current user: public

If you have questions about the server, please let us know.

Query: [R] COG1203 Predicted helicases, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370    .  380    .  390    .  400    .  410    .  420    .  430    .  440    .  450    .  460    .  470    .  480    .  490    .  500    .  510    .  520    .  530    .  540    .  550    .  560    .  570    .  580    .  590    .  600    .  610    .  620    .  630    .  640    .  650    .  660    .  670    .  680    .  690    .  700    .  710    .  720    .  730    .  740    .  750    .
# Score Template Links and tools%idFirst MVIKAFRKLTGHSPYEYQKEAMDNLLEGKSLIIRAPTGAGKTEASLIPFIYGLNDYLPPQLIYSLPTRTLVESIGERAIKYASFKKLRVAIHHGKKATSSLFEEDIIVTTIDQTAGAYLSVPLSMPKRWGNIFVGGIASALTVFDEVHTLDPEKGLQTAAAIAMQSAKLGLPSIIMSATLPDVFIERVKERIEKNGGKVEIMDVKNESEIKSRRNRKVELINRPDEMLTADTVLKEAENCRKLVVVVNTVERAQNLYLDLRKKIDYPIFLLHSRYLEKDRAEKEKSFEKVFGKNGKGECIFISTQVIEVGMDISSPIILSEVAPIDALIQRAGRCARWGGNGEFHVFGLARDSSNPYAPYLKELIESTITEIRSKGDFPLDWQTELQLVNNVLSSHFEFFMDSKFFYQRLGELARAVYEGSKAKVEQNVREIFSCDITLHENPDTLEPEEILALPRIRVDARVLSGKVEKLAELGIKTYKLEENPVIGDYESKYTLVLVKSKEDVTPFQLYVLSGACYSPEVGLVLGKSAPNAIKSFEPDKLKLKGIKSQADYKLEKESWVEHAKNSLWVLDCYLIPRYYYVIKNFADYFGYEYNEFVNLIKCITALHDLGKLNINWQEKVGWNGKIPLAHSDESDVRKLPPHATVSAKALQPYLESLFDDAGVFKAFYLAIAHHHGPWAREYKEYRLIPEFNKFIEEVWSVPKELIKVHDSANRLDFTYLNVADENEAYRLYGLLSKLIRISDRLATGGASYESIFSALast
1 -158.000[R] COG1203 Predicted helicases  ali  100  1MVIKAFRKLTGHSPYEYQKEAMDNLLEGKSLIIRAPTGAGKTEASLIPFIYGLNDYLPPQLIYSLPTRTLVESIGERAIKYASFKKLRVAIHHGKKATSSLFEEDIIVTTIDQTAGAYLSVPLSMPKRWGNIFVGGIASALTVFDEVHTLDPEKGLQTAAAIAMQSAKLGLPSIIMSATLPDVFIERVKERIEKNGGKVEIMDVKNESEIKSRRNRKVELINRPDEMLTADTVLKEAENCRKLVVVVNTVERAQNLYLDLRKKIDYPIFLLHSRYLEKDRAEKEKSFEKVFGKNGKGECIFISTQVIEVGMDISSPIILSEVAPIDALIQRAGRCARWGGNGEFHVFGLARDSSNPYAPYLKELIESTITEIRSKGDFPLDWQTELQLVNNVLSSHFEFFMDSKFFYQRLGELARAVYEGSKAKVEQNVREIFSCDITLHENPDTLEPEEILALPRIRVDARVLSGKVEKLAELGIKTYKLEENPVIGDYESKYTLVLVKSKEDVTPFQLYVLSGACYSPEVGLVLGKSAPNAIKSFEPDKLKLKGIKSQADYKLEKESWVEHAKNSLWVLDCYLIPRYYYVIKNFADYFGYEYNEFVNLIKCITALHDLGKLNINWQEKVGWNGKIPLAHSDESDVRKLPPHATVSAKALQPYLESLFDDAGVFKAFYLAIAHHHGPWAREYKEYRLIPEFNKFIEEVWSVPKELIKVHDSANRLDFTYLNVADENEAYRLYGLLSKLIRISDRLATGGASYESIFSA 759
2 -37.700[R] COG1201 Lhr-like helicases  ali follow..  19  14.IQEALRTLGFTRPTEPQERAFPHILDGKHTLLIAPTGSGKTESAVLPVFNAILKKKPESALYITPLRALNRDMLSRIEVMGKLLDIKVQVRHGDTPQSERQRQDLLITTPETL--QAMFSGSRLRKNMETV-------THVVVDEIHELSSKRGAQLAIGLERLVEISGFQRIGLSATVGN--PWEIAKFLAGANRDFTVIEVALLKLLEFDVISPQVSGEAEDREVHLSLIRKIVEESQSTLIFVNTRQSAEALAAGFRK-LGASIGVHHGSLSFEARVEAEEAFKA------GALRGLICTSSMELGIDINVDRVVQYGSPVSRLLQRVGRAHRLHEVSRGTVLSMEADDTAESMAITKAALEGRVEDIS------PHVNSLDVVANQIAGMVMDFGEVGIEKIFRILRRAYPFRDLRPEELQRVVDQIGDYRLV................................................................................................................................................................................................................................................................................................................................. 457
3 -36.900[R] COG1202 Superfamily II helicase, archaea-specific  ali follow..  17  205.FKNVLKLEGITELLPVQVLAIKNLLKGENLLVVSATASGKTLIGELAGIPKALEG--KKMLFLVPLVALANQKYEDFKRRYSKLGLKVAIRVGMSRIKT--DADIIVGTYEGV---------YLLRSGKKIG------GTVVIDEIHMIDEERGPRLDGLIARLRK--KAQFIGLSATVGN--PQELARSLGMKLVLYDERPVDLERHLIIARNESEKWRIIAKLCKAEVMRKSSKGFKGQTIVFTYSRKRCHELASFLTGK-GLKAKPYHSGLPYKQRKITEMEFQA---------DVVVTTAALGAGVDFPASQVIFESLSVREFHQMLGRAGRPLYHEKGKVYLIVEPGKKYSAQMDETEDEVALKLLTSPIEPVIVEWSDEIEEDNVLAHACVFNR-------SVIEEVNSLTLGANRSAKKVLEKLEELGMV................................................................................................................................................................................................................................................................................................................................. 631
4 -30.700[A] KOG0350 DEAD-box ATP-dependent RNA helicase  ali follow..  15  137.LVERLQKQNITRGFAVQAAVLPLLLQGGDVCVSAATGSGKTLSYVIPIVQCLSHRTVPRLVVIVPTRELTVQVAKTFEYYMSGAGLQVCAWTGQKSLRHETYQDVLVSTPGRLVDHI--------RNDESFSLQHL--RYMVIDEARLLDQSFQDWVDTVMMEISHP-PLQKLVFSATLTRDPSKIASLKLDMEVDDGGEIEDDAIVFSVPPTLQEYHVSVSSEKPILLYHLIHS-KNLTNILCFVKSNEAAARLHRLLE-NQSFSCGLFTSSLSRDERKKIISRFAT------GDLNLLVCSDLMARGIDVNTQNVINYDPPVRSYVHRIGRTARAGREGFAWTLVQSHEGH--------SKLVKQLRRTLPIKRIKIEFSHISEEFVVAYDKALEALRVEVFNSRYPQQ........................................................................................................................................................................................................................................................................................................................................................... 599
5 -30.400[R] KOG0354 DEAD-box like helicase  ali follow..  16  63...QQWVYPINVSFRDYQFNIVQKALF-ENVLVALPTGLGKTFIAAVVMMNYLRWFPKSYIVFMAPTKPLVTQQMEACYKITGIPKSQTAELSGTTRNQYYQSRNVFFVT--QTILNDIKHGICDRTRI----------SCLVIDEAHSTGNYAYVEVVHLLSLSNKN---RILALSAT-PGNKLEAIQNVIDSSRIEIRTENSIDISQYVQKKEVDFFPVDLSAERIVTEYFEKEQTKDTRIMIFVEIRSSAEEILRFLGKFVRPAIFIGQSAVRKAASQKLQNETVKQFQKGEVN--TLIATSIGEEGLDIEVDMIICDASA--RMLQRMGRTGR--KRKGYIYMLLTRGKEEAKWERAKDAYRTLQDNIVSGRGLSLSEKSYRILPEKFRPVCDKRVIEIPKENEEVVV........................................................................................................................................................................................................................................................................................................................................................... 608
6 -30.300[KL] KOG1123 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 3`-5` helicase subunit SSL2  ali follow..  12  331............VLRPYQEKSLRKMFGNG--VIVLPCGAGKSLVGVTACCTV-----RKRALVLCNSGVSVEQWKQQFKMWSTADDSMICRFTSEAKDKP--GCGILVTTY-SMITHTQKRSWEAEQTMRWLQEQEW--GIMVLDEVHTIPAKMFRRVLTIVQS-HCKLG-----LTAT-EDDKIADLNFLIGPKLYEANWLELQKKLTTKTSKKMLLYVMNPSKFRSCQFLIKYHEQRGDKTIVFSDNVFALKHYAIKMNKP------FIYGPTSQNERIQILQNF-----KFNSKVNTIFVSKVADTSFDLEANVLIQISSHGGSEAQRLGRILRAKKGAIAEEYNAFFYTLVSQDTMEMSYSRKRQRFLVN-QGYSYKVITHLKGMDTDSDLMYGTQEEQGQLLQLVLSASDLDCEDEKLPGE............................................................................................................................................................................................................................................................................................................................................. 749
7 -30.100[R] COG1204 Superfamily II helicase  ali follow..  12 1366..............NKIQTQVFNSVYTNDSVFIGAPNGSGKTVCAELALLHHWSQEDYGTAVYIAPIQEIVDRRYEEWYGKFSDLGDGKVLVKRSQDLKLIQVADLIFCTPSQ----------SLSKRWRSMRSIQKV-DFYICDELQLLGGFYGPLYEIVISRIRYEKNIRVVGLSVSVANA--RDLGEWLGTSPQCIKDRPNPLTIHLQSFSITHFPSLMLAMSKPIYRSLKNFISQRKSTIVFTPDRKVAKQL-AALQQSLKHGIAYISEITSSNDQNIVQYLYRH---------KVLIASRDVIYSLKAKSNAVIIDYPISE-LLQMLGFTASIGSSELSQVILMTVTTKNEPLPMESHLQVWLHDAFVSE-QTIESKQDAVDWLTWSY---YRRLVANPAYYGLQDITHESVSEFLSDLVETTMNDLSEARLI................................................................................................................................................................................................................................................................................................................................. 1837
8 -29.800[A] KOG0342 ATP-dependent RNA helicase pitchoune  ali follow..  18  100.IQKAIKEMGFETMTEIQKRSIPPLLAGRDVLGAAKTGSGKTLAFLIPTIEMLYALKFKGVIIISPTRELALQIFGVAKELLKYHHQTFGIVIGGANRRAEADKNLLVATPGRLLDHL--------QNTKGFVFRNL--RSLVIDEARILEIGFEDEMRQIMKILPSE-NRQTLLFSATQTTKVEDLARISLKPGPLYVNVDS-GKPTSTVEGLEQGYVVVDSDKRFLLLFSFLKRNLK-KKVIVFMSSCASVKYMAELL-NYIDLPVLDLHGKQKQQRRTNTFFEFCN------AEKGILLCTNVAARGLDIAVDWIVQYDPPDDDYIHRVGRTARGTKGTGKSLMFLAPSE------------LGFLRYLKTAKVSLNEFEFPANKVANVQSQLEKLVSKNYYLQQSAKDGYRSYLQAYASYSLKSIFDINKLDL.................................................................................................................................................................................................................................................................................................................................. 517
