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Query: [M] COG1213 Predicted sugar nucleotidyltransferases, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEAVILAAGFGSRLGHHTREIPKALLKIGKRPLIYYTVQTLMENGIRDVVVVTGHKGYVLREYLSQFDLNFKFVHNSLYKKTNNIYSLYLAMDHVSKGFYILNSDVLFHPGIFRELHSSTKENLILSVDTFKELGEEEMKVKIEDGVVKRISKQLNPSEADGEYIGIARVEENIIDDLYNHVSRVMERKGRRVFYEEAFQSMMDDGIAVYYETTKGLPWIEIDTPADLMKARYEIYPKIQFLast
1 -83.600[M] COG1213 Predicted sugar nucleotidyltransferases  ali  100  1MEAVILAAGFGSRLGHHTREIPKALLKIGKRPLIYYTVQTLMENGIRDVVVVTGHKGYVLREYLSQFDLNFKFVHNSLYKKTNNIYSLYLAMDHVSKGFYILNSDVLFHPGIFRELHSSTKENLILSVDTFKELGEEEMKVKIEDGVVKRISKQLNPSEADGEYIGIARVEENIIDDLYNHVSRVMERKGRRVFYEEAFQSMMDDGIAVYYETTKGLPWIEIDTPADLMKARYEIYPKIQF 241
2 -62.600[M] COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes  ali follow..  25  1MKAIILAAGLGTRLRPMTENTPKALVQVNQKPLIEYQIEFLKEKGINDIIIIVGYLKEQFDYLKEK--YGVRLVFNDKYADYNNFYSLYLVKEELANSYVIDADNYLFKNMFRNDLTRST-----YFSVYREDCTNEWFLVYGDDYKVQDIIVD---SKAGRILSGVSFWDAPTAEKIVSFIDKAYVSGEFVDLYWDNMVKDNIKELDVYVEELEGNSIYEIDSVQDYRKLEEILKNE... 228
3 -53.700[M] COG1209 dTDP-glucose pyrophosphorylase  ali follow..  14  4RKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPDTPRFQQLLGDGSWGLNLQYKVQPSPDGLAQAFIIGEEFIGGDALVLGDNIFYGHDLLMEAAVNKESGATVFAYHVNDPERYGVVEFDKNGTAISLEEKPLEPKSNYAVTGLYFYDNDVVQMA----KNLKPSARGELEITDINRIYLEQGRLSVAMMGRGYAWLDTGTHQSLIEASNFIAT.... 242
4 -48.200[MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)  ali follow..  18  1MRAVLMAGGSGTRLRPLTCDLPKPMVPILNRPIAEHIINLLKRHHITEVIATLHYLPDVLRDYFQDGGFGVQMTYAEEDQPLGTAGCVKNIAELLDETFLVISGDSITDFDLAIAFHKQKQSKATLILTRVPNPIEFGVVITDEAGKIKRFLEKPSTSESDTVNTGTYILEPEVLEYL--------PSNTECDFSKDLFPLLLAKDEPMYGYVAEGY-WCDVGHLDAYREAQYDGLDR... 235
5 -41.900[M] COG1210 UDP-glucose pyrophosphorylase  ali follow..  17  6RKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVEEAAESGIEDILIITGRNKRSIEDHFDRSA-LANIHYIRQKEPLGLGHAVLCAEHFIDEPFAVLLGDDIMVSELMDVYDVYGTEVVGVQSVLPEDVSKYGIINTSGSQEVNDLVEKPSPEESEIAVMGRYVLNSSIFSVL----KTIGRGAGNEIQLTDALREVCRKE-PIHARLLEGN-RYDIGDKLGCFKASTEIG..... 270
6 -40.500[GMO] KOG1460 GDP-mannose pyrophosphorylase  ali follow..  15  9VVAVIMVGGKGTRFRPLSLNIPKPLFPIAGQPMVHHPISACKRIPLAQIYLVGFYEEREFALYVSANELKVPVRYLREDKPHGSAGGLYHFRNLIPSHIFLLNCDVCCSFPLMLEAHRGYGGIGTLLVIKVSPESASQLVADPVTNELLHYTEKPETFVSDRINCGVYVFTPEIFNAIGDALQPATRIPTDFVRLDQDILSPLAGKKRLYTYETMDF-WEQIKSPGMSLRCSGLYLSQFR. 279
