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Query: [R] COG1202 Superfamily II helicase, archaea-specific, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLFVIREGRKKGELEAFLIENPPEKLSQIRNVKADRIFRLIMRDGRLFKVLEGSQYRNPKEIEKLLRSSRIILADADEWEDYFRKKLMNKNVEKASLCRLCLLEGRITVLTEGNRIKYRNEYICERCAEEELKNELRVRFNSLGMLEQAKRLLAKFRDLDKVLYAFDPRFDPTEHPEVTKWDELKAKHVRVERMKVDEVDIPESFKNVLKLEGITELLPVQVLAIKNGLLKGENLLVVSATASGKTLIGELAGIPKALEGKKMLFLVPLVALANQKYEDFKRRYSKLGLKVAIRVGMSRIKTREEPVVVDTGIDADIIVGTYEGVDYLLRSGKKIGNVGTVVIDEIHMIDDEERGPRLDGLIARLRKLYPKAQFIGLSATVGNPQELARSLGMKLVLYDERPVDLERHLIIARNESEKWRIIAKLCKAEVMRKSSKGFKGQTIVFTYSRKRCHELASFLTGKGLKAKPYHSGLPYKQRKITEMEFQAQMIDVVVTTAALGAGVDFPASQVIFESLAMGNKWLSVREFHQMLGRAGRPLYHEKGKVYLIVEPGKKYSAQMDETEDEVALKLLTSPIEPVIVEWSDEIEEDNVLAHACVFNRLSVIEEVNSLTLGANRSAKKVLEKLEELGMVSIRGDIVRVTPYGRAVSMSFLLPSEGEFIRENLESMDPLGMAIHLLPFENAYLPGFLQREIESAVRGRISSNIFSSSFASVLEELDKIIPEISPNAADRLFLIYQDFFNCLEQDCTEFAMEMLSRKIAELRRDGYEPSKISEYFRKVYGLILYPGDVFTWLDGLIRKLEAIQRIAGVFKKKEVENEALLVKKELEEGRRFKVRGKDKLKGGEERWKKIARERRLLast
1 -159.000[R] COG1202 Superfamily II helicase, archaea-specific  ali  100  1MLFVIREGRKKGELEAFLIENPPEKLSQIRNVKADRIFRLIMRDGRLFKVLEGSQYRNPKEIEKLLRSSRIILADADEWEDYFRKKLMNKNVEKASLCRLCLLEGRITVLTEGNRIKYRNEYICERCAEEELKNELRVRFNSLGMLEQAKRLLAKFRDLDKVLYAFDPRFDPTEHPEVTKWDELKAKHVRVERMKVDEVDIPESFKNVLKLEGITELLPVQVLAIKNGLLKGENLLVVSATASGKTLIGELAGIPKALEGKKMLFLVPLVALANQKYEDFKRRYSKLGLKVAIRVGMSRIKTREEPVVVDTGIDADIIVGTYEGVDYLLRSGKKIGNVGTVVIDEIHMIDDEERGPRLDGLIARLRKLYPKAQFIGLSATVGNPQELARSLGMKLVLYDERPVDLERHLIIARNESEKWRIIAKLCKAEVMRKSSKGFKGQTIVFTYSRKRCHELASFLTGKGLKAKPYHSGLPYKQRKITEMEFQAQMIDVVVTTAALGAGVDFPASQVIFESLAMGNKWLSVREFHQMLGRAGRPLYHEKGKVYLIVEPGKKYSAQMDETEDEVALKLLTSPIEPVIVEWSDEIEEDNVLAHACVFNRLSVIEEVNSLTLGANRSAKKVLEKLEELGMVSIRGDIVRVTPYGRAVSMSFLLPSEGEFIRENLESMDPLGMAIHLLPFENAYLPGFLQREIESAVRGRISSNIFSSSFASVLEELDKIIPEISPNAADRLFLIYQDFFNCLEQDCTEFAMEMLSRKIAELRRDGYEPSKISEYFRKVYGLILYPGDVFTWLDGLIRKLEAIQRIAGVFKKKEVENEALLVKKELEEGRRFKVRGKDKLKGGEERWKKIARERRL 855
2 -98.200[R] COG1204 Superfamily II helicase  ali follow..  14 1335........................................................................................................................................................................................APTPLLDLQNAPVSSLNNPSFISLYP--NFKFFNKIQTQVFNSVYKTNDSVFIGAPNGSGKTVCAELALLHHWSQYGTAVYIAPIQEIVDRRYEEWYGKFSDLGDVLVKLTGERSQDLKL-------IQVADLIFCTPSQWDSLSKRWRSIQKVDFYICDELQLLGG-FYGPLYEIVISRIRYMEKNIRVVGLSVSVANARDLGEWLGTSNFSPKDRPNPLTIHLQSFSITHFPSLMLAMSKPIYRSLKNFISQRKSTIVFTPDRKVAKQLAFDLVTLKHGIAYISEITSSNDQNIVQYLYRHGLIKVLIASRDVIYSLKAKSNAVIVMGTQYYDGDYPISELLQMLGFTASIGSSELSQVILMTVTTKKYYKKFLNEPLPMESHLQVWLHDAFVSEISTQTIAVDWLTWSYMYRRLVANPAYYGLSEFLSDLVETTMNDLSEARLITVDDEDCVALNLAMIASHYGITYITMQTFALSLSERTKMKGLLEIVTSAAEYEQLPIRKYEDIVLERIHSRLPVRLSNPNY------------EDPHTKSFILLAAHFSRFELP---------PGLVIDQKFILTRVHNLLGACVD-----------TLSSEGHLIACIRPMEMSQMVTQALWDRD-SPLKQI............................... 1999
3 -70.500[R] COG1201 Lhr-like helicases  ali follow..  16  10........................................................................................................................................................................................................FHPKIQEALRTLGFTRPTEPQERAFPH-ILDGKHTLLIAPTGSGKTESAVLPVFNAILKGISALYITPLRALNRDMLSRIEVMGKLLDIKVQVRHGDTPQSERQRQSR----NPPDLLITTPETLQAMFRLRKNMETVTHVVVDEIHELASSKRGAQLAIGLERLVEISGEFQRIGLSATVGNPWEIAKFLAGA--VALLKLLEFDVISPQVSGEAEDREVMEIFASHLSLIRKIVEESQSTLIFVNTRQSAEALAAGFRKLGASIGVHHGSLSFEARVEAEEAFKAGALRGLICTSSMELGIDIGNVDRVVQ----YGSPRQVSRLLQRVGRAGHRLHEVSRGTVLSMEADDTAESMA------ITKAALEGRVEDISHVNSLDVVANQIAGMVMDFGEVGIEKRAYPFRDLRPEELQRVVDQIGDYRLVWHEKGSQIVKKRRKSWQYYYMIPDEKKYEIYDIVGGRSIGVLDEAFVVGAVFITKGDMWRVIEMPDREREPSRDREGMGEVPSWTGEEIP-VPFEVAQDVGKLRAEIAALLRDG--LEDEAVAEKLRLKYPVSRSAVLELIRLIRDQVEGFPLPDAETIVIEDEGDAV----TLNACFGHNTNGTLARVLTSLLS............................. 661
4 -52.800[L] COG4581 Superfamily II RNA helicase  ali follow..  23  262....................................................................................................................................................................................................PIENFQQLVPEMALDFPFE-LDNFQKEAIYH-LEMGDSVFVAAHTSAGKTVVAEYAIALAQKHMTKAIYTSPIKALSNQKFRDFKHKFEDVGI----LTGDVQVNP-----------EGSCLLMTTEILSMLYRGADLIRDVEFVIFDEVHYVNDLERGVVWEEVIIML----PHVTLILLSATVPNTKEFASWVGIYVISTLKRPVPLEHYLWVKQNRGSAKSVERRDANTWVHLIGHLHKQNPVIVFVFSKKRCEEYVDTLTNLSRGLAVHHGGLLPIIKEIVEILFQRGLVKVLFATETFAMGVNMPAKSVVFSGTQKHDRDLLPGEYTQCSGRAGRRGLDVTGTVIILSRSEASLRHMIMGPSSKLISQF------RLTYNMILNLLRVETLRIEDMIKRSFSENVNQTLVPQHEEKIKSFEEKLSALK.................................................................................................................................................................................................................................. 781
5 -38.300[A] KOG0350 DEAD-box ATP-dependent RNA helicase  ali follow..  18  126.................................................................................................................................................................................................VEFSSLNISSKLVERLQKQNITRGFAVQAAVLPLLLQDGGDVCVSAATGSGKTLSYVIPIVQCLSHRTRCVVIVPTRELTVQVAKTFEYYMSGAGLQVCAWTGQKSLRHETYQLN-ENECRIDVLVSTPGRLVDHIRNDESLQHLRYMVIDEADRLLDQSFQDWVDTVMMEISRLPSPLQKLVFSATLTDPSKIAS----------HNPRLVLVQNKDMEVDDGGEIEDDAIVFSVPPTLQEYKNLTNILCFVKSNEAAARLHRLLENQSFSCGLFTSSLSRDERKKIISRFATGDLNLLVCSDLMARGIDVANTQNVIN----YDPPLSVRSYVHRIGRTARAG--REGFAWTLVQSHEG............................................................................................................................................................................................................................................................................................................. 546
6 -37.500[R] KOG0354 DEAD-box like helicase  ali follow..  17  72.......................................................................................................................................................................................................................SFRDYQFNIVQKALF--ENVLVALPTGLGKTFIAAVVMMNYLRPKSYIVFMAPTKPLVTQQMEACYKITGIPKSQTAELSGHVPVTTRN-----QYYQSRNVFFVTPQTINDIKHGICDRTRISCLVIDEAH---RSTGNYAYVEVVHLLSLSNKNFRILALSATLEAIQNVIDSLHISRIEITENSIDISQYVQKKEVDFFPVDLSAEITDIRDRFSSILTKDTRIMIFVEIRSSAEEILRFLGKIGQSAVRKAAGMSQKLQNETVKQFQKGEVNTLIATSIGEEGLDIGEVDMIIC----YDASASPIRMLQRMGRTGR---KRKGYIYMLLTREEAKWERAKDAYRTLQDNIVS........................................................................................................................................................................................................................................................................................... 570
7 -36.900[R] COG1203 Predicted helicases  ali follow..  17  2............................................................................................................................................................................................................VIKAFRKLTGHSPYEYQKEAMDN-LLEGKSLIIRAPTGAGKTEASLIPFIYGLNDYPQLIYSLPTRTLVESIGERAIKYASFKKLRVAIHHGKKATSS-----------EEDIIVTTIDQT-SMPKRWGNIF--ALTVFDEVHTL-DPEKGLQTAAAIAMQSA---GLPSIIMSATLPDIERVKERIEKNGGKVEIMDVKNESEIKSRRNRKVELINRPDEMLTADTVLKEAENCRKLVVVVNTVERAQNLYLDLRKKDYPIFLLHSRYLEKDRAEKEKSFEK---CIFISTQVIEVGMDISSPIILSEVA-------PIDALIQRAGRCARWGGNGEFHVFGLARDSSNPYAPYLKELIESTITEIRSKGDFPLDWQTELQLVNNVLSSHFEFFM-RLGELARAVYEGSKAKVEQNVREIFSCDIT................................................................................................................................................................................................................................ 438
8 -36.700[A] KOG0331 ATP-dependent RNA helicase  ali follow..  17  83......................................................................................................................................................................................TVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVAL-SGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFCLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLE----RGVEICIATPGRLDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIR---PDRQTLMWSATWPEVRQLAE-IGALELSANHN---ILQIVDVCHDVEKDEKLIRLMEEIMS------EKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVIN----YDYPNSSEDYIHRIGRTARST--KTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVED.................................................................................................................................................................................................................................................................................. 477