9 -29.600[A] KOG0348 ATP-dependent RNA helicase  ali follow..  21  40.LSDQLKERMGFEPTLVQAQAIPVILSGRDVLVNAPTGTGKTIAYLAPLIHHLQGHSPKFALVIVPTRELCLQVYETLEKLLHFHWIVPGYVMGGEKKAKEKARSILIATPGRLLDHL--------KNTASFVHKNL--RWVIFDEASILELGYGKEIEQIIKLLGSGQNEQNLLLSATLNDKVNDLAKLSLDDIHVNKSANPLSEDYGIPSQLVQRYLRVPCGARLVALLSVLKNLEASQKVVVFFSTRDAVDFHYSLLSEFLKCKTFRLHGSMEQEDRRSAFGTFKT------EKQAVLLSTDVAARGLDFKVRCIIQYDCPATEYVHRVGRTARIGEKGEALLFLQPIEID..................................................................................................................................................................................................................................................................................................................................................................................................................... 459
10 -29.300[A] KOG0332 ATP-dependent RNA helicase  ali follow..  19  220.VLKALDTMNFQFPTRIQETALPLLLPPSNLIAQAQSGTGKTAAFVLTMLCRIDVNLMCQCICLAPTLELAKQIGEVVEKMGKFIDLKIHYAIKGGNMAAM-TEQIVIGTPGITRDYL--------QKYKCIDPSKI--RCLVLDEAVMIYHQGFTDISTTIYNMVEDASVQSMLFSATYDEPVINFATKIIKNA----IVVMLKREEQALPNIKQFYVQCACRDSKYAAIVNLYSGLAVASSVIFCHTKASVMWLYENMRAR-GHQVDVLHGDMTVVERADTIIHFKR------GDFKVLITTNVFARGIDVAVSVVINYDLPIETYLHRIGRTGRFGKTGIAINLIDSEDS------------MNMINVLENHFQMKIARMDPSNLVE................................................................................................................................................................................................................................................................................................................................................................................. 606
11 -28.800[LKJ] COG0513 Superfamily II DNA and RNA helicases  ali follow..  19  13.VIAAVEAAGYTAPTPIQAGAIPPALERKDVLGIAQTGTGKTASFVLPMLTLLEKGRARRTLILEPTRELAAQVEENFVKYGINHRLNVALLIGGVSFEEQERKDVLIATPGRMLDHFERGKLLLTG------------EILVIDEARMLDMGFIPDIERICKLIPFT---QTLFFSATMPPEITK-LTEQFLHSPVRIEVAKASSTAKTVTQRLVKSGKKDWDKRAVLRDLIQSEGDSLKNAIIFCNRKKDVSELFRSLTRH-EFDAGALHGDMDQRARMAMLSSFKD------GKLRLLVASDVAARGLDIPVSHVFNFDVP-EDYVHRIGRTGRAGRSGKAFTIVTSSDTK..................................................................................................................................................................................................................................................................................................................................................................................................................... 357
12 -28.600[A] KOG0345 ATP-dependent RNA helicase  ali follow..  17  27.IIEALNQSDFEFCTPVQAATIPLLCSYKDVAVDAATGSGKTLAFVVPLVEILRRSTSFMGVIISPTRELSTQIYNVAQPFVSTANVNSVLLVGGREVKADMKINVLIGTPGRLSDIM--------ERMEILDFRNL--EILILDEARLLEMGFQRQVNYIISRLPKQ---RTGLFSATQTEGVEELAKAGLRRAKSKSESSQQLTNSKTPSGLHLEYMECEADKKSSQLVDLLIK-NSDKKLIVFFMTVDYWGLVLSKIPALKSISLIPIHGDMKQNARDKALASFTK------ASSGALLCTDVAARGLDIGIDYVVQYDPPQDMFNHRAGRTARLGRQGRAIVFLLPKEEA--------------VEFMRIRR-VPLEERKCSEDASDVIPIIRSAAMKDRAVMEKGLKAFVSFVRAYKEHHCSFIFRWKDLEI.................................................................................................................................................................................................................................................................................................................................. 457
13 -28.500[A] KOG0340 ATP-dependent RNA helicase  ali follow..  19  69.AVETCKELGMRKPTPVQTHCVPKILAGRDVLGLAQTGSGKTAAFALPILHRLAEDPYGFALVVTPTRELAFQLAEQFKALGSCLNLRCSVIVGGMDMLTQTMSHIVITTPGRIKV-LLENNPDVPPVFSRT-------KFLVLDEARVLDVGFQDELRTIFQCLPKS---QTLLFSATMTSNLQALLEHSSNKA----YFYEAYEGLKTVDTLTQQFIFEDKDAKELYLVHILSQMEDKRSAMIFVSTCRTCQRLSLMLDEL-EVENIAMHSLNSQSMRLSALSKFKS------GKVPILLATDVASRGLDIPVDLVINYDIP-RDYVHRVGRTARAGRGGLAVSIITETD....................................................................................................................................................................................................................................................................................................................................................................................................................... 410
14 -28.500[A] KOG0331 ATP-dependent RNA helicase  ali follow..  18  105.VMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLECLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDEICIATPGRLIDFLECGKTNLRR------------TYLVLDEARMLDMGFEPQIRKIVDQIRPD---QTLMWSATWPKEVRQLAEDFLK---DYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIEKENKTIVFVETKRRCDELTRKMRRD-GWPAMGIHGDKSQQERDWVLNEFKH------GKAPILIATDVASRGLDVDVKFVINYDYPSEDYIHRIGRTARSTKTGTAYTFFTPNNIK-----QVSDLISVLREANQAINPKLLQ.......................................................................................................................................................................................................................................................................................................................................................................................... 473
15 -28.300[L] COG4098 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein)  ali follow..  18  93...........GQLTPFQEKVSEGLLQQKPTLVHAVTGAGKTEMIYQVVAKVINAG--GAVCLASPRIDVCLELYKRLQQDF---SCGIALLHGES--EPYFRTPLVVATTHQLLKFYQAF------------------DLLIVDEVDAFPYVDNPMLYHAVKNSVKE-NGLRIFLTATSTNELDKKVRL------GELKRLNLPRRPKPIWLSDFNRYLDKNRLSPKLKSYIEKQRKTAYPLLIFASEIKKGEQLAEILQEQFNEKIGFVSSV--TEDRLEQVQAFRD------GELTILISTTILERGVTFCVDVFVVELFTKSSLIQIGGRVGRSMDRPTGDLLFFHDGLN--------ASIKKAIKEIQMMNK.............................................................................................................................................................................................................................................................................................................................................................................................. 428
16 -28.100[A] KOG0344 ATP-dependent RNA helicase  ali follow..  19  68.LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKRALIISPTRELASQIHRELIKISEGTGFRIHMIHKAAVAAKKFGPDILVTTPNRLIYLLKQDPPGIDLAS----------EWLVVDESDKLFEDGKTGFRDQLASIFLACKVRRAMFSATFAYDVEQWCKLNLD----NVISVSIGARNSAVETVEQELLFVGSETGKLLAMRELVKKGFNPPVLVFVQSIERAKELFHELIYE-GINVDVIHAERTQQQRDNTVHSFRA------GKIWVLICTALLARGIDFGVNLVINYDFPSVEYIHRIGRTGRAGNKGKAITFF--TEDDKPLLRSVANVIQQAGCPVPE................................................................................................................................................................................................................................................................................................................................................................................................. 432
17 -28.100[A] KOG0336 ATP-dependent RNA helicase  ali follow..  19  233.LLKSIIRVGIVKPTPIQSQAWPIILQGIDLIVVAQTGTGKTLSYLMPGFIHLDSQPISRMLVLTPTRELALHVEAECSKYSYKGLKSICIYGGRNRNGQIEDVDIIIATPGRLNDLQMNNSVNLRS------------TYLVIDEAKMLDMEFEPQIRKILLDVRPD---QTVMTSATWPDTVRQLALSYLK---DPMIVYVGNLNLVAVNTVKQNIIVTTEKEKRALTQEFVENMSPNDKVIMFVSQKHIADDLSSDFNIQ-GISAESLHGNSEQSDQERAVEDFKS------GNIKILITTDIVSRGLDLDVTHVYNYDFPIDVYVHRVGYIGRTGKTGTSVTLITQRDSK-----MAGELIKILDRANQSVPEDLVV.......................................................................................................................................................................................................................................................................................................................................................................................... 599
