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Query: [S] COG1288 Predicted membrane protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTEEKKRGFRIPSSYTVLFIIIAIMAVLTWFIPAGAYETAKGGGVISGTYKTVASNPQGFFDILMAPVRGMLGVEGTDGAIQVSFFILMVGGFLGVVNKTGALDTGIASVVRKNKGREKMLIAILIPLFALGGTTYGMGEETMAFYPLLIPVMIAVGFDSIVAVAIILIGSQIGCLASTINPFATGVAADAAGVSIADGMIWRVIQWVILVGMSIWFVYNYASKIEEDPSKSLVADKEEEHKELFQLQNSGEDLNKRQRNVLTIFTLTFVIMILSLIPWEDFGIKFFTNINTWLTTMPILGGVIGKTMGAFGTWYFPEITMLFIMMGVLVAIVYRMSEEDFFSSFLTGAGEFLGVAMICAIARGIQVIMNGGMITATILHLGETSLSGLSSQVFVILAYIFYLPMSFLIPSTSGLAGATMGIMAPLGQFSNVPAHLVITAFQSASGILNMISPTSAIVMGALALGRVDLGTWWKFIGKFIVMVMLVSVLLLVVATFFLast
1 -150.000[S] COG1288 Predicted membrane protein  ali  100  1MTEEKKRGFRIPSSYTVLFIIIAIMAVLTWFIPAGAYETAKGGGVISGTYKTVASNPQGFFDILMAPVRGMLGVEGTDGAIQVSFFILMVGGFLGVVNKTGALDTGIASVVRKNKGREKMLIAILIPLFALGGTTYGMGEETMAFYPLLIPVMIAVGFDSIVAVAIILIGSQIGCLASTINPFATGVAADAAGVSIADGMIWRVIQWVILVGMSIWFVYNYASKIEEDPSKSLVADKEEEHKELFQLQNSGEDLNKRQRNVLTIFTLTFVIMILSLIPWEDFGIKFFTNINTWLTTMPILGGVIGKTMGAFGTWYFPEITMLFIMMGVLVAIVYRMSEEDFFSSFLTGAGEFLGVAMICAIARGIQVIMNGGMITATILHLGETSLSGLSSQVFVILAYIFYLPMSFLIPSTSGLAGATMGIMAPLGQFSNVPAHLVITAFQSASGILNMISPTSAIVMGALALGRVDLGTWWKFIGKFIVMVMLVSVLLLVVATFF 497
2 -73.300[I] COG2031 Short chain fatty acids transporter  ali follow..  14  26..........LPDPFIFCALLTFIVFIGAIFL-----------------------TKATPLQVVGFWADGFWS------LLSFSMQMALVLVTGHTLASSRLFKKMLSTFASGIKGPKQAILIVSIVSGIACALNWGFGEIAKKVKGVDYRLLIASAYTGFLVWHGGLSGSIPLQLASGGEGLAKQTAGVVTEIPTSQTLFSPMNIFIIVGLLIIVPLLNMAMFPSKDEIVEVDPKLLVEPEEVVMDTSKMTPAERVENSSAVSILLSIMGFVY----------------------------IGYYLKTKGFALNLNLVNFIFLFLGILLHGTPRRYLNALAEATKGAGGILLQFPFYAGIMGIMVGADADGMSLAKLMSNFFVSIS--TEKTFPVFSFISAGVVNFFVPSGGGQWAVQAPIVMPAGQAIGVSAAKSAMAIAWGDAWTNMIQPFWALPA--LGIAGLGAKDIMGYCLIVTVVSGIFICTGFLL.... 457
3 -72.300[H] COG2978 Putative p-aminobenzoyl-glutamate transporter  ali follow..  14  1MSQTDTQRDMLPHPVTLFIIFIVLLLIASAAGAYFGLSVPPVGAKGRADDGLIHVDADGLIKILTHTVKNFTG-------FAPLGTVLVSLLGVGIAEKSGLISALMRLLLTKSPRKLTTFMVVFTGILSNTASELGYVVLIPLSAIIFHSLGRHPLAGLAAAFAGVSGGYSANLFLGTIDPLLAGITQQAAQIIHPDYVVGPEANWFFMVASTFVIALIGYFVTEKIVEPQLGPYQSDLSQEEKDIRHSTPLEYKGLIWAGVVFVALSALLAWSIVPADGILRHPETGLVS-------------------GSPFLKSIVVFIFLLFALPGIVYGRGEQEVVNAMAESMSTLGLYLVIIFFAAQFVAFFNWTNIGQYIAVKGATFLKGLGGSVLFIGFILICAFINLMIGSASAQWAVTAPIFVPMLMLAGYAPEVIQAAYRIGDSVTNIITPMMSYFGLIMATVI-KYKKDAGVGTLISMMLPYSAFFLIAWIALF 500
