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Query: [I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTTPIAKSTRRIVAVVPAAGIGSRMQMDKPKQYLHIHGKTILEHTLSVLLGYPLIEKIILAVAANDPYISTCPLLTHPKIQLVEGGSSRADSVLNGLNAVKSAVQNSEDFWVMVHDAARPCLTHQDLDKLVQVEDQNGAILAIPATDTIKRALHNQQIHYTEDRSQLWLAQTPQFFPIATLAQALEQALAQGLQVTDEASAMEFAGFRPHLVAGRSDNIKVTRPEDFALAEFYLSRTKLast
1 -114.000[I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase  ali  100  1MTTPIAKSTRRIVAVVPAAGIGSRMQMDKPKQYLHIHGKTILEHTLSVLLGYPLIEKIILAVAANDPYISTCPLLTHPKIQLVEGGSSRADSVLNGLNAVKSAVQNSEDFWVMVHDAARPCLTHQDLDKLVQVEDQNGAILAIPATDTIKRALHNQQIHYTEDRSQLWLAQTPQFFPIATLAQALEQALAQGLQVTDEASAMEFAGFRPHLVAGRSDNIKVTRPEDFALAEFYLSRTK 238
2 -23.700[H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase  ali follow..  12  1...........MLTLLMCGGKGTRLGRG-EKPLFEVCGMKLIDHSLLQYKDFD-----VIAITSPHTPATESYLAEKGVEVYRAAGKGYIEDYSEACREL------AINEPVIVASADIVYIRDIAFDIVDAYMKTIKPALTVVMEG--------------------------EPVGVNIIDSLLINTWQEEEIYSIEKDSV----------------VNVNTVADVERAERLWTTMR 173
3 -20.100[M] COG1083 CMP-N-acetylneuraminic acid synthetase  ali follow..  9  3.......IIMTRIAIIPARAGSKGIKD---KNLQLVGGVSLVGRAILAAQESGMFDQIVVTSDGENILKEATKYGAKRPESLAQSDTRTIDAILHCLETLNI-----SQGTAALLQPTSPLRNALDIRNAMEIFLGGKYKSVVSACESFTLEGTEVQPIHELTDFESPRQKLPKSYRANIYINDIQSLFEEKRFFIAPMRFY---------LMPTYRSIDIDSTLDLQLAESLISKE. 227
4 -19.400[H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A  ali follow..  10  2..........KHVNVLLAGGASRRFGEP--KAFVKWKGRMLYECAKEALGE----QTVIISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKT-------DGDLYTVLSCDTPLIQRRTMLELKRLMIAGADAVVPISDGQVQPLIA--------------------IYHKRIMPVLYDQLSEKRLRISDLLGRISVCYVQAENIGANPAEFNINTRDDFSCLEEKSNSLK 197
5 -19.100[M] COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)  ali follow..  15  2.......PQNTLNIVILAAGKGTRMYSKMPKVLHEIGGETMLGRVIDTAAALN-PQNICVVVGHGKEQVLDTVKRDVVWV-------EQTEQLGTGHAVKTALPHLAAEGRTLVLYGDVPLIDVETLETLLEAAGNEVGLLTDVPADP--IRDSSGSVTAIVEEKDADAAQKALVLPNAKLEAWLNSLSSNNYYLTDLIAKAVADGIKIHPVRSSHLAAGVNNKLQLAELERIFQTE. 241
6 -18.700[M] COG1213 Predicted sugar nucleotidyltransferases  ali follow..  11  1...........MEAVILAAGFGSRLGREIPKALLKIGKRPLIYYTVQTLMENG-IRDVVVVTGHKGYVLREYLSQFDLNFKFVHNSLYKKTNNIYSLYLAMDHV---SKGFYILNSDV--LFHPGIFRELHSSTKENLILSVDTFKEEMKVKIEDGVVKRISKQLNIARVEENIIDDLYNHVSRVMERKGRRVFYEEAFQSMMDDGIAVYYETTKGLPIEIDTPADLMKARYEIYPK. 238