18 -27.900[A] KOG0341 DEAD-box protein abstrakt  ali follow..  17  157.VLDTLKEKGIVQPTPIQVQGLPVILAGRDMIGIAFTGSGKTLVFVLPMIMIAAAGEGPIGLIVCPSRELARQTYEVVEQFVAYPPLRSLLCIGGIDMRSQLEVHIVVATPGRLKDMLAKKKMSLDA------------RYLTLDEARLVDLGFEDDIREVFDHFKSQ---QTLLFSATMPTKIQIFARSALVK------TVNVGRAGAANLDVIQEVEYVKQEAKIVYLLECLQ--KTSPPVLIFCENKADVDDIHEYLLLK-GVEAVAIHGGKDQEDREYAISSFKA------GKKDVLVATDVASKGLDFDIQHVINYDMPIENYVHRIGRTGRCGKTGIATTF-INKNQSETTLLDLKHLLQEAKQRIPP................................................................................................................................................................................................................................................................................................................................................................................................. 526
19 -27.900[L] COG2254 Predicted HD superfamily hydrolase, possibly a nuclease  ali follow..  16  8.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ENKVCVETMEDHIRKGLEIIEGLYLRRGYG--HFLSKILNIDVKLAEELLKKAYIFHDIGKCLEEFQQRRE----------------KFRFHEVYSALVAREVFKK---YGDIGGVVSVAILLHHHNWIRRPRNLKLCNECLSIIKKLSGEKIPEEIPWRNWIEFTEEAEEIMRTN--LRGVYSILLPLVVADNYAAAVNRGGK.... 193
20 -27.400[A] KOG0330 ATP-dependent RNA helicase  ali follow..  19  57.LCEACEKLGFKTPTPIQQEAIPVVLNKRDVIGLAQTGSGKTAAFALPVIQELWNNPSPFAVVLAPTRELAYQISEQFEAIGGSIGVRSVVIVGGMDMVTQAVAHVLVCTPGRLMDHL--------ENTKGFSLKNL--KYLIMDEARLLDMDFGPIIDKILKIIPHE---RTLLFSATMTSKVEKLQRASLHQP----VRVAVSSKFSTVDTLIQRYLFFPFKHKDTYLVYLVNE-LAGNSIIIFARTVNDTQRLAILLRTL-GFSAIPLHGQLSQSNRLGALNKFKS------GARSTLVATDVAARGLDIPVDVVINYDIP-KAYIHRVGRTARAGRAGKSIALVTQYD....................................................................................................................................................................................................................................................................................................................................................................................................................... 393
21 -26.900[V] COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases  ali follow..  16  462............GLRYYQEDAVRAVEKQQEILLAMATGTGKTRTAIAMMFRLIQSQRFKRILFLVDRRSLGEQALGAFEDTRINGDTFNSIFDIKGLTDKF-STKIHVATVQSLVKRTLQSDEPMPVARYDC---------IVVDEAH-LQFRSQLDYVSAYRRILDHFDAVKIALTAT-PATYRTAVIDGF-ISPQGEVINDTLEDDQDFEVADFNRGLVIPAFNRAVCNELTNYLDPTGKTLVFCVTNAHADMVVEELRAAFKKKYPQLEHDAIIKKDARKVQTMITRF-NKERLPNIVVTVDLLTTGVDISICNIV--LRKVRSRIQMKGRATREVNKTSFKIFDCVVRPKVELQTLVNEITDSETYKITEADGRSFAEHSHEQLVAKLQRIIGLATFNRDRSETIDKQVRR........................................................................................................................................................................................................................................................................................................................................................ 944
22 -26.700[KL] COG1061 DNA or RNA helicases of superfamily II  ali follow..  16  78............EPYPHQSEALAAWKLAG--VVVLPTAAGKTYLAQLAMQAT-----PRTTLIVVPTLDLMHQWYAHLVAAFP--DAEVGLLGGGSRD----KSPVLVATYDSAAIHAEALGNQY--------------ALIVFDECHHLPTDFSKVIAEYAIA-PYRLG-----LSATPERTAEDLAGKALAEHEIVQIKVKLSQQERERYNNREAKEIALGTDSKLRILANLLAKHYPERVLIFTADNATVYKISQDLL------IPAITHQTPVKERHEILTKFRE------GEYNTLVASHVLNEGVDVAAAIAI--LSGTGSYIQRLGRILRNIQNKQAILYEV.......................................................................................................................................................................................................................................................................................................................................................................................................................... 438
23 -26.300[A] KOG0326 ATP-dependent RNA helicase  ali follow..  16  96.LLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNQAMVIVPTRELALQVSQICIQVSKHGGAKVMATTGGTNLRDDIMRHVVIATPGRILDLIKKGVAKVDH------------QMIVLDEAKLLSQDFVQIMEDIILTLPKN---QILLYSATFPLSVQK-FMNSHLQKPYEINLMEELTLKGV----TQYYAYVTERQKVHCLNTLFSRLQ--NQSIIFCNSSQRVELLAKKISQL-GYSCFYIHAKMRQEHRNRVFHDFRN------GLCRNLVCTDLFTRGIDIQVNVVINFDFP-ETYLHRIGRSGRFGHLGLAINLITYDD....................................................................................................................................................................................................................................................................................................................................................................................................................... 431
24 -26.000[A] KOG0347 RNA helicase  ali follow..  17  202.LMKSIYRLDFKEPTKIQKACFNAAYQGKDVIGAAETGSGKTLAFGLPILQRLLDEREKRALIITPTRELALQVTEHLENAAKNLSVKVVPIVGGMFSEKQERREIVVATPGRLWE-LMSAGEKHLVELHSL-------SFFVLDEARMVERGHFRELQSILDLLVPKKKRQTFVFSATIALSSKKLKRGSSKSKQSSSGEVNSIEVLSERAGMRDNVAIIDLTTTSILAPKIEESFHGQGRTIVFCTSVTDLRHISGLLKIL-GLDVCTLFSEMKQRARLKSIDRFRA------SENGILIATDLVARGIDINVRTIIHYKLPAEVYVHRCGRTARAFADGCSIALIEPNETS..................................................................................................................................................................................................................................................................................................................................................................................................................... 613
25 -25.700[A] KOG0346 RNA helicase  ali follow..  22  25.LQRAIHKCEFEKPTSVQSETIPLALEGKDLVAQARTGSGKTAAYLIPILELLENQRGIFALLLVPTRELAQQVYNVLEKLTAFCSKHIRFIDTVQRPLLLDLPDIVIATPSRCVVHVASGVLPLDK------------KFLVIDEADMLSFGYNEDMKTLSRSLPRGT--QSFLMSATLSKNI-ASLQKLVCRNPFILAV----KDKEASGKLTQYVVKCSEQDKFLLAYILLKLRLIKGKILIFVNEINRCYRLKLFL-EQFGLKSLVLNSELPVNSRLHILEQYNK----------IIIATDESGMMGEIEVACVLNFDMPTKSYIHRIGRTARAGKPGTAMSFVVPKSEV..................................................................................................................................................................................................................................................................................................................................................................................................................... 436
26 -25.500[L] COG1111 ERCC4-like helicases  ali follow..  13  5.IEHPLIKPEKIEARTYQQLLAADVIRKGNSMIVAPTALGKTVVAVLVAAERLRKYRGSKVLILSPSKPLAIQHEESFREFMLATCTSLTGSIKPEERKERWIKSQIISATPQTVESDILAGRYDLRDV----------SLIVFDECHAVGSYSYVFLASNYIQNARH---LILGLTAS-PGADEDKIKTVCENLFMNEVVVKTEGDPDVRPYLKPIKIEWVKVRMTPELEDIRELLGDEARIIVFTQFRDTLEEIYQRCKREGINAVKFYGQNSRSGEKQKQQRDIIKSFRMGNHD--VLLSTSVAEEGIDIDLVVMYEPVPSEIRMIQRRGRTGRK-RKGRMVVLITEKTRDEAYYYSSIRKERSMKENLRGGSV.............................................................................................................................................................................................................................................................................................................................................................................................. 503
27 -25.300[A] KOG0335 ATP-dependent RNA helicase  ali follow..  19  299.LNNNIAKAGYTKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMKELQEPECIIVAPTRELVNQIYLEARKFSFGTCVRAVVIYGGTQLGHSIRQNILCATPGRLMDIIGKEKIGLKQ------------KYLVLDEARMLDMGFGPEMKKLISCMPSKEQRQTLMFSATFPEEIQRLAAEFLKSNYLFVAVGQVGGACR---DVQQTVLQVGQFSKREKLVEILRNIGDE-RTMVFVETKKKADFIATFLCQE-KISTTSIHGDREQREREQALGDFRF------GKCPVLVATSVAARGLDINVQHVINFDLPIDEYVHRIGRTGRCGNTGRAISF-FDLESDNHLAQPLVKVLTDAQQDVPA................................................................................................................................................................................................................................................................................................................................................................................................. 669
28 -24.900[J] KOG0327 Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases  ali follow..  19  43.LLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKAQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKHIIVGTPGRVFDMLNRRYLSPKY------------KMFVLDEAEMLSRGFKDQIYDIFQKLNSN--TQVVLLSATMPSDVLEVTKKFMRDP----IRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHAR-DFTVSAMHGDMDQKERDVIMREFRS------GSSRVLITTDLLARGIDVQVSLVINYDLP-ENYIHRIGRGGRFGRKGVAINMVTEED....................................................................................................................................................................................................................................................................................................................................................................................................................... 380
