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Query: [M] COG1089 GDP-D-mannose dehydratase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTKVALITGVTGQDGSYLAEFLLDKGYEVHGIKRRASSFNTERIDHIYQDPHGSNPNFHLHYGDLTDSSNLTRILKEVQPDEVYNLAAMSHVAVSFESPEYTADVDAIGTLRLLEAIRFLGLENKTRFYQASTSELYGLVQEIPQKESTPFYPRSPYAVAKLYAYWITVNYRESYGIYACNGILFNHESPRRGETFVTRKITRGLANIAQGLESCLYLGNMDSLRDWGHAKDYVRMQWLMLQQEQPEDFVIATGVQYSVRQFVEMAAAQLGIKMSFVGKGIEEKGIVDSVEGQDAPGVKPGDVIVAVDPRYFRPAEVDTLLGDPSKANLKLGWRPEITLAEMISEMVAKDLEAAKKHSLLKSHGFSVSLALELast
1 -109.000[M] COG1089 GDP-D-mannose dehydratase  ali  100  1MTKVALITGVTGQDGSYLAEFLLDKGYEVHGIKRRASSFNTERIDHIYQDPHGSNPNFHLHYGDLTDSSNLTRILKEVQPDEVYNLAAMSHVAVSFESPEYTADVDAIGTLRLLEAIRFLGLENKTRFYQASTSELYGLVQEIPQKESTPFYPRSPYAVAKLYAYWITVNYRESYGIYACNGILFNHESPRRGETFVTRKITRGLANIAQGLESCLYLGNMDSLRDWGHAKDYVRMQWLMLQQEQPEDFVIATGVQYSVRQFVEMAAAQLGIKMSFVGKGIEEKGIVDSVEGQDAPGVKPGDVIVAVDPRYFRPAEVDTLLGDPSKANLKLGWRPEITLAEMISEMVAKDLEAAKKHSLLKSHGFSVSLALE 372
2 -80.800[M] COG1088 dTDP-D-glucose 4,6-dehydratase  ali follow..  23  2..RKILITGGAGFIGSALVRYIINETDAVVVVDKLTYAGNLMSLAPVAQ-----SERFAFEKVDICDRAELARVFTEHQPDCVMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEAARAYWNKSAFRFHHISTDEVYGDLHDDFFTETTPYAPSSPYSASKASSDHLVRAWLRTYGLPTLITNCSNNYGPYHFPE----KLIPLMILNALAGKPLPVYGNGQQIRDWLYVEDHARALYCVATTGKGETYNIGGHNERKNLDVVETICELLEELAP-------------------NKPQGVVHYRDLITFVADRPGHDLRYAIDASKIARELGWLPQETFESGMRKTVQWYLANESWRKQVQDGSYQGER... 350
3 -74.900[MG] COG0451 Nucleoside-diphosphate-sugar epimerases  ali follow..  21  2...RYLVTGTAGFIGFYVAKRLLDAGHFVTGFDGMTK-YYDVSLKEKRHAILARSNGFRAEIGMLEDTDALKRAAEAAEPEIIIHLAAQAGVRYSLENPRAYIDSNLIGSFNMLELARSLKVK---HLMLASTSSIYGANEKIPFAESDADEPMTLYAATKKSMELMAHSYAHLHKLPTTAFRFFTVYGPWGRPDMAPIKFVDAVSN----GQPIDIYGQGNMSRDFTYIDDLVEGIVRLSAHAPFRVVNIGGGQPVELMHFVETIEKAVGKP-------------------------------AIRNMLPMQQGDVPRTFASPDLLRALTGYVPQTPVEEGIKALVAWYRGINGNLTE............. 339
4 -70.500[GM] KOG1429 dTDP-glucose 4-6-dehydratase/UDP-glucuronic acid decarboxylase  ali follow..  23  30.NMRILVTGGAGFIGSHLVDKLMQEKNEVIVADNY-FTGSKDNLKKWIG-----HPRFELIRHDVTEPLF-------VEVDQIYHLACPASPIFYKYNPVKTIKTNVIGTLNMLGLAKRVGA----RILLTSTSEVYGDPLVHPQTESNPIGVRSCYDEGKRVAETLMFDYHRQHGIEIRIARIFNTYGPRMNIDD--GRVVSNFIAQALRGEALTVQKPGTQTRSFCYVSDMVEGLMRLMEGDQTGPINIGNPGEFTMVELAETVKELIKPD-------------------------------VEIKMVENTPDDPRQRKPDISKAKEVLGWEPKVKLREGLPLMEEDFRLRLGVPK.............. 342
5 -65.300[M] COG1087 UDP-glucose 4-epimerase  ali follow..  21  2...TILVTGGAGYIGSHTCVQLIEAGHEVVVVDNFDNS----HPEALHRIEKITGRAPRREPGDIRDRALMEQMIKRHKCTAVIHFAGLKAVGESSEKPLLYYDCNVLGTLRLLQAMEATGVK---KLVFSSSATVYGDPDKLPITEDQPLSATNPYGRTKLVIEDMLRLYNSDNSWAIAILRYFNPVGAHEDPKGIPNNLMPIIAQVATGRREKLIWGDGTGVRDYIHVNDLAAGHLKALKKPKCFAVNLGTGQGYSVLDVIKAFEHVSNRE-------------------------------IKYEIAPRRPGDVAECYADPGFAKKFLGWSAEKNLREMCQDMWNWQSKNPNGYE.............. 335