7 -18.600[M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase  ali follow..  12  2.........TNFTVIIPARYASTRLPG---KPLAEIAGKPMIAHVFEKAMQSG-AKRVIVATDHEQVATVARGFGAEVCMT--QSGTERLAEVVEKLGI-------AEDEIIVNIQGDEPLIPPAIVRQVAENLAKYQVKMASLAVTDPEELFNPNAVKVLTDHAGLYFSRAPYAYRAGFIKQQWQPSVLEQIESLEQLRVLWY-GEKIHVELREVPPVGVDTAEDLEKVRSILEK.. 258
8 -18.300[R] COG2068 Uncharacterized MobA-related protein  ali follow..  20  5.....AKSRLKVGIVLLAAGRSSRMGGP-NKLLALFDGKPLVRRTAERALGSKASGTIVVTGHQRERVRAALSGLDVTFADNPDFANGLSTSLKAGIAYLPEDT---AGAMIVLGD--MPGVVSGDLDRLI---------------DAFRKAGGNSVVRASHQGKR-----NPVLLPRALFPAIAHLEGDTGAR-----HLVEAEGLDVVDVEGEGASVDVDTREALEGAGGVLQD.. 206
9 -17.900[M] COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog  ali follow..  9  2.........NDILFIIQARMGSTRLPG---KVLRPLGSNRLLDILVHRVRQSKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEE------RVLDRFVKVIEAVKPSVIIRLTGDNPFVDPELLDVMIQAHFDQGICGEVVNANLLIDIRIQALEDQYQEHVTLYIRNHPALYRVQFLEAPERFRAPQ--------------------------RLTIDTKEDYESIKALYQK.. 211
10 -17.900[M] COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes  ali follow..  12  1...........MKAIILAAGLGTRLRENTPKALVQVNQKPLIEYQIEFLKEKG-INDIIIIVG-----YLKEQFDYLKEKYGVRLVFNDKYADYNNFYSLYLVKEELANSYVIDAD----YLFKNMFRNDLTRSTYFSVYREDCTNEWFLVYGDDYKVQDIIVDSKAGRILSGVSFWDAPTAEKIVSFIDKAYVSGEFVDNIKELDVYVEELEGNS--YEIDSVQDYRKLEEILKNEN 229
11 -17.000[M] COG1209 dTDP-glucose pyrophosphorylase  ali follow..  14  6.............GIILAGGSGTRLYMAVSKQLLPIYDKPMIYYPLSTLMLAG-IRDILIISTPQDTPRFQQLLGDGSQLNLQYKVQPSPDGLAQAFIIGEEFIG-GDDCALVLGDNIFYGHDLPKLMEAAVNKESGATVFAYHVNDPVVEFDKNGTAISLEEKPL--YFYDNDVVQ---MAKNLKPSARGELEITD-RIYLEQGRLSVAMMGRGYAWLDTGTHQSLIEASNFIATIE 244
12 -13.500[M] COG1210 UDP-glucose pyrophosphorylase  ali follow..  15  1MRKKVRK------AVIPAAGLGTRFTKAQPKEMLPIVDKPAIQYIVEEAAESG-IEDILIITGRNKRETLKEMQQIADLANIHYIRQKEPLGLGHAVLCAEHFI-GDEPFAVLLGDDI----ETPALRQLMDVYDVYGTEVVGVQSVLPEDVSKYGIINTSGSQGHVYEVNNSSIFS---VLKTIGRGAGNEIQLTD-REVCRKEPIHARLLEGNRYDI---DKLGCFKASTEIGLMR 273
13 -13.300[GMO] KOG1460 GDP-mannose pyrophosphorylase  ali follow..  13  3.....SSMEEKVVAVIMVGGKGTRFRLNIPKPLFPIAGQPMVHHPISACKRIPNLAQIYLVGFYEEREFALYVSAISNEVPVRYLREDKPHGSAGGLYHFRNLIMEDSPSHIFLLNC--DVCCSFPLPKMLEAHRGYGGIGTLLVIKSPESASQFGELVADPVTNELLHTEKPETFVSDRINCGVYVFTPEIFNAIGDVSTQR................................... 207
