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Query: [R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MANSATITSKKGVKSHQKDWKIPLKVLILICIAVASVSSRLFSVIRYESIIHEFDPWFNFRASKILVEQGFYNFLNWFDERSWYPLGRVAGGTLYPGLMVTSGIIFKVLHLLRINVNIRDVCVLLAPAFSGITAIATYYLARELKSDACGLLAAAFMGIAPGYTSRSVAGSYDNEAIAITLLMSTFALWIKAVKSGSSFWGACTGLLYFYMVTAWGGYVFITNMIPLHVFVLLLMGRYTSKLYIAYTTYYVIGTLASMQVPFVGFQPVSTSEHMSALGVFGLLQLFAFYNYVKGLVSSKQFQILIRFALVCLVGLATVVLFALSSTGVIAPWTGRFYSLWDTNYAKIHIPIIASVSEHQPPTWSSLFFDLQFLIWLLPVGVYLCFKELRNEHVFIIIYSVLGTYFCGVMVRLVLTLTPCVCIAAAVAISTLLDTYMGPEVEEDKVSEEAASAKSKNKKGIFSILSFFTSGSKNIGIYSLLSRVLVISSTAYFLIMFVYHSSWVTSNAYSSPTVVLSTVLNDGSLMYIDDFREAYDWLRRNTPYDTKVMSWWDYGYQIAGMADRITLVDNNTWNNTHIATVGKAMSSPEEKAYPILRKHDVDYILIIYGGTLGYSSDDMNKFLWMIRISQGLWPDEIVERNFFTPNGEYRTDDAATPTMRESLLYKMSYHGAWKLFPPNQGYDRARNQKLPSKDPQLFTIEEAFTTVHHLVRLYKVKKPDTLGRDLKQVTLFEEGKRKKLRRPAKTNEIPLRVLast
1 -179.000[R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation  ali  100  1MANSATITSKKGVKSHQKDWKIPLKVLILICIAVASVSSRLFSVIRYESIIHEFDPWFNFRASKILVEQGFYNFLNWFDERSWYPLGRVAGGTLYPGLMVTSGIIFKVLHLLRINVNIRDVCVLLAPAFSGITAIATYYLARELKSDACGLLAAAFMGIAPGYTSRSVAGSYDNEAIAITLLMSTFALWIKAVKSGSSFWGACTGLLYFYMVTAWGGYVFITNMIPLHVFVLLLMGRYTSKLYIAYTTYYVIGTLASMQVPFVGFQPVSTSEHMSALGVFGLLQLFAFYNYVKGLVSSKQFQILIRFALVCLVGLATVVLFALSSTGVIAPWTGRFYSLWDTNYAKIHIPIIASVSEHQPPTWSSLFFDLQFLIWLLPVGVYLCFKELRNEHVFIIIYSVLGTYFCGVMVRLVLTLTPCVCIAAAVAISTLLDTYMGPEVEEDKVSEEAASAKSKNKKGIFSILSFFTSGSKNIGIYSLLSRVLVISSTAYFLIMFVYHSSWVTSNAYSSPTVVLSTVLNDGSLMYIDDFREAYDWLRRNTPYDTKVMSWWDYGYQIAGMADRITLVDNNTWNNTHIATVGKAMSSPEEKAYPILRKHDVDYILIIYGGTLGYSSDDMNKFLWMIRISQGLWPDEIVERNFFTPNGEYRTDDAATPTMRESLLYKMSYHGAWKLFPPNQGYDRARNQKLPSKDPQLFTIEEAFTTVHHLVRLYKVKKPDTLGRDLKQVTLFEEGKRKKLRRPAKTNEIPLRV 752
2 -160.000[O] KOG2292 Oligosaccharyltransferase, STT3 subunit  ali follow..  51  1MN-----RTPKMLNSKVAGYSSLITFAILLIAWLAGFSSRLFAVIRFESIIHEFDPWFNYRATAYMVQNGWYNFLNWFDERAWYPLGRIVGGTVYPGLMITSGGIHWLLHVLNIPVHIRDICVFLAPIFSGLTSISTYLLTKELWSAGAGLFAASFIAIVPGYISRSVAGSYDNEGIAIFALQFTYFLWVRSVKTGSVFWSAAAALSYFYMVSAWGGYVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILGLLFSMQIPFVGFQPIRTSEHMAALGVFVLLMAVATLRHLQSVLSRNEFRKLFIVGGLLVGVGVFVAVVVLTMLGVVAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTTWFSFFFDLHILVCAFPVGVWYCIKQINDERVFVVLYAISAVYFAGVMVRLMLTLTPVVCMLAGVAFSGLLDVFLQEDSSKRMGTAISAATEVDEAEDSIELKHRTKHDAQQDTGVSSNLKSIVILAVLMLLMMFAVHCTWVTSNAYSSPSIVAFHNSQDGSRNILDDFREAYYWLSQNTADDARVMSWWDYGYQIAGMANRTTLVDNNTWNNSHIALVGKAMSSTEEKSYEIMTSLDVDYVLVIFGGVIGYSGDDINKFLWMVRIAEGEHPKDIKESDYFTDRGEFRVDAEGAPALLNCLMYKLSYYRFGELKRGPSGYDRTRNAVIGNKDFDLTYLEEAYTTEHWLVRIYRVKKPHEFNRPSLKTKERTIPPISRKNSKRRKGYIRNR. 763
