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Query: [R] COG1453 Predicted oxidoreductases of the aldo/keto reductase family, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLYRKMPKNGDELSILGFGCMRLPVKEDGSVDEERATRQVRYAIDQGVNYVDTAWPYHMGESEPFLGRALADGYREKVKLATKLPSWMVKSREDMDKFLNAQLEKLKTDHIDYYLIHNLSGETWDRIEALNVIDFFEKAKSDGRIVNAGFSFHGLANDFKRIVDAYPWTFCQIQYNFMDEKHQAGTEGLKYAASKGLGVMIMEPLRGGNLARTVPLAIENIWSEADVERTPVEWALRWVWNHPEVTVVLSGMNEEVHIKENLKIASEAYPNSLTEAELQLVSKVEQKYRQIMKVGCTGCQYCMPCPSGVNIPECFSIYNHLSTFGNAEDANLLYIGLLSGAVSGGKPGMASQCVQCGQCLEKCPQHIDIPTILESVAEELEGSDLEERIAIVKQEMHKQILast
1 -106.000[R] COG1453 Predicted oxidoreductases of the aldo/keto reductase family  ali  100  1MLYRKMPKNGDELSILGFGCMRLPVKEDGSVDEERATRQVRYAIDQGVNYVDTAWPYHMGESEPFLGRALADGYREKVKLATKLPSWMVKSREDMDKFLNAQLEKLKTDHIDYYLIHNLSGETWDRIEALNVIDFFEKAKSDGRIVNAGFSFHGLANDFKRIVDAYPWTFCQIQYNFMDEKHQAGTEGLKYAASKGLGVMIMEPLRGGNLARTVPLAIENIWSEADVERTPVEWALRWVWNHPEVTVVLSGMNEEVHIKENLKIASEAYPNSLTEAELQLVSKVEQKYRQIMKVGCTGCQYCMPCPSGVNIPECFSIYNHLSTFGNAEDANLLYIGLLSGAVSGGKPGMASQCVQCGQCLEKCPQHIDIPTILESVAEELEGSDLEERIAIVKQEMHKQI 400
2 -65.100[C] KOG1576 Predicted oxidoreductase  ali follow..  20  22MEYRQLGSTGLRVSKIALGGATLSKLFSDDFDREEGILTVQEAIRSGINYIDTAPFYGQGKSEELLGQALKDVPREAYYIATKVANMFDYTAAKARESVKRSLELLQLDRVDVLQVHDVDAAPSLDMVLNETIPVLEEYVQAGKARFIGVTAYDVDVLKECAERGKGRIQVVLNYARYTLLDNTLLRHMKAFQEMGVGVVCAAAHSLGLLSNAGPQSKRGAEICQKRNVELGKLAMYYTMQLDGAATFLIGIPNRKLLRINLDAIFDGLTSHEQEVLQYLRENV.................................................................................................................... 324
3 -63.600[C] COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)  ali follow..  21  1MQYNTLGNTDLRVSRLCLGCMTFGEPSRWTLPEESSRPIIKRALEGGINFFDTANSYSDGSSEEIVGRALRDARRDEVVVATKVDLPEGLSRAQILRSIDDSLARLGMEYVDILQIHRWDYTT----PIEETLEALNDVVKAGKARYIGASSMHASQFAQAQKQHGWAPFVTMQDHYNLIYREEEREMLPLCWQEGVAVIPWSPLARGRLTRPWGETTRLAGVSEALGATRAQVALGWLLSKRGVAAPIIGASREEQLDELLNAVDLTLKPEQIAELETPYKQ..................................................................................................................... 317
4 -59.600[R] COG4989 Predicted oxidoreductase  ali follow..  19  1MQRIQLA-EDLQFSRVIHGLWRLN---EWNYSDAELLSLIEWCIDHGITTFDHADIYGGYTCEKLFGNALALGLRENIELVTKCGHHYNTSKSHILASVEQSLMNLRTDYIDMLLIHRPDP----LMDPEGVAEAFQALKCSGKVRYFGVSNFKDHQ-YRMLESYLPEKLVTNQIELSAYELENLDGTLNLCQEKRIPPMAWSPLAGGKVFTENTDKDRRVVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAINALSYKLDQDQWFRIFTAVQ...................................................................................................................... 295
5 -57.500[C] KOG1575 Voltage-gated shaker-like K+ channel, subunit beta/KCNAB  ali follow..  19  16GRLRVLSKTGIRVSPLILGGASIGDAFMGSMNKEQAFELLDAFYEAGGNCIDTANSYQNEESEIWIGEWMASKLRDQIVIATKFANYCGNHKRSLHVSVRDSLRKLQTDWIDILYIHWWDYMS----SIEEVMDSLHILVQQGKVLYLGVSDTPAWVVSAAATSHGKTPFSVYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAMEERTKIAEEHGTESVTAIAIAYVRSKAKNVFPLIGGRKIEHLKQNIEALSIKLTPEQIEYLESIVP...................................................................................................................... 342
6 -39.200[R] COG0656 Aldo/keto reductases, related to diketogulonate reductase  ali follow..  23  1MNTYQL-NNGVEIPVLGFGTFKAK-------DGEEAYRAVLEALKAGYRHIDTAAIYQ---NEESVGQAIKDSPREEMFVTTKL--NSQQTYEQTRQALEKSIEKLGLDYLDLYLIHPLRENDAWKTRNAEVWRAMEDLYQEGKIRAIGVSNFLPHH-LDALLETATIVPAVNQVRLAPGVYQ--DQVVAYCREKGILLEAWGPFGQGELFDS----KQVQEIAANHGKSVAQIALAWSLAEGFL--PLPKSVTTSRIQANLDCFGIELSHEERETLKTI........................................................................................................................ 266
