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Query: [C] COG1035 Coenzyme F420-reducing hydrogenase, beta subunit, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPPKIAEVIDYDVCAACGACEAVCPIGAVTVKKAAGIRDPNDLSLYEKGGGYQVCEGCLTCSRVCPVVDGFIQDELTNVRKFFGARSKDNVGSQDGGVASGILKSLFKQGKIDCAVGITRNEKWEPEVVLLTSAEDVERTRGTKYTSDPVLAALREAFEKYDRIAVIGVPCQAHAAHLIRENVNEKIVLIIGLLCMESFHHDVMLEKIIPEILKVKLEDIRKMEFTKGKFWVYTKDGEVHSVPIKDVAKFARNPCHHCCDYTSVFADISVGSVGAPDGWNSVFIRTEIGEKYFDMVREDMEIMEDPKPGLELVEKLIGMKRKGNAEHFLEVCEKFSFETGIRNETILast
1 -108.000[C] COG1035 Coenzyme F420-reducing hydrogenase, beta subunit  ali  100  1MPPKIAEVIDYDVCAACGACEAVCPIGAVTVKKAAGIRDPNDLSLYEKGGGYQVCEGCLTCSRVCPVVDGFIQDELTNVRKFFGARSKDNVGSQDGGVASGILKSLFKQGKIDCAVGITRNEKWEPEVVLLTSAEDVERTRGTKYTSDPVLAALREAFEKYDRIAVIGVPCQAHAAHLIRENVNEKIVLIIGLLCMESFHHDVMLEKIIPEILKVKLEDIRKMEFTKGKFWVYTKDGEVHSVPIKDVAKFARNPCHHCCDYTSVFADISVGSVGAPDGWNSVFIRTEIGEKYFDMVREDMEIMEDPKPGLELVEKLIGMKRKGNAEHFLEVCEKFSFETGIRNETI 346
2 -21.800[C] COG1146 Ferredoxin  ali follow..  33  40.......TIDYDKCVTCGICFVTCGRRVFDFDKKEGKVIV--------ARPYNCMVACQTCMNLCP........................................................................................................................................................................................................................................................................................ 90
3 -21.600[C] COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB  ali follow..  30  105.PARMVAVIDENNCIGCTKCIQACPVDAIVGATRA-----------MHTVMSDLCTGCNLCVDPCPT....................................................................................................................................................................................................................................................................................... 159
4 -21.100[C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit  ali follow..  31  42..RTFMPVIDESKCVKCYICWKFCPEPAIYIKEDG-----------FVAIDYDYCKGCGICANECPT....................................................................................................................................................................................................................................................................................... 95
5 -20.100[C] KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit  ali follow..  25  105EHALRRYPSGEERCIACKLCEAICPAQAITIEAEERADGSRRTTRYD--IDMTKCIYCGFCQEACP........................................................................................................................................................................................................................................................................................ 168
6 -19.300[C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)  ali follow..  25  58.........GEERCVACNLCAVACPVGCISLQKAETEDGRWYPEFFR--INFSRCIFCGLCEEACP........................................................................................................................................................................................................................................................................................ 112
7 -17.200[C] COG1145 Ferredoxin  ali follow..  21  276AHSSYLATVDTSRCIACGICMLRCPMKAIKAKINREPAS----------VDAEKCLGCGVCVPTCPMEAIELVERDELLELPDGMTYVQELLADKGRDPSGLF................................................................................................................................................................................................................................................... 368
8 -15.800[C] COG1150 Heterodisulfide reductase, subunit C  ali follow..  25  33.....EEVLSVQACYQCGTCTGSCPSGRRTSYRTRLIMRKLQLGLVDEVIKSDMCTTCYTCYERCP------------------------RGVKIVDAVKAARNLAAKKGYM.......................................................................................................................................................................................................................................... 118
9 -14.400[C] COG1141 Ferredoxin  ali follow..  17  43..RQKGVYVDEITCIGCKHCAHVAR-NTFYIEPDYGRSRVIRQ-------DGDAEEVIQEAIDTCPV....................................................................................................................................................................................................................................................................................... 99
10 -14.000[R] COG2768 Uncharacterized Fe-S center protein  ali follow..  14  199........IDEEKCTKCDECVKICPSNAIE----------------DYQINREKCVKCLGCSEACDYGAVKTFWVFGRDVSERIVECTKGVFKVQKGIMASKDILAIDRASVDLYRQAENLSGALLKEGMLNYAEKL-ELGTQNYRLIEI.................................................................................................................................................................................................... 362
11 -13.900[C] COG1142 Fe-S-cluster-containing hydrogenase components 2  ali follow..  24  1MNRFV--IADSTLCIGCHTCAVVCPVNAITRVDGAVQ------------LNESLCVSCKLCGIACP........................................................................................................................................................................................................................................................................................ 93