9 -36.300[A] KOG0347 RNA helicase  ali follow..  18  180......................................................................................................................................................................................QVEEEEIPPEFSAWSSMRLHPLLMKSIYRLDFKEPTKIQKACFNVAAYQGKDVIGAAETGSGKTLAFGLPILQRLLDERRALIITPTRELALQVTEHLENAAKNLSVKVVPIVGGMFSEKQERRLK----EKPEIVVATPGRLWELMSAGEELHSLSFFVLDEADRMVERGHFRELQSILDLLPVTDKP-QTFVFSATIAEVNSIEVLSERAGMRDNVAIIDLTTTSILAPKIEESFIKCEEKEKDAYLYILSVHGQGRTIVFCTSVTDLRHISGLLKILGLDVCTLFSEMKQRARLKSIDRFRASENGILIATDLVARGIDIKNVRTIIH----YKLPHSAEVYVHRCGRTARAF--ADGCSIALIEPNET............................................................................................................................................................................................................................................................................................................. 612
10 -35.900[A] KOG0336 ATP-dependent RNA helicase  ali follow..  18  230.........................................................................................................................................................................................................YPDLLKSIIRVGIVKPTPIQSQAWP-IILQGIDLIVVAQTGTGKTLSYLMPGFIHLDSQPIMLVLTPTRELALHVEAECSK-YSYKGLKSICIYGGRNRNGQIEDIS----KGVDIIIATPGRLDLQMNNSVNLRSITYLVIDEADKMLDMEFEPQIRKILLDVR---PDRQTVMTSATWPTVRQLASYLK--------DPMIVYVGNLNLVAVNTVKQNIIVTTEKTQEFVENMSPNDKVIMFVSQKHIADDLSSDFNIQGISAESLHGNSEQSDQERAVEDFKSGNIKILITTDIVSRGLDLNDVTHVYN----YDFPRNIDVYVHRVGYIGRTG--KTGTSVTLITQRDSKMAGELIKILDRANQSVPEDLVVMAEQ.................................................................................................................................................................................................................................................................................. 603
11 -35.100[A] KOG0342 ATP-dependent RNA helicase pitchoune  ali follow..  16  7...............................................................................................................KRKKHQSGNEEVKEKRQKPLKNDKKIAEELPQDEDDYEQEEENEDADQNTSVESESEELDNENEDERVQKSVNLNASSTSDIEKFSDLQLSENIQKAIKEMGFETMTEIQKRSIPPLL-AGRDVLGAAKTGSGKTLAFLIPTIEMLYAGTGVIIISPTRELALQIFGVAKELLKYHHQTFGIVIGGANRRAEADKLV----KGVNLLVATPGRLLDHLQNTKVFRNLRSLVIDEADRILEIGFEDEMRQIMKIL---SENRQTLLFSATQTTVEDLARYVNVDSGKPTSTVEGLEQGYVVVDSDKRFLLLFSFLKR---------NLKKKVIVFMSSCASVKYMAELLNYIDLPVLDLHGKQKQQRRTNTFFEFCNAEKGILLCTNVAARGLDIPAVDWIVQ----YDPPDDPRDYIHRVGRTARGTKGTGKSLMFLAPSELGFLRYLKTAKVSLNE............................................................................................................................................................................................................................................................................................... 461
12 -35.100[A] KOG0332 ATP-dependent RNA helicase  ali follow..  15  207...............................................................................................................................................................................................SISSFRELRLKPEVLKALDTMNFQFPTRIQETALPLLLMPPSNLIAQAQSGTGKTAAFVLTMLCRILMCPQCICLAPTLELAKQIGEVVEKMGKFINLKIHYAIKGGNMAAMRGRK-----LTEQIVIGTPGITRDYLQKYKCISKIRCLVLDEADVMIYHQGFTDISTTIYNVEDASDSVQSMLFSATYDE--PVINF--ATKIIKNAIVVMLKREEQALPNIKQFYVQCACRDSKYAAIVNLYSGLASSVIFCHTKASVMWLYENMRARGHQVDVLHGDMTVVERADTIIHFKRGDFKVLITTNVFARGIDVAQVSVVIN-VVDGFTQPDCETYLHRIGRTGR--FGKTGIAINLIDSEDSM............................................................................................................................................................................................................................................................................................................ 582
13 -34.800[A] KOG0341 DEAD-box protein abstrakt  ali follow..  19  135......................................................................................................................................................................................IVNGDDIPPPIKNFKDMKFPRPVLDTLKEKGIVQPTPIQVQGLPVIL-AGRDMIGIAFTGSGKTLVFVLPMIMIALQEEMGLIVCPSRELARQTYEVVEQFVAPLPLRSLLCIGGIDMRSQLEVVK----RGVHIVVATPGRLDMLAKKKMSLDACRYLTLDEADRLVDLGFEDDIREVFDHFK---SQRQTLLFSATMPKIQIFAR-----SALVKPVTVNVGRAGAANLDVIQEVEYVKQEAKIVYLLECLQKTSPPVLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDREYAISSFKAGKKDVLVATDVASKGLDFPDIQHVIN----YDMPAEIENYVHRIGRTGRCGKTGIATTFINKNQSETTLLDLKHLLQEAKQRIPPVLAE....................................................................................................................................................................................................................................................................................... 530
14 -34.500[A] KOG0340 ATP-dependent RNA helicase  ali follow..  18  36...........................................................................................................................................................................DQNTPQFEKFTNPNPSSDTTSATNFEGLGLAEWAVETCKELGMRKPTPVQTHCVPKIL-AGRDVLGLAQTGSGKTAAFALPILHRLAEDPYALVVTPTRELAFQLAEQFKALGSCLNLRCSVIVGGMDMLTQTMSLV----SRPHIVITTPGRIKVLLENNPVFSRTKFLVLDEADRVLDVGFQDELRTIFQCL----KSRQTLLFSATMTNLQALLE-YFYEAYEGLKTVDTLTQQFIFEDKDAKELYLVHILSQ------MEDKGIRSAMIFVSTCRTCQRLSLMLDELEVENIAMHSLNSQSMRLSALSKFKSGKVPILLATDVASRGLDIPTVDLVIN----YDIPRDPRDYVHRVGRTARAG--RGGLAVSIITETDVKLIHKIEE..................................................................................................................................................................................................................................................................................................... 419
15 -34.300[A] KOG0344 ATP-dependent RNA helicase  ali follow..  21  49.........................................................................................................................................................................................PDPIATFQQLDQEYKINSRLLQNILDAGFQMPTPIQMQAIPVML-HGRELLASAPTGSGKTLAFSIPILMQLKKGFRALIISPTRELASQIHRELIKISEGTGFRIHMIHKAAVAAKK---FGPKSSKKFDILVTTPNRLIYLLKQDPDLASVEWLVVDESKLFEDGKTGDQLASIFLACT--SHKVRRAMFSATFADVEQWCK-ISVSIGARNSAVETVEQELLFVGSETGKLLAMRELVKK--------GFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVIN----YDFPTSSVEYIHRIGRTGRAG--NKGKAITFFTEDDKPLLRSVANVIQQAGCPVPEYIKGFQKL.................................................................................................................................................................................................................................................................................. 440
16 -34.000[LKJ] COG0513 Superfamily II DNA and RNA helicases  ali follow..  20  2.................................................................................................................................................................................................TTFAELGLSPKVIAAVEAAGYTAPTPIQAGAIPPAL-ERKDVLGIAQTGTGKTASFVLPMLTLLEKGRRTLILEPTRELAAQVEENFVKYGINHRLNVALLIGGVSFEEQERKLE----RGADVLIATPGRMDHFERGKLLLTGVEILVIDEADRMLDMGFIPDIERICKLI---PFTRQTLFFSATMPPITKLTEQFLHSPVRIEVAKASSTAKTVTQRLVKSGKKDWDKRAVLRDLIQSEGDSLKNAIIFCNRKKDVSELFRSLTRHEFDAGALHGDMDQRARMAMLSSFKDGKLRLLVASDVAARGLDIPDVSHVFN----FDVPIHAEDYVHRIGRTGRAG--RSGKAFTIVTSSDTKYLAAIES..................................................................................................................................................................................................................................................................................................... 364
17 -34.000[A] KOG0348 ATP-dependent RNA helicase  ali follow..  19  32....................................................................................................................................................................................................SSLGLDTKLSDQLKERGFEAPTLVQAQAIPVIL-SGRDVLVNAPTGTGKTIAYLAPLIHHLQGGTFALVIVPTRELCLQVYETLEKLLHRFWIVPGYVMGGEKKAKEKARLR----KGISILIATPGRLLDHLKNTAVHKNLRWVIFDEADSILELGYGKEIEQIIKLLGSGQNE-QNLLLSATLNKVNDLAK---NPLSEDYGIPSQLVQRYLRVPCGARLVALLSVLKNLFER-----EASQKVVVFFSTRDAVDFHYSLLSEFKCKTFRLHGSMEQEDRRSAFGTFKTEKQAVLLSTDVAARGLDFPKVRCIIQ----YDCPGEATEYVHRVGRTARIG--EKGEALLFLQPIEIDYLKELKKH.................................................................................................................................................................................................................................................................................................... 467
18 -34.000[A] KOG0346 RNA helicase  ali follow..  16  1....................................................................................................................................................................................MEKSGGIREESSEKTFSDFNLDPRLQRAIHKCEFEKPTSVQSETIPLAL-EGKDLVAQARTGSGKTAAYLIPILELLLKQKFALLLVPTRELAQQVYNVLEKAFCSKHIRFINVATNSSDTVQRPLLL----DLPDIVIATPSRCVHVASGVLPLDKLKFLVIDEADLMLSFGYNEDMKTLSRSL----RGTQSFLMSATLSNIASLQKLV---------NPFILAVKDKEASGKLTQYVVKCSEQDKFLLAYILLKLRGKILIFVNEINRCYRLKLFLEQFGLKSLVLNSELPVNSRLHILEQYNKGLYQIIIATYGVARGLDFENVACVLN----FDMPSNTKSYIHRIGRTARAG--KPGTAMSFVVPKSEVGKHKPTS..................................................................................................................................................................................................................................................................................................... 443