6 -64.800[GO] KOG1431 GDP-L-fucose synthetase  ali follow..  15  7.SMRILVTGGSGLVGKAIQK-VVADGAGLPGEDWVFVSSK---------------------DADLTDTAQTRALFEKVQPTHVIHLAAMGGLFRNIKYNLDFWRKNVHMNDNVLHSAFEVGAR---KVVSCLSTCIFPDKTTYPIDETPPHNSNFGYSYAKRMIDVQNRAYFQQYGCTFTAVIPTNVFGPHDNFNHVLPGLIHKVHLAKSSGSALTVWGTGNPRRQFIYSLDLAQLFIWVLREYNPIILSVGEEDEVSIKEAAEAVVEAMDFHGE-------------------------------VTFDTTKSDGQFKKTASNSKLRTYLPDFRFTPFKQAVKETCAWFTDNYEQAR.............. 320
7 -64.400[M] KOG1371 UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase  ali follow..  22  95..THVLVTGGAGYIGSHAALRLLRDSYRVTIVDNL-SRGNLGAVKTL-QQLFPQTGRLQFIYADLGDPLAVEKIFSENAFDAVMHFAAVAYVGESTLYPLKYYHNITSNTLGVLEAMARHKVK---KLIYSSTCATYGEPEKMPITEDTPQVPINPYGKAKKMAEDMILDFSKNSDMAVMILRYFNVIGSDPGGRLEQGRISGACFDAARGFIPGLQVSDGTCIRDYIDVTDLVDAHVKALEKRKVGIYNVGTGKGRSVKEFVEACKKATGVE-------------------------------IKVDFLPRRPGDYAEVYSDPTKILKDLNWTARFTLQDSLQVAWRWQKIHPHGYNS............. 435
8 -61.500[G] KOG0747 Putative NAD+-dependent epimerases  ali follow..  21  6.PKNILITGAAGFIASHVANRLIRSDYKIVVLDKLDYCSNLKNLNPSKH-----SPNFKFVKGDIASADLVNHLLITEGIDTIMHFAAQTHVDNSFGNSFEFTKNNIYGTHVLLEACKVTG--QIRRFIHVSTDEVYGETDEDALHEASQLLPTNPYSATKAGAEMLVMAYGRSYGLPVITTRGNNVYGPNQFPE----KLIPKFILLAMRGQVLPIHGDGSNVRSYLYCEDVAEAFEVVLHKGEGHVYNIGTKKERRVNDVAKDICKLFNMDPEANIKFVDN-----------------------------RPFNDQRYFLDDQKLKK-LGWSERTTWEEGLKKTMDWYTQNPEWWGDVSGA......... 332
9 -42.900[IE] KOG1430 C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases  ali follow..  12  6.GEVLLVTGGSGFLGQHLIKQLLERKEELGIKEIRSLDIVPYK----NIGHEETSLLRTYVADIGGDLKALSPIFNGV--DGVFHCAASVKIEYP-PNYEELERVNVNGTLAVVDLCIQNNVK---RLVYTSCTSVCFVLDSSTLWEQDNQFLIPGYASSKLRAENIVLNSNGA-YLATSAMRAPLTYGECD-----SHFITEIFDFLSTRGWVFPRIAGVGGKQQLVYAGNVAWGHICAYKA-NGLPVFVTDDTGINFVQKMAVLGERFKVKTSWWYVPHFLFFFLAFLLEVVVRVAYPYTKYRLRYSLRAIASYTSMLMYNRLRASIHMDYMPLFDPDASAERSAKWYATWWDQRQQAQKLK........ 395
10 -34.200[R] KOG4288 Predicted oxidoreductase  ali follow..  8  2...KIVVLGGSGFLGHNICKLAIAKGYEVVSVSRRGAGGL--------HNKEPWMDDVEWETLDAKDPNSLLPVLRDA--SAVVNSVGILMENNYKKNKVTFEAINRDLAIETAKIAAKANVP---VYCYVSA-------------HAAAPGLDPRYIKTKREAEREIS---KISNLRSIFLRPGFMYNFNDRPFTGALASLFTVSSSINRATSGALNFLGTASAEPLPSEEVALAALEAISDPSKGPVEIS-----ELKSMAHKFKQ........................................................................................................ 273
