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Query: [M] COG1210 UDP-glucose pyrophosphorylase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVEEAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHYIRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGVQSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVLKTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEMRSQLLAYLEDVIKRETKEMLRLast
1 -106.000[M] COG1210 UDP-glucose pyrophosphorylase  ali  100  1MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVEEAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHYIRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGVQSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVLKTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEMRSQLLAYLEDVIKRETKEMLR 297
2 -68.100[M] COG1209 dTDP-glucose pyrophosphorylase  ali follow..  27  2...KMRKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPDTPRFQQLLGDGSQWG---------------------LNLQYKVQPSPDGLAQAFIIGEEFIGGDDCALVLGDNIFYGHD---LPKLMEAAVNKESGATVFAYHVNDPERYGVVEFDKNG----TAISLEEKPL--EPKSNYAVTGLYFYDNDVVQMAKNLKPSARGELEITDINRIYLEQGRSVAMMGRGYWLDTGTHQSLIEASNFIATIEERQGLKVSC-PEEIAFRKGFIDV. 266
3 -54.300[MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)  ali follow..  19  1.....MRAVLMAGGSGTRLRPLTCDLPKPMVPILNRPIAEHIINLLKRHHITEVIATLHYLPDVLRDYFQDGGDFG---------------------VQMTYVEEDQPLGTAGCVKNIAELL-DETFLVISGDSITDFDLGEAIA----FHKQKQSKATLILTRVPNPIEFGVVITDEAG----KIKRFLEKPSTSEIFSDTVNTGTYILEPEVLEYLPSNTECDFSK----DLFPLLLAKDPMYGYVAEGYWCDVGHLDAYREAQYDGLDRKVKLDFAYREWIGQNTYIDPSAHIE 265
4 -48.600[GMO] KOG1460 GDP-mannose pyrophosphorylase  ali follow..  16  5.MEEKVVAVIMVGGKGTRFRPLSLNIPKPLFPIAGQPMVHHPISACKRIPLAQIYLVGFYEEREFALYVSAISN----------------------KVPVRYLREDKPHGSAGGLYHFRNLISPSHIFLLNCDVCCSFPLPKMLEAHR--GYGGIGTLLVIKVSPESASQFGELVADPVTN---ELLHYTEKP--ETFVSDRINCGVYVFTPEIFNAIGDVSTQRKDRATLKDILSPLAGKKRLYTYETMDFWEQIKSPGMSLRCSGLYLSQFRLTSPQLSGDGTRSAIVIGDVYI. 303
5 -44.000[M] KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase  ali follow..  19  81.DPKNVASIILGGGAGTRLFPLTSKRAKPAVPIGGCRLIDIPMSNCINSGIRKIFILTQFNSFSLNRHLSRTYNFGNGVNFGD------FVEVLAATQTSGDAGKKWFQGTADAVRQFIWVFNVEHVLILSGDHLYRMD---YMNFVQKHIESNADIVSCLPMDESRASDFGLLKIDQSG----KIIQFSEKPKGDDLKAYIASMGVYVFRKEVLLKLLRSSYPTSNDFG-SEIIPLAVGEHNVQAFLFNDYWEDIGTIGSFFDANLALTEQPPKFQ.................... 370
6 -41.900[M] COG1213 Predicted sugar nucleotidyltransferases  ali follow..  17  1.....MEAVILAAGFGSRLGHHTREIPKALLKIGKRPLIYYTVQTLMENGIRDVVVVTGHKGYVLREYLSQFD-----------------------NFKFVHNSLYKKTNNIYSLYLAMDHV-SKGFYILNSDVLFHPG------IFRELHSSTKENLILSVDTFKELGEEEMKVKIEDG----VVKRISKQLNPSE--ADGEYIGIARVEENIIDDLSRVMERKGRRVFYEEAFQSMMDDGAVYYETTKGLWIEIDTPADLMKARYEIY........................... 236