19 -33.600[A] KOG0953 Mitochondrial RNA helicase SUV3, DEAD-box superfamily  ali follow..  16  128.............................................................................................................................................................................................................................DDIFPYFLRHAKTVFPLDCMDDLKKISD----LRQPANWYSARAITRKILLATEVYNKANER----GTPCDLVTGE------ERKFGISESLPANHVACTVEMTSV--------TPYEVAVIDEIQQIRDPQRGWAWTRAFLGLI--ADEVHVCGEPGALDLLQKICETTGETVEVRLYRLTELT------------------VENTALGSLDNIVPGDCIVCF--SKHDIYTVSREIEARGKEVAVIYGGLPPGTKLAQAAKFNANSCKVMVATDAIGMGLNLSIRRIIFYSLIKPSDTISVSSALQIAGRAGRFRTQWEHGYVTAFKSEDLLQRILARTPEPIKQAGLHPTADQIEL................................................................................................................................................................................................................................................................................... 459
20 -33.500[L] COG0514 Superfamily II DNA helicase  ali follow..  17  24.......................................................................................................................................................................................................TPERVLHEVF---GYQQFRVGQQEVIEAAL-AGRDSLVIMPTGGGKSLCYQIPAL---VLEGVTLVISPLISLMKDQVDQLKA----NGVAAECVNSTLAREELIAIYNRMHAGQLKLLYVSPERVLT-FIERLSHLPLAMIAVDEAHCISQ---GHDFR--LGQLKQRFPNVPVMALTATADD-HDIMQRLQLNQYLGSFDRPNIRYMLVEKHKPVSQVIRYLE-----------TQRGQCGIIYCGSRKKVEMLTEKLCGNHIRAASYHAGMDADERAWVQEAFQRDDLQIVVATVAFGMGINKPNVRFVV----HFDIPRNIESYYQETGRAGRDGLPAEAMMLYDPADMNWLRRMLDEKPDGAQKQVESHKLTAMGAFAEAQTCRRQVLLNYF................................................................................................................................................................................................................................................................... 401
21 -33.300[A] KOG0326 ATP-dependent RNA helicase  ali follow..  16  80............................................................................................................................................................................................TSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIAL-SGRDILARAKNGTGKSGAYLIPLLERLKDNIQAMVIVPTRELALQVSQICIQVSKHMGAKVMATTGGTNLRDDIMRLD----DTVHVVIATPGRIDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTL---PKNRQILLYSATFPSVQKFMN-----SHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVIN----FDFPKLAETYLHRIGRSGRFG--HLGLAINLITYDDRFNLKSIEE..................................................................................................................................................................................................................................................................................................... 440
22 -33.200[A] KOG0330 ATP-dependent RNA helicase  ali follow..  18  24...........................................................................................................................................................................SNSSSEKSSENNNGDSQNNEAPKTFKELGVIDELCEACEKLGFKTPTPIQQEAIPVVL-NKRDVIGLAQTGSGKTAAFALPVIQELWNNPSAVVLAPTRELAYQISEQFEAIGGSIGVRSVVIVGGMDMVTQAVALS----KKPHVLVCTPGRLMDHLENTKSLKNLKYLIMDEADRLLDMDFGPIIDKILKII----HERRTLLFSATMTSVEKLQR-----------QPVRVAKFSTVDTLIQRYLFFPFKHKDTYLVYLVNELAGNSIIIFARTVNDTQRLAILLRTLGFSAIPLHGQLSQSNRLGALNKFKSGARSTLVATDVAARGLDIPLVDVVIN----YDIPTDSKAYIHRVGRTARAG--RAGKSIALVTQYDLEPFLRIEA..................................................................................................................................................................................................................................................................................................... 402
23 -32.300[A] KOG0335 ATP-dependent RNA helicase  ali follow..  18  277......................................................................................................................................................................................EVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIP-IILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGICIIVAPTRELVNQIYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIV----QGCNILCATPGRLDIIGKEKIGLKQIKYLVLDEADRMLDMGFGPEMKKLISCPGMSKEQRQTLMFSATFPEIQRLAEFLKSNYLFVAVGQVDVQQTVLQVGQFSKREKLVEILRNI---------GDERTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKCPVLVATSVAARGLDIENVQHVIN----FDLPSTIDEYVHRIGRTGRCGNTGRAISFFDLESDNHLAQPLVKVLTDAQQDVPAWLEE....................................................................................................................................................................................................................................................................................... 673
24 -32.000[A] KOG0345 ATP-dependent RNA helicase  ali follow..  15  22.......................................................................................................................................................................................................PLSGDIIEALNQSDFEFCTPVQAATIPLLC-SYKDVAVDAATGSGKTLAFVVPLVEILRRQVMGVIISPTRELSTQIYNVAQPFVSTLNVNSVLLVGGREVKADMKIIEEEGC---NVLIGTPGRLSDIMERMEILRNLEILILDEADRLLEMGFQRQVNYIISRL----KQRRTGLFSATQTEVEELAK--SSQQLTNSKTPSGLHLEYMECEADKKSSQLVDLLIK---------NSDKKLIVFFMTCASVDYWGLVLSKISISLIPIHGDMKQNARDKALASFTKASSGALLCTDVAARGLDIPGIDYVVQ----YDPPQDPNMFNHRAGRTAR--LGRQGRAIVFLLPKEEAYVEFMRRRVPLEERKCSEDASDVIPII................................................................................................................................................................................................................................................................................. 416
25 -31.500[A] KOG0333 U5 snRNP-like RNA helicase subunit  ali follow..  19  290......................................................................................................................................................................................SIKGGRVPRPLRNWEEAGFPDEVYQAVKEIGYLEPTPIQRQAIPIGL-QNRDVIGVAETGSGKTAAFLLPLLVWITSLPKAIIMAPTRELAQQIEEETNKFGKLLGIKTVSVIGGASREDQGMKLR----MGVEVVIATPGRLDVLENRYLLLNQCTYVILDEADRMLDMGFEPDVQKVLEYMPDTNMK-QTVMFTATMSAIERLAR-AVVHIGSAGKPTERVEQVVYMVPEDRKRKKLVEVLES---------QFQPPIIIFVNQKKGADMLSKGLTKLGFKPTVLHGGKGQDQREYALQALKEGTSDILVATDVAGRGIDVKDVSLVLN----YDMAKSIEDYTHRIGRTGRAG--KHGKAITFLTPDDTAVYF------DLKQVLVESPVSSCPPEL................................................................................................................................................................................................................................................................................. 704
26 -31.400[L] COG1111 ERCC4-like helicases  ali follow..  20  1........................................................................................................................................................................................................MARYIEHPLIKPEKIEARTYQQLLAADVI-RKGNSMIVAPTALGKTVVAVLVAAERLYRGSKVLILSPSKPLAIQHEESFRE----MLATCTSLTGSIKPEERK-----ERWIKSQIISATPQTVSDILAGRYDLRDVSLIVFDECH---RAVGSYSYVFLASNYIQNARHPLILGLTASPGAKTVCENLFMNEVVVKTEGDPDVRPYLKPIKIEWVKVRMTPELEDIRELLRKVLGDEARIIVFTQFRDTLEEIYQRCKRYGQNSRSGEKGLTQKQQRDIIKSFRMGNHDVLLSTSVAEEGIDIPSVDLVVM----YEPVPSEIRMIQRRGRTGR---KRKGRMVVLITEDEAYYYSSIRKERSMKENLRG........................................................................................................................................................................................................................................................................................... 500
27 -31.200[J] KOG0327 Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases  ali follow..  17  1..................................................................................................................................................................MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCI-KGYDVIAQAQSGTGKTATFAISILQQILKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQME---APHIIVGTPGRFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKL---NSNTQVVLLSATMPDVLEVTK-----KFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVIN----YDLPTNRENYIHRIGRGGR--FGRKGVAINMVTEEDKRTLRDIET..................................................................................................................................................................................................................................................................................................... 389
