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Query: [C] COG1142 Fe-S-cluster-containing hydrogenase components 2, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNRFVIADSTLCIGCHTCEAACSETHRQHGLQSMPRLRVMLNEKESAPQLCHHCEDAPCAVVCPVNAITRVDGAVQLNESLCVSCKLCGIACPFGAIEFSGSRPLDIPANANTPKAPPAPPAPARISTLLDWVPGIRAIAVKCDLCSFDEQGPACVRMCPTKALHLVDNTDIARVSKRKRELTFNTDFGDLTLFQQAQSGEAKLast
1 -85.300[C] COG1142 Fe-S-cluster-containing hydrogenase components 2  ali  100  1MNRFVIADSTLCIGCHTCEAACSETHRQHGLQSMPRLRVMLNEKESAPQLCHHCEDAPCAVVCPVNAITRVDGAVQLNESLCVSCKLCGIACPFGAIEFSGSRPLDIPANANTPKAPPAPPAPARISTLLDWVPGIRAIAVKCDLCSFDEQGPACVRMCPTKALHLVDNTDIARVSKRKRELTFNTDFGDLTLFQQAQSGEAK 203
2 -62.100[C] COG0437 Fe-S-cluster-containing hydrogenase components 1  ali follow..  23  3TQYGFFIDSSRCTGCKTCELACKDFKDLGPEVSFRRIYEYAGGDYYLSISCNHCDDPACTKVCPSGAMHKEDGFVVVDEDVCIGCRYCHMACPYGAPQYN----------------------------------AEKGHMTKCDGCYSRGKQPICVESCPLRALEFGPIEELQKHGTLAAVAPLPRAHFTKPNIVIKPNANSR 190
3 -47.400[C] COG1140 Nitrate reductase beta subunit  ali follow..  16  120.SQPIARPRSLITGERMAKIEKGPNWEDDLGGEFDKLQFENTFMMYLPRLCEHCLNPACVATCPSGAIYKEDGIVLIDQDKCRGWRMCITGCPYKKIYFNWK----------------------------------SGKSEKCIFCYPRIEATVCSETCVGRIRYLGVLLYDADAIERKDLYQRQLEVFLDPNDPKVIEQAIK 314
4 -34.400[C] COG1036 Archaeal flavoproteins  ali follow..  19  100....SNTVSKIAYGIADSLVTNAVAQAVKGKVPVYVVPVDIEGSIIDRKQCRHCETCPPRENCPHGAITKNGVTDQIELLKCKGCGICKELCPYNAIKGG----------------------------------PVEVLVRDVDMRNVEGLQGITVLESPEAILEL..................................... 238
5 -24.100[C] COG2440 Ferredoxin-like protein  ali follow..  18  32...............................................PHERPSANLLALTHICPAKCYENDKGQVETTSDGCMECGTCRVLCEASGE.......................................................................................................... 82
6 -22.900[C] COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB  ali follow..  16  39....KIDEILPQSQCGQCGYPGCRPYAEAISCNGEKINRCAPGGEAVMLKIAELLNVEPQPLDGEAQELTPARVAVIDENNCIGCTKCIQACPVDAIVGATRAMHTVMS-------------------------------DLCTGCN------LCVDPCPTHCISLQPVAE................................ 169
7 -21.400[C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit  ali follow..  19  6....GKAKEEARVISPKSVDEYPEAPTLGTTLVNFTGDWRTFMPVIDESKCVKC--YICWKFCPEPAIYKEDGFVAIDYDYCKGCGICANECPTKAITMVREEK................................................................................................... 105
8 -20.800[C] KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit  ali follow..  21  113............................................................................SGEERCIACKLCEAICPAQAITIEAEERADGSRRTTRYDID----------------------MTKCIYCG------FCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLCNGDK.......... 201
9 -20.100[C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)  ali follow..  20  19..............................................LVMIFGHAFRKRDTLQYPEEPVYLPPGRIVLGEERCVACNLCAVACPVGCISLQKAETEDGRWYPEFFRIN----------------------FSRCIFCG------LCEEACPTTAIQLTPDFEMGEFKRQDLVYEKHD................. 138
10 -20.100[C] COG1146 Ferredoxin  ali follow..  16  9.....LIGKDALGREVRDLSKVPWWGVD--------RKEIEWYPTIDYDKCVTC--GICFVTCGRRVFDFDKKIVARPYNCMVACQTCMNLCPTGAISFPDAS.................................................................................................... 100
