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Query: [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon), from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRAVLMAGGSGTRLRPLTCDLPKPMVPILNRPIAEHIINLLKRHHITEVIATLHYLPDVLRDYFQDGGDFGVQMTYAVEEDQPLGTAGCVKNIAELLDETFLVISGDSITDFDLGEAIAFHKQKQSKATLILTRVPNPIEFGVVITDEAGKIKRFLEKPSTSEIFSDTVNTGTYILEPEVLEYLPSNTECDFSKDLFPLLLAKDEPMYGYVAEGYWCDVGHLDAYREAQYDGLDRKVKLDFAYRENSPGLWIGQNTYIDPSAHIEAPAVIGNNCRIGARVQIEAGTVIGDNVTIGADANLKRPIVWNGAIIGEEAQLSACVISRGTRVDRRAHVLEASVVGSLSTVGEEAQISPGVRVWPSKKIESGAILNINLILast
1 -106.000[MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)  ali  100  1MRAVLMAGGSGTRLRPLTCDLPKPMVPILNRPIAEHIINLLKRHHITEVIATLHYLPDVLRDYFQDGGDFGVQMTYAVEEDQPLGTAGCVKNIAELLDETFLVISGDSITDFDLGEAIAFHKQKQSKATLILTRVPNPIEFGVVITDEAGKIKRFLEKPSTSEIFSDTVNTGTYILEPEVLEYLPSNTECDFSKDLFPLLLAKDEPMYGYVAEGYWCDVGHLDAYREAQYDGLDRKVKLDFAYRENSPGLWIGQNTYIDPSAHIEAPAVIGNNCRIGARVQIEAGTVIGDNVTIGADANLKRPIVWNGAIIGEEAQLSACVISRGTRVDRRAHVLEASVVGSLSTVGEEAQISPGVRVWPSKKIESGAILNINLI 375
2 -79.200[GMO] KOG1460 GDP-mannose pyrophosphorylase  ali follow..  21  9VVAVIMVGGKGTRFRPLSLNIPKPLFPIAGQPMVHHPISACKRIPLAQIYLVGFYEEREFALYVSASNELKVPVRY-LREDKPHGSAGGLYHFRNLIPSHIFLLNCDVCCSFPLPKMLEAHRGYGGIGTLLVIKVESASQFGELVADVTNELLHYTEKPE--TFVSDRINCGVYVFTPEIFNAIGDVSTQRKDRATLKRPLAGKKRLYTYETMDFWEQIKSPGMSLRCSGLYLSQFR---------LTSPQLLASGDGTRSAIVIGDVYIHPSAKVHPTAKIGPNVSISANARVGPGVRLMSCIILDDVEIMENAVVTNAIVGWKSSIGRWSRVQAVTILGDSVAVEDEVVVTSSI-VLPNKTLNVS--VQDEII 414
3 -71.200[M] KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase  ali follow..  19  85VASIILGGGAGTRLFPLTSKRAKPAVPIGGCRLIDIPMSNCINSGIRKIFILTQFNSFSLNRHLSRTYNFGNGVEVLAATQTSQGTADAVRQFIWVFEEHVLILSGDHLYRMDYMNFVQKHIESNADITVSCLPMSRASDFGLLKIDQSGKIIQFSEKPKGDDLKAYIASMGVYVFRKEVLLKLLRSTSNDFGSEIIPLAVGEH-NVQAFLFNDYWEDIGTIGSFFDANLALTEQPPKFQFQKTPFFTSPRFLPPTKVDKCRILDSIVSHGCFLRECS-----QHSIVGIRSRLESGVELQDTMMMGADFYQTEAEIASLLAEGKVPVGVGQNTKKNCIIDKNAKIGKNVVIANADGVEEGDRPEEGFHIRSGIT 504
4 -70.800[M] COG1209 dTDP-glucose pyrophosphorylase  ali follow..  21  4RKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPDTPRFQQLLGDGSQWGLNLQYKVQP-SPDGLAQAFIIGEEFIGGDALVLGDNIFYGHDLPKLMEAAVNKESGATVFAYHVNDPERYGVVEFDKNGTAISLEEKPL--EPKSNYAVTGLYFYDNDVVQMAKNLKPSARGTDINRIYLEQGRLSVAMMGRGYWLDTGTHQSLIEASNFIATIEERQGLKVSCPEEIAFRKGFIDVEQVRKLAVPLIKNNYGQYLYKMT.............................................................................................. 289
5 -70.600[J] KOG1461 Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6)  ali follow..  18  25LQAILLADSFATKLLPLTLERPNVLLPLVNIPMIDYTLAWLESAGIEEVFVFCSMQVIDYLNNSDWYSHKDFTVKTIESPQNSTSAGDALRYIYEQIQGDFVLVNGCIVSNMPLTQLIQEHRDRKKKDEKAIMTAVNPLTKQLLYYDEDNICKSLLDRNPSVLLCSDMQDCYIDICSLEVLSLFVDNFDYDFVEGVLADDIIGYKIFTHEISSCYASRIENFRSYDMVSKDIIQRRTFPYVPDMKFRQGIYKASDATQLPSAHVGASYVIGHATNIGSGTKI-LNSVIGNGCSIGSNVVIQGSYIWNNVTVEDGCEIRNAIVCDEVKVCAGAIVKPGVVLSFKVVVGRDFVVPAYSQVSLLRQPMEEDSDEENLL 435
6 -67.700[G] COG0448 ADP-glucose pyrophosphorylase  ali follow..  21  22TLVLILAGGRGSRLYELTDKRAKPALYFGGNRIIDFALSNCLNSGLNRIGVVTQYAAHSLLRHLQNGWSFLPAERGIDDSTWYRGTADAVYQNMAIIPKYILILAGDHIYKQDYSQMLLDHIHSGAKCTVGCIEVEKATEFGVMAVNENLKVKSFVEKPKVGKPNTSLASMGIYVFDADYLYDVSPYTSHDFGKDILPKALEEGVMGRNTEGEIYWRDVGTLDSFWQSNIDLVCENPQLDIYDQSNPVQTYPSKFFYKKENARPVDNSLISGGCVITDASI--SYSVLFDRIKINEGSQIDHCVVLPQVTIGKNCKLKRCIIDRHSVIPDGMEIGVDLELDQRFRVSSGGVVPSMLKKLNGEEVASEAHLD.... 439