11 -33.300[C] KOG2865 NADH:ubiquinone oxidoreductase, NDUFA9/39kDa subunit  ali follow..  14  67SGIVATVFGATGFLGRYLVQQLAKMGSQVLVPFRGSEDSPR------HLKLMGDLGQVVPMKFDPRDEDSIKAVMAKA--NVVINLIGREYETRNFS----FEDANHHIAEKLALVCEHGGIM---RYIQVSCLGASVS-------------SPSRMLRAKAAAEEAVL----NALPEATIMRPATMIGTEDRILNPWSMFVKKY--------GFLPLIGGGTTKYPVYVVDVAAAIVAALKDDGGKTYELGGPDVFTTHELAEIMYDMIREWPRYVKLPFPIAKAMAAPRDFMVNKVPFPPSPQIFNLDQINALTTDTLVSDNALKFQDLDLVPH-KLKGYPVEFLIQYRKG................... 382
12 -31.600[MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases  ali follow..  13  34LPPLVTVFGGSGFVGRHVVRMLAKRGYRIRVAVRRPDLAG-------FLQPLGNVGQISFAQANLRYRDSIIKAVEDA--DHVVNCVGILAESGR----NTFDAVQEFGAKAIAEAARDTGA----TLTHISAIGADAN-------------SQTGYGRTKGRAEAAIH----SVLPGAVILRPSIIFGPE-------DDFFNKFAKMARNLPFLPLIGGGKTKFQPVYVEDVAEAVARSVDGKLGAIYELGGPDVMTFRDCLEAVLAATYRERSFVNLPFGVASMIGKLASL----VPLITPPLTPDQVTMLKKD---NVVSAEAEKKGLTLEGPVRVASVLPSYMVQYRQH................... 344
13 -30.100[M] COG1091 dTDP-4-dehydrorhamnose reductase  ali follow..  18  2...RLAVTGRNGQVVSALQA-LAGADLEIVTLGRP--------------------------ELDLVRPENVLQALREAKPDVVVSAAAYTAVDKAESEPDIAFAVNRDGAKAVAQAAKELGV----PVIHLSTDYVFDGSKATAYVESDPTGPTSIYGRSKLKGERAVSEATDNYVV-LRTAWVYSEYG---------NNFVKTMLKLSESRDEINVVAD-------TSATDIAAAVVAIARKSLRGIFHLSGTGETTWANFAKQIFAFS------AENGGKSMIVNDITTKQYPTPAP-------------RPAN---SRLNCRKLEEIYGLKLP-SWQTSTREVVTALAQTKKEKS.............. 297
14 -29.900[V] KOG1502 Flavonol reductase/cinnamoyl-CoA reductase  ali follow..  16  7.GKVVCVTGASGYIASWLVKFLLSRGYTVKASVR--DPSDPKKTQHLV-SLEGAKERLHLFKADLLEQGSFDSAIDGC--HGVFHTASPFFNDAK-DPQAELIDPAVKGTLNVLNSCAKASSVK--RVVVTSSMAAVPRTPDVTVDETW--ASKMWYVLSKTLAEDAAWKLAKEKGLDIVTINPAMVIGPLLQPTLNTS--AAAILNLINGAKTFP-----NLSFGWVNVKDVANAHIQAFEVPSANGRYCLVERVVHHSEIVNILRELYP--------------------------------NLPLPERCVDENPYVPTYQVSKDKTRSLGIDYI-PLKVSIKETVESLKEK................... 321
15 -23.000[MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases  ali follow..  14  281.EKSVMVTGAGGSIGSELCRQILAQKPKTLVLFELNEYNLYTIDQELQAIKQNLKLNTKIVAGSVQRENRVKKLMQAHQVETVYHAAAYKHVPLVEDNVIEGIRNNVFGTLACANAAIEAGVK---NFTLISTDKA--------------VRPTNIMGASKRMAELVLQALADKNSTIFTMVRFGNVLGSS-------GSVVPLFKKQIRAGGPVTVT-HPDIIRYFMLIPEAAQLVIQAGAMSHGQVFVLDMGEPVKIVDLAKRMIHLMGMKE--------------------FCDGRSDEGDIEIKFTGLRPGE---------KLYEEL......................................... 560
16 -22.600[R] COG1090 Predicted nucleoside-diphosphate sugar epimerase  ali follow..  18  32.LMKIILTGATGFVGCSLVPLLHQQGHELTLLVRSVSKAQRL--------APGSFPQLKAIAYEATKSGDWQKVVDGQ--DAVINLAGEPISERTEAYKAEIFDSRKLGTEKLVEAIAKADRKPQV-MISGSAIGYYGTSETATFTESSK--PGDDFLAEVCQAWENAAHQVEQLGVRLVVFRIGIVLGADGG---ALAKMLPPF-KLFAGGP----LGSGEQWFSWIDRRDLIALIDKALTDSTRGTYNATAPNPVKMKEFCHTLGKVLARP................................................................................................... 285
