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Query: [M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTNFTVIIPARYASTRLPGKPLAEIAGKPMIAHVFEKAMQSGAKRVIVATDHEQVATVARGFGAEVCMTSETHQSGTERLAEVVEKLGIAEDEIIVNIQGDEPLIPPAIVRQVAENLAKYQVKMASLAVNITDPEELFNPNAVKVLTDHAGYVLYFSRAPIPWHRDQFASLPKEKSTRGQLVLSDHYLRHIGIYAYRAGFIKQYIQWQPSVLEQIESLEQLRVLWYGEKIHVELAREVPPVGVDTAEDLEKVRSILEKLast
1 -116.000[M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase  ali  100  1MTNFTVIIPARYASTRLPGKPLAEIAGKPMIAHVFEKAMQSGAKRVIVATDHEQVATVARGFGAEVCMTSETHQSGTERLAEVVEKLGIAEDEIIVNIQGDEPLIPPAIVRQVAENLAKYQVKMASLAVNITDPEELFNPNAVKVLTDHAGYVLYFSRAPIPWHRDQFASLPKEKSTRGQLVLSDHYLRHIGIYAYRAGFIKQYIQWQPSVLEQIESLEQLRVLWYGEKIHVELAREVPPVGVDTAEDLEKVRSILEK 258
2 -42.800[M] COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog  ali follow..  18  1MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSARDNLVIATSDKETDDILEAHCIKFRVFRGSEERVLDRFVKVIEAVKP---SVIIRLTGDNPFVDPELLDVMIQAHFDQGSDTYILNAPLGICGEVVNANLLIDISRIQALEDQYQE-------------------------------HVTLYIRNHPALYRVQFLE---APERFRAPQYR------------------LTIDTKEDYESIKALYQK 211
3 -35.600[M] COG1083 CMP-N-acetylneuraminic acid synthetase  ali follow..  17  4IMTRIAIIPARAGSKGIKDKNLQLVGGVSLVGRAILAAQESGFDQIVVTSDGENILKEATKYGAKPVALAQSDTRTIDAILHCLETLN-ISQGTAALLQPTSPLRNALDIRNAMEIFLGGKYKSVVSACECEH-----HPYKSFTLEGTEVQPIHELTD----------------FESPRQKLPKSYRANGAIYINDIQSLFEEKRF------------------FIAPMRFYLMPTYRSIDIDSTLDLQLAESLISK 226
4 -21.800[M] COG1209 dTDP-glucose pyrophosphorylase  ali follow..  18  1MKMRKGIILAGGSGTRL-SKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPQQLLGDGSQWGLNLQYKVQPSPDGLAQAFIIGEEFIGGDDCALV---GDN-IFYGHDLPKLMEAAVNKESGATVFAYHVNDPERY-------VEFDKNGTAISLEEKP---------------------LEPKSNYAVTGLYFYDNDVVQMAKNLKPSARGELEITDINRYLEQGRLSVAMMGRGYAWLDTGTHQSLIEASNFIAT 242
5 -20.800[R] COG2068 Uncharacterized MobA-related protein  ali follow..  21  10..KVGIVLLAAGRSSRMPNKLLALFDGKPLVRRTAERALGSKASGTIVVTQRERVRAALSGLDVTFADNPDFANGLSTSLKAGIAYLPEDTAGAMIVL-GDMPGVVSGDLDRLIDAFRKAGGNSV----------------VRASHQGKRGNPVLLPRALFP------------------------------------------------AIAHLEGDTGARHLAEGLDVVDVEIGEGASVDVDTREALEGAGGVLQD 206
6 -20.300[M] COG1213 Predicted sugar nucleotidyltransferases  ali follow..  17  1...MEAVILAAGFGSRL--KALLKIGKRPLIYYTVQTLMENGIRDVVVVTGGYVLREYLSQFDLNFKFVHNSLYKKTNNIYSLYLAMDHVSKGFYI-LNSD--LFHPGIFRELHSSTKENLILSVDTFKELGEEE---------KVKIEDGVVKRISKQL---------------------NPSEADGEYIGIARVEENIIDDLYNHVSRVMERKGRRVFYSMMDDGIAVYYETTKGLPWIEIDTPADLMKARYEI.. 235
