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Query: [C] COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLDTPMQGDLMAEEKKEETMEEPRIGVYVCHCGVNIGGVVDIEAVRDYAAKLPNVVVSKDYKYYCSDPGQLEIQKDIKELGLNRVVVAACSPRLHEPTFRRCVEEAGLNQFLFEFANLREQDSWVHMDDPEGATEKAKDLVRMAVAKARLLEPLEASKVSVDDKALVIGGGVAGIQTALDLADMGFKTYMVEKRPSISGRMGQLDKTFPTLDCSMCILAPKMVDVGKHDNIELITYAEVKEVDGYIGNFKVKIEKKPRYIDEDLCTGCGSCVEVCPIEMPNYFDEGIGMTKAVYIPFPQAVPLCATIDKDYCIECMLCDEICERGAVKHDQEPEEIEIEVGTIIVATGYDAYDPTEKLEYGYGRHTNVITGLELERMINASGPTDGKVIKPSDGEKPKRVAFIHCVGSRDEQIGKPYCSRVCCMYIMKNAQLIKDKMPDTEVTLYYMDIRAFGKGFEEFYKRSQEKYGIKFIRGRPAEILENPDLTLTVRSEDTLLGKVTEYDYDMVVLGVGLVPPEGSEKLRQTIGLSKSADGFLMEAHPKLRPVDTLTDGVYLAGVAQGPKDIPDAVAQASGAAARAAIPMVKGEVEIEPIVAVTDSDVCGGCEVCIELCPFGAISIEEGHANVNVALCKGCGTCVAACPSGAMDQQHFRTEQIMAQIEAALNEQAKLast
1 -157.000[C] COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins  ali  100  1MLDTPMQGDLMAEEKKEETMEEPRIGVYVCHCGVNIGGVVDIEAVRDYAAKLPNVVVSKDYKYYCSDPGQLEIQKDIKELGLNRVVVAACSPRLHEPTFRRCVEEAGLNQFLFEFANLREQDSWVHMDDPEGATEKAKDLVRMAVAKARLLEPLEASKVSVDDKALVIGGGVAGIQTALDLADMGFKTYMVEKRPSISGRMGQLDKTFPTLDCSMCILAPKMVDVGKHDNIELITYAEVKEVDGYIGNFKVKIEKKPRYIDEDLCTGCGSCVEVCPIEMPNYFDEGIGMTKAVYIPFPQAVPLCATIDKDYCIECMLCDEICERGAVKHDQEPEEIEIEVGTIIVATGYDAYDPTEKLEYGYGRHTNVITGLELERMINASGPTDGKVIKPSDGEKPKRVAFIHCVGSRDEQIGKPYCSRVCCMYIMKNAQLIKDKMPDTEVTLYYMDIRAFGKGFEEFYKRSQEKYGIKFIRGRPAEILENPDLTLTVRSEDTLLGKVTEYDYDMVVLGVGLVPPEGSEKLRQTIGLSKSADGFLMEAHPKLRPVDTLTDGVYLAGVAQGPKDIPDAVAQASGAAARAAIPMVKGEVEIEPIVAVTDSDVCGGCEVCIELCPFGAISIEEGHANVNVALCKGCGTCVAACPSGAMDQQHFRTEQIMAQIEAALNEQAK 669
2 -25.400[C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit  ali follow..  25  2......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NTLFGKAKEEARVISPKSVDEYPEAPITLGTTLVNFTGDWRTFMPVIDESKCVKCYICWKFCPEPAIYIEDGFVAIDYDYCKGCGICANECPTKAITMVR................... 102
3 -21.600[C] COG1146 Ferredoxin  ali follow..  18  1..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAEAKNAPLIGKDALGREVRDLSKVPWWGVDRKEIYPTIDYDKCVTCGICFVTCGRRVFDFDKKIVARPYNCMVACQTCMNLCPTGAISFPDASYIKKLVAQNKIVKKAFE 117
4 -18.800[C] COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB  ali follow..  22  61.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AEAISCNGEKINRCAPGGEAVMLKIAELLNVEPQPLDGEAQELTPARMVAVIDENNCIGCTKCIQACPVDAIVGATRMHTVMSDLCTGCNLCVDPCPTHCISLQPVAET............... 170
5 -16.600[C] KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit  ali follow..  28  111..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YPSGEERCIACKLCEAICPAQAITIEAEERDIDMTKCIYCGFCQEACPVDAIEFSTETHEELLYNKEKLLCNGDK 201
6 -16.000[C] COG1145 Ferredoxin  ali follow..  21  240........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VHLTERSKHVATICNCCSDCCVFFKAVHEAKHPNTIAHSSYLATVDTSRCIACGICMLRCPMKAIKAKINPASVDAEKCLGCGVCVPTCPMEAIELVERDEPDGMTYVQELLADKGR 362
7 -15.400[R] KOG2960 Protein involved in thiamine biosynthesis and DNA damage tolerance  ali follow..  15  5......................................................................................TAVVTPQTAFKTDLPVEKTAHNTVVKSEMGALSKAYPTYSLDESFSFAPIRESTVSRAMTR----RYFSDLDKYAESDIVIVGAGSAGLTAAYYIGTRDLKIAIIEASVAPGGGA.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 117
8 -15.300[C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)  ali follow..  26  58.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GEERCVACNLCAVACPVGCISLQKAETRINFSRCIFCGLCEEACPTTAIEMGEFKRQDLVYEKHDLLISGPG 145
9 -14.200[H] COG1635 Flavoprotein involved in thiazole biosynthesis  ali follow..  19  1.........................................................................................................................................MELDEVIITRAIFDEYSKTFLDYTDIDVALVGGGPANLVAAKYLAEAGVKVALYEQKLSLGGGMWAGGMMFP-----RIVVQEEATRILDDFGIRYKEYESVANSVESVGKLIAGATSAGAEV......................................................................................................................................................................................................................................................................................................................................................................................................................... 121