7 -40.400[G] COG0448 ADP-glucose pyrophosphorylase  ali follow..  19  22.....TLVLILAGGRGSRLYELTDKRAKPALYFGGNRIIDFALSNCLNSGLNRIGVVTQYAAHSLLRHLQNGWSFLPAERGEFIDML---------PARQQIDDSTWYRGTADAVYQNMAIIRDKYILILAGDHIYKQD---YSQMLLDHIHSGAKCVGCIEVEREKATEFGVMAVNENL----KVKSFVEKPKVGKPNTSLASMGIYVFDADYLDVLEREVSSPYTSHDFKDILPKALEEGVLYAHPFEIYWRDVGTLDSFWQSNIDLVCENPQLD.................... 301
8 -39.800[M] COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes  ali follow..  18  1.....MKAIILAAGLGTRLRPMTENTPKALVQVNQKPLIEYQIEFLKEKGINDIIIIVGYLKEQFDYLKEK-------------------------GVRLVFNDKYADYNNFYSLYLVKEEL-ANSYVIDADNYLFKNMFRNDLTR------------TYFSVYREDCTNEWFLVYGDDY----KVQDIIVDSK-----AGRILSGVSFWDAPTAEKIVSYVSGEFVDLYWDNMVKDNIKELDVYVEELEGSIYEIDSVQDYRKLEEILKNEN........................ 229
9 -33.800[J] KOG1461 Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6)  ali follow..  11  21.RRQRLQAILLADSFATKLLPLTLERPNVLLPLVNIPMIDYTLAWLESAGIEEVFVFCSMQVIDYLNNSDWYSHKDFTVK--------------------TIESPQNSTSAGDALRYIYE---QGDFVLVNGCIVSNMPLTQLIQEHRDRKKKDEKAIMTMVIRAVNPLTKQLLYYDEDNICF---KSLLDRNPSVLLCSDMQDCYIDICSLEVLSLFVDNFDYQHMRCDFVEGVDDIIGYKIFTHEISSCYASRIENFRSYDMVSKDIIQR......................... 287
10 -29.100[J] KOG1462 Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1)  ali follow..  12  35.IPIEFQAVVFA-GFGNSLYPLTDALPKALLPIGNKPMLHYPLYWLEAAGFTSAILICMEEAEAHINAW-----------------LRSGYEGHMRIHVEAPTILDDSKSSADALRAVSHLIKQNDFVCLSCDSIVGLP---PIYGLDKFRLDNPSALAVYSPQSKEIDAKQLIGIEEKTSRLLYAKSLLWKHPRVTLNTNLSDAHIFVFKHWVIDLIREKESISSIR---GDLIPYLVKCQQKSFTVRENIQRFLSSPNNIDNYDGGLSSQEIKI..................... 319
11 -27.900[M] COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)  ali follow..  23  1MPQNTLNIVILAAGKGTRMY---SKMPKVLHEIGGETMLGRVIDTAAALNPQNICVVVGHGKEQVLDTVKR---------------------------DVVWVEQTEQLGTGHAVKTALPHLAAEGRTLVLYGDVPLIDVETLETLLE----AAGNEVGLLTDVPADPSGLGRIIRDSSG----SVTAIVEEKDADAAQKAVINTGILVLPNALEAWLNSLSSNAQGEYYLTDLIAKAVADGKIHPVQVRSSHLAAGVNNKLQLAELERIFQTEQAQELLKADLRGRLKHGQDVVI. 273
12 -19.600[M] COG0836 Mannose-1-phosphate guanylyltransferase  ali follow..  15  1MNEQSRKPVLLAGGAGSRLWPVSRQLPKQFQPLVNLSTYQQTLKRVGDSLYSEPLVITNEDFRFF---------------------ARRQAEEIDLPATV--VLEPARRDSAAAMAAAAVLAPGCLVLALAADHVVLDVDKFSEAVKLGAKADQGNIVVFGLVPTEPRTSYGYIKPGDAEKDLSTVDAFVEKPDVTTAISYLENSGNFLFRPEILAAVTQAVEQYESDLGFVRLHQAIEKTKRMAVVHGHFRWSDIGSWDAIWEIADKHDNDNALEGDGVFIDSEGCLIHSTQLLT. 317