3 -33.200[S] KOG4587 Predicted membrane protein  ali follow..  10  1MAKKPKNSPEKSKYSSLYSQTWLASVVIIGLLVGYINYQHVYTLFENDKHFSHLADFLYYSYYKTIINAPSFLQEITHDTVTEHGHEINTLNRFNLYPEVILAFLYRPFRAFAKSANWQIFYITGVFIVAGTVASSIFYLGVLVSDS-GGFLSVLCFAFNHGEATRVQWTPPLRESFAFPFIIGHIAILTFVIKYKKHSMILLLTSMAVPALLFWQFTQFAFFTQICSIFLAFSLDLIPFSTAKTVIHSHIISFLIGFLLLF-------GNEMMITALYFPSILALGMIIYISPLLSNLKFRPAYVLFLAIIFASITLGLKIGLSKGLGIEDDAHIFDILRSKFTSFANTRLYTCSAEFDFIQYSTIEKLCGTLLIPLALISLVTIGENGEILYNVVQLCCSTVMAFLIMRLKLFMTPHLCIVAALFAN--------------------------------------SKLLGGDRISKTIRVSALVGVIAILFYRGIPN---------------IRQQLNVKGEYSNPDQEMLFDWIQHNTKQDAVFAGTMPVMANVKLTTLRPIVNEHVGIRERTLKVYSMFSKKPIAEVHKIMKEMGVNYFVFQLMNCSNDERRP------------------------------------------ECVYRGMWDEEDPKNSGRTALCDLWILAANSKDNSRIAPFKIVYNANRNY-IVLKI..................................... 683
4 -31.100[O] COG4745 Predicted membrane-bound mannosyltransferase  ali follow..  10  1MRRSRDDSSPR-------------VAAAVVAVTAAALLARLWAL---GWRVAHQDEARVADWTLQYMDLGAWQ----YRPIIHGPF-----------LPHVNGVVFDVF---------DFTMRLVVAVVGGLLPLTAWLYRTRL-SDVEVGALAVLLAANPVVLYYS---FMRNDLLLAGFMFTAVGLFVRFLDTHRARYLYASAVPFALAFTTKENSLLYPLCWLGALALVTDDRMAVAGATDTSRLAVVRRAAARIRHRAWRAKAALAGSALTAAVIVVSFY-----------------------APKPDLYRLFEQPGRAPAVLEAATIGTYHEFADLWASTSTVAHSYVAFLSHDLSVLVACGTVVSVAAVVGYLANRYATETPRPLVSFAFYWGVFSVLGYPAVVDIAVNALVPLAIPAAVGVGAVVRYGRRGAAAGD--------------------------------TAAVRLAVTVLVVSAAGMGAVAAETTYAHPQSPSNPLVQYAQPGGT------QPTIDDIQRAATATSGLDVLYGWW-Y---LSQVGANATTVQTAAEVPDTPPPVVISVVSEEDDFAALLAAANSQYERHTYPRYLTDGHNTLVIYV.................................................................................................................................. 561
5 -23.700[S] COG5427 Uncharacterized membrane protein  ali follow..  8  95..........................GVFTVAFVFLIVVRAWA----GVQPAGGEQFLDFGLLQALDRAGQLP--MWFERVVYYYGG-----------QLMASIGAHL-----TDTAPRFAYEPALAGVYAMGCTAAYGLASTIAAGNAGVLGAFAFGFMETGLNE-LNGDLHAHMVSVPVLFVAVAVGVAYYRTRWALLWGGFPVAGAAILTTWS-LPTVFGVAALAVALADPAPATLLPTGVQRWTRRESAVGQSVQRVLLAVGVAAVGGVLAVVIAWPFVQNVLLAGASNQHLAVLPVPSQAGALVFVHGLFLAAFGAYFVSRVATSVAGWVVAAAAAGAAVAVAVAVGPVVG----------GVGITAVVLVGPVLGAAWWLRRRNAAGVECVLVAAGAGLVVTVFKVYAQVWALWSVAGGVALAGVSERR----------------------------------------ASTGGLGAVFVVGLVVAASVYGGLAVTTHAANADDASLDALEYAGNAHPG-----AAAARWLGDRRRGTRIVAA-YTWQNPAASLSGVPTVAGQAAWEQRVDDIGVVYETTDAASRAAILEKYDVTYVWVGPVERARYEIPDLSAD---------------------------------------------------------------------------PGIEPVHRTPA--VTIYRVTDDELVAPRSGPITVTTTPQAATATAPGAQTARS... 813
6 -20.900[O] KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase  ali follow..  12  41.DERDAEDFSKEKPAAQSSLLRLESVVMPVIFTALALFTRMYKIGINNHVV--WDEAHFGKFGSYYLRHEFY-----HDVH---PLGK---------LVGLSGYLWDFLLEIYPDYLDYVKMRLFNASFSALCVPLAYFTAKAIGSLPTVWLMTVLVLFENSYSTLGRFILLD--SMLLFFTVASFFSFVMFHNQRSKPFSLITGISLGCTISVMVG-LFIITMVGIYTVIDLWTFLADKSMSWKTYINHWLARIFGLII............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 294
