................................................................................................................. 143
22 -10.300[Q] COG5310 Homospermidine synthase  ali follow..  11  18GPVVMIGFGSIGRGTLPLIERHF-RMTVLDPRDTDRKLLDERGIAFVQEAVTE------------------NNYKKLLTPLLTNGGGQGFCVNL--SVDTGSVDLMRLCRKLGVLYIDTVVEPWLGFYFDAKADNASRTNYALREAMIKEKHDKPG----------------GATVVSTCG-ANPG-----MVSWFVKQALVNLATDLGLEFSEPAQEDREGWAKLMKKAGVKGIHIAERDTQRTKKPKPMDVFWNTWSVEGFISEGLQPAEL................................................................... 252
23 -10.200[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  18  4.TVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAGLATKRALSLIKGSGDINDLAQADLVIEAVTEDETVKRKIYGQVCPVMRPDAILATNTSSLSITRLASATDRPEGIHFMNPVPVMKLVELVRGIAT----EEETFKAAKEFVAHLDKTVTVAEDFPA............................................................................................................................................................................... 185
24 -10.100[Q] COG4569 Acetaldehyde dehydrogenase (acetylating)  ali follow..  12  4RKVAIIGSGNIGTDLMIKILRHGAVMVGIDPQSDGLARARRMGVATTHEGVIGLMNMPEFADIDIVFDATSAGAHVKNDAALREAKPDIRLIDLTPAA-VPVVNLEANVDQLNVNMVTC-------GGQATIPMVAAVSRVARVHYAEIIASIASKSAGPGTRANIDEFTETTSRAIEVVGGAAKGKAIIVLNPAEPPLMMRDTV....................................................................................................................................... 210
25 -10.100[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali follow..  15  24.NVTIIGAGLMGSGIAQVSANAKLNVTVVDSNQSALEKAQQSSVLDRIKMSTNVSDSVKDADLVIEAIVENIDIKRKLFAEVEVAAKPTTLITTNTSSLRLADIGLNLKDKSGLHFFNVPMMKLLEVVRHTET-----SDATFNQLVDYGKTVGKTTVACKDTPG............................................................................................................................................................................... 211
26 -9.990[S] COG3804 Uncharacterized conserved protein related to dihydrodipicolinate reductase  ali follow..  17  3IPVVQLGTGNVGVHSLRALIADEFELTVWVSSDAKAAELAGLADSTGVRASTDLNAVLAGPRCAVYNAMADNRLPEALEDYRRILAAGINIVGSGVIPDEIIKPLQDAARAGNSSLYVNGIDPGFANDL--LPMALAGTCESIEQIR................................................................................................................................................................................................. 163
27 -9.960[E] COG1748 Saccharopine dehydrogenase and related proteins  ali follow..  13  3KNVLIIGAGGVAQVVAHKCAQNS-DIHIASRTVDKCRKIVESVRALDALDVEATKALIVSTGSQIVINVGSAFVNMSV--LRACMDTGVAYMDTAIHE-NYEWKRAAECKEKGITAIGVGFDPGVVNA.................................................................................................................................................................................................................... 158
28 -9.880[R] COG2910 Putative NADH-flavin reductase  ali follow..  21  2AKIALIGAGNAGSRILKELSDRGHQVTAIARNPEKIAALPNVVAKKGVFDQAALSELLKGHDAVISSVFTASDPATLIEAVRASGVQRYLVVGGAGSATKGAEFLDKLKQEKQLDWTFLSPSAEFVPGERTGKFRIGKDN........................................................................................................................................................................................................ 166
29 -9.120[S] COG4408 Uncharacterized protein conserved in bacteria  ali follow..  8  3.KLLMIGTGPVAIQLANICYLKSDYIDMVGRASTSEKSKRLYQAYKKEKQFKDVKNVKGEYETVVMACTA-DAYYDTLQQLSLETLQSVKHVILISPTFGSQMIVEQFMSKFSQDIEVISFS--TTGVKKKLYMSTHSNSTMCQRISALAEQLKIQLEVVESP----HAETRNSSLYVHPPLF-EGPITMTLIREMRLMW----KEMMAILQAFRVPSVNLLQFMVKEVRPETLDEGDIEHFEILPDILQEYLLYVRYTAILIDPFSQPDENGHYFDFSAVPFKQPRMPSEDGKMLGIKTPMIDQFLTR-YEASCQAYKDMHQDQQLSSQFNTNLFEGD. 418
30 -9.050[H] COG0499 S-adenosylhomocysteine hydrolase  ali follow..  11  259KNVLVCGYGDVGKGCAEAFDGQGARVKVTEADPINALQALMDG------SVVTVDEAIEDADIVITATGNKDIISF---EQMLKMKDHALLGNIGHFDNEIDMHSLLHRDDVTRTTIKPQVDEFTFSTGRSIIVLSEGRLLNLGNATGH............................................................................................................................................................................................... 399
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.