11 -19.200[C] COG1145 Ferredoxin  ali follow..  21  253..............CNCCSDCCVFFKAVHEAKHPNTIAHSSYLATVDTSRCIACGI--CMLRCPMKAIKINREPASVDAEKCLGCGVCVPTCPMEAIELVERDE................................................................................................... 342
12 -18.900[C] COG0348 Polyferredoxin  ali follow..  21  197..........................................................CGHLCPIGAAYGVIGAKGLHRQQCDNCMDCYNVCPEPQV--------------------------LRDPLHAKKSESPLVLSKDCISCG------RCIDVCPEKVFIFTTRFNHSVNHSGE........................ 291
13 -18.300[R] COG2768 Uncharacterized Fe-S center protein  ali follow..  19  203.................................................KCTKCDE--CVKICPSNAIED----YQINREKCVKCLGCSEACDYGAVKTFWVFGRDV-----SERIVECTKGVFKVQKNFAYLNFLMDITPHCD-CHPYSDLPVVPDL-ASVDLYRQAENLSGALLKDKKFWDWTDVEGMLNYAEKLELGTQN 356
14 -17.500[C] COG1141 Ferredoxin  ali follow..  17  36...............................................................PELGGILRQKGVYVDEITCIGCKHCAHVAR----------------------------NTFYIEPDYGRSRVIRQDGDAEEVIQ------EAIDTCPVDCIHWVDYTELKNLEEDRKFQVIPVV................ 125
15 -17.000[C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit  ali follow..  16  253.............................................................AYPPGTAAYEKRVPEWISENCTMCNECAFVCPHAAIRPILTNEEEM-------ESAPEGFMTREMRGKDGLRYRIQVSPMDCTGCN------LCAETCPAKDKALVMKPFEEVAAKENPNWSFAINVKPKKN.......... 376
16 -16.800[R] COG3383 Uncharacterized anaerobic dehydrogenase  ali follow..  18  34........PHIC-SCDTCMCACSTNLTDGMEIKTNSELAKDAQLEAMLLYCTVCDNN-----CKVHNTTELLGVYRYDPDQCILCGRCVEAC------------------QQVQVNETLSIDWERSQPRVIWDDDRPANLSSCVSC-------LCATVCPCNALM...................................... 207
17 -15.600[C] COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit  ali follow..  11  153................................................................EWKQSHEDRLKLDGLYECILCACCSTSCP----SYWWNGDRYLGPAVLLQAYRWLIDSRDEATGERLDNLEDPFRLYRCHTIM------NCAQACPKGLNPAKAIAEIKKMMVERR....................... 258
18 -15.600[C] COG1034 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)  ali follow..  12  36...........C-ACRQCAVSCMTPSIDDEEAKQFRESVVEWLMTNHPHDCPVCEEG-----CHLQDMTVMTGFISHEMNRCIACYRCVRYY---------------------KDYADGTDLGVYGAHDNVYFGRPEDGTLESEFSGN------LVEICPTGVFT...................................... 209
19 -15.100[C] COG1600 Uncharacterized Fe-S protein  ali follow..  22  184....................................IDLPLPVDQPVEEGCGKCVA--CMTICPTGAIVEP----TVDARRCIGCDDCQLICPWN............................................................................................................ 261
20 -15.000[C] KOG3049 Succinate dehydrogenase, Fe-S protein subunit  ali follow..  10  169................................................................QYLQSIEEREKLDGLYECILCACCSTSCP----SYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIM------NCTRTCPKGLNPGKAIAEIKKMMATYK....................... 274
21 -14.500[C] KOG2282 NADH-ubiquinone oxidoreductase, NDUFS1/75 kDa subunit  ali follow..  14  64...........C-NCRMCLVACAMPLTNSEKSKKAREGVMEFLLANHPLDCPICDQG-----CDLQDQSMMFGLVKTIMTRCIQCTRCIRFA-------------------------------SEIAGVDDLGTTGRGNDMQSELSGN------IIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGE. 269