12 -13.800[C] COG2440 Ferredoxin-like protein  ali follow..  16  29.......KVRPHERPSALALTHICPAKCYELNDKGQVE-----------TTSDGCMECGTCRVLCE........................................................................................................................................................................................................................................................................................ 78
13 -13.800[R] COG4624 Iron only hydrogenase large subunit, C-terminal domain  ali follow..  1MDALIRPPMFADLPKDNKKCIKIGSPLALSLSD---------------------CLACSGCVSADEALSPQTSFVLSPQSKINIFNLYREDGMEYREFEAVLSSFLRSKFNIHRIVDTSYLRSKIYEETYREYMATNHLIVSATYIERTAPYLIGYLSRVKSPQQMAFSPCQDKKLENGRDGVKFDFILTTRGFCKALDSLGFRRPARASGKSLCSMEEAE-----TTQWNIGTSSGGYAEFILGKHCVVETREIRNGIKEHLLDDGRTISQITGLENSINYFKSSKTKGKMTEIFLRVNDVEMDIREYDRNGREQPRIFYSSPGLEEKRVFRE............ 353
14 -13.600[C] COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit  ali follow..  13  158.HEDRLKLDGLYECILCACCSTSCPSYWWNLIDSRDEATGERLDNLEDPFRLYRCHTIMNCAQACP------------------------KGLNPAKAIAEIKKMMVERR............................................................................................................................................................................................................................................ 258
15 -13.300[C] COG0437 Fe-S-cluster-containing hydrogenase components 1  ali follow..  17  1MTTQYGFFIDSSRCTGCKTCTKVCPSGAMHKREDGFVV-----------VDEDVCIGCRYCHMACPYGAPQYNAEKGHMTKCDGCYSRVA-EGKQPICVESCPLRALEFGPIE---------ELRQKHGTLAAVAPLPRAHFTK--PNIVIKPNANSRPTGDTTGYLANPEEV............................................................................................................................................................................. 205
16 -13.300[C] COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit  ali follow..  17  396LPDIDEIIELASECTDCGWCQRVCPNS-LPVMDAVKKAADGDLSKLEEMAIEELCYTCGRCEQECER-NIPIVSMVTKAGERRVKDEKYRIRAGRGPAQDVEIRRVIVLGDIPGVVA-------------------FVGCSNYPEGGKDVALMAKEFLERNYIVVTTG--CGAMSIGEYRDEDGQTLYEKYG--CVSNAHVSGAAIKIANIFAQKPLEG-----------------------NFEEIADYILNRVGACGVAWGAYSQKAAAIATGVNRWGIPVVLGPHGSKYRRLFLGR--ADDEEKWKLKDLRTGEVIDGEPAPEHLLYAAENR........... 696
17 -13.300[C] COG0348 Polyferredoxin  ali follow..  27  222.........HRQQCDNCMDCYNVCPEPQVLRDPLHAKKSESPL------VLSKDCISCGRCIDVCP........................................................................................................................................................................................................................................................................................ 272
18 -13.200[C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit  ali follow..  16  272.......EWISENCTMCNECAFVCPHAAIRPILTNEEEMESAPEGFMTQVSPMDCTGCNLCAETCPAVAAKENPNWSFAINVKPKKNPGKKNTVPG.......................................................................................................................................................................................................................................................... 385
19 -12.900[C] KOG3049 Succinate dehydrogenase, Fe-S protein subunit  ali follow..  16  174.IEEREKLDGLYECILCACCSTSCPSYWWNMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPK....................................................................................................................................................................................................................................................................................... 255
20 -12.600[Y] KOG2439 Nuclear architecture related protein  ali follow..  10  8..SDLNDFISP--ALACVKPTQVSGGKKDNVNMNGEYEVSTEPDQLEKSITLSDCLACSGCITSSEEILLSSQSHSVFLKNWGKLSQQQDKGLTLEAADLCLMNFFQKHFQCKYMVGTEMGRII----SISKTVEKIIAHKKQK------------ENTGADRKPLLSAVC---GFLIYTEKTKPQLVPMLL----NVKSPQQITGSLIRATFE------------------------SLAIARESFYHLSLMPC-FDKKLEASRPESLDDGI------DCVITPREIVTMLQELNLDFKSFLTEDTSL..................................... 278
21 -11.500[C] COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain  ali follow..  15  312.............CIRCGACLNTCPAYRQIGGHGYGVISPILGGYEEFKDLPSACSLCTACNQVCPVKIPLAN-----LLKHRRHIAESGMNPLAERLSVKAFTLANSHPSL-MNVGAKVAKLAIRDGKMPIQVGAIAEWTKARDLPDAEGESFRSWFKN.......................................................................................................................................................................................... 466
22 -10.700[C] COG1140 Nitrate reductase beta subunit  ali follow..  12  211.......LIDQDKCRGWRMCITGCPYKKIYFNWKSGKS--------------EKCIFC-VCSETCVADAIERAASTENEKDLYQRQLEVFLDPNDPKVIEQAIKDGIPLSVIEAAQQSPVYKMAMEWKLALPLHPEYRTLPMVWYVPNGILPDVESLRIPVQYLANLLTAGDTKPVLRALKRMLAMRHYKRAETVDGKVDTRALEEVGLTEAQAQEMYRYLAIANYEDRFVVPSSHRELAREAFPE-----KNGCGFTFGDGCHGSDTKFNLFNSRRIDAIVTSKTE........................................................... 509
23 -9.430[C] COG1600 Uncharacterized Fe-S protein  ali follow..  12  195..........EEGCGKCVACMTICPTGAIV------------------TVDARRCIGCDDCQLICPWNRYSQLTDEADLLELFSWSEAQFLKVTEGSAIRRIGHLRWLRNVAVALGNAPWSNAVITALESRKGEHPLLDEHIEQQIEKRNACIIEVQLPKKQRLV..................................................................................................................................................................................... 373

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Comparative analysis of protein domain organization. Genome Res. 2004 Mar;14(3):343-53.