10 -13.600[ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases  ali follow..  15  60.............................CPLHNHIPQWIELVKAGNIDAAVELSHLTNTLPEITG-----------------RVCPQDCEGACTIRDEHGAVTIGNIERYISDQ------------------------------ALAKGWRPDLSHVTKVDKRVAIIGAGPAGLACADVLIRNGVAVTVYDRHPEIGGLLT-----IPSFKLDKSLLARRREIFSA--GIHFELNCEVGK----------------------------------------------------------------------------------------DVSLDSLLEQYDAVFVGVGTYR---SMKAGLPNEDAPGVYDALPFLIANTKQV---------MGLEELPEEPFINTAGLNVVVLGGGDTAMDCVRTALRHG--------ASNVTCAYRRDEANMPGSKKEVKNAREEGANFEFNVQPVALELNEQGHVC-RRPVPVEGSEFVMPADAVIMAFGFNPHGMP--WLESHGVTVDKWGRIIADVESQYRYQTTNPKIFAGGAVRGADLVVTAMAEGRHAAQGIIDWLGVKSVKSH.............................................................................. 479
11 -12.500[C] COG1142 Fe-S-cluster-containing hydrogenase components 2  ali follow..  24  16......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HTCEAACSETHRQHGLQSMPRLRVMLNEKESAPQLCHHCEDCAVVCPVNAITRVDGAVQLNESLCVSCKLCGIACPFGAIEFSGSRPLDIPANANTPKAPPAP 120
12 -12.400[O] COG3634 Alkyl hydroperoxide reductase, large subunit  ali follow..  14  105.................................................................AQSLLEQIRDIDGDFEFETYYSLSCH-AVLNPRIKHTAIDGGTFQNEITERNVMGVPAVFVNGKEFGQGRMTLTEIVAKVDTGAEKRAAEALNKRDAYDVLIVGSGPAGAAAAVYSARKGIRTGLMGER--FGGQVLD------------------TVDIENYISVPKTEGQKLAALKAHVSDYDVDVIDS--------------------------------------------------------QSASKLVPAATEGGLHQIETASGAVLKARSIIIATGAK-----------WRNMNVPGEDQYRTKGVTYCPHCDGPLFK-------KRVAVIGGGNS-----------------GVEAAIDLAGIVEHVTLLEFAPEMKADQVLQD---KVRSLKNVDIILNAQTTEVKGDGSKVVGLEYRDRVSGDIHSVALAGIFVQIGLLPNTHWLE------LERNRMGEIIID----AKCETSVKGVFAAGDCTT-KQIIIATGEGAKASLSAFDYLIRTKIA................................................................................ 521
13 -11.900[S] COG3349 Uncharacterized conserved protein  ali follow..  16  2...................................................................................................................................................................RVAIAGAGLAGLSCAKYLTDAGHTPIVLERRDVLGGLVAAYETGLHAFFGAYPNMLQLLKELGIEDRLQWKEHTLIFNQPDKPGTLS................................................................................................................................................................................................................................................................................................................................................................................................................................... 96
14 -11.700[C] COG1141 Ferredoxin  ali follow..  13  41............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ILRQKGVYVDEITCIGCKHCAHVAR--YIEPDYGRSRVIRQAEEVIQEAIDTCPVDCIHWVDYTELKNLEED......... 116
15 -11.600[C] KOG2415 Electron transfer flavoprotein ubiquinone oxidoreductase  ali follow..  10  32.............................................................................................................................RWSSTSTVPRITTHYTIYPRDKDKRWEGVNMERFAEEADVVIVGAGPAGLSAAVRLKQLDIRVCLVEKAAQIGACLGAFKELFPNYIVRLGHLVSWMGEQAEALGVEVYPGYAAAEVLFHDDGSVKGIATNDVGIQKD------------APKATFERGLELHAKVTIFAEGCHGHLAKQLYKKFDLRANCEPQTYGIGLKELWVIDEKNWKPGRVDHTVGWPLDRHTYGGSFLYHLNEEPLVALGLVVGLDYQNPYLSPFREFQRWKHHPSIRPTLEGGKRIAYGARALNEGGFQSIPKLTFPGGLL------GCSPGFMNVPKIKGTHTAMKSGILAAESIF-------NQLTSENLQSKTIGLHVTEYEDNLKNSWVWKLYSVRNIRPSCHGVLGVYGGMIYTGIFYWILRGMEPWTLKHKGSDFERLKPAKDCTPIEYPKPDGQISFDLLSSVALSGTNHEHDQPAHLNRNLSIYDGPEQRFCPAGVYEFVPFRLQINAQNCVHCKTCDIKDPSQNIN...................... 602