7 -35.700[R] KOG1577 Aldo/keto reductase family proteins  ali follow..  20  8.......NNGAKMPILGLGTWK--------SPPGQVTEAVKVAIDVGYRHIDCAHVYQ---NENEVGVAIQEKKREELFIVSKL--CTYHEKGLVKGACQKTLSDLKLDYLDLYLIH--GNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQ-VEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLAIAAKHNKTTAQVLIRFPMQRN--LVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSY........................................................................................................................ 292
8 -22.900[E] KOG3023 Glutamate-cysteine ligase regulatory subunit  ali follow..  12  20.......HTGNVNGYTQLKVRRF----------ETSAEELAACLDLQLSSNPIADDFKENSC-LCDNDHIDNYERDEIKITMKV---SAWDVQQIDQAVTSLKEQLKTKDIEVLILS--DENNRWFEKVKPLYTYMEKLVETSEIASIGVSDFSA-RQLKTIIDHFDVKPSINHVRLDG---QVPPELQALANDNDVQLLVHNDP-TPFPTNNIFKTFCEIDSGSQKAVCSPLFETTWLSRYSVWVRKRSIMTSKGYIVQFFRKHD...................................................................................................................................... 276
9 -16.500[C] COG1146 Ferredoxin  ali follow..  14  1........................................................................................................................................................................................................................................................MAEAKNAPLIGKD--ALGREVRDLSKVPWWGVDRKEIEWYPTIDYDKCVTCGICFVCGRRV--------------------------DFDKKEGKVIVARPYNCMVACQTCMNLCPTGISFPDASYIKKLVAQNKIVKKAFEIIKPLLAED. 126
10 -16.300[C] COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit  ali follow..  9  69.....YAPFCDMCCLCTYGKCELLGKKG-DAATQQARTVLLACLIGTAAHAGHARHLVDHLIERLLREVMDYAEEQMSHLLSACHTGQEGDSKDFEPLVELGFGTIDTEKPVVLC------IGHNVLPGADIVDYLDENEMEDQVEVCGICCAAIDVTRLRFIRSGVADVIVVDEQCV------RTDVLEEALKNRSAVIATTDKMCLGLPDMTD--------------EDPDKIVNDLINGNIEGALILDPEKVGEVAVKTAM-------KLAPIRKSLKKLPDIDEIIELASECTDCGWCQRCPNSLPVMDAVKKAAD------------------GDLSKLEEMAIEELCYTCGRCEQECERNIPIVSMVTKAGERRVKDEKYRIRAGRGPAQDVEI 496
11 -16.000[C] COG1150 Heterodisulfide reductase, subunit C  ali follow..  19  4..................................................................................................................................................................................................................................................................PRDTVIREEDLNPDFLEELSELVEPVFEEEEVLSVQACYQCGTCTGCPSGRRTSYRTRLIMRKLQLGLVDEV---------------KSDELWMCTTCYTCYERCPRGVKIVDAVKAARNLAAKK................. 115
12 -14.900[C] COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit  ali follow..  10  16.....................................................................................................................................KVWPKPDGAKNVREYRIYRWNPDDGQNPRIDTYYIDVDDCGPMVL--------DALLYIKNNIDPTLTLRRSCREGICGSCAMNIDGTNTLACTKGMEEIKGTVKVYPLPHMPVVKDLVPDLSNFYAQHRSIEPWLKTVSPTPAKEWKQSHEDRLKLDGLYECILCACCSTCPS----PAVLLQAYRWLIDSRDEATGERLDNLEDPFRLY-------RCHTIMNCAQACPKGLNPAKAIAEIKKMMVERRV............... 259
13 -14.300[C] COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB  ali follow..  17  6............................................................................................................................................................................................IAVAAVXLLGLAFGAILGYASRRFAVEDDPVVEKIDEILPQSQCGQCGY-PGCRPYAEAISCNGEKINRCAVMLKIAELLNVEPQPLDGEAQELTPARMVAVIDENNCIGCTKCIQCPVDA----------------------------IVGATRAMHTVMSDLCTGCNLCVDPCPTHISLQPVAETPDS...................... 173
14 -14.300[C] KOG3049 Succinate dehydrogenase, Fe-S protein subunit  ali follow..  10  7.................................................................LSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDHMQTYEVDLNKCGPM-------VLDALIKIKNE------------------------------------------VDSTLTFRRSCREGIC-------GSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYE--CILCACCSTCPS----PAVLMQAYRWMIDSRDDFTEERLAKLQ-------DPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKK............. 277