28 -30.900[J] KOG0328 Predicted ATP-dependent RNA helicase FAL1, involved in rRNA maturation, DEAD-box superfamily  ali follow..  16  15......................................................................................................................................................................................EFETSEDVEVIPTFNAMNLKEELLRGIYAYGFEKPSAIQQRSITPIV-KGRDVIAQAQSGTGKTATFSISILQSLLRETQVLCLSPTRELAVQIQKVILALGDMMNVQCHVCIGGTNLGEDIRKLD----YGQHIVSGTPGRVDMIKRRVLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYL---PPATQVVLISATLPEILEMTS-----KFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERDEIMKEFRAGQSRVLITTDVWARGIDVQQVSLVIN----YDLPNNRELYIHRIGRSGR--FGRKGVAINFVKSDDIRILRDIEQ..................................................................................................................................................................................................................................................................................................... 382
29 -30.800[A] KOG0343 RNA Helicase  ali follow..  17  32........................................................................................................................................................................................EYDPKITKAKFFKDLPISDPTLKGLRESSFIKLTEIQADSIPVSL-QGHDVLAAAKTGSGKTLAFLVPVIEKLYRGLGALIISPTRELAMQIYEVLTKIGSHTSFSAGLVIGGKDVKFE-----LERISRINILIGTPGRILQHLDQAVNTSNLQMLVLDEADRCLDMGFKKTLDAIVSTL---SPSRQTLLFSATQSQVADLAR-----------DYKTVGTHDVMDGSVNKEASTPETLQQFYIEVPLADKLKCKMIVFLSSSKQVHFVYETFRKMQPGISL-HGRQKQRARTETLDKFNRAQQVCLFATDVVARGIDFPAVDWVVQ----VDCPEDVDTYIHRVGRCAR--YGKKGKSLIMLTPQEQEAFLKRLNARKIEKSIKPQLQSLLFKDPELKYLGQKAFISYVRSIYVQKDKQVFKFDELPTEEFAYSLGLPGAPKI................................................................................................................................................................................................................................. 489
30 -30.600[A] KOG0329 ATP-dependent RNA helicase  ali follow..  19  33.....................................................................................................................................................................................KDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAI-LGMDVLCQAKSGMGKTAVFVLATLQQLTGQVSVLVMCHTRELAFQISKEYERFSKYMNVKVAVFFGGLSIKKDEEVLKKNC---PHIVVGTPGRIALARNKSLNLKHIKHFILDECDKMLEQ-----RRDVQEIFRMTPHEKQVMMFSATLS--KEIRPVCRKFMQDPMEIFVDDETKLTLHGLQQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFN----YDMPEDSDTYLHRVARAGR--FGTKGLAITFVSDEND............................................................................................................................................................................................................................................................................................................. 396
31 -30.300[A] KOG0338 ATP-dependent RNA helicase  ali follow..  17  209........................................................................................................................................................................................EDASQYDENLSFQDMNLSRPLLKAITAMGFKQPTPIQKACIPVGL-LGKDICACAATGTGKTAAFALPVLERLIYKPRVLVLVPTRELGIQVHSVTRQLAQFCNITTCLAVGGLDVKSQEAALR----AAPDILIATPGRLDHLHNCPSHLSSIEVLILDEADRMLDEYFEEQMKEIIRMC---SHHRQTMLFSATMTDVKDLAS-----------NPVRIFV--------NSNTDVAPFLRQEFIRIRPNREGDRHVMLFTQTKKQAHRMHILLGLMGLQVGELHGNLSQTQRLEALRRFKDEQIDILVATDVAARGLDIEGVKTVIN----FTMPNTIKHYVHRVGRTARAG--RAGRSVSLVGEDERKMLKEIVK..................................................................................................................................................................................................................................................................................................... 580
32 -29.900[KL] KOG1123 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 3`-5` helicase subunit SSL2  ali follow..  17  331.......................................................................................................................................................................................................................VLRPYQEKSLRKMFGNGRA-VIVLPCGAGKSLVGVTACCTV---RKRALVLCNSGVSVEQWKQQFKMWSTADDSMICRFTSEAK----------DKPMGCGILVTTYSMITHTQKRSWEAEQTGIMVLDEVHTIPAKMFRRVLTIVQSHCK--------LGLTATLLREDDLNFLIGPKLYEANWLELQKKGYIATSKKMLLYVMNPSKFRSCQFLIKYHEQRGDKTIVFSDNVFALKHYAIKMNKPFI-----YGPTSQNERIQILQNFKNSKVNTIFVSKVADTSFDLPEANVLIQISSHGG---SRRQEAQRLGRILRAKKGAIAEEYN.................................................................................................................................................................................................................................................................................................................... 672
33 -29.700[A] KOG0349 Putative DEAD-box RNA helicase DDX1  ali follow..  17  2.................................................................................................................................................................................................AAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLIL-GGGDVLMAAETGSGKTGAFSIPVIQIVYETLKALIVEPSRELAEQTLNNFKKYIDNPKLRELLIIGGVAARDQLSVLE----NGVDIVVGTPGRDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVGKRLQVIVCSATLHSVKKLSEKI-VDLKGEDSVPDTVHHVVVPVNPKTDRSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVIN----VTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCEMQLLSEIEEHLNCTIS................................................................................................................................................................................................................................................................................ 671
34 -29.200[LK] COG1200 RecG-like helicase  ali follow..  20  268.......................................................................................................................................................................................................................QPTNAQKRVVSDIEQD--MRLVQGDVGSGKTLVAALAALTAIDNGKQVALMAPTEILAEQHANNFRRWFKPFGIEVGWLAGKVKGKSRQAELEKIKTGAVQMVVGT----HALFQEEVEFSDLALVIIDEQHRFGVHQR----LMLREKGEKAGFYPHQLIMTATIPRTLAMTVYADLDTSIIDELPTPITTVVVSEERRAEIVMRVKN---------ACVNEKRQAYWVCTEAQAAEAIWEDLTKAMLNIGLVHGRMKPQEKQDVMMRFKNAELDLLVATTVIEVGVDVPASLMIIENAERLG----LSQLHQLRGRVGR---CTASFCVLMYKPP............................................................................................................................................................................................................................................................................................................... 601
35 -28.700[A] KOG0339 ATP-dependent RNA helicase  ali follow..  16  254......................................................................................................................................................................................RVGGLKPPRPVCSFAHFSFDKLLMEAIRKSEYEQPTPIQAMAIPSAL-SGRDVLGIAKTGSGKTAAYLWPAIVHIMDQPDAVIVVPTRELAIQVFQEAKKFCKVYNINPICAYGGGSKWEQSNELQNE---GAEMVVCTPGRIDLVKMGATNFLRTTFLVFDEADRMFDMGFEAQVKSISDHVR---PDRQCLMFSATFKKVERLAR-VRIVQGEVGEANADIEQKVFVMQNQDVKL-------HWLIRNLVEFASLGKVLIFVTKKLDSEDVAKKLKMKDFDIVLLHGDMLQAERNENLLKFRKK-SQILVATDVAARGLDISEIRTVIN----FDMARDIDTHVHRIGRTGRAG--HKGTAYTLVTEKDIEMVGHLVKNLESVSQEVPKPLMDLAMK.................................................................................................................................................................................................................................................................................. 646
36 -28.500[L] COG4098 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein)  ali follow..  14  94.......................................................................................................................................................................................................................QLTPFQEKVSEGLVDKQKPTLVHAVTGAGKTEMIYQVVAKVINAGGAVCLASPRIDVCLELYKRLQQDF---SCGIALLHGESEPYFR-----------TPLVVATTHQL-------KFYQAFDLLIVDEVDAFPYVDNPMLYHAVKNSVK---ENGLRIFLTAT-STNELDKKVRLGEL-RFHGNPLIIPKPIWLSD--NRYLDKNRLSPKLKSYIEKQRKTAYPLLIFASEIKKGEQLAEILQEQFPNEKIGFVSSVTEDRLEQVQAFRDGELTILISTTILERGVTFPCVDVFVVEAN--HRLFTKSSLIQIGGRVGRSMDRPTGDLLFFHDGLNASIKKAIKEIQMMNK............................................................................................................................................................................................................................................................................................... 428
37 -27.900[KL] COG1061 DNA or RNA helicases of superfamily II  ali follow..  20  78.......................................................................................................................................................................................................................EPYPHQSEALAAWKLAGRQGVVVLPTAAGKTYLAQLAMQAT---PRTTLIVVPTLDLMHQWYAHLVAAFPD---EVGLLGGGSR-------------DKSPVLVATYDSA--AIHAEALGNQYALIVFDECHHLPTDFSKVIAEYAIAPYR--------LGLSATPERTDGLNILIGQEVYRKRAEDLQSGRRAMLAHREAKEIALGTDSKLRILANLLAKHYPERVLIFTADNATVYKISQDLL-----IPAITHQTPVKERHEILTKFREGEYNTLVASHVLNEGVDVPAAAIAI----ILSGTGSTREYIQRLGRILRKGNIQNKQAILY................................................................................................................................................................................................................................................................................................................... 436