7 -60.400[J] KOG1462 Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1)  ali follow..  15  39FQAVVFAGF-GNSLYPLTGSLPKALLPIGNKPMLHYPLYWLEAAGFTSAILICMEEAEAINAWLRSGYEGHMRIHVETILDDSKSSADALRAVSHLIQNDFVCLSCDSIVGLPPIYGLDKFRLDNPSALAVYSPVLKYEAKQLIGIEEKTSRLLYAKSSADVGLNTNLSDAHIFVFKHWVIDLIREKESISIRGDLIPYLVKCQYQKSFTVRENIQRFLSSPNNIDNYDGGLSSQEIKIAKDGIICSRANNLPNYFELNKCIAKLTPEQRLVDVTVSERALVGADCMVNEGTTIKDNSNIKKSIIGKNCVIGKGVVVSNSILMDNIVVEDGVRLES-CIVASGAQIGAKSKLR-ECEIGVDHRVEAGRIARGERL 457
8 -54.300[M] COG1210 UDP-glucose pyrophosphorylase  ali follow..  19  6RKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVEEAAESGIEDILIITGRNKRSIEDHFDRSAELEANIHY-IRQKEPLGLGHAVLCAEHFIDEPFAVLLGDDIMVSETPALRQYDVYGTEVVGVQSVLPEDVSKYGIINTSGSQEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVLKTIGRGAGNEDALREVCRKE-PIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEMRSQLLA-----YLEDVIKRETKEMLR.............................................................................................................. 297
9 -49.400[M] COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes  ali follow..  14  1MKAIILAAGLGTRLRPMTENTPKALVQVNQKPLIEYQIEFLKEKGINDIIIIVGYLKEQFDYL---KEKYGVRLVFN-DKYADYNNFYSLYLVKEELANSYVIDADNYLFKNMFRNDLTRS-------TYFSVYREDCTNEWFLVYGDDYKVQDIIVDSK-----AGRILSGVSFWDAPTAEKIVSFIDKAYVSNMVKDNIKELDVYVEELEGNSIYEIDSVQDYRKLEEILKNE............................................................................................................................................ 228
10 -48.200[M] COG1213 Predicted sugar nucleotidyltransferases  ali follow..  18  1MEAVILAAGFGSRLGHHTREIPKALLKIGKRPLIYYTVQTLMENGIRDVVVVTGHKGYVLREYLSQFD-LNFKFVHN-SLYKKTNNIYSLYLAMDHVSKGFYILNSDVLFHPGI--FRELHSSTKENLILSVDTFKELGEEEMKVKIEDGVVKRISKQLNPSE--ADGEYIGIARVEENIIDDLERKGRRVFYEEAFQSMMDDGIAVYYETTKGLWIEIDTPADLMKARYEIYPK............................................................................................................................................ 238
11 -42.600[M] COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)  ali follow..  18  6LNIVILAAGKGTRMYS---KMPKVLHEIGGETMLGRVIDTAAALNPQNICVVVGHGKEQVLDTVKRDVVW-------VEQTEQLGTGHAVKTALPHLAARTLVLYGDVIDVETLETLLEAA---GNEVGLLTDVPADPSGLGRIIRDSSGSVTAIVEEKDAAQKAVKEINTGILVLPNAKLEAWLNSLSSNNAQDLIAKAVADGIKIHPVQVRSSHLAAGVNNKLQLAELELKAGVTLRDPARFDLRGRLKHGQDVVIDVNCIFEGKIELGDNVEIGANARLRPQAKLADDVHVGNFVEIKNAAIGKGTKANHLTYIGDAEVGSKTNFGAGTIIANKTVIGDEVRIGSNCVLVSPVKIGNKVTTGAGSTITRNV. 430
12 -17.000[M] COG0836 Mannose-1-phosphate guanylyltransferase  ali follow..  17  8ITPVLLAGGAGSRLWPVSDQLPKQFQPLVGLSTYQQTLKRVGDKSLYSLVITNEDFRFFARRQAEE--------ATVVLEPARRDSAAAMAAAAVLAGCLVLALAADHVVLSEAVKLGAKAADQGNIVVFGLVPTEPRTSYGYIKPGDA-TVDAFVEKPDVTTAISYL-NSGNFLFRPEILAAVSDLGFVRLHQASFEAVIEKTKRMAVVHGHFRWSDIGSWDAIWEIADKHDNDNALEGDGVFIDSEGCLIHSTQLLTTVVGAKDLVVVATKDAV................................................................................................... 334