29 -24.700[J] KOG0328 Predicted ATP-dependent RNA helicase FAL1, involved in rRNA maturation, DEAD-box superfamily  ali follow..  18  37.LLRGIYAYGFEKPSAIQQRSITPIVKGRDVIAQAQSGTGKTATFSISILQSLDTTLREQVLCLSPTRELAVQIQKVILALGDMMNVQCHVCIGGTNLGEDIRKHIVSGTPGRVFDMIKRRVLRTRA------------KMLVLDEAEMLNKGFKEQIYDVYRYLPPA--TQVVLISATLPHEILEMTSKFMTDP----IRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREA-NFTVSSMHGDMPQKERDEIMKEFRA------GQSRVLITTDVWARGIDVQVSLVINYDLP-ELYIHRIGRSGRFGRKGVAINFVKSDD....................................................................................................................................................................................................................................................................................................................................................................................................................... 373
30 -24.400[LK] COG1200 RecG-like helicase  ali follow..  17  257.LKQRFLATLPFQPTNAQKRVVSDIEQD-MRLVQGDVGSGKTLVAALAALTAIDNG---QVALMAPTEILAEQHANNFRRWFKPFGIEVGWLAGKVKGKSR-AVQMVVGT-----HALFQEEVEFSD------------ALVIIDEQHRFGVHQRLMLRE--KGEKAGFYPHQLIMTATIPRTLAMTVYADLDTSI----------DELPPGRTPITTVVVSEERRAEIVMRVKNAVNEKRQAYWVCTLIDEAEAIWEDLTKALMLNIGLVHGRMKPQEKQDVMMRFKN------AELDLLVATTVIEVGVDVNASLMIIENAELSQLHQLRGRVGRGCTASFCVLM--------YKPPLGKVSQKRLQVLRDSQDGFVISEKDLE..................................................................................................................................................................................................................................................................................................................................................................................... 628
31 -24.300[A] KOG0329 ATP-dependent RNA helicase  ali follow..  17  56.LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQSVLVMCHTRELAFQISKEYERFSKYPNVKVAVFFGGLSIKKDEEVHIVVGTPGRILALARNKSLNLKH------------KHFILDECDKMLEQL---MRRDVQEIFRMTEKQVMMFSATLSKEIRPVCRKFMQ---DPMEIFVDDETKLTLHGLQQYYVKLKDNEKNRKLFDLLDVLE--NQVVIFVKSVQRCIALAQLLVEQ-NFPAIAIHRGMPQEERLSRYQQFKD------FQRRILVATNLFGRGMDIEVNIAFNYDMP-DTYLHRVARAGRFGTKGLA-ITFVSDENDAKILNDVQDRFEVNISELPDEID.............................................................................................................................................................................................................................................................................................................................................................................................. 419
32 -24.300[A] KOG0343 RNA Helicase  ali follow..  17  52.TLKGLRESSFIKLTEIQADSIPVSLQGHDVLAAAKTGSGKTLAFLVPVIEKLYREKWTEALIISPTRELAMQIYEVLTKIGSHTSFSAGLVIGGKDVKFELERNILIGTPGRILQHL--------DQAVGLNTSNL--QMLVLDEARCLDMGFKKTLDAIVSTLSPS---QTLLFSATQSQSVADSLTDYKTVGTHDVMDGSVNKEASTPETLQQFYIEVPLADKLDILFSFIKSHLK-CKMIVFLSSSKQVHFVYETFRKQPGISLMHLHGRQKQRARTETLDKFNR------AQQVCLFATDVVARGIDFAVDWVVQVDCPEDTYIHRVGRCARYGKKGKSLIMLTPQEQ------------EAFLKRLNARKIEPGKLNIKQSKKKSIKPQLQSLLFKDPELKYLGQKAFISYVRSIYVQKDKQVFKFDELPT.................................................................................................................................................................................................................................................................................................................................. 474
33 -23.800[A] KOG0333 U5 snRNP-like RNA helicase subunit  ali follow..  15  312.VYQAVKEIGYLEPTPIQRQAIPIGLQNRDVIGVAETGSGKTAAFLLPLLVWITSLPKMEAIIMAPTRELAQQIEEETNKFGKLLGIKTVSVIGGASREDQGMKEVVIATPGRLLDVLENRYLLLNQ------------TYVILDEARMLDMGFEPDVQKVLEYM-REKYRQTVMFTATMSSAIERLARQYLRR------VVHIGSAGKPTERVEQVVYMVPEDRKRKKLVEVLESQFQP-PIIIFVNQKKGADMLSKGLTKL-GFKPTVLHGGKGQDQREYALQALKE------GTSDILVATDVAGRGIDVDVSLVLNYDMAIEDYTHRIGRTGRAGKHGKAITFLTPDDT---------AVYFDLKQVLVESPVSSCPPE........................................................................................................................................................................................................................................................................................................................................................................................ 703
34 -23.400[A] KOG0338 ATP-dependent RNA helicase  ali follow..  18  229.LLKAITAMGFKQPTPIQKACIPVGLLGKDICACAATGTGKTAAFALPVLERLRQAPVTRVLVLVPTRELGIQVHSVTRQLAQFCNITTCLAVGGLDVKSQEAADILIATPGRLIDHL--------HNCPSFHLSSI--EVLILDEARMLDEYFEEQMKEIIRMCSHH---QTMLFSATMTDEVKD-LASVSLKNPVRIFVNSNTDVAPFLRQEFIRIRPNREGDREAIVAALLTR-TFTDHVMLFTQTKKQAHRMHILLGLM-GLQVGELHGNLSQTQRLEALRRFKD------EQIDILVATDVAARGLDIEVKTVINFTMPIKHYVHRVGRTARAGRAGRSVSLVGEDERK-----MLKEIVKAAKAPVKARILPQDVILKFRDKIEKMEKDVYAVLQLEA................................................................................................................................................................................................................................................................................................................................................................... 618
35 -23.000[A] KOG0349 Putative DEAD-box RNA helicase DDX1  ali follow..  18  13.IAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPVIQIVYETNAPKALIVEPSRELAEQTLKQFKKYIDNPKLRELLIIGGVAARDQLSVDIVVGTPGRLDDLVSTGKLNLSQ------------RFLVLDEAGLLSQGYSDFINRMHNQIPQVTSDQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVEMWSEAIKILKGEYAVRAIKEHKQAIIFCRTKIDCDNLEQYFIQQ-QFSCVCLHGDRKPHERKQNLERFKK------GDVRFLICTDVAARGIDIGVPYVINVTLP-QNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTINEMQLLSEIEEHLNCTISQVFDGKVTYGQKRAAGGGSYKGHVDILAPTVQELAALE................................................................................................................................................................................................................................................................................................................................... 719
36 -22.400[L] COG0514 Superfamily II DNA helicase  ali follow..  15  25.PERVLHEVFGYQ-RVGQQEVIEAALAGRDSLVIMPTGGGKSLCYQIPALVL-----EGVTLVISPLISLMKDQVDQLKA------NGVAAECVNSTLAREELIAIYNRMHAGQLKLLYVSPERVLTAEFIERLSHLPLAMIAVDEAHCISQHDFRPEYASLGQLKQRFNVPVMALTATADDATRHDIMQRLQLNEPHQYLGSFD-------RPNIRYMLVEKHKPVSQVIRYLETQ-RGQCGIIYCGSRKKVEMLTEKLCGN-HIRAASYHAGMDADERAWVQEAFQR------DDLQIVVATVAFGMGIN-NVRFVVHFDIPIESYYQETGRAGRDGLPAEAMML------------YDPADMNWLRRMLDEKPDGAQKQVESHKLTAMG............................................................................................................................................................................................................................................................................................................................................................................... 384
37 -22.300[A] KOG0339 ATP-dependent RNA helicase  ali follow..  20  276.LMEAIRKSEYEQPTPIQAMAIPSALSGRDVLGIAKTGSGKTAAYLWPAIVHIMDQPDLKAVIVVPTRELAIQVFQEAKKFCKVYNINPICAYGGGSKWEQSNEEMVVCTPGRIIDLVKMGATNFLR------------TFLVFDEARMFDMGFEAQVKSISDHVRPD---QCLMFSATFKQKVERLARDALVD------RIVQGEVGEANADIEQKVFVMQNQDVKLHLIRNLVEFASLGKVLIFVTKKLDSEDVAKKLKMK-DFDIVLLHGDMLQAERNENLLKFRK-------KSQILVATDVAARGLDIEIRTVINFDMAIDTHVHRIGRTGRAGHKGTAYTLVTEKDIE-----MVGHLVKNLESVSQEVPKPLMD.......................................................................................................................................................................................................................................................................................................................................................................................... 642