17 -20.700[Q] COG3320 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes  ali follow..  14  9..RTVLLTGATGFLGRYLALKWLEREGKVIALVRAKSNEDRARLDKTFDSQELATDHLEVIAGDKGDRQTWRRLADTV--DLIVDPAALVNHVLPYSE---LFGPNTLGTAELIRIALTSKQKP---YIYVSTIGVGNQIEPAKFTEDSDIRVISPYGNSKWAGEVLLREAHDLCGLPVTVFRCDMILADTSNVPDMFTRMMLSLAATGSFYELDAESNRQRAHYDGLPVEFIAEAISTLGDRDGFTTYHVMNDDGIGMDEFVDWLIDA....................................................................................................... 314
18 -20.200[Q] KOG1204 Predicted dehydrogenase  ali follow..  14  1MGKVILITGASRGIGLQLVKTVIEEDDECIVYGVARTEAGLQSLQR-----EYGADKFVYRVLDITDRSRMEALVEEIKLDGIVANAGQSNSEHDIKQWERLFDVNFFSIVSLVALCLPLLKSSP-NIVFVSSGA-----------SVKPYNGWSAYGCSKAALNHFAMDIASEEPSDKVRA---VCIAPGVVDTQMQKDIRETLGPQGMTPKALERFTQLYKTSSLLDPKVPAAVLAQLVLKGIPDSL---NGQYLRYND............................................................................................................... 255
19 -18.700[Q] KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes  ali follow..  17  644.GQYFLLTGATGYFGRRFLEYLVKLNISVVCLVRESSDEAKERLISLVPSLRISSENIIVWAAHVEDDAKWEFLVENV--SRIYHMAAEVHWMKSYQ---ELRPANVLGTKTVLELS----VMGPKALYFISGGGQ----QEVELDDDTQSAKASGYALSKYVAELLCRKISDL-GHPLIYGFIIANDGEILSRDFFWRFVATALRMGIWPQSDE----SQSLVFHISTTDALCMTLTQILEKEADAYAPLLAYDKFDGDEFACICESMKNVKLDFV............................................................................................... 912
20 -16.500[R] KOG0725 Reductases with broad range of substrate specificities  ali follow..  13  2..SCALVIGATSTLGKAVVRRLAFTGYKVAAAAD-----CPNSVGKVAEDNIKVGGDVTAFSLDVANAEHRKELITKVGLDTLIIVPPQNEIETSGEDFDKLFANNLTTPFRLSQAAMSTLAKSQ-SIIYLTS-----------CFGFTPSIDMGLYSVASSSVLSLTKSVAQSAAKQGVRV---NSVVSGMIEGDGTGAVWDHASGEEARQIKQHLESMIPLGR-LGRPSDVASYVEFLASTKTGENCIVGGGVSYRL................................................................................................................. 253
21 -16.400[M] COG3967 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)  ali follow..  15  5.NNTVLITGGSAGIGLELAKRLLELGNEVIICGR-----SEARLAEAKQQ-----PNIHTKQCDVADRSQREALYEWANLNVLVNNAGIQKGTEELFVDGDEIELNFQAPVHLSALTPHLMKQPEAAIVQVTSGLAF-----------NPLAVYPVYCATKAALHSFSLTLRRDTSVEVVDTGLNQKSRDKQGLTYSSEEYVQYFLDGLKEGKQEITNE......................................................................................................................................................... 227
22 -16.200[IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  15  6.GKTALITGASQGIGEGIARVFARHGANLILLDI------SDEIEKLADELGGRGHRCTAVKADVRDFASVQAAVARARIDILVNNAGVCRLDMSEEDRDFHIDINIKGVWNVTKAVLPEMIKRKDGRI-VMMSSVTGDMVADP---------ETAYALSKAAIVGLTKSLAVEYAQSGIRV---NAICPGYVRTPMAESIARQSNPDDPESVLTEMAKAIPLRR-LADPLEVGELAAFLASDETGTQNVIDGGSTLP.................................................................................................................. 256