13 -15.900[H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase  ali follow..  22  1MLTLLMCGGKGTRLG----RGEKPLFEVCGMKLIDHSLLQYKDF---DVIAITSPHTPATESYLAE--------GVEVYRAAGKGYIEDYSEACRELNEPVIVASADIIRDIAFDIVDAYMKTIKPALTVVMEGEPVG-----VNIIDSLLINTWQEEEIYSIEKDSVVNVN........................................................................................................................................................................................................... 157
14 -15.300[Z] KOG3121 Dynactin, subunit p25  ali follow..  15  16...........................................................................................................................................................................................................................................................TASGNKVSRHTVLCGNIILNGKVIVQSGAIIRGNVRTGRYCVIGKNSVIRPPHVGEHVFVGEGAVVSAATIGSYVYIGKNAIIGRRCVLKDCCVIEDGAVLPPETTVSSYMRY........... 146
15 -15.200[E] COG2171 Tetrahydrodipicolinate N-succinyltransferase  ali follow..  14  99.............................................................................................................................................................................................................................................................................QKEGFRVVPPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVSCAQIGKNVHLSGGVGIANPTIIEDNCFIGARSEVVEGVIVEEGSVISMGVYIGQST. 212
16 -15.200[R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily  ali follow..  18  13...........................................................................................................................................................................................................................................................VHPDAFVHPSAVLIGDVIVGAGVYIGPLASLRGDLILEAGSNLQDGCIMHDTIVHENGHIGHGAILHGCVVGRDALVGMNSVIMDGAVIGEESIVAAMSFVKAGFQGEARQLL........... 133
17 -14.000[M] COG1043 Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase  ali follow..  16  32.....................................................................................................................................................................................................................................................VGPQVEIGEGTVLKSHVVVNGQTKIGRDNEIYQFASIGTRVEIGDRNRIRESVTIHRGTVQGGTKVGSDNLLHDCTVGNRCILANNATLAGHVSVDDFAIIGGMTAVHQFCIIGAHVMVGGCSGVAQDV. 181
18 -13.900[M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase  ali follow..  17  4FTVIIPARYASTRL--------KPLAEIAGKPMIAHVFEKAMQSGAKRVIVATD--HEQVATVA---RGFGAEV-CMTSETHQSGTAEVVEKLGIAEDEIIVNIQGDLIPPAIVRQVAENLAKYQVKMASLAVNITDPEEL--VLTDHAGYVLYFSRAPQLVLSDHYLRHIGIYAYRAGFIKQYIQWQPSVLEQESLEQLLWYGEKIHVELAREV-VGVDTAEDLEKVRSILEK............................................................................................................................................. 258
19 -13.800[G] KOG2638 UDP-glucose pyrophosphorylase  ali follow..  13  108LVVVKLNGGLGTSM----CKGPKSLIGVNENTFLDLTVQQIEHLNVPLVLMNSFNTDEDTKKILQKYNHCRVKIYTFNQSRYPFYNSGLLDTFIGEGKEYIFVSNIDNLGAT-LNHLINPPNGKRCEFVMEVTNKTRADVKGGTLTQYEGKLVEIAQVPKAHVDEFKIFNTNNLWISLAAVKRLGGLNVIQLETAVGAAIKSFENSLGINVPRSRFLPVKTTSDLLLVMSNLYSLNAGSLT--QDYLRRFESIPDMLELDHLTVSGDVTFGKNVSLKGTVIIIANH--GDRIDIPPGAVLENKIVSGNLRILDH............................................................. 508