7 -34.500[M] KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase  ali follow..  15  85VASIILGGGAGTRLFPLTSKRAKPAVPIGGCRLIDIPMSNCINSGIRKIFILTQFNSFSLNRHLSRTY-DGFVEVLAATQTSGTADAVRQFIWVFEEHVLILSGDHLYRMDYFVQKHIESNADITVSCLPMSRASDFGLLKIDQSGKIIQFSEKPKGDDLKAASMGVYVFRKEVLLKLLRS-----SYPTSNDFGSEIIPLAVGEH-NVQAFLFNDY-WEDIGTIGSFFDANLALTEQ... 365
8 -33.200[G] COG0448 ADP-glucose pyrophosphorylase  ali follow..  16  22TLVLILAGGRGSRLYELTDKRAKPALYFGGNRIIDFALSNCLNSGLNRIGVVTQYAAHSLLRHLQNGWLPARQQIDDSTWYRGTADAVYQNMAIIRKYILILAGDHIYKQDYMLLDHIHSGAKCTVGCIEVEKATEFGVMAVNENLKVKSFVEKPKDPPTSLASMGIYVFDADYLYDVLE--REVSSPYTSHDFGKDILPKALEEGVMGRNTEGEIY-WRDVGTLDSFWQSNIDLVCE... 296
9 -29.900[J] KOG1461 Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6)  ali follow..  14  25LQAILLADSFATKLLPLTLERPNVLLPLVNIPMIDYTLAWLESAGIEEVFVFCSMQVIDYLNNSDWYSKDFTVKTIESPQNSTSAGDALIETSQIQGDFVLVNGCIVSNMPLTQLIRKKKDEKAIMTMVIRQSLITDHQLFIAVNPLTKQLLYYDEDNCSDMQDCYIDICSLEVLSLFVDNFD----QHMRCDFVEGVLADDIIGYKIFTHEISSCY-ASRIENFRSYDMVSKDIIQR... 287
10 -28.900[M] COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)  ali follow..  16  6LNIVILAAGKGTRMY---SKMPKVLHEIGGETMLGRVIDTAAALNPQNICVVVGHGKEQVLDTVKR-----DVVWVEQTEQLGTGHAVKTALPHLAAETLVLYGDVLIDVETLETLLEAAGNEVGLLTDVPADPSGLGRIIRDSSGSVTAIVEEKDADAAQKANTGILVLPNAKLEAWLNSLSS--NNAQGEYYLTDLIAKAVADGIKIHPVQVRSSH-AGVNNKLQLAELERIFQTEQA. 243
11 -25.600[J] KOG1462 Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1)  ali follow..  14  39FQAVVFA-GFGNSLYPLTDALPKALLPIGNKPMLHYPLYWLEAAGFTSAILICMEEAEAHINAWLRSGYEGHEAPTILDDSKSSADALRAVSHLIQNDFVCLSCDSIVGLPPIYGLDKFRLDNPSALASQSKEIDAKQLIGIEEKTSRLLYAKSSADVGTNLSDAHIFVFKHWVIDLIRE-------KESISSIRGDLIPYLVKCQYQKSFTVRENI-QRFLSSPNNIDNYDGGLSS.... 314
12 -23.200[H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase  ali follow..  16  1MLTLLMCGGKGTRLG----RGEKPLFEVCGMKLIDHSLLQYKDF---DVIAITSPHTPATESYLAEKGVEV------RAAGKGYIEDYSEACRELNEPVIVASADIYIRDIAFDIVDAYMKTIKPALT------------------------------VMEGEPVGVNIIDSLLINTWQEEEIYSIEKD----------------------------SVVNVNTVADVERAERLWTTM... 172