7 -20.800[O] COG1928 Dolichyl-phosphate-mannose--protein O-mannosyl transferase  ali follow..  12  34.NFLKDDAELYDKVKNESAVSHLDTIVMPIIFTVLGMFTRMYKIGRNNHVV--WDEAHFGKFGSYYLRHEFY-----HDVH---PLGKMLVGLSGYLAGYNGSWDFPSGEVYPDYIDYVKM-RLFQAMFSSLCVPLAYFTGRAIGSRLSVWLFTILVIFENSYATLGKFILLD--SMLLFFTVSSYFCLAKFHTMRKSPFSCLTGLNLGCAISVMVG-LFIISVVGIYTISELWNLLSDRSVSWKVYVNHWLARIFGLII............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 288
8 -19.800[S] COG5617 Predicted integral membrane protein  ali follow..  9  1................MKRKLYYLTLATISVIEYIPLYL------APSPPALQINGNGHLFKVHKLMTSGWKPW------IEDWYAGYPFLRFYPPLSYLTAGVLGKVLGSDTKGYAATLMLTSF------LGALALHHYLKST--GREPCISPLIFLLFPWHLTEGNFP----RANAIHLAPLFLLSLYWLREKRE-RYLIASALGISIVALT---HYSILPLLIITGILILWDDLRTMTALGNGIKVLGAVIGLTSFWYVPFLFDKKWVE--------FWNISENKALFKSFSLNPTLLKSPFGILLILLLLIFAIFAIKNLVDRKKVILAGLYLYLSLGFYSPTTWLYSFPLLSIVPP-----YRWFDLEALIIPLLIGESLKRVQRKSMVALVIIPFTVLAFMNVPKI.................................................................................................................................................................................................................................................................................................................................................... 359
9 -19.300[M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family  ali follow..  11  1...................MKSVRYLIGLFAFIACYYLLPI-----STRLLWQPDETRYAEISREMLASGHLLGLRYFEK----P----------IAGYWINSIGQWLF---------NFGVRAGVIFATLLTAALVTWFTLRLWDKRLALLATVIYLSLFIVYAIGTYAVLD--PFIAFWLVAGMCSFWLAMQKGKSAGFLLLGITCGMGVMTKGALAVPVLSVLPWVAT--------QKRWKDLFIYGWLAVISCVLTVLPWGLAIAQREPNFWHYFFWVEHI---------------------------------------------------------------QRFALDDAQHRAPFWPVIIAGSLPWLGLLPGALYTGWKNRKHSTVYLLSWTIMPLFFSVAKGKLPTYILASLAMLMAHYALLAAK............................................................................................................................................................................................................................................................................................................................... 336
10 -18.100[O] COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  9  173....................................................................................FLGK----------DIIALGMLIEDKPFYWR--------IPGIIEHALIVIIVTLVAYKITSYLASSIAATFAALDPLLFATGIVAMLD--IHVAFFIALFMLFLALD-------RIRLSGIALGLAAATLSG------AFAFPILWFKILKEKDLKEYLISGLVLPMVSFLIPEITIIKAIGFIPWLEEFIASFSWHLSFKGEHPSEAPFWM----------------------------------------------WFVSLKPFPFHFDPDVYAVTDPILMISMIVFVFAVPYVSLRRKGLSEIFWMFWSIIAFFAYILGGKTQFIFYLIPPGAVALGVISYEIIK............................................................................................................................................................................................................................................................................................................................... 449