4 -23.500[R] COG2056 Predicted permease  ali follow..  12  1..........MFNAVVISVVVMIVLSLLRVNV---------------------------ILAIILAAITAGL-LSGMGGQANTALSYILLGGFAVMIGYSGITSFLVKRLISVLKGRRAFMLLAIAGIASL---SQNVIPVHIAFIPILIPPLLLL---KVDRRGVAASLTFGLKAPYILIPAGYGLLFHSIIADEMTANGMSISIGLAMVVGLLVAIFITYGKDREPRNDAQVDEQSTINETAATEEREFFSLKHVLTLLAIVAALTVQILFQSLV-------------------------------------------LGALTGIILMFAFRVVPFHRGDEVMNEGVKMMGTIAFVMLIASGYATVLKETGAVEQLVASTSSSLGS-HSFLIALVLIFIGLVITMGIGSSFGTIPIIAALYVPLCAAVGFSPLATAALIGTAGVLGDAGSPASDSTLGPTSGLNADGKH-WDTCVPTFLHYNIPLIVFGLIAAMV 438
5 -21.200[C] COG2851 H+/citrate symporter  ali follow..  13  1...............MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKDLGEMMI---------QGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPFKIAVGTAVLTMTISLDGDGTTTYMITIRAMLPLYKRLGMNRLVLAGIAMLGSGV------IIPWGEPTARVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEAAPLKRPALQWFNLLLTVALMAALITSLL-------------------------------------------PLPVLFMTAFAVALMVNYPNVKEQQKRISAHAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSTRSLIPDAMGPHLPLITAIVSMPFTFFMSNDAFYFGV-LPIIAEAASAYGIDAAEIGRASLLGQ-PVHLLSPLVPSTYLLVGMAGVSFGDHQKFTIKWAVGTTIVMTIAALLIGII 424
6 -18.900[C] COG3069 C4-dicarboxylate transporter  ali follow..  13  1..........MLTFIELLIGVVVIVGVARYIIK--GYSAT--VLFVGGLLLLIASTGYSATDIVEYVKILLMS-----RGGDLGMMIMMLCGFAAYMTHIGANDMVVKLASKPLQNSPYLLMIAAYFVACLMSLAVSSATGLVLLMATLFPVMVNVGISRGAAAAICASPAAIILAPTSGD---VVLAAQASEMSLIDFAFKTTLPISIAAIIGMAIAHFFWQR----------YLDKKEHISHEMLDVSEITTTAPAFYAILPFTPIIGVLIFDGKWGPQLH--------------------------------IITILVICMLIASILEFLRSFNTQKVLEVAYRGMADAFANVVMLLVAAGVFA-LSTIGFIQSLISIATSF--GSASIILMLVLVILTMLAAVTTGSGNAPFYAFVEMIPKLAHSSGINPAYLTIPMLQASNLGRTLSPVSGVVVAVAGMAKISPFEVVKRTSVPVLVGLVIVIVATEL.... 449
7 -18.400[C] COG1620 L-lactate permease  ali follow..  13  24.............PIIFFFWALAATLGIALIIAVLVYR-------------------MPAEKALMSATQGAV------GLLPIGWIIVTSVFLYKITVKTGQFDIIRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVA----ISAALLVGLGFNPLYAAGICLIAVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLLVSMAALAVFLKWWKPKTTFRFAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHYEGSAVFLKWLNAVGEKLTFSPGV--LGSAGTAILIAAVLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT-----GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTGKMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHV 557