13 -22.700[R] COG2068 Uncharacterized MobA-related protein  ali follow..  21  11VGIVLLAAGRSSRMG----GPNKLLALFDGKPLVRRTAERALGSKASGTIVVTGHQRERVRAALSG--LDVTFADNPDFAN-GLSTSLKAGIAYLPEDAMIVLGDMGVVSGDLDRLIDAFRKAGGNSVVRASHQGKRGNPVLLPRALFPAIAHLEGDTGAR--------------------------------------HLVEAEGLDVVDVEIGEGASVDVDTREALEGAGGVL...... 204
14 -20.300[M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase  ali follow..  17  4FTVIIPARYASTRL--------KPLAEIAGKPMIAHVFEKAMQSGAKRVIVATD--HEQVATVARGFGAEVCMTSETHQSGTERLAEVVEKLGIAEDEIIVIQGD-LIPPAIVRQVAENLAKYQVKMASLAVNITDPE-VLTDHAGYVLYFSRAPVLSDHYLRHIGIYAYRAGFIKQYIQWQPSVLEQIESLEQL-----RVLWYGEKIHVELAREVPPVGVDTAEDLEKVRSIL...... 256
15 -18.700[H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A  ali follow..  19  3HVNVLLAGGASRRFG-----EPKAFVKWKGRMLYECAKEALG----EQTVIIS---RPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDYTVLSCDTLIQRRTMLELKRLMIA-------------GADAVVPISDGQVQPL---------------IAIYHKRIMPVLYDQLSE------KRLRISDLLGRISVCYVQAENIGANPAEFININTRDDFSCLEEKS...... 193
16 -18.700[I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase  ali follow..  11  12IVAVVPAAGIGSRMQ---MDKPKQYLHIHGKTILEHTLSVLLGYPIEKIILAVAANDPYISTCPLLTHPKIQLVEGGSSRADSVLNGLNAVKSAVEDFWVMVHDAACLTHQDLDKLVQVEDQNGAILAIPATD----TIKRALHNQQIHYTEDRSQ----------LWLAQTPQFFPIATLAQALEQALAQGLQVTDEASAMEFAGFRPHLVAGRSDN-IKVTRPEDFALAEFYLSRT... 237
17 -14.400[M] COG0836 Mannose-1-phosphate guanylyltransferase  ali follow..  12  8ITPVLLAGGAGSRLWPVSDQLPKQFQPLGNLSTYQQTLKRVGDSLYSEPLVITN-FRFFARRQAEEIDLPATVVLEPARRDSAAAAAVLAERREPGCLVLALAADHVVLDEAVKLGAKAADQGNIVVFGLVPTEPRTSYGYIKPGDTVDAFVEKPDVTTAIS-NSGNFLFRSDVMPEILAAVTQAVEQYESDLGFVRLHQAVIEKTKRMAVVHGH-FRWSDIGSWDAIWEIAD........ 288
18 -12.200[M] COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog  ali follow..  13  4ILFIIQARMGSTRL-------PKVLRPLGSNRLLDILVHRVRQSARDNLVIATSDKEDILEAHCIKQGFRV------RGSEERVLDRFVKVIEAVKPSVIILTGD-FVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEV-VNANLLIDISRIQALEDQYQEHVTLYIRNHPALYRVQFLEAPERFRAPQ----------------------------LTIDTKEDYESIKALY...... 209
19 -11.900[M] COG1083 CMP-N-acetylneuraminic acid synthetase  ali follow..  15  9..AIIPARAGSKGIKD------KNLQLVGGVSLVGRAILAAQESGMFDQIVVTSDGENILKEATKYGAKPVARPESLAQSDTRTIDAILHCLETLNISLLQPTSPLRNALDIRNAMEIFLGGKYKSVVSACECEHHPYKSFTLEGTEVQPIHELTDFESPRQKLPKSYRANGAIY-----------------NDIQSLFEEKRFFIAPMRFYLMPTYRSIDIDSTLDLQLAESLISKEF.. 228
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;