38 -27.800[A] KOG0337 ATP-dependent RNA helicase  ali follow..  20  72..........................................................................................................................................................................DNDAGTSDRGADILKSKSKKNKSGGFQSMGLGFELIKGITKRGYKVPTPIQRKTIPLIL-EGRDVVAMAKTGSGKTACFLIPLFEKLTKGARALILSPTRELAVQTYKFIKELGRFMELKSILVLGGDSMDSQFSAIH----TCPDVIVATPGRFHLCVEMDLKLNSIEYVVFDEADRLFEMGFGEQLNETLHRL----SSRQTVMFSATLPK--LLVEFARAGL-----DPVLIRLDVESKLPDALALKFDDRYTALVVLLKYVIPVQSQTVVFAGTQHHVELISYILTEAGISNASVYSSLDPAARKINTAKFVNKKVSVLIVTDVAARGIDIPSLDFVVN----LHFPGKPKLFVHRVGRCARAG--RTGTAYSIVSTDDTAHLLDLH...................................................................................................................................................................................................................................................................................................... 453
39 -25.700[V] COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases  ali follow..  19  462.......................................................................................................................................................................................................................GLRYYQEDAVRAVEKAQQEILLAMATGTGKTRTA-IAMMFRLIQSKRILFLVDRRSLGEQALGAFEDTRINGDTDIKGLTDKFPED------------STKIHVATVQSLVKRTLQSDE-ARYDCIVVDEAH------RGYILD-YVSAYRRILDDAVKIALTAT--PALHTVQIFGEPVYRYTYRTPPIQIITRNAQEEVADFNRGLVIPAFNRAVCNELTNSQKTLVFCVTNAHADMVVEELRAAFKKKYPQLEH-ARKVQTMITRFNKERLPNIVVTVDLLTTGVDIPSICNIV----FLRKVRSRILYEQMKGRATRLCPEVNKTSFKIFD................................................................................................................................................................................................................................................................................................................. 861
40 -25.500[R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster  ali follow..  20  85............................................................................................................................................................................................................................QARAFQRLGSAPQPTLVATGTGSGKTECFMFPLLNHCAGGVKAIIIYPMNALATDQASRFAKTIAS-KVTVGLFVGDSEIEPSKKMSAEKVISPPDILLTNYKMLDYLLMRPGD-GSLRYLVVDELHTFDGA-QGSDLACLVRRLKHHNQRFACVGTSATVGD-GQLLDYAK-TIFDQPFTDVQLRSQLWL-NSKQGISILGSRAASLSAVMIHQLNEHKKLITFSDSVQDAAHRASFFTARTWPLMIHTGLLSREDREVTEKSFYRGNINLLSATPTLEMGIDVGDLSTVLLC----SVPPAQANYLQRIGRAGRKD----GNALNITVAEGNPHDQFFFEE---PLEMMQGQVQAPGVFLNATAILERQLAAFCMDNWVKTGVPESAICKNVKQMLDE........................................................................................................................................................................................................................................... 1142
41 -24.700[LK] COG1197 Transcription-repair coupling factor (superfamily II helicase)  ali follow..  16  588.........................................................................................................................................................................................................DREEFQQFSATFPFEETYDQEMAINAVISDMCQ-LVCGDVGFGKTEVAMRAAFLAVMNHKQVAVLVPTTLLAQQHYENFKDRFANLPVNVEVLSRFKTAKEQKQILENLAEGKVDILIGTHK----LIQSDVKFNDLGLLIIDEEHRFGVGQK--------EKIKQLRANIDILTLTATIPRTLNMA-MNGIRDLSIISTPPARRLSIKTFVRQNDDLVVREAILREI--------LRGGQVYYLHNDASIENTAEKLTALEARVIVGHGQMRERELERVMSDFYHQRYNVLVCSTIIETGIDVPANTIIIERADHFG----LAQLHQLRGRVGRS--HHQAYAYLLTPPPKMMTKDAERRLDALEN------LDNLGAGFILATHDLEIRGAGELLGNEQSGQIESIGFSLYMELLDAAVKALKEGREPSLEELTQQQADIELRVPALYLGDVNMRLFYKRIAAAESKAELDEL................................................................................................................................................................................... 1044
42 -24.600[A] KOG0923 mRNA splicing factor ATP-dependent RNA helicase  ali follow..  14  257............................................................................................................................................................................................................................FKEDLIAAVKEHQVLIIEGETGSGKTTVPQYLVEAGFTKDKKMIGCTPRRVAAMSVAARVA---EEMGVKLGNEVG-------SIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAH-----ERTLHTDILFGLVKDIRPELKLLISSATL-DAEKFSAFFDAPIFRIPGRRYPVDIFYTKAPEADYIDACCVSVLQ-----IHATQPLGDILVFLTGQDEIETCQEVLHDRVKRLG--YANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPQNNFNVPISKASANQRAGRAGRTA---PGKCFRLYT----------------AWAYKHELEDNTVPEIQRINLGNAVLMLKAL--GINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGE---LTKLGRRMAEFPVDPMMGKMLLAS-EKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKN........................................................................................................................................................ 723
43 -24.600[L] COG1643 HrpA-like helicases  ali follow..  14  82............................................................................................................................................................................................................................KKQDILEAIRDHQVVIVAGETGSGKTTLPKICMELGRGIKGLIGHTQPRRLAARTVANRIA---EELQTEPGGCIG-------KVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQYDTLIIDEAH-----ERSLNIDFLLGYLKELRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPIVEEADDTERDQLQAIFDAVDELGRESPGDILIFMSGEREIRDTADALNKLNLRVLPLYARLSNSEQNRV---FQHSGRRIVLATNVAETSLTVPGIKYVIDPISRYSEPISQASANQRKGRCGRVS---EGICIRLYSEDD-----------------FLSRPEFTDPEILRTNLASVILQMTAL--GLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITADQTAYKLTPLGRQLSQLPVDPRLARMVLEAQKHGCVREAM--IITSALSIQDPRERPVDKQQASDEKHRR........................................................................................................................................................ 547
44 -22.800[L] COG1198 Primosomal protein N` (replication factor Y) - superfamily II helicase  ali follow..  20  261.......................................................................................................................................................................................................................ELNPEQRQARDAVVSSIGSFLLQGITGSGKTEVYLQIIQGALDKGKTAILLVPEISLTPQMTERFIARF---GDKVAILHSGLSNGEKYDEWRKVERGDAQVVVGARSAIFA-------LKNLGVMIIDEEH--DSNPRYHAREVAILRAQYNQATL-VLG-SAT-PSLESRARHLRLTQRANPLATIP-EVQVIDFRDYIGQNETSNFTPPLLEAIQDRLVKKEQVVLMLNRRGYSSDISLTLHMDTKTMNCHYCGILRMDVDTTRDQFGRGEADILLGTQMIAKGLDFPNVTLVLNLPDFRSSERTFQLLTQVAGRSGR---EKAGQVLIQSYNPQHYAIRFAKDQD................................................................................................................................................................................................................................................................................................... 681
45 -22.700[A] KOG0925 mRNA splicing factor ATP-dependent RNA helicase  ali follow..  15  80............................................................................................................................................................................................................................QREEFLKIYHENQIIVFVGETGSGKTTQIPQFVLYD--TNTQIACTQPRRVAAMSVAKRVA---DEMDVDLGEEVG-------NIRFEDCSGPNTLLKYMTDGMLLREAMTDHMLSRYSCIILDEAH-----ERTLATDILMGLMKRLRPDLKIIVMSATL-DAKKFQKYFFAPLLAVPGRTYPVEIYYTQEPERDYLEAALRTVLQ-----IHVEEGPGDILVFLTGEEEIEDACRKITLEADDLV--YGSLPPNQQQRIFEPTPEDT-KVVISTNIAETSLTIDGIVYVVDPQKIYNSPISKASAQQRAGRAGRTR---PGKCFRLYT----------------EEAFRKELIEQTYPEILRSNLSSTVLELKKL--GIDDLVHFDYMDPPAPETMMRALEELNYLNCLDDNGD---LTPLGRKASEFPLDPNLAVMLIRSPEFYNEVLSLTALLSVPNVFVRPNSARKLADEMRQQFTHP........................................................................................................................................................ 557
46 -22.200[R] COG4889 Predicted helicase  ali follow..  15  174......................................................................................................................................................................................................................YSPRPHQQTAIEKAFQTHDRGKLIMACGTGKTFTA-LRLSEEVANKARILFLVPSISLLSQTLKEWTAQ-KTMDLRPVAVCSDSKVSKAAEDIAAYDLAGLTVVFSTYQSLPAVHAAQEAAEPFDLVICDEAHRTTGITLAGEDPSNFTRISYIKAAKR-LYMTAT-DHSAEVSSMDDEAIYGPEFHRLGFGEAVLTLDMTSAIIGAWNGLAKRSGKEQDTKTGFERAVAFARDIKTSQQIAESFPRVNLSVACQHGSMNALERNSRLTWLKAMETKILTNARCLSEGVDVPALDSVI----FFNPRNSMVDVVQSVGRVMRKSPGKNYGYIIL................................................................................................................................................................................................................................................................................................................... 611