23 -16.100[I] KOG1221 Acyl-CoA reductase  ali follow..  18  21.NKTILITGATGFMGKVLVEKLLRSCADLNVIVRKEQYFKCVIFGKLLEKNPGIVDKVRVVKGDLLSANDTNTLASNV--EVVFHCAANVRFDQPLRP---MVMMNVVGTLKVLRLAEK--MSQLQALVHVSTS--YCQCNESVLEERAYPAPQNPYAYSKALSEDLICRYNN--KLPIIITRPSGVNGPTGLMIGAARGVIRSM------------HCNPDYASTVIPVDKAINGMILCGKQTGVEFCNLCISSKALMS................................................................................................................ 331
24 -16.000[R] KOG1611 Predicted short chain-type dehydrogenase  ali follow..  14  3.PKSVVVTGSNRGLGFGLVQQFLKDPNVQHVIATARDVDKATALKGI------CDPRLHILQLSLGSDESIANFAEKVS-TLLINNAAVMLPYVTKQKPLDLFESNTIGPMMLTQSLDTLSVSRGAIINIASEF--LGSISEN--TSGSGEYKAMAYRMTKCAVNQFTKTLSIDL----------------KDDHILTAGICPGMVQTDMSKGKGQL------------IEESSSQILAAFNKLGATH............................................................................................................................ 237
25 -15.900[I] KOG1478 3-keto sterol reductase  ali follow..  16  1MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHP-TAEVTIVQVDVSNLQSVFRASKELRLDCIYLNAGIMPNPITADGLQEVFETNVFGHFILIRELEPLHSDNPSQLIWTSSRS--ARKSNFSLEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVAC---PGTALTNLTYGILPPFI...................................................................................................................................................................... 239
26 -15.800[QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases  ali follow..  13  29.DKYVFITGCDSGFGNLLARQLDARGLRVLA--------ACLTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVLVNNAGILTP-LNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSS--ILGRVAFF----------VGGYCVSKYGVEAFSDILRQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKET--YGQ-GLLNCSTNLNLVTDCMEHALTSVHPRTYSAG........................................................................................................................ 284
27 -15.700[I] COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH)  ali follow..  12  6.GKRILVTGVAS-IAYGIAQAMHREGAELAFTYQ------NDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELKFDGFVHSIGFAPNAVTREGFKIAHDISSYSFVAMAKACRSM-LNPGSALLTLSY-----------LGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRV---NAISAGPIRTLAASGIFRKMLAHCEAVTPIRRTVT---------IEDVGNSAAFLCSDLSGEVVHVDGGFSIA.................................................................................................................. 254