38 -21.200[A] KOG0337 ATP-dependent RNA helicase  ali follow..  22  106.LIKGITKRGYKVPTPIQRKTIPLILEGRDVVAMAKTGSGKTACFLIPLFEKLQRREPTRALILSPTRELAVQTYKFIKELGRFMELKSILVLGGDSMDSQFSADVIVATPGRFLHLCVEMDLKLNS------------EYVVFDEARLFEMGFGEQLNETLHRLPSS---QTVMFSATLPKLLVEFARAGLNDP----VLIRLDVESKLPDALALKFLYCRPDDRYTALVVLLKYVPVQSQTVVFAGTQHHVELISYILTEA-GISNASVYSSLDPAARKINTAKFVN------KKVSVLIVTDVAARGIDIPLDFVVNLHFP-KLFVHRVGRCARAGRTGTAYSIVSTDD....................................................................................................................................................................................................................................................................................................................................................................................................................... 445
39 -20.800[L] COG4581 Superfamily II RNA helicase  ali follow..  16  269.LVPEMALDFPFELDNFQKEAIYHLEMGDSVFVAAHTSAGKTVVAEYAIALAQKHM--TKAIYTSPIKALSNQKFRDFKHKFE----DVGILTGDVQVNP--EGSCLLMTTE-ILRSMLYRGADLIRDV----------EFVIFDEVHYVDLERGVVWEEVIIMLPPH--VTLILLSATVPNTKE--LEHYLWVKQNMFKIVDQHGRFLMDGYKSANDALKKPDKPVIAKDHLIGHLHKQNLLPVIVNNHQEKSEVIGRMREMLSRGLAVHHGGLLPIIKEIVEILFQRGLVK------VLFATETFAMGVNMPASVVFSGTQKHDGYTQCSGRAGRRGLDVTGTVIILSRSELPDTASLRHMIMGPSSKLISQFR---LTYNMILNLLRV--ETLRIEDMIKRSFSENVNQTLVPQHEEKIKSFEEKLSALKKEM................................................................................................................................................................................................................................................................................................................................... 784
40 -20.300[S] COG3421 Uncharacterized protein conserved in bacteria  ali follow..  11  45...EFVERNLKYPFFEWQKSALENFVRPTHLLFNMATGAGKT--MMAALILYYFEKGYRHFLFFVNQNNIVDKTENNFID-ILQGDTVIPIRKVEMFSPHSDGIEIKFTSIQKLYNDI-----TERENQTTLADLHKLNLVMLGDEAHHLNAQTKHMVLELLLNKNGNPGQNVLLFTATLKEFLQKGYTKEINFKPVMLFRSKTIDESKADYSAFLNWAENVQADDFEFLDTFSGSLNNEQALKFMQDNKFGFAHLANWVKQNYQKNVIITNSE-KTEKTDSETEKLLNNLEAADNPIRAIFTVDRLTEGWDV-----LFDIVRLYSEKQLIGRGVR--------YFPFAFEGKQPNKRKFDNDMQHELRILEELF--YYTHDEQSRYISELKNELRK......................................................................................................................................................................................................................................................................................................................................................................... 565
41 -19.900[A] KOG0925 mRNA splicing factor ATP-dependent RNA helicase  ali follow..  15  78..............YQQREEFLKIYHENQIIVFVGETGSGKTTQIPQFVLYDELPHLTNTQICTQPRRVAAMSVAKRVADEMD-VDLGEEVGYNIRFEDCSGPNTLLKYMTDGMLLREAMTDHMLSRY-----------SCIILDEAHERTLATDILMGLMKRLATRRPDLKIIVMSATLDA-------KKFQKYFFDAPLLAVPGRTYPVEIYYTQEPERDYLEAALRTVLQIHVEEGPGDILVFLTGEEEIEDACRKITLEADDKVYPLYGSLPPNQQQRIFEPTPE--TKSGYGRKVVISTNIAETSLTIDGIVYVVDVSPISSAQQRAGRAGRTRPGKCFRLY--------TEEAFRKELIEQTYPEILRSNLSSTVLELKKLGIDDLVHFDYMDPPAPETMMRALEELNYLNCLDDNGDLTPLGRKASEFPL.................................................................................................................................................................................................................................................................................................................................. 504
42 -19.900[A] KOG0953 Mitochondrial RNA helicase SUV3, DEAD-box superfamily  ali follow..  12  137.........................HAKTVFPHLDCMDDLKKISDL-----RQPANWYSNARAITRKILLATEVYNKANE----RGTPCDLVTGEERISESLPANHVACTVEMTSVNT---------------------EVAVIDEIQQIDPQRGWAWTRAFLGLIAD---EVHVCGE---PGALDLLQKICETTGETVEVRLYDRLTELTVENTALGS--------------LDNIVPGD--CIVCFSKHDIYTVSREIEAR-GKEVAVIYGGLPPGTKLAQ----AAKFNDPANSCKVMVATDAIGMGLNLSIRIIFYSLIKPSSALQIAGRAGRFRTQWEHGYVTAFKSEDLQTL---QRILARTPEPIKQ................................................................................................................................................................................................................................................................................................................................................................................................. 447
43 -19.600[L] COG1198 Primosomal protein N` (replication factor Y) - superfamily II helicase  ali follow..  15  261............ELNPEQRQARDAVVSSPPFLLQGITGSGKTEVYLQIIQGALDKG--KTAILLVPEISLTPQMTERFIARF---GDKVAILHSGLSNGEKYDEQVVVGARSAIFAPLKNLG------------------VMIIDEEH--DSNPRYHAREVAILRAQYNQATLVLGSAT-PS-----LESRARAGKGVYQHLRLTQRAN-PLATIPEVQVIDFRDYPPLLEAIQDRLVKKEQVVLMLNRVDTCPNCDISLTLHMDTKTMNCH-RYYGTGTQKAYDELAELFPQGRGEADILLGTQMIAKGLDFPNVTLVGVLNAFQLLTQVAGRSGRAEKAGQVLIQSYNPQHYAIRFAKDQDYEGFYAYEMGIRRQLGYPPYYFTIGITLSHKKEEEVFKRAYEVMNILRS........................................................................................................................................................................................................................................................................................................................................................... 730
44 -19.500[LK] COG1197 Transcription-repair coupling factor (superfamily II helicase)  ali follow..  14  593...QQFSATFPFEETYDQEMAINAVISD---LVCGDVGFGKTEVAMRAAFLAVMNH--KQVAVLVPTTLLAQQHYENFKDRFANLPVNVEVLSRFKTAKEQKQ-DILIGT-HKLIQS-------------DVKFNDL--GLLIIDEEHRFGVGQKEKIKQL------RANIDILTLTATIPRTLNMAM----------NGIRDLSIISTPPARRLSIKTFVRQNDDLVVREAILREILRGGQVYYLHNDVASIENTAEKLTALVEARVIVGHGQM---RERELERVMSDFYHQRYN---VLVCSTIIETGIDVTANTIIIERADLAQLHQLRGRVGRSHHQAYAYLLTPPPKM--------TKDAERRLDALENLDNLGAGFILATHDLEELLGNEQSGQIESSLYMELLDAAVKALKEGREPSLEELTQQQADIELRV................................................................................................................................................................................................................................................................................................................................ 1010
45 -19.500[R] COG4889 Predicted helicase  ali follow..  13  169......QLKEPYSPRPHQQTAIEKAIEHDRGKLIMACGTGKTFTALRLSEEVARLNGNARILFLVPSISLLSQTLKEWTAQKTMDLRPVAVCSDSKVSKAAYDLEVPVSTDGALIAEKLEHRKRAAGL--TVVFSTYQSLLVICDEAHTTGITLAGEDPSNFTRIHDASYIKALYMTAT-PRLFDDSVKGKAADHSAEVSSMDDEAGEAVEKGLLTDYKVVVMTVDEQVAASALTVLGS-ERAVAFARDIKTSQQIAESFPRVVNAACQHVDGSMNALERNSRLTWLKA--PTQSMETKILTNARCLSEGVDVDSVIFFNPRNSMVDVVQSVGRVMRKSPGKNYGYIIVPPGVAPSAALNDSRRFKVVWQVLNALRA.............................................................................................................................................................................................................................................................................................................................................................................................. 643
46 -19.400[A] KOG0923 mRNA splicing factor ATP-dependent RNA helicase  ali follow..  14  255..............YPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMG-VKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASY-----------SVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDA-------EKFSAFFDDAPIFRIPGRRYPVDIFYTKAPEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVELIVIPVYANLPSDMQAKIFEP------TPPNARKVILATNIAETSLTIDNIIYVIDVVPISSANQRAGRAGRTAPGKCFRLY--------TAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPV.................................................................................................................................................................................................................................................................................................................................. 673