7 -19.100[H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase  ali follow..  16  1...MLTLLMCGGKGTRLGRKPLFEVCGMKLIDHSLLQYKDFDV-IAITSPHTPATESYLAEKGVEVYRAA-----GKGYIEDYSEACRLAINEPVIVASADIVYIRDIAFDIVDAYMKTIKPALTVVMEG----------------------------------------------------------EPVGVNIIDSLLINTWQE------------------------EIYSIEKDSVVNVNTVADVERAERLWTT 171
8 -18.600[I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase  ali follow..  12  10.RRIVAVVPAAGIGSRMQMKQYLHIHGKTILEHTLSVLLGYPIEKIILAVAANDPYISTCPLLTHPKIQ----EGGSSRADSVLNGLNASEDFWVMVHDAARPCLTHQDLDKLVQVEDQNGAILAIPAT--DTIKRALHNQQIHYTEDRSQ--LWLAQTP---------------------------------QFFPIATLAQ--ALEQALAQGLQVTDEASAMEFGFRPHLVA-GRSDNIKVTRPEDFALAEFYLSR 236
9 -18.000[M] COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)  ali follow..  23  3QNTLNIVILAAGKGTRMYSKVLHEIGGETMLGRVIDTAAALNPQNICVVVGHGK-EQVLDTVKRDVVWVEQTEQLGTGHAVKTALPHLAAEGRTLV-LYGDVPLIDVETLETLLE---AAGNEVGLLTDVPADPSGL------RIIRDSSGSVT-----AIVEEKDADAAQKAVKEI------------NTGILVLPNAKLEAWLNSLSSNNAQGE-LTDL-AVADGIKIHPVQVRSSHLAGVNNKLQLAELERIFQT 240
10 -17.600[M] COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes  ali follow..  14  3.....AIILAAGLGTRL--KALVQVNQKPLIEYQIEFLKEKGINDIIIIVGKEQFDYLKEKYGVRLVFNDKYADYNN-----------------FYSLYLVKEELANSYVIDADNYLFKNMFRNDLTRSTYFSVYREDCTNEWFLVYGDDYKVQDIIVDS------------------------KAGRILSGVSFWDAPTAEKIVSFIDKAYVSGEFVDLVKDNIKELDVYVEELEGNSIYEIDSVQDYRKLEEILKN 227
11 -16.800[H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A  ali follow..  13  2..KHVNVLLAGGASRRFEPKAFVKWKGRMLYECAKEA-----LGEQTVIISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQRRTMLELKRLMIA-------------------GADAVVPISDGQVQPLI---------------------------------------IYHKRIMPVLYDLSEKRLRISDLLGRISVCY--VQAENIGANPAEFININTRDDFSCLEEKSNS 195
12 -14.700[M] COG1210 UDP-glucose pyrophosphorylase  ali follow..  15  1MRKKVAVIPAAGLGTRF--KEMLPIVDKPAIQYIVEEAAESGIEDILIITRSAELEFNLREKGKTETLKEMQQIADLANIHYIRQKEPLGLGHAVLCAEGDEPFAETPALRQLMDVYDVYGTEVVGVQ--SVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSE-----------------IAVMGRYVLNSSIFSVLKTIGRGAGNEIQLTDALREVCRKEPIHARLLEGN--YDIGDKLGCFKASTEI.. 269
13 -14.600[S] COG1920 Uncharacterized conserved protein  ali follow..  20  2..KTCAIIPVS-AKTRL-SPTLSPSEREGLLKAMLMGALARHVDRVLVISADEDVLEYAYSLGLKILEEEGE--RDLNGALEQAMDFCAPEFDRVIITPSDIPLIGKADVSNLLDHASRADVVIA----------PANGGGTNTLILRPSAMSLRFGDC--------------------------SFFEHIH-----------------------------EARERGLSVSVYDSFYL-SLDVNTAEDLGEIIL.... 190