22 -14.200[C] COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain  ali follow..  24  311................................................................................RCIRCGACLNTCPYRQI------------GGHGYGSIYPGPIGSVISPILGGYEEFKDLPSACSLCT------ACNQVCPVKI-------PLANLLLKHRRHIAESG................ 393
23 -13.900[C] COG1035 Coenzyme F420-reducing hydrogenase, beta subunit  ali follow..  24  1MPPKIVIDYDVCAACGAC-----------------------------------------EAVCPIGAVTVKKAAGIGGYQVCEGCLTCSRVCP.............................................................................................................. 66
24 -13.600[C] COG1150 Heterodisulfide reductase, subunit C  ali follow..  25  40.................................................ACYQC--GTCTGSCPSGRRTSYRTRLIMRKLQCTTCYTCYERCPRGV........................................................................................................... 99
25 -12.900[C] COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits  ali follow..  24  531....VLRRALNHDGVAVVIAPCAILWSRARRREGKIVTYKVTED------CTLCMECVNTFACP--ALIFDGEKVSIDQSLCVGCAVCAKICPNRAI.......................................................................................................... 617
26 -12.500[Y] KOG2439 Nuclear architecture related protein  ali follow..  11  1MSALLSESISPALACVKPTQVSGGKKDNVNMNGEYEVSTEPDQLEKVSITCLACSG--CITSSEEILLSSQSHSVFLKLSQQQDKFLVVSVSPQCRLSLAQYYGLTLEAADLCLMNFFQKHFQCKYMVGTEMGRIISISKTVEKI-TGADRKPLLSAVCPG--LIYTEKTKPQLVPMLLNVKSPQQITGSLIRATFESLA... 217
27 -12.500[C] COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins  ali follow..  24  567...............DAVAQASGAAARAAIPMVKGEVEIEPIVAVTDSDVCGGCEV--CIELCPFGAISIEEGHANVNVALCKGCGTCVAACPSGAMDQQHFRTEQIMAQIEAALNEQAK................................................................................... 669
28 -12.100[R] COG4624 Iron only hydrogenase large subunit, C-terminal domain  ali follow..  16  15.................................................LPKDNKK--CIKIGSPLA---------LSLSDCLACSGCVSADEAGALSEDLSFVLDLSPQTSFVLSPQSKINIFNLYREDGMEYRERSKIYEETYREYMATNHLIVSACPG.......................................... 139
29 -12.000[C] COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit  ali follow..  14  377..................EVAVKTAMKLAPIRKSLKKLPDIDEIIELASECTDCGW--CQRVCPNSLPVMSKLEEMAIEELCYTCGRCEQECERNIPIVSMVTKAGERRVKDEKYRIRAGRGPAQDVEIRRVGAP---------IVLGDIPGVVAFVGCSNYPEGGKDVALMAKEFLERNYIVVTT................. 544
30 -11.800[C] COG0247 Fe-S oxidoreductase  ali follow..  20  266FRQSQLLDLYACVECGRCTNMCPATGTLSPMDLILRLRDHLTEKGAAVTSRSPW--VPAAAFRHTRGNQLAAASAGSGSQACTTCRNCEDQCPVMNEHVD....................................................................................................... 389
31 -11.400[C] COG2221 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits  ali follow..  14  128.......GINSCTAFLTCTTAVV--DSPSITKALGDALAPYFKEESLPAKCPACAGGFLVQVCPTGAHTGDKVKLVLLGEKCINCARCKENCDAFDYDPENVGVAILVGGKMSNTGGGARLARVLIPWLPAKPPRYEEIIAVVKHVIEVWRQHAKPGERLADFIDRVGWSKFLELVGLKEVHDYYQRVPEFARTF........ 365
32 -11.000[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  17  273..............CDFCLGDSKINKKTGQPEEL--------------VSCSDCGHPSCLQFTPVMMAAVKTY-------QCIECKCC-NIC----------------------------------------TSENDDQLLFCDDC-DRGYHMYCLTSCH........................................... 372