8 -18.200[C] COG1757 Na+/H+ antiporter  ali follow..  11  2...DSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVMLSAAALWFGFPWK--SIEKGIVDGI------KNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALSFIEPS--HLLLTALFSCMIISTLVGSSLTTVSTIVALIGVASAAGVPLEWTAGAVICGACFGDKMSPMSD-TTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAAST------------DNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFVPYSSLQAFMTALQNGTTFETDNEAAAKIINR---------------GGLQSMMGSVSLIMIAFALGGLMEKIGLISALLEGVMKGIRSKGRLVAA--TVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQRKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGFV..... 451
9 -17.800[GE] COG2610 H+/gluconate symporter and related permeases  ali follow..  10  1.................MPLVIVAIGVILLLLLMIRFKMNGFIALVLVALAVGLMQGMPLDKVIGSIKAGV------GGTLGSLALIMGFGAMLGMLADCGGAQRIATTLIAKFGKKHIQWAVVLTGFTVGFALFYEVG--FVLMLPLVFTIAASANIPLLYVGVPMAAALSVTHGFLPPHPGPTAIATIF-NADMGKTLLYGTILAIPTVILAGPVYARVLKGIDKPIPEGLYSAKTFSEEE-----------MPSFGVSVWTSLVPVVLMAMRAIAEMILPKGHAFLPVAEFLGDPVMATLIA-----------------VLIAMFTFGLNRGRSMDQINDTLVSSIKIIAMMLLIIGGGGAFKQVLVDSGVDKYIASMMHET-----NISPLLMAWSIAAVLRIALGSATVAAITAGGIAAPLIATTGVSPELMVIAVGSGSVIFSHVNDPGFWLFK--EYFNLTIGETIKSWSMLETIISVCGLVGCLLLNMV 437
10 -15.600[P] COG3067 Na+/H+ antiporter  ali follow..  9  16.........QSPDWYKLALLVFLIVNPFIFLANP----IAGWLLVAEFIFLKCYPLLPGGLLAIEAVIIGMTSAAHVREEVAANLEVLLLLMFMGIYFMKQLLLFIFTRLLLSIRSKMVLSLAFIYHRVASSRGEENDMLDDSHIDPHYKTVLEQFRGFLRSLMMHAGVGTALGGVMTMVEPQNLIIAK-AAGWHFGDFFLRMSPVTVPVLVCGLLTCMLVEKMRWFGYGETLPEKVRDVLQQFDDQSRKKRTRQDKIKLIVQAIIGVWLVTALAL--------------------------------------HLAEVGLIGLSVIILATALTGVTDEHAIGKA------------SLPFTALLTVFVAVIIDQHLFAPIIQFVLQASEHAQLTLFYLFNGLLSSIS--DNVFVGTIYINEAKAAMENGAISLELLAVAINTGTNLPSVATPNGQAALFLLTSARLSYGRMVWMALPYTIVLTLIGLLCVEF.... 495
11 -14.900[R] COG2704 Anaerobic C4-dicarboxylate transporter  ali follow..  12  49................................................................................VDVMLVIIAVVAASATLQASGGLDVMLQIAEKLLRRNPKYVSIVAPFVTCTLTILCGTGHVVYTILPIIYDVAIKNNIRPERPMAASSIGAQMGIIASPVSVAVVSLVAMLGHLEFLDLLSITIPSTLLGILAIGIFSWFRGKDLDKDEAKFISVPENRQYVYGDTATLLDKKLPKSNWLAMWIFLAAIAVVALLGADSDLRPTFGGKPLSM------------------------LVIQMFMLLTGALIIILTKTNPASISKNEV---SGMIAIVAVYGIAWMAETMFGAH--MSEIQGVLGEMVKEYP-WAYAIVLLLVSKFVN--------SQAAALAAIVPVALAIGVDPAYIVASAPACYGY--YILPTYPSDLAAIQFDRSGTTRIGRFVINHSFILPGLIGVSVSCVF.. 435