20 -12.800[R] COG2068 Uncharacterized MobA-related protein  ali follow..  16  11VGIVLLAAGRSSRMG----GPNKLLALFDGKPLVRRTAERALGSKASGTIVVTGHQRERVRAALS-----GLDVTFADNPDFANGLSTSLKAGIAYLPAGAMIVLGDMVVSGDLDRLIDAFRKAGGNSVVR---------------------------ASHQGKRGNPV-----LLPRALFPAIAHLEGDTGARHLVEAEGLDVVDV---IGEGASVDVDTREALEGAGGVLQD............................................................................................................................................. 206
21 -12.300[M] COG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase  ali follow..  18  138.................................................................................................................................................................................................................................................AGCFIGKQARLGDNTKLWANVTIYHKVEIGSDCLIQSGTVIGGSVRIGDRVEIGACTTIDRGAL-DDTVIEDNVIIDNQLIGYGSALAGGTVIAGSTRIGKYCIIGGASVINGHIEIADGVTITGMGMVMRSI. 295
22 -12.100[I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase  ali follow..  14  12IVAVVPAAGIGSRMQ---MDKPKQYLHIHGKTILEHTLSVLLGYPIEKIILAVA--PYISTCPLLTHPKIQLVEGGSSRADSVLNGLNAVKSAVQNSEDFWVMVHDAALTHQDLDKLVQVEDQNGAILAIPATDT-------IKRALHNQQIHYTEDRSQLWLAQTPQF---IATLAQALEQALAQGLQVTDEASAMEFA---GFRPHLVAGRSDNIKVTRPEDFALAEFYLSRTK........................................................................................................................................... 238
23 -11.800[R] COG4801 Predicted acyltransferase  ali follow..  13  51.................................................................................................................................................................................................................................................GDVVACSDTRIDMWSKMGSNVEVGKNAYLGEFVSIEGKLTVEGDLDVGKEVKIKGGFVAKGWIVGGDAVVGNNCYLIGNLKAQSVETGNALILKGSIYSEGKINIGENSTIYGNLSSKGQVNIGRNTKVFGGI. 252
24 -10.200[H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A  ali follow..  14  3HVNVLLAGGASRRF-----GEPKAFVKWKGRMLYECAKEALGEQ----VIISRPEFIDRFQEN--------NEVYQDAEPFQGMGPLAGIYTAFKKTDGDLTVLSCDTLIQRRTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLGRISVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD............................................................................................................................................................................ 199
25 -9.780[M] COG1083 CMP-N-acetylneuraminic acid synthetase  ali follow..  11  9..AIIPARA-GSKGIK------KNLQLVGGVSLVGRAILAAQESGMFDQIVVTSDGENILKEATKYGAKPVARPESLAQSDTR--TIDAILHCLETLNISQLQPTSPLRNALDIRNAMEIFLGGKYKSVVSACECEHHPYKSFTL--EGTEVQPIHELTDFESPRQKLANGAIYINDIQSL----FEEKRFFIAPMRFYLMPTYRSI----------DIDSTLDLQLAESLISKE............................................................................................................................................ 227
26 -9.280[G] COG4284 UDP-glucose pyrophosphorylase  ali follow..  17  104VAVILMAGGQGTRL----SSQPKGCYDISKKSLFQIQAEKLIRVEIPWYIMTSGPTRAATEAYFQEHNYFGLQITFFNQGTLPAGNGGLYRAIKENIKHVYMYCVDNVLSKIADPVFIGFAIKHGFELATKAVRKRDAHESVIATKNEKPCVIEYSEISNELAEAKDAGNIVNHYYLVDLLKRDLDQWCENMPYHIAKKKIPAYDSVTGKYTKPTEPNGIKLEQFIFDVFDTVPL............................................................................................................................................ 391
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.