28 -15.500[Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related dehydrogenases  ali follow..  16  7.SPVVLITGCSGGIGHALAREFTEKGCRVVATSR-----SRSTMTDLEQD-----SRLFVKELDVQSDQNVSKVLSEVKIDVLVNNAGVQCVETPISAMENTFNTNVFGNKDLIFSFNYY-MRMTQAVVPHMVSKKKGKIVNVGSITVMAPGPAGVYTATKAAIHALTDTLRRPFGIDVINVVPGGIRTNIANSAVATFNKMPELKLYKPYEEAIRERAFISQRMNPTPAETFARDTVAAVLKKNPPAW-FSSGRYSTLMAVMYHM.......................................................................................................... 283
29 -15.400[R] COG0300 Short-chain dehydrogenases of various substrate specificities  ali follow..  16  3.KKTIFITGASSGLGRQLAIDFSWEETVLCLFAR-----SQERLENVQRIVVENGGEAHIYPVDLADPQSIDRSFAEAVVDVLINNAGYGVFDSQMDENERMFRVNVFGLMRATAAVLPTMREQGSGHI-INIASQAGKI---------ATAKSAIYSATKHAVLGFTNSLRKGTGIHVSAVN--AYTSKVQRIMLDPEDVSEKIVQLTKKPKRELNLP......................................................................................................................................................... 231
30 -15.300[I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase  ali follow..  15  76.SPVVVITGASRGIGKAIALALGKAGCKVL----VNYARSAKEAEEVAKQIEEYGGQAITFGGDVSKATDVDAMMKTATIDVVVNNAGITRIRMKQSQWDEVIALNLTGVFLCTQG----------RIINISSVGLIGNIGQ------------ANYAAAKGGVISFSKTAAREGASRNINV---NVVCPGFIASDMTAELGEDMEKKILGTIPLGRYGK---------AEEVAGLVEFLALSPAGQAFTIDGG...................................................................................................................... 305
31 -15.300[I] COG4982 3-oxoacyl-[acyl-carrier protein] reductase  ali follow..  10  358.SEIAVVTGASGSIAASVAARLLDGGATVIATTSKLDEERITFYRALYRDHARYGAALWVVAANMASYSDIDALVEWITPTLLFPFAAPRDLSEAGARSEIEMKVLLWAVQRLIVGLSKIGTERDV-HVVLPGSPNRGMFGG-----------DGAYGEAKSALDAVVSRWHAE-SLAHALIGWTRGTGLMGHNDVIVSAVEEAGVTT-------------------YSTDEMAAMLLDLCNAESKVA----AAGTPITVDLLGEVDLDMAELAAKAREDHAAQAAEDEATEASEVAGTIAALPSPPRGYTPASPHWDDLDVDPADLVVIVGFEMEVAGELSAAGVLE........................ 718
32 -15.100[R] COG4221 Short-chain alcohol dehydrogenase of unknown specificity  ali follow..  15  7.GKIAVITGAASGIGLATTEALLEQGATVVMVDW--------NEKALNDLAAKLGERAIPQVTNLLDADSCNAMIPEIHIDILYCNAGTYITETTPEAIDKMLNLNVNAVMKNVQAVVPHMSERKTGDI-IVTCSIAGHFPTY----------EPVYSGSKWAITSFVQGMRRQMIPHGVRV---AQVSPGPVVSALLADWPEENLRKAK------------ESGSLIDASEVADAVVYMLTRKRRDMLVLPTN...................................................................................................................... 239
33 -14.400[Q] KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  17  46.GLVAVVTGSNCGIGFETVRELNLRKADVYMLCR--SEEKANEAKRMLVRQGCDATRLHFIECDLTDFESVRRAAKETTIDILINNAGIMFQSKTKDGHEKTWQSNHLGTELFLPAVKK---SSYARIINVSSRI--EKINLATVDDKKSFGMMKSYRQSKLANVMHARALTKELRKDGAEHVTVNSLHP...................................................................................................................................................................................... 243