12 -14.700[P] COG0471 Di- and tricarboxylate transporters  ali follow..  10  1MSLSKDNIWKLLAPLVVMGVMVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLFDASELADPAFKASKQALKWGLAGFSSTTVWLVFGAFILGYEVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTGGTVFPVIKNLPPLFKSWMMVISTSLSSSMFVTGAAPNVLGLEFVSKIAGVQILQWFLSFLPVGIILLIVAPWLSYVLYKPEVTHSAEV--------AAWAGGELKNMGRLSRKEWTLIGLVLLSLGLWVFGGKIINA--------------------------------------TAVGLLAVSLMLALHVVPWKDITRYNSA------NTLVNLATLVVMANGLTRSGFIDWFANTMSTHLEGFSPDATVIVLVLVFYFAHYLFASLSAHTATMLPVILAVGKGIPGVP-LCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSRDYWRLGAIFGVIYIAMLLLV....... 478
13 -14.500[P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases  ali follow..  10  4................MILAVFIFLLTLVLVI-------------------NLSIGWSACGGAVLALIAGVVNFHDVLTVTNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVSLLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIFIADTTSLPFVVSNLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRK-------SIPKRYDLTEVKKPVEAIKDQNMFRLSWYILGLLLIGYFASEF-------------------------------------------PVSVVAGSIAIIFLIAAQKSPAVHTKKVVKEAP-------IVFFSIGMYVVVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAILSSIM--NNLPTVMIDALAIAGTD-THGMMREALIYANVIGSDLGPKITPIGSLALLWLHVLSISWGTYFKTGIILTIPTLLITLVGLYIWLLI 430
14 -13.900[Q] COG4664 TRAP-type mannitol/chloroaromatic compound transport system, large permease component  ali follow..  14  2........IEFVAENLAPIMFVSLIVFLLLGYPVA-FSLAANGLLIGVELAPLSDSINLSWPLLNALPERFWGVMSNDTLLAIPFFTFM-----IVLERSGMAEDLLDTIGQLFGPVRGGLAYAVIFVGALLAATTGVVAASVIAMLISLPIMLRYGYDRRIASGVIAASGTLAQIIPPSLVLIVDQLGRSVGDMYAGALIPGLVLTGLYMGYILLMTFVKRHSMPALPLEARTLGSGVASLAIAL----HVYLSPTQGENADILGATVGIIFIYLAALADRTLKINALSRLAQQVIIVLIPPLALIFLVLGTIFLTEGGAMGAVGALVMAAGKGLNMEVVRAALASTTRLSAFVLFILIGARVFSLTFYGVNGHLWVEHLLTALPG--GEIGFLIAVNVLVFFLAFFL-DFFELAFIIVPLLAPAADKLGIDL-LLGINMQTS-----FMHPPFGFALFYLRMQPVTTGQIYWGAVPFVCIQVVMVALTLMFPQM. 514
15 -11.600[G] COG1593 TRAP-type C4-dicarboxylate transport system, large permease component  ali follow..  13  1..............MTILFLFLLLFLLMFIGVPIA-------SLGLSGALTILLFSPDSVRSLAIKLFETSEH------TLLAIPFFLLSGAFMTTGGVARRLIDFANACVGHIRGGLAIAAVLACMLFAALSGSSPATVAAVG--SIAIAGMVRSGYPQAFGAGIVCNAGTLGIL---IPPSIVMVVYAAATETSVGKLFIAGVVPGLLLGLILMVVIYIVARVKKLPAMPRV------------SLREWLASARKALWGLLLMVIILGGIYSGAFT--------------------------------------TEAAAVAAVYSAFVALFVDMRLSECPKVLLESGKLTIMLMFIIANAMLFAHVLTTEQIPQSIASWVTELGL--SPWMFLLVVNIVLLIAGNFM-EPSAIILILAPIFFPIAMELGIDPIHLGIIMVVNMEIGLITPPVGLNLFVTSAVTGMPLGATIRAALPWLMILLVFLIIVTYIPAV. 416