16 -11.600[C] COG1150 Heterodisulfide reductase, subunit C  ali follow..  15  5.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RDTVIREEDLNPDFLEELSELVEPVFEEEEVLSVQACYQCGTCTGSCPSGRRTSYRTRLIMRKLQCTTCYTCYERCPRGV------KIVDAVKAARNLAAKK.. 115
17 -11.600[C] COG0348 Polyferredoxin  ali follow..  20  222.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HRQQCDNCMDCYNVCPEPQVAKKSESPLVLSKDCISCGRCIDVCPEKVFIFTTRFNHSVNHSGE........ 291
18 -11.200[S] COG4716 Myosin-crossreactive antigen  ali follow..  17  1............................................................................................................................................MYYTSGNYEAFATPRKPEGVDQKSAYIVGTGLAGLAAAVFLIRAGERIHLFEELPLAGGSLDGI................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 68
19 -11.000[C] COG2440 Ferredoxin-like protein  ali follow..  16  20..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LVDPGRPHIKVRPHERPSALALTHICPAKCYELDKGQVETTSDGCMECGTCRVLCEASG........................ 81
20 -10.800[C] KOG2495 NADH-dehydrogenase (ubiquinone)  ali follow..  11  44..LKRILHADATLDSDGNPIRKKKVVVL----GSGWSGYSFLSYLNNTNGTVEARSIVEPIRGLMRKKGFEYKEAECVKIDASNIHCRSKEGSSLKGTYDILILAVGAKPNTFNTPGVEEHAYFLKEAED---ALNIRHSVIDCFERASLPNLTEEERKKI--HFVVVGGGPTGVEFSAELHDF-TKITLLEAGDHI---LNMFDKR----------ITAFAEEKFQRDGIDLKTGSMVVGVTAD----EISTKERETGKIVSEPYGMVVWSTG........................................................................................................................................................................................................................................................................................................................................................................................................... 335
21 -10.500[C] COG0437 Fe-S-cluster-containing hydrogenase components 1  ali follow..  23  73...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PACTKVCPSGAMHKREDGFVVVDEDVCIGCRYCHMACPYGAPQYNAEKGHMT--KCDGC-ICVESCPLRALEFGPIEELR--QKHGTLAAVAP. 170
22 -10.400[E] COG1231 Monoamine oxidase  ali follow..  16  18...................................................................................................................PTRRQLLSAIAKVGGTAALYQAMTSLGHAAETRFPGPPNLQGARP-GASVIVLGAGLAGLLAAFELRKAGYKVQILEFQNRPGGRNWSLRGGDSYTELGGATQKVGYAAGNYFNPGPWRIPHHHRTLLHYCKQFGVALEP.............................................................................................................................................................................................................................................................................................................................................................................................................................. 156
23 -10.200[R] COG3380 Predicted NAD/FAD-dependent oxidoreductase  ali follow..  16  1................................................................................................................................................................MSVPIAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRMASKRSEAGTLDLGAQYFTARDRRFLD-TDLQVVFSCRITEVFRGKQHWHLQDSEGQNHGPFN...................................................................................................................................................................................................................................................................................................................................................................................................................... 152
24 -10.100[C] COG1251 NAD(P)H-nitrite reductase  ali follow..  14  1...................MSKVRLAII----GNGMVGHRFIEDLLDKDASLFDITVFCEEPRK----DRVHLSSYFSHHTAEELSLVR----------EGFYEKHGVK------VLVGERAITINRQEKVIHSSAGRDKLIMATGSYPWIPPIKGSETQ-SKRGAVVGGGLLGLEAAGALKNLGVETHVIEFAPML------MAEQLDQM------GGEQLRRKIESMGVRVHTSKNTQEIVQQGNEARKTMRFADG-----------------------------------------------------------------------------SELEVDFIVFSTGIRP------------------DKLATQCGLAVAQRGGIVINDTCQTSDPDIYAIGECASWNNRVYGL---AQVAVDHILGSENAFEGADLSAKLKLLGVDVGGIGDAHGRTPGARSYVYLDESKEVYKRLIVSEDNKTLL----------------GAVLVGDTSDYGNLLQLVLNAIELPENPDSLILPSHAGSGKPAIGVDKLPDSAQICSCFDVTKDLIAAINKGCHTVAALKAETKAG------------TGCGGCINLCEHFAYSRQELFHLIRVEGIKGCEVCK---PTVGSLLASCWNEYILKPQHTPLQDTND 553