47 -18.900[L] COG1643 HrpA-like helicases  ali follow..  14  80..............SQKKQDILEAIRDHQVVIVAGETGSGKT-TQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELQ-TEPGGCIGYKVRFSDHVSSNTMVKLMTDGILLAEIQQDRLLMQY-----------DTLIIDEAHERSLNIDFLLGYLKELLPRRPDLKVIITSATIDP-------ERFSRHFNNAPIIEVSGRTYPVEVRYRPIVEEADDTERDQLQAIFDAVDEPGDILIFMSGEREIRDTADALNKLNHTEVLPLYARLSNSEQNRV---------QSHSGRRIVLATNVAETSLTVPGIKYVIDIEPISSANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVE................................................................................................................................................................................................................................................................................................................................................................................. 455
48 -17.700[L] COG1110 Reverse gyrase  ali follow..  15  73.VEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYFAIKG--KRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIKDGDFDILVTSSQFLATRFDEL-LRDKRFDLIFVDDVDAF--------------LKASKNIDRSLLLLGFTQEVINRAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIER-------YRRENNIGILIVASATGSARKLYRELLGEVGSGRSVLRN-TYIIPERSIEEEVENLLRKLGKGGLIFVPIDLKSKGFKVEVDYLVGVATYYGTIVR--G---RFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKARLRRLIRNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVI................................................................................................................................................................................................................................................................................................................................. 525
49 -17.100[A] KOG0922 DEAH-box RNA helicase  ali follow..  10  41..............ASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGKMIGITQPRRIAAVTVAKRVAEECE-VQLGQKVGYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRY-----------SVIIVDEAHDRSVHTDVLLALLKKIQRTRSQPVSEKTEFGNVAS-LKLIIMSASLDARVFSEYFGGAKAVHVQGRQFPVDILYTVHPESDVDATLVTIEKPGDILVFLTGQDEIESVERLVQERLKLLPLAIFSALPSEQQMKVFAP------APTGFRKVILATNIAETSITIPMESLDVVPASKAQTLQRSGRAGREGPGKSFRLYPEREFEKLEDSTKPEIKRCNLSNIILQLKALGIDDIVGFDFID................................................................................................................................................................................................................................................................................................................................................................................. 457
50 -16.900[B] KOG0389 SNF2 family DNA-dependent ATPase  ali follow..  15  286..........GLQLADYQIILTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQA-LIVVPSSTLDN--EAEISRWCP--ELVVEKYHGSQDERRRMRGDVLLTTYHIVGSTPEERKM----------FRVCKLDYVIFDEAHMLK-NMTTQRYANLITINARMR---ILLTGTMPKFLKKDVLKNLPKKLSLVEKVPMSSQQKIYYHELVD-NLICDSGKFLYLDTLLPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVR----QDLITDFNGDDSIFVFLLSTKAGGVGINLTADTCVIDFNPYNDK-QAEDRCHRMGQQRPVTIYRLISESTIEEGILMEEKLKLEKDITSNEKGEVHEQRCVVKLLTTALGLDKDQEEQLNNSLNNS............................................................................................................................................................................................................................................................................................................................................................. 838
51 -16.700[KL] COG4646 DNA methylase  ali follow..  13  488...........FVLYGHQKRGIWRIISAGSTYLAHAVGAGKTMTMAASIMEQRRLGLVAKAMQVVP-GHCLAQAAREFLALYPTARILVADETNSKDKRARFLSRAATATWDAIIIT--RLEALSTRKDDLLTIAEIGVDQIIVDEAQEFGSQRAWDLYVKSRFIETINPGRLVLASGTLMERGLHEFDAWASTFGDTTTELELQPSRKYKPVSRQIVTSKPTQAFKHYQMVLAERIKGDDILLSVITDGRHAASAYRWIRDELASQIAFMQDFKKSEAKQRLFGDV-----RAGSVRFLIGSSETMGTGVNAQLRLKALH-LPSQ-IEQREGRIVRQGNQHEVDIFAYATEGSLDATMW--QNNERKARFIAAALSGDTSIRRLEDLGEGQFAMAKAIASGDQRLMQKAGERLRAAHLDDQHAVRRQIRDAER..................................................................................................................................................................................................................................................................................................................................... 1134
52 -16.600[R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster  ali follow..  15  78..........PFPPHAHQARAFQRLGAPQPTLVATGTGSGKTECFMFPLLNHCAGASQAKAIIIYPMNALATDQASRFAKTIASGKVTVGLFVGDSEIEPSKKMDILLTNLDYLLMRPGDQPLWRYNQPGSLRY-------LVVDELHTFDGAQGSDLACLVRRLKHHIGVDCVGTSATVGGQLLDYAKTIFDQPFTDDAVIREDRYTAAEYLQNYAIAYSQYPGPEVASALDPQSYATPVAYLESDDGREKRIALGSLLRRHSVMHVLLHDLQGGILSERECLENLQVMLAESADHARRVLQSILALIAVQLRSQLWLREMRRLVASVA............................................................................................................................................................................................................................................................................................................................................................................................................................................. 474
53 -15.700[V] COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases  ali follow..  14  258.............MRSYQIQATREILQKEGGYIWHTTGSGKTVTSFKVAQLLASAPRIKNVLFIVDRIDLIDQTLENFKSFAYAHFKNRIKKVNGRELKRELGSSQILLISVQGLTKAVKKGLENDDWN-----------VIIMDEAHSASGESVKLIKKALISTHDIFGKRLHTYTNVLGFDVTYFKPHWVVEHPQEDFSEKDYEKEVYQSDVYRQEVVKDILDNTKTSSGALIAGKREEQAMFAVSGKQAAVNYYNIFKSKGSHLNVAMARAYMLDITKRLARKRPYNQGKEKDRLDLVIVSDQLLTGFDSKINVIYMD-KMLKMLIQAISRTNR--------TFDLNSKPHGKVRFYGDEMREFVENALRIYTR.............................................................................................................................................................................................................................................................................................................................................................................................. 702
54 -15.400[A] KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1)  ali follow..  14  408............QLNSSQSNAVSHVLQRPLSLIQGPPGTGKTVT-SATIVYHLSKIHKDRILVCAPSNVAVDHLAAKLRDLSASDTKRFVKLVRKTEAEILNKADVVCCTCVGAGDKRLDTKF----------------RTVLIDESQASEPECLIPIVK---------GAKQVILVGQLGPVILERKAADAGLKQSLFERLISLGHVPIRLEVQYRMNLSEFPSNMFYEGSLQNGVTIEQRTV----PIRGIPMMFWANYGREEIS----TSFLNRIEAMNCERIITKLFRDGVKPEQIGVITQRAYILQYMQMNGSLDEVASVDAF-Q--GR------EKDYIILSCVRANEQQAIGFLRDPRRLNVGLTRAKYGLVILGNPRSLARNTLWNHLLIHFREKGCLVE............................................................................................................................................................................................................................................................................................................................................................... 836
55 -15.300[V] COG3587 Restriction endonuclease  ali follow..  12  1MSGFNYEK------QPHQMRAVSAVLG--ILDISMETGTGKTYTYTQTMFELHRWLGVFKFIVVVPTLSIKAGTQQFLQSKALAEGVRLKTYVVESAKKNKGKKSNAPITIEQFVKHVLLINAGMVNSSSMVDALAAVRPFMIVDEPHKFPTRDSAKTWGNIKRLKPQY---ILRYGATFNDEYYNLLYRLTAVDAFNDGLVKAVINPYSYSQTVQDAMMQRAVAEHFKLERALLAERAPQPTLFFIDDIAGSDPFYRDYLQKTLDDVSACHGGYFSKDNTDSDDR-KEKLLSLDNPRRFIFSKWTLREGWDNPNVFQICKLRSSGSTTQEVGRVNELMARVRDVPYKLNYFVDSSEKDFVKQLVGEINDNSFQEEISKKFTEELKQKILQKYPDIKPLVLVNQLFLDGIIDDNENFAEDGYDKLKAAYPEAFPKGL.................................................................................................................................................................................................................................................................................................................................. 642
56 -13.900[A] KOG1804 RNA helicase  ali follow..  10  309............VLNENQKLAVKRILSGDCYILFGPPGTGKTVTIIEAVLQVHFALPDSRILVCAPSNSAADLVCLRLHESKVLQPATMVRVNATCRFEEIVIDAVKASRFRIIITTCSSSGLFYQIGVRVGHF-----THVFVDEAQASEPECLIPLGLMSDI-----SGQIVLAGMQLGPVIKSRLAMAYGLNVSFLERLMSRPAYQRDENAFGA----CGAHNPLLVTKLVKNYRSHEALLMLPSRL-----FYHELEVCADPTVLIFHG----RGSEAREGKSPSWFNPAEAVQVLRYCCLLAHSI-DIGV------ITPYRKQVEKIRILLRNVDLMDIKVGSVEEFQGQEYLVIIISTV-RSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLI...................................................................................................................................................................................................................................................................................................................................................................... 709