47 -21.000[A] KOG0922 DEAH-box RNA helicase  ali follow..  14  43............................................................................................................................................................................................................................VEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNA-REGKMIGITQPRRIAAVTVAKRVA---EECEVQLGQKVG-------SIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAH-----DRSVHTDVLLALLKKIQRTLKLIIMSASL-DARVFSEYFGAKAVHVQGRQFPVDILYTVHPESDYVDATLVTIFQ---------EKPGDILVFLTGQDEIESVERLVQERLQNIPEDFSALPSEQQMKVFAPAPTGFRKVILATNIAETSITIPGIRYVIDP-SLDVVPASKAQTLQRSGRAGREG---PGKSFRLYPERE-----------------FEKLEDSTKPEIKRCNLSNIILQLKAL--GIDDIVGFDFIDKPSRGAIIKALAELHSLGAL--ADDGKLENPVGYQMSRLPLEPVYSKALILANQFNEEMLITVAVLSVESIFYDPREKREEARTSKNHFASV........................................................................................................................................................ 549
48 -20.500[S] COG3421 Uncharacterized protein conserved in bacteria  ali follow..  14  54.......................................................................................................................................................................................................................PFFEWQKSALENFVIRPTHLLFNMATGAGKTMMMAALILYYFEKGRHFLFFVNQNNIVDKTENNFIDPAHAKFLTEKILQGDTVIPIRKVEMFSPHSDGIEIKFTSIQKLYNDIHTERENQTT-VMLGDEAHHLNAQTKGKMVLELLLNKNGNPGQNVLLEFTATLPENADVQQKYADKII-ANFKPVMLFRSKTIDESKADYSAFLNWAENVQADDFEFLDTEQALKFMQDNKFGFAHLANWVKQNYQKHNVTNKNKTEKTDSETEKLLNNNPIRAIFTVDRLTEGWDVLNLFDIVSNKKSGKTAAATVSEKQLIGRGVR-AFEGKQPNKRKFDNDMQHELRILEELFYYTHDEQSRYISELKNEL................................................................................................................................................................................................................................................................................. 563
49 -20.400[L] COG1110 Reverse gyrase  ali follow..  14  71..........................................................................................................................................................................................................SEVEDLFKRATGFRFWSAQ-RTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVRLVYYHGNLKKKEKEEALKRIKDGDFDILVTSSTRFDELLRDKR----FDLIFVDDVDAFLKASKGFTQEVINRAWEVIKLKKQLAKLLQAQGKEKEVEE-VASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEGKGGLIFVPIIEFAEELTNYLKSKGFKVELVSAK----NKRGLEL-FERGEVDYLVGVATIVRGLDLPIRFAVFAGVPKFREQPTIYRVLGLMSEILE----------FLPQEKREEGEKLYARLRRLIRNIPQYELMKIEEALAEGIELEGFHNHVLAVEFLREVLRDEEVIRRISENPFLSLKEVEGKLYIEIPDVRTYIQASGR-TSRLFAGGITKGLSVIIVDDQKVFNGLIRQM.................................................................................................................................................................................. 590
50 -20.000[S] KOG2340 Uncharacterized conserved protein  ali follow..  10  21...........................................................EALLYLMNKNKKRKPEKKDDKEKSSKKVQKKNKVIESLNEMEVEMEDENENENDEQEAIQYYINVESQDADETLHQEAQDSSEDPFHQHFDYDDSEAYDEGKLCKSIEESKLGVSQSFFPDVTKRLPCSCLSEIKNIDDLGLKQRILDSYKKQKPSGLTSMQIELAK-AMFNYQDVFFTNMSHKLGTSLLALHALNHVFKTRKVLILLPTRNSAFEFINLLISYSGTNQVERYLFSGNTDDMTRKTVKLFSQFYNSDIIVASPLGLRLAIGNKGDLSSIEIAMVDQAHALVMQN--EHIECIFDELNGLPKEAQTILFSQYNNL--DINSFFSHYMSNIAGK-YKVTQTFVRISVDSIIKVPDARFSYFTGSILVQLKKYSGILVYIPSYFDFVRVRNYMDEEGINYSAISEYSSVSDMTRARNLFYQGRTNIMLYTERAHHRFDFRGVKAVV----MYGPPTNPQFYVELVRMPMRTISEGNLDSIMYTKFDSICLEGIVGYQ--RVSNMCHGKHE....................................................................................................................................................................................................................................................................................... 647
51 -17.300[B] KOG0389 SNF2 family DNA-dependent ATPase  ali follow..  14  288.......................................................................................................................................................................................................................QLADYQIIGLNVMHKQEMNGILADEMGLGKT-IQVIAFLAYLKENGLSLIVVPSSTL-----DNWEAEISRWELVVEKYHGSQDERRRRGRFAKDGFTGFDVLLTTYHIVGSTPEERKMFRVCDYVIFDEAHMLKNMT-----TQRYANLITINARMRIL-LTGTLLELISLLCFVMPKFFAKSMKPFVLRSLVEKVPMSSQQKIYYHELVDYYSLLPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDD--FLLSTKAGGVGINLTAADTCV----IHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESEEGILMAAEEKLKLEKDITSNEKGEVHEQRCVVKLLTTALG...................................................................................................................................................................................................................................................................... 822
52 -17.000[KL] COG4646 DNA methylase  ali follow..  13  489.......................................................................................................................................................................................................................VLYGHQKRGIWRIISAG-STYLAHAVGAGKTMTMAASIMRRLGLVAKAMQVVP-GHCLAQAAREFLALYPTARILVADET-NFSKDKRARFLSRAATATWDAIIITHSAFRFIGVPAAFEQQVDQIIVDEAQEFNGSQRAWDLYVKSRFIETINPGRALVLASGTITNLHEFDAWASTFSVITDGRHAAIDLRLVDADNDNEADNKLNNLISNAFNIWKATEGSTYLMIFSDL-SAYRWIRDELIRLGVQIAFMQDFKKSEAKQRLFGDVRAGSVRFLISSETMGTGVNAQLRLKALHHL---DVPWLPSQIEQREGRIVRQGNQHDEVDIFAYATEGSLDATMWQNNERKARFIAAALSGDTSIRRLEDLGEGQANQFAMAKAIASGDQRLMQKAG-----LEADIARLERLRAAHLDDQHAVRRQIRDAERYVESATRRIAEIGQDIERLVP.......................................................................................................................................................................................... 1155
53 -16.000[V] COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases  ali follow..  15  262............................................................................................................................................................................................................................QIQATREILQQKEGGYIWHTTGSGKTVTSFKVALASAPRIKNVLFIVDRIDLIDQTLENFK--------SFAYAHFKNRIKKVNGRELKRELKRKGILLISVQGLTKAVKKGLENDDWNVIIMDEAH---RSASGE----SVKLIKKALKKTTWFGFTGT-STHDIFGKRLHTYTIKDAIGDLGFDVTYFKPHWVVEHPQEDTKTSSGALIAGKREENAFQAMFAVSGKQAAVNYYNIFKSKGSHLNVYMLDITKRLARKRPYNQGKDRLDLVIVSDQLLTGFDSKFINVI-----YMDKMLKEGMLIQAISRTNRDLNSKPHGKVRMREFVENALRIYTRGGNDTLQEAEEETKNQLPKDLE................................................................................................................................................................................................................................................................................ 724
54 -15.800[KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family  ali follow..  15  689...................................................................................................................................................................................................FDFQDVPQQIQATYQTEGVHWLERLRKMHL----------ILADDMGLGKTLIIAVTQSKLEKGSGCSLIVCPTSLVYN-----WKEEFRKFEFRTLVIDG----VPSQRRKQLTALADRDVAITS---YNLLQKDVELYKSFDYVVLDEAHHIKNRTTGTPIEFILRRMKELTESQKELYQSYAASAKQELSRLVKQEGFERILKQICCHPAIF--AKDAPEPGDSAKYDMLMDLLSSLVDSGHKTVVFSQYTKMLGIIKKDLESR--GIPFVYLDGSTKNRLDLVNQFNEDPLLVLISLKAGGTGLNLVGADTVI----HYDMWWNPAVENQATDRVHRIGQSREEKILTLQNRKKSLVKKVINSDDEVVSKLTWEEVLELLQ................................................................................................................................................................................................................................................................................... 1165
55 -15.200[KL] KOG0387 Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain)  ali follow..  15  275......................................................................................................................................................................................................................PHLFRYQVTCVQELYCQEAGGIIGDEMGLGKT-IQIVSFLSSLHHSGKFLIVCPATLMKQ-----WVNEFHT-PLRVVVLHATSSFHRYAKNLVESVFTRGHILITTYA---GLRIYGDLILPRGYCVLDEGHKIRNPD-----SEISISCKQIRTVNRII-LSGT-NNLTELWNLFDACMLRDLISPYRMKLDVAADLPKKSEQVLFCKLTPLQRKAYQDFKQGHRTLLFSQTRQMLDILEIGLKDLP-DVHYCRGSTSIALRQDLVDNFNKYFDVFLLTTRVGGLGVNLTGADRVI----LFDPDWNPSTDAQARERAWRLGQKKD--RLMTAGTIEEKIYHRQIFKQFLTNKILKD.......................................................................................................................................................................................................................................................................................... 776