25 -10.000[R] COG2768 Uncharacterized Fe-S center protein  ali follow..  25  197..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PQIDEEKCTKCDECVKICPSNAIE----DYQINREKCVKCLGCSEACDYGAVKTFWVFGRDVSERIVECTKG... 264
26 -9.850[C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit  ali follow..  20  241....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VGDLISNGMVSGAYPPGTAAYEKRGIALEVPEWISENCTMCNECAFVCPHAAIRPIRYRIQVSPMDCTGCNLCAETCPAKDKALVMKPFEEVAAKENPNWS.... 366
27 -9.750[C] KOG1335 Dihydrolipoamide dehydrogenase  ali follow..  12  9.................................................................................................................................CSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVG--IPSKA------------LNNSHYYHMAHGTDFASRGIEMSEVRLKMMEQKSTAVKALTGGIAHL---------------FKQNKVVHVNGYGKITGKNQVTAT-------------------KADGGTQVIDTKNILIATGSEVTPFP-------------GITIDEDTIVSSTGA--------SLKKVPEKMVVI--------------------VIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMENFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGL-EELGIELDPRGRIPVN----TRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLPFAAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCED... 479
28 -9.590[Q] KOG0029 Amine oxidase  ali follow..  23  2.......................................................................................................................................ESGGKTNRQLRKAICVSTDEKMKKKRSPSVIVIGGGMAGISAARTLQDASFQVVVLESRDRIGGRVHTDYSFGFPVDLGASWLHGV----KENPLAAVIGRLGLP............................................................................................................................................................................................................................................................................................................................................................................................................................................. 103
29 -9.530[O] COG0492 Thioredoxin reductase  ali follow..  15  9...................................................................................................................................................................DITIIGGGPTGLFAAFYGGMRQAKVKIIESMPQLGGQLAALYPE---------------KYIYDVAGFPKVKAQDLNDLKRQAEQFNPTIALEQSVQNVTK-----------------------------------------------------------ETDDTFTIKTDKETHYSKAIIITAGAGAFQPR---------------RLEVEGAKQYEGKNLQYFVNDLNAYAGKNVLISGGGDS-----------------AVDWALMLEPVAKNVTLIHRRDKFRA----HEHSVELLQKSSVNILTPFAISELSGDGEKIHHVTIQEVKGDAVETLDVDEVIVNFGFVSSLGPIK------GLEIEKNSIVVN----TKMETNIPGIYAAGDICT-KLIATGFGEAPTAVNNAKAFIDPTARVFPGHSTSL........................................................................ 329
30 -9.190[C] COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits  ali follow..  13  1.......................................................................MLNDVVRDAEGEKVFLLG------NEAIARGAIEAGID---------------VFAAYPGTPSSEIADTLSDACRLLRGKMDFEYSANEKVAFEVAVGASLAGKRAMATMKHVGVNVAFVEQDNRWYGKAAKLPVVEPSSVQEAKDYAKLCFDLSEKFGMILRSYTRLSHASGVVELGKIPEKEFSRVEWERHPETDVVLPAHARK-----------LKPILLEKLEKIERYFNSSEMNWVDEGDGDVGIIACGLSYAYTKEALENLNLNLPVLKLSSMHPLPERLIENFVSQMKKVIVVEEVDPFVELHGRVETGIAKALGIKPSRDYEGIVAESQKLAAKAPPRPPVLCCPHS-ASFYAIRRVVDELGDAALPSDIGCYTLGINKPLEGVDITICMGASVGVSNGLAHVLNNKIIATIGDSINAVYNHADFVLVILDNSTTGMTGHQPHP---GTGFRGCGEAGKAVRIEDIVRGCGVEFVEVVNPYNVRKMVDVLRRALNARQPCAILWSRARRREGKIVTYKVTEDCTLCMECVNACP--ALIFDGEKVSIDQSLCVGCAVCAKICPNRAI....................... 617

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Comparative analysis of protein domain organization. Genome Res. 2004 Mar;14(3):343-53.