34 -14.000[R] COG2910 Putative NADH-flavin reductase  ali follow..  18  2..AKIALIGASGNAGSRILKELSDRGHQVTAIAR-------------NPEKIAALPNVVAKKGDVFDQAALSELLKGH--DAVISSVHFTA-----------------DPATLIEAVRASGVQ---RYLVVGGAGSLEIAPGQRVVDLPDFPAA--YKAEATKGAEFLDKLKQEKQL------------------------------------------------DWT----FLSPSAEFVPGERTGKFRIGKGSRISFEDYAIALADEIEKP................................................................................................... 192
35 -13.600[Q] KOG1210 Predicted 3-ketosphinganine reductase  ali follow..  12  32.GAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLL-QAKKEIEMHSINDKQVVLCISVDVSDYNQVENVIKQAPVDMLVNCAGMAVEDLEVSTFERLMSINYLGSVYPSRAVTTMKERRVGRIVFVSS--QAGQL---------GLFGFTAYSASKFAIRGLAEALQKPYNVYITVAYPPDTDTPETTSVCKPEQVAKQIVKDAIQGNFNSSLG......................................................................................................................................................... 268
36 -13.600[Q] KOG1205 Predicted dehydrogenase  ali follow..  16  47.GKVVIITGSSSGIGEHLAYEYARRGAYLTLVAR-----REDRLQVVADRRKLGSPDVAVVRGDVSVIKDCKRFVQETRLDHLVNNAGIAEAKSEISDVLPIVNTNFWGPVYATHFAIPHLKKTKGKIIAVAS--PAGWS---------GVPRMSIYAASKAA----MINFYETLRIELHPEVGVTIVFP--------GLIENGNTNPDLLAESLLQKQDWSQVVTIESAAECAKAVVNGICRGKTFVA........................................................................................................................... 277
37 -13.100[IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases  ali follow..  11  5.GKNVVYLGGFGGIGQKCVQELLQRPIKALAIFDL----NANEQLLAKWKSQHPDTDVFYHKLDITQKSDIDAAYKATHFDVVVNGSGLMNDRL-----ELTIQINLLGVINALEYMDKAKGGKGGLIVNISSVAGLQPTAIMAI-----------YSAAKTGVTTFTRAMANPYFYAHSGVGFLTI------PGFTDTGLLEDIGNKTTFTYDTPMLAMFNRVK--QKAEDCARNLVSAIETSKNGTVLMLEMGETTEGLAIFDLIVDDDLLAEWKKQHPDTEIFYQKMD------TQKSDIDAAYKATAEKLGHFDVVVNGSGLLDDR-RIELTIQIN................................ 321
38 -12.400[G] KOG1203 Predicted dehydrogenase  ali follow..  22  122.SGIILVAGATGGVGRRIVDILRKRGLPVKALVR-----NEEKARKML------GPEIDLIVADITKENTVPEKFKGV--RKVINAVSVIVGPKEGDTPERQKYNQIKGDS..................................................................................................................................................................................................................................................................... 219