11 -14.900[S] COG4485 Predicted membrane protein  ali follow..  9  1............MKSFLKTYRTYFISFIIPVVIMSGVYLSQSIYWNSDNSPLLGDIFDVA-LRNILHGNSNL----------FYTFTSGLGLNFYALSSYYLGSFLAPLVYFFDLTNMPDAIYLTTLLKFGLIGLSTFFSLNKLFPQILKLALSTSYALMSFTVSQLE--WLD----VFILIPLIITGLHLLITEKKLLLYFTS-LSILFIQ-------YFGYMTVLFLIFWYLCQISWDSSVLDFIVISFLAGMASLIMTLPTLFDLQTHGEKLTEVTKFQTESSWYLDLFAKQFSFDTTKYGAIPMIFVGLFPFILTILFFTLKSIKFHVKLIYVIFFAFLIASFYIEALDLF-HTPNMFLHRYAWIFSTLLIYTAAEVLKRLKELKVWNFLVSLFLVVAGFLATIYLKSHYSFLTDLNILLTLEFLVVYSLLLLAVIKKFISVN----------------------------LFAILISLFILVEMSLNASSQMDGIAKEWGFASRSAYSRDIPAMESFSTYIGNQFTR-TEKLQTQTGNDSMKFNYNGISQFSSVRNRSSSST--DKLGFKSSGTNLNLRYANNSILADSL--FGIQYNISDSP................................................................................................................................................ 563
12 -14.900[S] COG5305 Predicted membrane protein  ali follow..  9  1...............................MFSLGNSFLPVPLDQA------PDILLQPLQPNP--ASGIGDVIHNLITEDNHP------------LYFVLVHLWMKLFPNQGELVSLLAARSFPALLGAVSIPLTYILGRLAFSSLVGQLAAGMMAVSPYAVYLG----VRHYTLAMIWVIASLSCLVIATRHIQNRTLLIILWVGINALGIATHYFFTLTLCAEALVLIFLAWQQSTQAKTLVFFSPLWWRIYAVAA---------------GTAVAGLVWLPSILENRYRSIQVQGIGLHLINPIFQAFAAWVTMIMLLPIESSQLAVVIASGLVMLIFAIWATPILVRGFKFQLQQPQTSLATQVFIGVVLGAIALF-----------FILTYIF-----ITRGARYNFVYFPAVIILVGASLAVYWQTSKKAVMIIWLMGFVSAVTVICNLGYQKYYRPDLLVQIIQQNSQVPVLIATTHKTLVQTGEMMGIARELKLSSSQTSTQFLLAHQ--------ETDPSTSTVSLEKTLKQLPRPFDLW......................................................................................................................................................................................................... 475
13 -14.400[R] KOG2647 Predicted Dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  10  1MAKALESNSKSRKETILIKYAIFSRLLVLFLTILWRSLLQPYDTSAA---SVVWDSVYFLR----ITECG----YEYEQTYAFLPL-------PFFISLLSRTVFAPLVPLIGLRAVMVLSGFTVSNLAFIFAAIYLFRVSVIILDTEASFRASIIFCFNPASIFYSSI----SESLYALFSIGGVYHLLSG-------TSNVGVLWFALSGCARSNGILNAGYICFQTMHRAYEALYQKRRAYLAMQVFIAGFLRCICI............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 261
14 -14.000[MU] KOG2515 Mannosyltransferase  ali follow..  10  1MPSKAPRKS---------SVSFVWTFSILAVLRLTSASFRV---------IDDCDEVYNYWEPLHYLLYGY--------GLQTWEYSPEYAIRSWFYIALHAVPGFLARGLGLSRLHVFYFIRGVLACFSAFCETNLILAVARNFNRAVALHLTSVLFVNSGMWSASTSFLPS--SFAMNMVTLALSAQLSPPSTKRTVKVVSFITIGAVIGWPFSA------ALSIPFILLELVDLKGRFRHLFCRWFKAIFVALLITGICITVDSLFYHRIQFVAWNIVKYNVLAKDGRGPDIYGTEPWWYYFANLSLQHNIVLWFAMACGP-----------------------------------------------LVLLAAFTNWINLDSFLDLSSVISPFYIWLFIFIIQKEERFMYPIYPVLCLAAAIGLDMSLKLM............................................................................................................................................................................................................................................................................................................................. 357