57 -13.800[KL] KOG0387 Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain)  ali follow..  14  274..........RPHLFRYQVTLWELYCQEAGGIIGDEMGLGKTIQIVSFLSSLHHSGKFQKALIVCPA-TLMKQWVNEFHTWWA--PLRVVVLHATGSGQRASREHILITTYAGLRIYG--------------LILPREWGYCVLDEGHKIR-NPDSEISISCKQIRTVNR---IILSGTLLRRMKLDVAADLPKKSEQVLFCKLTPREYLLHKEDYNYGDPEKSGKLKVIRALLTLWKQGHRTLLFSQTRQMLDILEIGLKDLPDVHYCRMDGSTSIALR----QDLVDNFNKNEYFDVFLLTTRVGGLGVNLGADRVIPDWNPSTDA-QARERAWRLGQKKDVVVYRLMTAGTIEEKIYHRQIFKQFLTNKDPKQRRFFKMTDLHDLFT................................................................................................................................................................................................................................................................................................................................................................................. 793
58 -13.400[KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family  ali follow..  15  701............TLRSYQTE-LERLRKMHL-ILADDMGLGKTLQAIIAVTQSKLEKGSGCSLIVCPTSLVYN--KEEFRKFNP--EFRTLVIDGRKQLTALADRDVAITSYNLLQKDV--------------LYKSFRFDYVVLDEAHHIK-NRTTRNAKSVKMIQSDHR---LILTGTMPVALKKKVSPFILRRMKEDVLKDLPPVSEILTESQKELYQSYAASAKQELSRLVKQEGFERIHIHVLATLTRLKQIYDMLMDLLSSLVTVVFSQYTKDGSTKNRLDLVNQFNEDPSLLVFLISLKAGGTGLNLVADTVI--YDMW----QATDRVHRIGQSRSVSSYKLVTLNEEKILTLQNRKKSLVKKVINSDDESKLTWEEVLELLQ................................................................................................................................................................................................................................................................................................................................................................................. 1165
59 -12.900[L] KOG1132 Helicase of the DEAD superfamily  ali follow..  13  38...........YQPYGTQLAFMSRVISHCHALLESPTGTGKSLSLLCSVLAWQQNYKSRTIYYASRTHSQITQVIREYRKTGYRVPMAVLVKVGKNSWSMAENAQLVFCPYSYIVNPVIRAGVEV----------DLKGAIIIFDEAHFFLMIRPSTKSFTVHSNMEDIARSVILTSGTLPNSFSSELGMQFGTSLEAPHVIDPNMQYPLNASYKTADAYSFQDALGKSLEEICTIVPGG--SLVQWSRLCLKKDLFVEPRGGAQDEFDSVLKGYYDSRRAKKAGPIKTETQDDSKKGAAFLAVKVSE-GIDFADDVVEDYT-NSNPKVKEEAECCREVIDLECGVQPDLGYCEVSSVTNCDEAPETSFVQETSGMINGISVASPCSCSMNESSSPATVGLRSPGSPDQLLKQHISTPNFRKSPLGT............................................................................................................................................................................................................................................................................................................................................ 786
60 -12.800[L] KOG1803 DNA helicase  ali follow..  13  238............TLNPSQVAAVSAAMNTQLLCIQGPPGTGKTRVIAEIVHQLMKKK--KKVLVCAPTHVAVRNAMDATTG-YKKMSYEYYLIRNSIFRSIFYPKLAVFSTLGTSSIQKLPE------------------DVMIVDEAQCTEPATWVPVLTT--------SCKKLILVGDLPAVVLSDKAMKGNFKLSLME------------------KLAEEFSSNNINILLNEQYRMNKKIMNWSN-----EVFYEQLTAHSTVSDITLHSFTNTDELNLVTEYVNRLVVDLGNPKAIAVISQIEKLRRSIPFRV---DVNTVDAF-Q--GH------ERQVVIFCLVRDNDEGQIGFLNETRRLNVAVTRARRQFVLIGNGRMMKGNKHLLKLYKHLQSEKVIFG............................................................................................................................................................................................................................................................................................................................................................... 672
61 -12.600[U] COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase)  ali follow..  13  69VVREASKRVLGMRHFDVQ--MVGGMVLHFSGISEMRTGEGKTLVATLPTYLNALEGKGVHVI------TVNDYLARRDADWMGQVYNFLGLSYGQGERQRAYRSDITYGTFDYLRDNLVYSVDEMVQRGHNFAIVDEVDSILI-DEARTYDAANVSVVHHVNQALRANIGGEVVLINQTLASVTIQNYFRLYKKLSGMTGTASTEAQE-QRIDDDDEVYRTEREKNEAILKQIADCHVRGQPILVGTVSIEKSEELSKLLSTFSFEKD-IPHQVLNARFHEQEAVIVADA----GVPGAVTIATNMAGRGTDIQLGVLGTERHESRRI-QLRGRTGRQGDPGRSKFFLSCEDD---LRIFAGERLDAIMRTFGVQEGEAITHKWLNNAIATAQKRVEQRNYEIRKNLLKYDDVVNDQRKAVFEQRQEFMESSDLSDII................................................................................................................................................................................................................................................................................................................................. 688
62 -12.000[S] KOG2340 Uncharacterized conserved protein  ali follow..  11  173.ILDSYKKQKPSGQTSMQIELAKAMFNYQDVFFTNMSMKSHKLGTSLLALHALNH-TRPKVLILLPTRNSAFEFINLLISYSGTNQVERYLFSGNKLFSQFYNSDIIVAS----LRLAIGNKGDKKRDLDYLS------EIAMVDQAHALVMQNWEHIECIFDELNARYMRQTILFSQYNNLDINSFFSHYMSNIAGKVKFRSLNRLGYKVTQTFVRISVDSIIKVPDATGSILVQLKKYSGILVYIPSYFDFVRVRNYMDEE-GINYSAISEYSSVSDMTRARNLFYQ------GRTNIMLYTERAH-RFDFGVKAVVMYGPP-QFYVELVRMPMRTISEGNL............................................................................................................................................................................................................................................................................................................................................................................................................................... 610
63 -11.600[R] COG1444 Predicted P-loop ATPase fused to an acetyltransferase  ali follow..  12  223.................QVEVLKLFEVKQALVIIADRGRGKSAALGLGLAGIGHKLARVQIVVSAMEYSNLETLLEFALKGLEALGYKPGVEREGGEIRAI-GIFIDVVTPYMLLKR--------------------NADIVAIDEAAGVPLPVLYAVHKKFNR---------LVFATTIHGYFLKYLKEARDTDVYLYEMEE--GRGDPVEEWLFDAFLLNAEPAKIEAEDLEYVKRQEVLYL-ILKSEEVFRQFFGIYVQA--------HYRNEPDDGMLLDAPHHTARALALPNGKIVVSVELAYEGGDLSIDQALRGLKLPGNIIPRIVRIAQDMGLGTLMLKKIEEEARELGMDYVGVGFGVYDRLLK.................................................................................................................................................................................................................................................................................................................................................................................................. 596
64 -11.400[R] COG3972 Superfamily I DNA and RNA helicases  ali follow..  210.................QRRAALVTIDGPQ-RIRGLAGSGKTVILAMKAAHLHMTRPNDKILVTFFTKSLRSPIKDLVTKFYRHNNIHIRHGWGGSNSSGTYADACRRSGRMPRSYSSARDAAPRGVEPFSFACEELINSHILIDEGQDFPDGFYKLCFELAKVLSKCYRNQVLVAAHALGFGIYSNIVQLLESPDHILRPVENSPVALDTDGLPPLIGNFIASSFEKEISWITKEIIN-EDIIVVALDDRHMRNYFRYLSESLASHEISVNNIHADPYSEPPFSI----------SGKITLSTVYRAKGNEAAVVFALG-----NKIFAAFTR-------TKAWLRVSGLGDS------ARRVAVEIDTALRNFPHLKFKMPDISEIDLIQRDLSKRSIKAKKIRNEYIQKLKDEGFT--EDEIADILSLEEKDE................................................................................................................................................................................................................................................................................................................................... 711
65 -10.900[K] COG2909 ATP-dependent transcriptional regulator  ali follow..  10  2LIPSKLSRPVRLQNTVVRDRLLVKLSSARLTLINCPAGYGKTTLILGWYSLDESDNQSERFATYLAIQLATGGHCSKSEALSQKHQYA---------------------NLSALFSQLFIELSNWDGPL-----------YLVIDDYHLITND---AIHEAMRFFLRHQNLTLIILSRTLPSLGIANL------------------------RVRDQLLELGMQQLAFNHHEAQQFFECRLSSPLEQGDSSRLCDEVESSRQPNSSAQKSAKRLAGLNASHLSDYLVDEVLDQVDSKRAFLLRCSVLRS-MNDALIVRLTGEDNGQQLLEELERQG---------LFIHRMDDSAEWFCFHPLFATFLRQRCQWELA---------LELPELHHAAAEGWMALGYPAEAIHHALAA---GDVGMLRDILLQ........................................................................................................................................................................................................................................................................................................................................ 379