39 -12.300[I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3  ali follow..  15  47MGQWAVITGAGDGIGKAYSFELAKRGLNVVLISR-----TLEKLEAIATEIERTTGSVKIIQADFTKDDIYEHILAGLEIGILVNNVGMLPFLNAPDEIQSLIHCNITSVVKMTQLLKHMESRQKGLILNISSGIAL-----------FPWPLYSMYSASKAFVCAFSKALQEEYEVIIQVL.............................................................................................................................................................................................. 226
40 -11.900[Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11  ali follow..  12  52.GEVAVVTGAGHGLGRAISLELAKKGCHIAVVDINVSGAE----DTVKQIQDIYKVRAKAYKANVTNYDDLVELNSKVPVTVLVNNAGVMMFNPDPADVQLMINVNLTSHFWTKLVFLPKMKELRKGFI-VTISSLAG----------FPLPYSATYTTTKSGALAHMRTLRMELDL-------------ENQKDIHVTTVLPSFLRTNSDVTQLTHTIGFGDVYPLFTGEEVAQRIVAGMVRGEAEIT........................................................................................................................... 281
41 -10.900[E] COG1748 Saccharopine dehydrogenase and related proteins  ali follow..  11  1MKKNVLIIG-AGGVAQVVAHKCAQNSGDIHIASRTVDKCRKIVESVREKKSLKTEVKLEAHALDALDVEATKALIVSTGSQIVINVGSAFV--------MSVLRACMDTGVAYMDTAIHEEPNKICETPPWYGNYEWKRAAECKEKGITAI--FDP-GVVNAYARLAKDEYFDKIT----DVDIVDINAGNHGKYFATNFDPEINFREFTGVVYSWQKGAWQTNRMFEVGKEF--------VVGKRQAYMTGHDEVHSLSKNMDG........................................................................................................... 252
42 -10.500[I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and related enzymes  ali follow..  15  322.NKVVVVTGAGGGLGKSHAIWFARYGAKVVVND-------IKDPFSVVEEINKLYGEGTAIPDSHDVVTEAPLIIQTARVDILVNNAGKSFLKMKDEEWFAVLKVHLFSTFSLSKAVWPIFTKQKSFIINTTSTSIYGNFGQ------------ANYAAAKAAILGFSKTIAAKRGIIV------NVIAPHAETAMTKTIFSE------------------KELSNHFDASQVSPLVVLLASEEIGQLFEVGGGWCGQTR................................................................................................................ 560
43 -9.940[T] KOG4039 Serine/threonine kinase TIP30/CC3  ali follow..  15  240KMSSAFVVGATGAVGSELVKLLAESTKKVVVLARRPVDG-------------ATGDKLIQKTVDFDKLEENAEDIQGV--DVAFCALGTTRGKSG---ADGFYKVDHDYVMSAAKMAKENGVK---QFVLVSS---VGADASSRF-----------YPKTKGEVEKEIGELNFEKFVIMRPGLIEAKRPEFRIGEFLGKIVTA-------------PLGLFSNRFS-SSATAIAQAMINATQTEETGNQIW------NNSKIVEESKKYTA..................................................................................................... 458
44 -9.220[S] COG3007 Uncharacterized paraquat-inducible protein B  ali follow..  9  42..KRVLVIGASTGYGLAARITAAGCGADTLGVEGKPGTSGWYNSAAFHKFAAQKGLYAKSINGDAFSDEIKQLTIDAIQVDQVIYSLASPRRTHPKTGEVRGLDTDKEVIKESLQPATQSEIDSTVAVMGGEDWQMW-AFTYLGEKITHDIYWNGSIGAAKKDLDQKVLAIRESLA----------------DARVSVLKAVVTQASSAIPMMPLYLSLLFKVMKEKGTHEGCIEQVYSLYKD-CGDSPHMDQEGRLRADY--------------------ELDPEVQNQVQQLWDQVTNDNIYQLTDFVGYK-----------SEFLNLFGFGDGVDYDADVNPDVKI....................... 393
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.