15 -13.000[S] COG5542 Predicted integral membrane protein  ali follow..  11  14.KSNSYLAIRMTRSGYNYFKGICVCTFLLILYLGIAVIMSHLCVFDDTA-WIRWDAIYFVD----MAVNG----SLFEQEWAFSS--------------LWPKIISFLAFRSKDVVLLGIVSCFASIFFHAIACYALYLLTKSIFNQKMTAYTVIFYCFSPSGIYMSVG----TESLFAAFSFLGLLLFIKK-------QQYPAAFLWSLATLIRSNGIFWCIFFGMPAIGTLKISLERLQLTFMQVSQLVGYGTKCLIILVVGFLRYWTLNNIPNFLFALLSIIPILFALFYSISGSTLHSFRSIKSHLVLSALYLYIGCFHMHTQVLNRMSSAL-----------------------------------PLLYWSMAHATLYAKSRNLKAFGHCILFVWIVYTVIQAGLYGSFLPPA............................................................................................................................................................................................................................................................................................................................................. 426
16 -12.900[G] KOG4123 Putative alpha 1,2 mannosyltransferase  ali follow..  10  1MRLTTLWQNRSPGDRHLS-------------TYFCFAAVRLLLVFVPQLGYVHPDEFFQSVEVMTGDHFRLEHTRTW-EFNNSLPVRSIVLPFALLRIPWSFYEFVAECLELLGTYAYVVFPRLIYTLISFSNDYCLFRICRLYGLRFIRLLAMGSSWILLVFGTRTF-----SNSLEMAMCSWLLCLVSECMLRTNTVVYKKEFLEEKYDKAE---------SISERVRIWKLKNSLPAHNLQHLMAMSTICVAGVFNRP--------------TFLLFGAPMVFFWLLRGMGTRSITFRDFNLRIALFCLCALPALVLFIFCDSLYYQHLTLGELHMMHLSIDNFVFTPWNFIKANLDSAQTASH--FNVLALASLGAFAQLLLRFFRAESGAIFVPLFFLLINHQEPRFLLPVTFPLILLHAPKLITG-----------------FSAKYPFQKDHPLLRLFYDKLLSSKASGPYLLKIWYVSNVALTLFFGFIHQAGVYPLAADISHVIA-----------------------TKPAATHVHLITSHIY-HLINIPSSRVLMYEYGGLPLDSLLQKVKLISGSCEVKKSGPSRRRYKLYLAIPASLSADLHEALVHSNASSYLN-------FELLKVFYPHLSTEAFPHLQGRHPCDVDAPHWAHDDLRGTCSAEQLPAFSFAYL------NKQFSSFVHQ----LALYEIDVTRNKPRY--VSLAYSGCSPTKGY............ 697
17 -12.900[MO] KOG1771 GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis  ali follow..  12  5...............................FWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFR----------GFLTWEWTSAIRSALHPLIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVS--VGVRTF-----SNSLETTLTSIGFYYFSYYLKYENSS-KAYSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVNIIADRILYGRFVFPIISFFQFN------------------------------------------------VTSGLSSLYGLNAWHYYLSQALPLICGGFLPFVLLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSS............................................................................................................................................................................................................................................................................................................................... 351