13 -15.900[H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase  ali follow..  13  1.....MLTLLMCGGKGTRL----GRGEKPLFEVCGMKLIDHSLLQYKDF---DVIAITSPHTPATESYLAE---------------------------KGVEVYRAAGKGYIEDYSEACRELAINEPVIVASADIVYIRDIAFDIVDAYMKTIKPALTVVM........................................................................................................................................ 122
14 -14.700[M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase  ali follow..  15  1MTNFT--VIIPARYASTRL--------KPLAEIAGKPMIAHVFEKAMQSGAKRVIVAT------------DHEQVATVARGFGAEVCMTSETHQSGTERLAEVVEKLGIAEDEIIVNIQ---GDEPLI----------PPAIVRQVAENLAKYQVKMASLAITDPEELFNPNAVKVLTDHAGYVLYFSRAPIPWHRDQFASLRHIGIYAYRAGFIKQYIQWQPSVLEQIESLEQLRVLWYGEKIHVELAREV-VGVDTAEDLEKVRSIL............................ 256
15 -13.600[R] COG2068 Uncharacterized MobA-related protein  ali follow..  17  13.......IVLLAAGRSSRM-----GPNKLLALFDGKPLVRRTAERALGSKASGTIVVTGHQRERVRAALSG--------------------------LDVTFADNPDANGLSTSLKAGIAYLPEAGAMIVLGDM--GVVSGDLDRLIDAFRKAGGNSVVRASHQGKR------------------------NP--------------VLLPRALFPAIAHLEGDTGARHLVEAEGLDVVD---------EGASVDVDTREALEGA................................ 200
16 -13.500[I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase  ali follow..  15  1MTTPIAKAVVPAAGIGSRM---QMDKPKQYLHIHGKTILEHTLSVLLGYPIEKIILAVAANDP----------------------YISTCPLLTHPKIQLVEGGSSRADSVLNGLNAVKSAVNSEDFWVMVHDAA---THQDLDKLVQVEDQNGAILAIPATDTIKRALHNQQIHYTEDRSQLWLAQ-----------------------TPQFFPLAQALEQALAQGLQVTD--ASAMEFAGFRPHLVAGRSDNI-RPEDFALAEFYLSRTK........................ 238
17 -10.500[M] COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog  ali follow..  14  1MNDIL--FIIQARMGSTRL-P------KVLRPLGSNRLLDILVHRVRQSARDNLVIATSDKETD------------------------DILEAHCIKQGFRVFRGSEERVLDRFVKVIEAV-KPSVIIRLTGDNPFV-DPELLDVMIQAHFDQGSDYTYILNAPL------GICGEVVNANLLIDISR-----IQALEDQYQEHVTLYIRNPALYRVLEAPERFRAPQYRLTDTKEDYESIKALYQKAGERPDVSASELITLLNRNPDAATETRG...................... 239
18 -10.100[M] COG1083 CMP-N-acetylneuraminic acid synthetase  ali follow..  15  1MKIIMT-AIIPARA-GSKGIK------KNLQLVGGVSLVGRAILAAQESGMFDQIVVTS-----------DGENILKEATKYGAKPVARPESLAQSDTRTI-----------DAILHCLETLNISGTAALLQPTSPLRNALDIRNAMEIFLGGKYK--SVVSACECEHHPYKSFTLEGTEVQPIHELTDFESPRQKLPKSYRANGAIYINDIQSLFEEKRFFIAPMRFYLMP-----------------TYRSIDIDSTLDLQLAESLISKE......................... 227
19 -9.120[G] KOG2638 UDP-glucose pyrophosphorylase  ali follow..  12  110.......VVKLNGGLGTSM-----KGPKSLIGV-ENTFLDLTVQQIEHTDVPLVLMNSFNTDEDTKKILQKYNHCRVKIYTFNQSRYPRINKESLRPVAKDVSYSGEPPGHGDIYASFYN--GKEYIFVSNIDNLGATVDLYILNHLINPPNGKRCEFVMEVTNKTRADV-GTLTQYEGKLRLVEIAQVPKAHVDEFKSVSIFNTNNLWISLAAVKRLAKTLDGGLNVIQLETAVGAAIK......................................................... 377
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.