14 -12.800[J] KOG1461 Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6)  ali follow..  12  15.SEEEQSRRQRLQAILLADSFATKLLLERPNVLLPLVNIPMIDYTLAWLESAG-IEEVFVFCSMQVIDYLNNSDWYSHKTIESPQNSTSAGDALRYIYEQQIETSQIQGDFVLVNGCI---VSNMPLTQLIQEKKDEKAIMTMVIRQSLITDHQLFIAVNPLTKQLLYYDEDNICFDKSLLDRNPSVLLCSDMQ---DCYID-----SLEVLSLFVDNFDYQHMRC-DFVEGVLADD. 252
15 -12.200[M] COG0836 Mannose-1-phosphate guanylyltransferase  ali follow..  14  1....MNEQSRKITPVLLAGGAGSRLRDQLPKQFQPLVGLSTYQQTLKRVGDKSLYSEPLVITNEDFRFFARRQAEEIDPATVVLEPARRDSAAAMAAAAVLAERREPGCLVLALHVVLDVDKFSEAVKLGAKAADQGNIVV-IKPGDAIDGEKDLSTVDAFVEKPDVTTAIS--LFRSDVMIAELKAFAPEILAAVTQAVEQYESDLGFVRLHQASFEASPKNSIDYAVIE....... 260
16 -12.100[MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)  ali follow..  14  1...........MRAVLMAGGSGTRLRCDLPKPMVPILNRPIAEHIINLLKRHH-ITEVIATLH---PDVLRDYFQDGGDFGVQMTYAVEEDQPLGTAGCVKNIAELLDETFLVISGDS---ITDFDLGEAIAFHKQKQSKATLILTRVVVITDEAGKIKRFLEKPSTSEIFSDTV--TYILEPEVLEYLPSNTECDFSKDLFPLLDEPMYGYVAEGYWCDVGHLDAYREAQYDGLDRK 236
17 -11.000[J] KOG1462 Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1)  ali follow..  13  29.NIQLQSIPIEFQAVVFA-GFGNSLSDALPKALLPIGNKPMLHYPLYWLEAAG-FTSAILICMEEAEAHINAWLRSGYEGHMSKSSADALRAVSHLIKSQKMLTDTHQNDFVCLSD----SIVGLPPIYGLDKFRLDNPSALAVYSPVLKYEHITSQSKEIDAKQLI----------------GIEEKTSRLLYAKSSADVGSDFTFRMSLLW-KHPRVTLNT--NLSDAHIFVFKHW 258
18 -10.800[M] KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase  ali follow..  14  74LLRTQNADPKNVASIILGGGAGTRLFSKRAKPAVPIGGCRLIDIPMSNCINSG-IRKIFILTQFNSFSLNRHLSRTYN-NGVNFGDQGTADAVRQFIWVFEDAKTKNVEHVLILSGDH---LYRMDYMNFVQKHIESNADITVSCLPMLLKIDQSGKIIQFSEKPKGDDLKAMQVFRKEVLLKLLRSSYPTSNDFGSEILAVGEHNVQAFLFNDYWEDI................... 349
19 -9.240[S] COG1920 Uncharacterized conserved protein  ali follow..  13  2..........KTCAIIPVSRFTTRLSPTLSPSEREGLLKAMLMDVSGALARH--VDRVLVISADEDVLEYAYSLGLK---------EEEGERDLNGALEQAMDFCAPEFDRVIITPSDIPLIGKADVSNLLDHASRADVVIA-PANGG---------------------------TNTLILRPSAMSLRFGDCSFFEHIHEARERGLSVSVYDSFYLSLDVNTAEDLG.......... 186
20 -9.030[G] COG0448 ADP-glucose pyrophosphorylase  ali follow..  14  14...NKYELVKDTLVLILAGGRGSRLYDKRAKPALYFGGNRIIDFALSNCLNSG-LNRIGVVTQYAAHSLLRDMLPARQQIDDSTWYRGTADAVYQNMAIIRDH---YCPKYILILAG--DHIYKQDYSQMLLDHIHSGAKCTVGCIEVVMAVNENLKVKSFVEKPKDPPAMVGKVFDADYLYDVLEREVSSPYTSHD......................................... 242
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 9 6 7   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;