18 -12.800[S] COG4906 Predicted membrane protein  ali follow..  10  182....................NRTFAIWSIAISLMWSTVFGVSW-----NYIWGYDINGEYYYANLVLARGI------WSISTYDQYN-----------TIASVNILGPVYSLILNMWIVPIFKIIYPLVFSLVPVILLKAYERLLGKIWAELSVLFFMFFFQFFVSNMA----RMMIVEVYLALLAYATIRKINP------LFLILFLASLAVSHYGTAYLTMFALLTLPLIRVLENEQRISNKLIAVFWVVTLLVGGGFQFNNLVIIGYQTLLMLKDLFNPQYSQGLELIVAKMTFMREIAKLINLFAQGLISIGVLTVLNRLIRGRKVKHLEFYALSFAFFAYDIAGIVVPYFSNRMNVN-RLYHLTQFFIAPYLLIGFDSVKRTLPLKNSVEIAGVFLVVYFIFTS....................................................................................................................................................................................................................................................................................................................................................... 554
19 -12.500[OKIT] KOG2642 Alpha-1,2 glucosyltransferase/transcriptional activator  ali follow..  10  1MTKSKPPRISLPFAAISRKSDFLLGASFSCIHVLLTTIVYHY-----------MDEIFHITQTRSYCSGN----YSWNPLITTPP-----------ALYVISMPLCGGNERYANSFAIPAFCRFRRMFVRVRIPTLKIYLKNTDLQQDV-WLTASIVGMLPILISSSILFYTD---------LLSLTSVIWGFSIGNPIASAFLFLISILTRQTW------AAIYAFSVIASRIDKSRSKMENLKIIISTAFSLWPFITLAIGFAMFIYFNDFQIVLGFFYMVAFCAAHTWTQIIPNLLSHLRHLTDMKSLVLQAVVAVLVYYYSYDHPYLLADNRHFTFYIWRRFLANPTMRVFSLRFMTTSTPSVHIFHKILFIIASLLVLVPAHLFEMRYYIIPYVLWRLSTVNNSRKSLLFLEIISQAVIFAANEFVQ................................................................................................................................................................................................................................................................................................................................ 422
20 -12.100[MU] KOG2516 Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family)  ali follow..  10  5.......................VLDTVLLTVISFHLIQ---------APFTKVEESFNIQAIHDILTYSVFDISQ-YDHLK-FP---GVVPRTFVGAVIIAMLSRPYLYLSSSRPTSIDVQLVVRGIVGLTNGLSFIYLKNCLQDMFDEITEKKKEENE---DKDIYIY----DSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPLTNVALGWVLLGRYNAAIFLSALVAIVFR------------------------------------------VSALSAGIALFSVIFKKISLFDAIKFGIFGLGLGSAISITVDSYFWQEWCLPEVDGFLF-----------NVVAGYASKWGVEPVTAYFTHFMPPTVLLLNYFGYKLAPAKLKIVSLASLFHIIVLSFQKEWRFIIYAVPSIMLLGATGAAHLWE............................................................................................................................................................................................................................................................................................................................... 353
21 -11.600[S] COG5650 Predicted integral membrane protein  ali follow..  6  50.......................VLITTSLVFLAMGFLTKANCIQGSRG--SGSRQYTSACYNDIVIDAPGFPYAF--TRYMEYP--------GGIFQWICGIITRFLYPVVDVIPFHTLPESGLYFIVTALALAFFWVLVIRMMVELTGVWDTVLVAASPLVA---VHAFTNWDTPAIAAVIGAMLAVKRG-------NPLVAGVLIGAGTA----FKLWPLYLLGAYLVLAVKNKNLKPFITMAAAAAVTWLVVNVPVMIAYPKAWNEFLRLNRERGAEWTTIYQVIDRNLPINLNDPVLLNVLSFGLFGASCVAILILGLKVQRTPRV----------------------------------------AELAFLIVAAFLLFNKVWSPQYSL--WLVPLAVLAFPQWKVLFPWMVTDAMVWPILMWHMLGT.............................................................................................................................................................................................................................................................................................................................. 419