33 -10.400[R] KOG4684 Uncharacterized conserved protein, contains C4-type Zn-finger  ali follow..  17  53.........IPVINCRVCQSLINLDGKLH----------------QHVVKCTVCNEATPIKNPPTGKKY-----------RC-PCN-CLLICKDTSRRIGCPRPN-----RRIINLGPVMLISEEQPAQPALPIQPEGTRVVCGHCGNMELRFNTLAKCP........................................... 175
34 -10.200[C] COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC  ali follow..  15  376.................................................SCIRC--GLCVDACPAGLLEEHEKARNHNLFDCIECGACAYVCPSNIPLVQYYRQEKAEIRALDQESARAAEAKARFEAKQARLAREK-LARELRHKQAAVKLTDADQQTVDAAVSRLTRQSDGSESVINIPAGQMPDNSAV............ 524
35 -9.790[R] COG1453 Predicted oxidoreductases of the aldo/keto reductase family  ali follow..  16  296.................................................................................CTGCQYCM-PCPSGV---NIPECFSIYNHLSTFGNAEDANLLYIGLLSGAVSGGKPGMASQCVQCG------QCLEKCPQHIDIPTILESVAEELEGSDLEERIAIVK.............. 393
36 -9.780[O] COG1180 Pyruvate-formate lyase-activating enzyme  ali follow..  15  15............IRCLACARKCLIGEGQVGFCGVRSVRNGKLYLDVYGKIAAAHID--PIEKKPLVHFNPGSKVFSFSTYGCWMCMYCQNYD............................................................................................................... 93
37 -9.700[R] KOG3183 Predicted Zn-finger protein  ali follow..  13  9............LG-KHCSVYCKQID-------------------FLPFTCDRCLQVYCLD---RSYMKHDCPKGNRGDVTVVICPLCAKGVRLNPDEDPNITWEKHVNTDCDPSNYEKAVKKKKCPVPRCRELLTFSNTIKCRDCSID-----CLKSCSGPKKPESSFSFMGFLSTNTKEAPASSSSSSR............ 169
38 -9.500[C] COG1149 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain  ali follow..  17  1MKQVAVISGKGGTGKTTFSATIHALEGGVVADLKAEDFIASKKARIMPEKCSSCG---CYDLCRFGAVVAEDGYY-VDEKKCEGCAFCFNVCPERAIEMENVKTGDLYVSKTEWGYFVHARLKPGEENTGRLVTEVKNRAKE--LIVDSAPGVGCPVM--VDAAIIVTEPTVSGLSDMLRILELCEHFRI............. 213
39 -9.250[R] COG5141 PHD zinc finger-containing protein  ali follow..  17  207.......NSNAIVFCDNCNTSCYGIPFVPEGQ-----------------FCKKCLLAPCA-FCPDGAFCTTLD------------RWCHTICAIAIPEISFHDTSRLDLVRNIASIPKSR-------------------KLVCCICKLRWG--TCVQTCARRAGFFYKIYSHSASYDSVDMETY................... 358
40 -9.210[OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger  ali follow..  15  62..........KCNNCKDCHIICSYCGATDDHYSRH-----------KAIQCSKCDEV--RSQCPHKW----------KKVQCTLCKHSKERCPSIWRAYI-----------------------LVDDNEKAKPKVLPFHTIYCYNCGGKGH----GDDCKE.......................................... 179
41 -9.170[R] KOG2858 Uncharacterized conserved protein  ali follow..  27  1..............................................MAVLCGVCGIKEFKYKCP----------------RC-LVQTCSLEC............................................................................................................... 29
42 -9.050[S] KOG4791 Uncharacterized conserved protein  ali follow..  17  1....MPNQGEDCY--STCTKGCPFRHCEAALGN--------------ETVCTLWQEGRCFRVCRFRHMEIDKKRSEIP---CYGCQ---LNCVF............................................................................................................. 82
43 -9.030[K] KOG2857 Predicted MYND Zn-finger protein/hormone receptor interactor  ali follow..  34  5..............................................ATQTCEICEKVVSKYKCP----------------SC-LVPYCSLGC............................................................................................................... 33

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Comparative analysis of protein domain organization. Genome Res. 2004 Mar;14(3):343-53.