56 -14.300[A] KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1)  ali follow..  12  406.....................................................................................................................................................................................................................FAQLNSSQSNAVSHVLQRP--SLIQGPPGTGKTVTSATIVYHLSIHKDRILVCAPSNVAVDHLAAKLRDL-EDVESSVSNLA-TKRFVKLVRKTEAEILNKADVVCCTCVGAGDKRLD----TKFRTVLIDE------STQASEPECLIP-IVKGAKQVILVGLGPVILERKAADAGLKQSLFEVQYR---MNPYLSEFPSNMSLQNGVTIEQRTVPNSKFPWPIRGIPMMFWANYGREEISAN-------GTSFLNRIEAMNCERIITKLFRDG-------VKPEQIGVITPILQYMQMNGSLDKDLYIKVEVASVDAFQGR-----EKDYIILSRANEQQAIGFLRDPRRLNVGLTRAKYGLVIRSLARNTLWNHLLIHF.................................................................................................................................................................................................................................................................... 828
57 -13.800[A] KOG1804 RNA helicase  ali follow..  13  308......................................................................................................................................................................................................................PVLNENQKLAVKRILSGDCRYILFGPPGTGKTVTIIEAVLQVHFADSRILVCAPSNSAADLVCLRLHESKVLQPATMVRVNATCRFEEIRDGEDIWKASRFRIIITTCSSSGLFYQIGVRVGHFTHVFVDEAGQASEP------ECLIPLGLMSDISGQIV-LGPVIKSRLAMAYGLNVSFLE------RLMSRPAYQRDENAFGACGAHNPLLVTKLVKNYRSHEALLLFYHREVTSLLGWEKLPKKGFPLIFHGVRGSEAREGKSPSWFNPAEAVQVLRCCLLDIGVITPYRKQVIRILNVDLMDIKVGSVEEFQGRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALL................................................................................................................................................................................................................................................................................................. 708
58 -13.500[V] COG3587 Restriction endonuclease  ali follow..  14  1................................................................................................................................................................................................................MSGFNYEKNQPHQMRAVSAVL-DQNILDISMETGTGKTYTQTMFELHRWLGVFKFIVVVPTLSIKAGTQQFLQSKALAEGVRLKTYVVESAKKNKEQFVKAENKKEIHVLLINAGMVNSSSMN-DALAAVRFMIVDEPHKFPTRDSAKTWGN-IKRLKPQ-----ILRYGATLTAVDAFNDGLNPYSYSQTVQDAMMQRAVAEHFKLERALLAERAPQPKIKPL---------TLFFIDDTESDPFYRDYLQKTLDDVSACHGGYFSKDNTDSDDRIEDNPRRFIFSKWTLREGWDNPNVFQICK-----RSSGSTTSKLQEVGRGLRLPVNELMANYFVDSSEKDFVKQLVGE..................................................................................................................................................................................................................................................................................................... 572
59 -12.700[L] KOG1514 Origin recognition complex, subunit 1, and related proteins  ali follow..  13  376........................................................................................................................................................................................KQSELEKAKATLLLATRPKSL----RSKEMEEITAFIKGSISDDQCLGRCMYIHGVPGTGKT-----ISVLSV-----------MKNLKAEVEAGSVSPYCFVEINGLKLASPENIYSV-EGLSGHRVGWKKALQSLNERFAEGKKIGKENEKPCILLIDELDVLVTRNQSVLYN-ILDWPTKPNSKLVVLGIANTMDLPEKLLPRISSRM-------------------------------------------GIQRLCFGP---NHRQLQEII----------------STRLEGINAFEKTAIEFASRKVAAISG--------------------DARRALEICRRAAEVADYRLKKSNISAKSQLVIMADVEVAIQEMFQAPHIQVMKSVLSRIFLTAMVHELTSFDRVATTVSSICLTNGEAFPGWDILLKIGCDLGECRIVLCEPGE------KHRLQKLQLNFPSDD-VAFALKDNKDLPWLANYL.................................................................................................................................................................................. 771
60 -12.500[U] COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase)  ali follow..  15  13..........................................................................................................................................................NERKVKTLATRVAKINAYEAEYAALSDEALKGKTAEFKARLEKGETLDDILNEAFAVVREASKRVLGMRHFDVQMVGGFSGISEMRTGEGKTLVATLPTYLNALEGKGVHVITVNDYLARRDADWMGQVYNFLGLSYGVIVNGLSQGERQRAY------RSDITYGTNNEFDNLVYSVDEMRGHNFAIVDEVDILIDEARTPLIDVLVKELILDKSMFDH-QVILTEDGQEKIEEILMSGGHLAEHQAIEAKEGADIQPENQTLASVTEKNEAILKQIADCHVRGQPILVGTVSIEKSEELSKLLSTFSFVKGIPHQVLNEQEAVIVADAGVPGAVTI--ATNMAGRGTDIAAGGLFVLGTERHESRR-----NQLRGRTGRQG--DPGRSKFFLSCEDDLLRIFVQEGEAITHKWLNNAIATAQKRV................................................................................................................................................................................................................................................................................. 646
61 -12.300[L] KOG1803 DNA helicase  ali follow..  237......................................................................................................................................................................................................................ETLNPSQVAAVSAAMNTQRNLCIQGPPGTGKTRVIAEIVHQLMKKKKKVLVCAPTHVAVRNAMDATTGRMIEETSDPLYKKMSYEYYLIRNSIFRSIFYPKLAVFSTLGTSSIQKLP-EYHWNADVMIVDEAAQCTEPA-------TWVPVLTTPSCKKLI-LPAVVLSDKAMKGNFKLSLMEEQYR-MNWSNEVFYENQLTAHSTVSDITLRDICPNLPEDHVLNNPIMMINMENVKDR--------------HEEFESHSFTNTDELNLVTEYVNRLVVDLGIAIAVISPYYAQIEKLRRSIPFRVDVNTVDAFQGH--------ERQVVIFVRDNDEGQIGFLNETRRLNVAVTRA.......................................................................................................................................................................................................................................................................................... 638
62 -12.100[L] KOG2228 Origin recognition complex, subunit 4  ali follow..  12  555.................................................................................................................................................................................................................HMDEQTKLYQWVRQTIVLG--EGNSVIIVGPRGSGKSVLVDDILSRAAQEINEKSYVVRLNGTYTDDKLALREISRQLSIELESIESDEALKSEMNFS--DTLTKLLATLSHPVDLGIAEDVMTTSAAV-IFVLEEFDLFVQHSRQMLLYNLFDIAQSRKAPILIIGLTTRYDCSESLEKRVKSRF---SHMVIQILKSVLYVSDEGGKDQIITCWNQRVDELLSDTRSHLHKLV--FASRNLKLLYVDLLFPILSMAPDRPLLADEDFANISLKVSDHKVELVKNLSLLELALLICAVRFEARDIPACNFNSAYQEYRQLHQSSVINAAASGALA---------------------------------------------------------------SSRLWGRDVALEAWETLGSIGLIIPVHPSTNVSGALSRQCQLWQPEVDINVVSVGLREHRRLPSHYY.................................................................................................................................................................................... 965
63 -11.900[L] KOG1132 Helicase of the DEAD superfamily  ali follow..  13  2.......................................................................................................................................................................................VSSTSKSDSKEEVKQTLNSKNPKNVYQIGGLQQPYGTQLAFMSRVISTHCHALLESPTGTGKSLSLLCSVLAWQQNYKTIYYASRTHSQITQVIREYRKPMAVLASRKHYCTNRHVLGKDNVDASWSMAENAQLVFCPYS-VNPVIRAGVEVD--AIIIFDEAHFFSMLLMLMIVHSNMEDIKDLADISLSVILSGTLSPMNSFSSELGMQF------GTSLEYPLNASYKTADAYSFQDALGKSLEEICTIVPGG--SLVFFPSYKLMEKLCMRWRETEQ------SRLCLKKDLFVEKGYYDGAAFLAVCRGKVSEGIDFAARAVVEDYTNS---SAQTFVQVKEEAECCREVID---ECGVQPDLGYCEVSSVTNCDEAPETSFVQE.......................................................................................................................................................................................................................................................................................... 731
64 -10.800[R] COG3972 Superfamily I DNA and RNA helicases  ali follow..  10  200..................................................................................................................................................................................................................ESEIANFDQKQRRAALV--TIDGPQRIRGLAGSGKTVILAMKAAHLHMTNDKILVTFFTKSLRSPIKDLVTKFYRHYNIHIRHGWG-RRSGRMPRSYSSARDAAPRGVEPFSFACEELINSAQSLEYYDHILIDEGQLAKGDRDKKNIVWAYDELQNILNV-NDTVLSKCYRNQREVLVAAHA--YDVLTPDFQVGNDIEILRPVESFEKEISWITKEIINFLDMGLLPEDIIVVALDDRHMRNYFRYLSESLASHEISVNNIHADPY---SEPPFSISGKITLSTVYRAKGNEAAVVFALGVDALSLRLRADRNKIFAAFTRT---------AWLRVSGLGDSARRVAVEIDTALRNFPHLKFKMPDISEID------------------LIQRDLSKRSIKAKKIRNEYIQKLKDEGFTEDE............................................................................................................................................................................................................................. 699
65 -10.500[R] COG1444 Predicted P-loop ATPase fused to an acetyltransferase  ali follow..  13  223............................................................................................................................................................................................................................QVEVLKLFEKKKQALVIIADRGRGKSAALGLGLAGIGHKLRQIVVSAMEYSNLETLLEFALKGLEALGYK-------PGVEREGGEIRAIKASGIFIDVVTPYML--------KRENADIVAIDEIHGYEGAGRGFSIRFLKYLKEARDTDVYLYEMEEPIGRGDPVEEWLFDAFLLNAEPAKIEAEDLEYVKRQEVLYLKEEDILKSEEVFRQFFG----IYVQAHYRNEPDDLGMLLDAPHHTAELAYEGGLDDLSIDQALRGLPGNIRIATHPELQDMGLGTLMLKKIEEEARGFGVYDRLLKFWVRNGHLSPERNPSSGEVLLVKPLNEKAEAYVKYANIEFRRRLLMGPYGDLLPTEVQLLLEDW--SPPALSKNQLDRLIAYAYGPMTYENVTDAVYMLATQYFY------------SSKGRRPALPDVAIRILISKVLQAKPWKEAAEAAGVRRGDLMLILREVVKVLLF.............................................................................................................................................................. 767