22 -10.600[S] COG3274 Uncharacterized protein conserved in bacteria  ali follow..  11  13...............................................................................................................................AVACIMVVMIHSTTYYVTRNSASRACVPLFFMISGYLFFGEKSAQKKHFMRIGLCLLFYSVIALIYISTLTPIDGWASLRNILQKPVFYHLWFFYAIIVVYLVSPLIKVKPVSGRYLAILILLLAVVANPQTSKFSLDDFRLLPANLYIYGDTFYYLLYALLGRAMGMLETQGRMISWGAALLFVVSVICIAISTEKQTRINGSFADTFYMYCSPLVFIAAVSLWVWFKN-----CLNQHIAWLSGLARHSLAIYGF-------HALIIHFIRTHHYDFTAYPVLDILYVFALTLGLSTLLSMGLQRI............................................................................................................................................................................................................................................................................................................................. 323
23 -9.870[S] COG4713 Predicted membrane protein  ali follow..  10  1................MNKRVVKVEYIFMAFALFFGVLFAVIN-------FQDPDEPIHFYRA-YQISTGQMRSATIYSDIVYIP----------------QSIGINLAKIFRASAL---YMMYFGRIANLICWTIIVFFSVKLIPFKKNLM--AFLALTPMNLY--QAASLSADAMTNSMAFLSIALVLRYAFGEEEAKLTKRQIVTMIIAFTLLAFSKRIYFVMCILFFIIPIKKFNSKKDYIGTFVIMLGACLMSLVTVSVISKILAIKVITYIHILLRTFHFKMSFYAISFIGVFGWLDTRLPLNLYLFYGVALVLIALFEHTLIEKNKDRIIMFIVFIINVGLIMSALYVSWTPKAA-GRYFIPIIPLLGCFIGVKANKSRNVYSKVVLAISTFTILTYSVLQLLLRFYGIR............................................................................................................................................................................................................................................................................................................................................... 454
24 -9.790[S] COG3463 Predicted membrane protein  ali follow..  12  9..........................LLVIIFIAYTFIIFKTCLVLYENFYKSLDLGIFSQSLYSTLNGKFMYNTVEAQLYS----APNHFAVHFQPILLLLLPVYAIMPS--------VVLLLIQAIFLALSATLALLIACEELNHREAILVASLYIFNSSLLGIALFEFHP-----VSLAVPLFFIAYMLLKRGKMKLFYLTSVLILLT----------SFLGVVSLSLWKILMDGLNPESFRKNRGLILLSIASMMYGIIVIKVVIPHLGMGYIYESLYSEFEL---------------TRRKLLYFIVFNASFGFLTFLSSKGLVSVALPWLESML------SSRDTQTMIGFHYPYML------LPLSYLVAIEGFKKSKKVAVSLIVAGILTSMATIPITFK........................................................................................................................................................................................................................................................................................................................................................ 341