66 -10.700[KL] KOG1131 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 5`-3` helicase subunit RAD3  ali follow..  13  1.................MLELKRSLDAKGHCLLEMPSGTGKTATLLSLIVAYMVEHPETKLIYCSRTVPEIEKVIAELQNLMVYYEREVSKEREGKAVDGK-HAHIVVYSYHYLLDPKIAQVVSKE---------MSRESCVVFDEAHNIDRRTVERSTNALNHLTKLVQDTVVITSGTLSP--MDMYPKILD-----FDPVVMSSFTMTLARPCLLPMIVSKGNDQVTISSKFETREDGQLLVEVAKTVPDGIVCYLYLESVVADTLLRYKLLFIETQDNAETSYALMNYVKDCGRGAVLLAVKVSE-GVDFDHHVLMFGI-PMRHAAQCVGRALRGKTDYGIMIFADKRFSRHDKRSRLPKWIQEHLVDSFCNLSTEEAVQLARRWLRRMAQPFTREDQLGISLLTLAQLENMEQEKLERQAQGKQGVGGEVQEL.................................................................................................................................................................................................................................................................................................................................. 745
67 -10.300[L] KOG1002 Nucleotide excision repair protein RAD16  ali follow..  450................................VAKPITVYGSFGKVLKDILLRRTKLGRAADLALPPRIITFDYYESLYK------------NSQAEFNTYIEAGTLMNNYAHIFDLLTRLRQAVD--HPYLVVYSNSSGANANLVDENKSEQECGLCHDPAEDYVVT-SCAHVFCKACLIGFSASLLTVDWTTKADTEHKASKTTLKGFRASSILNRIKLDDFQTSTKIEALREEIRDGSAKAIVFSQFTSFLDLINYTLGKCGVSCVQLVGSMTMAAR----DTAINKFKEDPDCRVFLMSLKAGGVALNLTVHVFMMDP-PVER--QAQDRIHRIGQYKPIRVFIIENTVEERILRLQKKKELVFEGTVGGSQEAILTEEDMRFLFTT................................................................................................................................................................................................................................................................................................................................................................................ 833
68 -10.200[L] COG3598 RecA-family ATPase  ali follow..  10  347.....LADEWDNLPELAPELIKGVLRQGHKMLIAGPSKAGKSFALIELSIALAEQCEQGKVLY-VNLELDRPSALHRFKDVYDAMGLPPANVANIDIWNLRGKTVPMDKLAPKLIRRSLKKNY----------------QAVIIDPIYKVSADQMAHFTNQFDKVATELGCSVIYCSGVFARDPDALIDLVELELTEDLIKARSEKAAAKIYQQALQEKALGYYQQEVTLDDLESRYQMQQHFDKAIKDIMVKQPYLEAVKKKKAKEARKSKEENLKERNQKLETAYSALFDGSTP-----VTVQEIREYLDLKSNSVENYIKEHDGYDVKKGVVFQISDNKE................................................................................................................................................................................................................................................................................................................................................................................................................................ 750
69 -10.100[L] KOG2108 3`-5` DNA helicase  ali follow..  12  246............SLNDRQRDAACSNISTPLMVI-AGPGSGKGLL-------------PSNILAMTFTKAATSEMRERIGKSAGKKAAK----------------DITISTFHSFSLQLCRM---------HADKLQRTSEFSVYGHGQQ---------RRAIIEAVRLYEEE----KNGSKTSVPCESGEGLNGAGAGAGKASGKSPEQCRKMGN---------------EIGAKILGNYNDILKACDALD-----YHDL---------ISCSVTLLSDFPEVFKECQDTW------KAIIVDTSTMQYKL-LGSHNHITIVGDDDQITVKECHNEEAQCAYVIDKIIEITNDGST-----PCCSHGDIAILYRRQVSGKVFQNAFRQRKIPFNVHGVAFYRKKVVQVILAMLKTTFSECDDASYRRVFKEEKKRIIEHIEKISTSRKCSFISAASDIFNAKISGTFKRSQLTQGRKVLQTLDMVAKLVDREQSLSAVVTCVANMIPQKYLLEQRAVVDNDGGKLLNEDN-------DLRSVLQYLMDDVAEFISTHCTTTEEEDAIKEKKGCNQLHSFINYISERETENFRSRRRDNENSVTLTTIHQSNGNASESGTSLEEERRLLYVAMTRARKKLFFLYVTVDSNW............................................................................................................. 809
70 -9.780[L] KOG2228 Origin recognition complex, subunit 4  ali follow..  566................VRQTIVLG--EGNSVIIVGPRGSGKS-VLVDDILSRAAQEINEKSYVV---KLALREISRQLSIELESIESDEALKSEMNFSDT-------LTKLLATLSHPVDLGIAEDVMTTSAAV------IFVLEEFDLFVQHSRQMLLYNLFDIAQSRKAPILIIGLTTRYDCSESLEKRVKSSHMVIPMRPPSSLSEFEQILKSVLYVSDEGGKDQIITCWNQRVDE-QHHYFASRNLKLLYVLLFPILSMAPDRPLLADEDFANISLKVSDHKVELVKNLSLLELALLICAVRFEAR-ACNFNSAYQE---YRQLHQSSV----------------SGALAHSSRLWGRDVALEAWETLGSIG............................................................................................................................................................................................................................................................................................................................................................................................... 919
71 -9.710[R] COG1483 Predicted ATPase (AAA+ superfamily)  ali follow..  56ILKRILDTFEGKE-------------RRNIFLIYSLFGGGKTHLLLTLYHAFKTPEALEDP-----LEGYIPEKRETIRELAERESVKVVPVYGKGRVGQPSIPLNVDPYSVKTIWGYIAHSLGKYSIVEKNDLFKGERVLLLIDEIADYDRRYAGNVDNFIDRLSSALNSTSSMVITLPMTEERGNLRTQEEYNHSVVR--ALWDAVRRVGGADSYTPVRTVGINDELVEVLKKRIFKHVDPDIRRRTLERIRSETNDVEIFGHGGFA-FHPEYI-----QILRTIIEKTDLQRTRDMIRITRIVVRIHIDLTNDRIRGM------LFGEKSKFADYASIIDAELVNDEKYRAFRHPELARMILTYIFTYPFDAPTPLNDFPTLTTISRAIYDPETFSKWIPADIKDTVEEIESHFVFLNRKDGVFWFWRVANVTKMVDSKTEELIQSNYGEI................................................................................................................................................................................................................................................................................................................. 541
72 -9.640[T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase  ali follow..  14  124.................QKHYVDAIDTNTIVFGLGPAGSGKTYLAMAKAVQALQSKQVSRIILTRPAVEAGEKLNEKIDPYLRPLHDALRDMVEPEVIPKLMEAGIV-----EVAPLAYMRGRT------------LNDAFVILDEAQNTTPAQMKMFLTRL-------GSKMVVTG----------------------DITQVDLPGGQKSGLRLVRHILRGVDDVHFSELTSSDVVRHQLVGHIVDAYEDYEEREARELKRKRQE............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 336
73 -9.530[L] KOG1514 Origin recognition complex, subunit 1, and related proteins  ali follow..  10  400..SKEMEEITAF----IKGSISDDQCLGRCMYIHGVPGTGKT-ISVLSVMKNLKAEVEAGSVSPYCFVEI-ENIYSVIYEGLSGHRVGW---------------KKALQSLNERFAEGKKIGKENEK-------------ILLIDELDVLVTRNQSVLYNILDW--TKPNSKLVVLGIALPEKLLPRISSRMGIQRLCFGPYNHRQLQEIISTRLEGINAFEKTAIEFASRKVAAISGDARRALEICRRAAEVADYRLKKSNISAKSQLVIMADVEVAIQEMFQAPHIQVMKSVSKLSRIFLTARVATTVSSIILLKIGCDLGECRIVLCEPGEKHRLQK-----LQLNFPSDDVAFALKDNKDLPWLANYL................................................................................................................................................................................................................................................................................................................................................................................................... 771
74 -9.440[R] COG3903 Predicted ATPase  ali follow..  11  1...................EVQEVLTNYRLVTLRGEGGVGKTRLAIQIAAASEFRDG----LCFVDLAPIADP-----------------------------------GMVSTTAAHALGLIDRPGSSTFDTLSHAIGNCLMVLDNCE----HVLDACAELVVELLGACPELSILATSRESIGVTGEVTWVVPSLSPANEAIQLFTERARLVQPNFEIV----ADNFDAVSEICRRLDGMPLAIELAAARLRSLSP-NEIANSLDDRFRLLTG---ARSTVQRQQTLRASMD-TDTERILFRRLAVFVGGFDLTAASEVAALDQLTLLVDKS---------------LVVAEESRGSTRY------RLLETVRQYALEKLNESEEIDGVRARHRT----------YATMAAGLNVPASTDYEQRLLQAEAEIDNLRAAFTWSRGNGDIAAALQL................................................................................................................................................................................................................................................................................................................. 374
75 -9.190[KL] COG1199 Rad3-related DNA helicases  ali follow..  14  16............RIYPEQCDLKHSLDAGGIALLEMPSGTGKTISLLSLIVYQQHYPEHRKLIYCSRTMSEIDKALAELKRLMAYRTSSVRREKNGNVVDAR-FCNVIIYSYHYLLDPKIAERVSRELS---------KDCIVVFDEAHNIDESSLRKASKSILSLEQKVNESVIITSGTLSP--LDMYPKMLQ-----FNTVMQESYGMSLARNCFLPMVVTRGSDQVAISSKFEARNDGNILVEFSKITPDGLVAYLYLESIVSDEVWKYKLILVETPDPHETTLALETYRASNGRGAVLLSVKVSE-GVDFDHHVIMFGI-PMRHAAQCLGRVLRGKDDHGIMVLADKRYGRSDKRTKLPKWIQQYITEGATNLSTDMSLALAKKFLRTMAQPFTASDQEGISWWSLDDLLIHQKKALKSAAIEQ............................................................................................................................................................................................................................................................................................................................................ 758

FFAS is supported by the NIH grant R01-GM087218-01
1 4 0 5 9 4   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster

Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A.; RIKEN GER Group; GSL Members. Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 2003 Jun;13(6B):1376-88.