66 -10.400[L] KOG0442 Structure-specific endonuclease ERCC1-XPF, catalytic component XPF/ERCC4  ali follow..  11  2........................................................................................................................................................................................................................ALKYHQQIISDLLEDSNGGLLILSSGLSLALIASLLILHSPSQGTLLLLLSPAAQSLKSRIIHYISSLDS---TPTEITADLPANQRYSL------TSGSPFFITPRILIVLLTQRIPVSSLAGIFILNAHSISET---STEAFIIRIVKSLNSSAYIRAFSDRFAKTERTMRALFLRKVSQELEREPPEVVDIRVSMSNYMVGIQKAIIEVMDACLKEMKKTNKVVESGLFKSFDEIVRRQLDPIWHTLGKRTKQLVSD-RKLLDYLVRYDAVSFLKFLDTL.................................................................................................................................................................................................................................................................................................................................................................... 302
67 -10.100[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  14  7..........................................................................................................................................................................................................................................IGVGGPVGAGKTMLIERLTRYLSTKGYSMAAIT-DASMNFAAIEEMCDKHPDLQLLFLESGGDNLSATFSPDLVDFSI----YIIDVAQGEKIPRKGGQGMIKSDLFIINKVDLA--PYVGANVEVMKADTLKSRGNKDFFVTNLKTDGLKSVADWI................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 195
68 -10.000[NU] COG2874 Predicted ATPases involved in biogenesis of archaeal flagella  ali follow..  16  1.................................................................................................................................................................................................MVESLADLEEEKKKNILSSGNGEID----KRLGGGIPLGSLTLIEGENDTGKSVLCQQFVYGGLMSGHNIAYYT-----TENTIKSFLRQMESLSLDVSDFY-------AWGYLRVFPVHLEGIDWSTEQMRSILNLVANHIKTIRIAIIDSLTMFTTYSTEDDVLEFLTRLKNLCDNGKTILITLHQHAFKE..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 179
69 -9.860[KL] COG1199 Rad3-related DNA helicases  ali follow..  15  14.....................................................................................................................................................................................................................YPRIYPEQYQYMCDLLDAGGIALLEMPSGTGKTLSLIVSYQQHYPEHRKLIYCSRTMSEIDKALAELKRLGLGLTSRKNLCLHPSVRREKNGNTVRRMLPFCNVIIYSYH-LDPKIAER-ELSKDCIVVFDEAHNIDNVCIESLLRKASKSILSLEQKVNVIITSGTLSPLDMYPKMLQFNTVMQESYGMSLARNISSKFEARNDPSVVRNYGNILVEFSKITPDG--LVAFFPSYLYLESIVSSWQSMGI------DEVWKYKLILVEETYRAGAVLLSVARGKVSEGVDFDGRAVIMFGIPYFLTFDAMRHAAQCLGRVLRGKDD---GIMVLADKRYGRSDKRTKLPKWIQQYI............................................................................................................................................................................................................................................................................................. 700
70 -9.860[KL] KOG1131 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 5`-3` helicase subunit RAD3  ali follow..  16  2..............................................................................................................................................................................................................................LELKRSLDAKGHCLLEMPSGTGKTATLLSLIVAYMVEHPKLIYCSRTVPEIEKVIAELQNTGLVLSSRKNMCIHPEVSKEREGKLARYAIAHAHIVVYSYH-LDPKIAQVVSKEMSRCVVFDEAHNIDNVCIDSTVERSTNALNHLTKLVQVVITSGTLSPMDMYPKILDFDPVVMSSFTMTLARPISSKFETREDTAVIRNYGQLLVEVAKTVPDG--IVCFFTSYLYLESVVASWYDQGI------DTLLRYKLLFIEMNYVKGAVLLAVARGKVSEGVDFDGRAVLMFGIPYFLTFDAMRHAAQCVGRALRGKTD---GIMIFADKRFSRHDKRSRLPKWIQEHLVDS.......................................................................................................................................................................................................................................................................................... 680
71 -9.560[O] KOG0734 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  14  283....................................................................................................................................................................................................HVKGVEEAKQELQEVVEFLK-NPQKFTILGGKLPKG--ILLVGPPGTGKTLLA--------------------RAVAGE-----------ADVPFYYASGSE----------------DEMFVGVASRIRNLFREAKANAPC-VIFIDELDSVGHPYSRQTINQLLAEMDGFKPNEGVIIIGAT--NFPEA---LDNALI----RPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVD-NQAALKAAVDGKEMERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVS----MGGRVAEELI---GTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKE............................................................................................................................................................................................................................ 703
72 -9.550[O] KOG0731 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  13  321....................................................................................................................................................................................................DVAGCDEAKQEIMEFVHFLK-NPKKYEDLGAKIPKG--ALLVGPPGTGKTLLAKATAGES----------VPFLSISGS---DFMEMFVGVGPS----------------------RVRHLFQEARQAAPSI------------IFIDEIDAIGNDERESTLNQLLVEMDGFGTTAGVVVLAGT--NRPDI---LDKALL----RPGRFDRQITIDKPDIKGRDQIFKIYLKKIKLDHEPSYYSQRLALIAARHEGATVTMAIDRVIGGLEKKNRVISKLERRTV--AYHESKVTIVPRGTAALGFAQYVPNENLLMTKEQLFDMTCMT----LGGRAAEQVL-STGAQNDLEKVTKMTYAQVAV-SDKVGLLSFPPRDDGYDFSKPYSNKTGAIIDEEVRDWVAKAYERTVELVEEHKVKVAEIAELLLEKEVLHQDD............................................................................................................................................................................................................................ 750
73 -9.280[D] KOG0987 DNA helicase PIF1/RRM3  ali follow..  10  541.....................................................................................................................................................................................................................LTMVTSEQKKIYDEIMDAGGVFFVYGFGGTGKTFLWK-LLSAAIRSKGDISLNVASSGIAALLLDGGRTTHSRFGIPIN-PNESSTCNISRGSDLGELVKEANLIISLDRTLRDIMNNPGDKPFGGKGIVDFRQVLPVINGAGREEIVFAALNSIWEHCKVLELTKNMRDIEYFSKWIKISQPNDGIALIDIPEEFLINGDNDPVESIIEAVYGNTFMEEKDPKFFQGRAILCPTNEDVNSINEHMMSMLDGEERIYLSSDSDTSSANNDAYSADFLNSVRVSGRLKVGCNMDPNKGLCNGTRLQVTQMAVIQARFITGRVGKIVL-----RMLITPSDTRLPFKMRRRQFPLSVAFAMTINKSQGQTLES--LPRPVFSHGQLYVAISRVTSKTGTK.................................................................................................................................................................................................................................................... 994
74 -9.200[O] COG0465 ATP-dependent Zn proteases  ali follow..  13  136......................................................................................................................................................................................KSKARMLTEDQIKTSFADVAGCDEAKEEVSELVDYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLA--------------------KAIAGEAKVPFFTISGSDFVEMFVGVGASRVR--------------DMFEQAKKAAPCI------------IFIDEIDAVGHDEREQTLNQMLVEMDGFEGNEGIIVIAAT--NRPDV---LDPALL----RPGRFDRQVVVGLPDVRGREQILKVHMRRVPLDTDID-NEAALFAARGNKRVERRSMVMTEAQKESTAYHEAGHAIIGRLVPEHDPVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTL----YGGRLAEEII---GPEKVSTGASNDIKVATSIARNMVTQWGFSEKLGPLLYAEEEGEITARIIDQEVKLLVERNYQRARKLLLENMDVLHSMKDALMKYETIDAPQ............................................................................................................................................................................................................................ 588
75 -9.190[R] COG3903 Predicted ATPase  ali follow..  11  2................................................................................................................................................................................................................................VQEVLTNYRLVTLRGEGGVGKTRLAQIAAASEFRDG---LCFVDLAPIADPGM---------VSTTAAHALGLIDRPGSSTFDTLSHAIGNCHMLMVLDNCEHVLDACAELVVELLGACPELSILATSREGEAIQLFTERARLVQPNFEI---ADNFDAVSEICRRLDG---------MPLAIELAAAR----RSLSPNEIANSLDDRFRLLTGGARS---TVQRQQTLRAS---------MDWSYALLTDTERILFRRLFVGGAASEVAAYSVLDQLTLLVDKSLVVAEESRGSTRYRLLETVRQYALE---KLNESEEIDGVRARHRTHYATMAAGLNVPASTDYEQRLLQAEAEIDNLRAAFTW........................................................................................................................................................................................................................................................................ 361

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A.; RIKEN GER Group; GSL Members. Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 2003 Jun;13(6B):1376-88.