14 -14.500[M] KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase  ali follow..  15  82PKNVASIILGGGAGTRL-AKPAVPIGGCRLIDIPMSNCINSGIRKIFILTQSFSLNRHLSR-DGFVEVLAATQTSGDAQFIWVFEDAKTKNVEHVLILSGDH--LYRMDYMNFVQKHIESNADITVSCLPMDESRASD------LKIDQSGKIIQFSEKPKGDDLKAMQVDTSILGLPPKEAAESPYIASMGVYVFRKEVLLKLLRSSYPTSNDFGS-EIIPLAVGEHNVQAFLFNDY--------EDIGTIGSFFD. 357
15 -14.500[GMO] KOG1460 GDP-mannose pyrophosphorylase  ali follow..  11  10..VAVIMVGGPTKGTRF--KPLFPIAGQPMVHHPISACKRIPLAQIYLVGFALYVSAISNELKVPVRYLREDKPHGSGGLYHFRNLIMEDSPSHIFLLNCD--VCCSFPLPKMLEAHRGYGGIGTLLVIKVSPESASQ----ELVADPVTNELLHYTEKPETFVSD---------------------RINCGVYVFTPEIFNAIGDVSTQRKDRATDQDILSPLAGKKRLYTYETMDF--EQIKSPGMSLRCSGLY.. 274
16 -13.900[MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)  ali follow..  17  1...MRAVLMAGGSGTRL--KPMVPILNRPIAEHIINLLKRHHITEVIATLHPDVLRDYFGDFGVQMYAVEEDQPLGT---AGCVKNIAELLDETFLVISGD--SITDFDLGEAIAFHKQKQSKATLILTRVPNPIEF-------VITDEAGKIKRFLEKP-------------------STSEIFSDTVNTGTYILEPEVLEYLPSNTECDFSK-DLFPLL--LAKDEPMYGYVAEGY--CDVGHLDAYREAQYDGLD 234
17 -11.900[J] KOG1462 Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1)  ali follow..  10  37.IEFQAVVFAGFGNSLYP-KALLPIGNKPMLHYPLYWLEAAGFTSAILICMEERIHVEAPTILDDSKSSADALRAVSHLIKSQKMLTDTHQNDFVC-LSCD--SIVGLPPIYGLDKFRLDNPSALAVYSPVLKYEHITSQSKEIIGIEEKTSRLLYAKS--SADVGSDFTFRMSLLWKHPRVTLNTNLSDAHIFVFKHWVIDLIREKESISSIRGDLIPYL..................................... 280
18 -11.500[G] COG0448 ADP-glucose pyrophosphorylase  ali follow..  15  19VKDTLVLILAGGRGSRL-AKPALYFGGNRIIDFALSNCLNSGLNRIGVVTQAHSLLRHLQNLPARQQIDDSTWYRGTDAVYQNMAIIDHYCPKYILILAGDH--IYKQDYSQMLLDHIHSGAKCTVGCIEVEREKATE------MAVNENLKVKSFVEKP--------------KDPPAMVGKPNTSLASMGIYVFDADYLYDVLEREVSSPYTSHDFGK-KALEEGVLYAHPFSRSCMGRNTEGERDVGTLDSFWQ. 288
19 -10.600[M] COG4092 Predicted glycosyltransferase involved in capsule biosynthesis  ali follow..  10  1MPLLSVIIPFGLSKER-----------ERVLQKAKFFQSDENIEFIFVSSKDHELKNFIQANHHIYLKDMDQKAFSQGRCRNLG--ASYAHSNVLLFLDVDC-YISLDNFEKILKLIQIKNISQNINALIVLPVVYLNKEANEKLKQYDDKFWDILIQEDL-FTAKNTWVKFFAPSSTSSIVINKHQFLRLG--GNDENFI-------------YEDFD-ARILKACVSFEKMPTNLSYDARNWNFFNFKGFRSWFS. 238
20 -10.100[J] KOG1461 Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6)  ali follow..  10  23.QRLQAILLADSFATKL--NVLLPLVNIPMIDYTLAWLESAGIEEVFVFCSMIDYLNNSDDFTVKTIESPQNSTSAGDRYIYEQQIETSQIQGDFVLVNGC--IVSNMPLTQLIQEHRDKKKDEKAIMTMVIRQSLITDHQLFIAVNPLTKQLLYYDEDNICFDKSLLDRNPSVLLCSD--------MQDCYIDICSLEVLSLFVDNFDYQHMRCDFVEGV----IGYKIFTHEISSCYASRIENFRSYDMVSKDI.. 284

FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 3 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.