16 -11.300[S] COG1906 Uncharacterized conserved protein  ali follow..  11  14...........PMVASSSLALLFSIAVVLILIRK----------VNIGLAIFVGSAILAYLTLGADGLLVMLKSLANPQTIEIVVIVILAFTLGYSMEYFGMLEKVTGGLSESFGVYSFLLIPLLIGLLPMPGGA-------LISAVMLGPLTKMYRISPEKATLLNYWFRHVWVTFWPLYP-SVIIGAAVVNVDYFHFAAATFPIGVFALTAGLTLTRGMERRFRVSRNLF--------------------DSLINLYPIAILLILSVLLRL--------------------------------------------DLLLALVVAIAAVSIHNRAKLEDFREIFRRTVD--KKIILLVFAVMVYKSVIQNSGAAESLFTDISLGFP------APAAAFLLTLLVGFATGIEMSYSSIALPLLTSFTGSGIVVAKNLMLVIAAG--IGVMLSPMHLCYILTAEYFGTEIGKTYRQLLAIAGITAALVWIAYLV.... 404
17 -10.500[P] KOG1281 Na+/dicarboxylate, Na+/tricarboxylate and phosphate transporters  ali follow..  10  14..............LFVVFTVLVLLPLP--IVLHTKEAECAYTLFVVATFWLTEALPLALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVIC-SIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQIVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTR-FTFSFPAALIILLLSWIWLQWLFLGFNFKEMFKCGKTKTVQQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIMALLWFSRDPGFVPGWSALFSEYPGFATD-----------------------STVALLIGLLFFLIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSP-LGSLPAWLIILISSLMVTSLT--VASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLNPPNAIV---FSYGHLKVIDMVKAGLGVNIVGVAVVMLGI...... 569
18 -9.160[R] COG4666 TRAP-type uncharacterized transport system, fused permease components  ali follow..  14  150.............TLPILSGVFIAYAFLGPWLP-GFLNHGGYSFDRFVTYIYSL--------------DGVFGVTVDVSSKYILLFIVF-----AFLQMSGVIDFSFSLAGGMRGGPAKVSVISSGLMGMMNGTSAG---NAVATGSLTIPLMRRVGYKGQFAAATEATASAGGQIMIPIMGAGAFIMAEITGIRYSEIIIAAAIPAFLYFLSVYFMVDFQAIKN--------------GMKGLSRKELPPLKGILKQSYLFIPVVLLIASLLMGYSI--------------------------------------IRSGTVSILACLIVSWITRMGLKKVLGALELGMKNVIQLLAVCACAGIIVGVIALTGVGLRFSSMLLG-IADANKLLALLFAMGISIILGMGMPTTAAY-AVAAAVVAPGLIQIGIEPLHAHMFVFYYAVMSAITPPVALAAYAAAGVAGTDPFKTGVDAFKLGLAAFIVPFMFIYSPAIM 564
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhang Y, Stec B, Godzik A. Between order and disorder in protein structures: analysis of "dual personality" fragments in proteins. Structure. 2007 Sep;15(9):1141-7.