25 -9.660[P] KOG4505 Na+/H+ antiporter  ali follow..  7  12.....................HLAYAIIGGFTSLFMLCSLIIK--------------LFLGEATMATATGLIFGPYVAKLFVPTSWGNTDYITEELARVLLVVEVFAAGAELPRAYSMFVMLLPVMIFGWLVSTGFMYALIPRLSFLESLAIAACITATDPVLASSIVGK---NDGMAIPFLYLAIYLIIEKPARHIILYECTFGCVLGAII----GV-----------IARKMIKFSERRGLMDRESFLVFYFVLALFC----GGIGTIIGVDDLLVSFCAGAAFSWDSWFSKKTEESHVSNVIDLLLNLSFFVYVGAIMPWPQFHMPHMDLSVWRLVVLAICILIARRIPAVLLNWREALFAGHFGPIGVGALYTCLVARAELEVHSTVPEPNDA-IENPEIPNWYCIQVMWPVVCFLVLSSIIVHGSSIAFFMLGKRINTLALSFTRTRDSHFAFNLPR.................................................................................................................................................................................................................................................................................................. 461
26 -9.590[T] KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit  ali follow..  8  85.HELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQANPGWYWASYAVFFA---YLTLACCSGPRRHFPWNLIL----LTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVF-SFQTKFDFTSCQGVLFVLLMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 316
27 -9.580[G] KOG3893 Mannosyltransferase  ali follow..  9  407LLSKYNSRENMITKLRESSLYLLYAPTDAFLLLLLGLLMRLVIWHDRRSALKFTDDYFVFSDASKYVSIGMSPYM---DTYRYTP--------------MLAILLLPTQYGFPSWGKYLFS------ISDLIAGWLMIKLLSRRISYKRSLIYSSFWILNPFVAIISTRG--NCEAILGILSIALLYLIEKK-------SVWLASLILGFSVHF------IYPFMYGIAFLVYFSKPKKGSTFMEKFLSLLSINQLKIVVGSLFMFTICNLLMYYLYGSPFLEHTYLYHFGRTDHRHNFSLHHLNLYYESSFGAKASSLFAFLPQLSLCMLIPLVFGKKNLPGTLFAQTFAFVTFNKVCTSQY------FMWYLVFLPLVLPNSKLLSKKGLICLSLWIIGQLLWLISVFIPLWLSGLLFFFFNVYELKIILDSL............................................................................................................................................................................................................................................................................................................................. 815
28 -9.210[G] COG2814 Arabinose efflux permease  ali follow..  9  1MTANVTTVPQDDSETPNEAPAQVASWSGVFAMSVCAFAL----------------------IASEFLPVSLLTPMARDLQVTEGMTGQGIA-----ISGAFAVLTSLFISALAGSLNRKTLLLGLTLAMGVSGAIVALMLGRAL----IGVVVGGFWSMSAATAIRMVPKRDVPRALAIVNGGNAL--------------ATVVAAPMGAYLIGWRGAFLCLVPVSLIALAWQVFTLFKHPGVVVGMLASSLLFMGQFGLFTYVRPFLETVTNVHGATISLFLLVLGAAGFIGTVLIGRVLQRSFYQTMIVIPVLMALTALALIAFGSSVAIVLVLLALWGLTGTSAPVGWWAWIAKVFPGGLFVAVVQMSIALGSTVGGILFDHSGYRTTFVASAVLLAICAVLTVVTAR..................................................................................................................................................................................................................................................................................................................................................... 403
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.