15 -13.900[C] COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain  ali follow..  12  67................................DAYLYQLSEKVIQNGGHVYFAAT---AEDATNYIKNVAKQKNAKKIVKSKSMVTEEIG--------MNHVLEAEGIKVVETDLGEYILQVAEDKPSHIVVPAIHKDRHQIRKVEKLGYTGSDTPEEMTLFIRETIRNDFL--------EADIGVSGCNFAVAETGSVCLVTNEGNLRLATSLPKTHIAVMGMERLAPTFKEVDVLITLLATGYNTWLTGPRLAGETDGPEEFHLVIVDNGRSKMLGSEFREVLR---------CIRCGACLNCP----------AYRQIGGHGYGSIYPGPIGSVISPILGGYEEDLPSACSLCTACNQVCPVKIPLANLLLKHRRHIAESG................ 393
16 -13.800[C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit  ali follow..  19  29...............................................................................................................................................................................................................................................................................TLGTTLVNFTGDWRTFMPVIDESKCVKCYICWKCPEPA----------------------------IYIKEDGFVAIDYDYCKGCGICANECPTKITMVREEK.......................... 105
17 -12.900[C] KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit  ali follow..  13  2......................................................................................................................................................................................SLTMRIFTASRNGQRLLLAAQRAEP---KDIVEVPKGYVYVNNKELSMEFADITDRAASTMFFGELLRGFATLAHI---KEPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEACPAQITIEA--------EERADGSRRTTRYD-------------DMTKCIYCGFCQEACPVD.................................. 170
18 -12.100[C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)  ali follow..  18  10..................................................................................................................................................................................................................................................HGTFTQLRSLVIFGHAFR--KRDTLQYPEEPVYLPPRYRGRIVLTRDPDGEERCVACNLCAVCPVGISLQK--------AETEDGRWYPEFFR-------------NFSRCIFCGLCEEACPTT.................................. 114
19 -11.900[C] COG1145 Ferredoxin  ali follow..  14  10..YEKLRE---KLNKAPIGL--------PKTVSGVEKELLSVLFD---------------EEEAKIAVHMPFIRFTAEQLAERTGKSLEYVEKILNEMAKKGT-KGEKDGQTYYRLFPAETPFWPGPGKDPRQEKLARLWSQYRKEGFLDEIGDREHPIMRALPERD----TISEKSEILPYEDAVKLVKERDYIAVGYCPCRVMAR-LVGEGCRHSIENCIHMGSVGKYMVEHGLGRRISADEAIEILRQSNREGLVHLTERSKHVAFFKAVHEAKHPNTIAHSSYLATVDTSRCIACGICMLCP---------------------------MKAIKAKINREPASVDAEKCLGCGVCVPTCPMEIELVERDELLELPDGMTYVQELLADKGRD..... 363
20 -11.200[C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit  ali follow..  11  10..........................................................GSDGTVGANKAAIKGDNTDLYAQGYFSYDSKKSGGLTVSHLRFGENRIRSA----YLIQQADFVSCSTSAYLRSYDLLKGLKPGGTF-----TIWEGEQLERHLPAAMREYIAKNNIQFYTL------NAMRIAGEAGLGRRINTVMQTAFFRVTDILPFEKALADLKASAIATYGKKDMAVAEKNILAMDQTVANLHKVEVPESWANPVLTAEASTATEKPARGIALEVPEWISENCTMCNECA-CPHAA----IRPILTNEEEMESAPEGFMTREMRGKDGLRYRIQVSPMDCTGCNLCAETCPAKDKALVMKPFEEVAAKENP................ 363
21 -11.100[C] COG0348 Polyferredoxin  ali follow..  24  226.......................................................................................................................................................................................................................................................................................................CDNCMDCYNCPEPQVLRDPLHA-----------------------KKSESPLVLSKDCISCGRCIDVCPEKV................................. 275
22 -10.900[C] COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC  ali follow..  13  137...DRIHQAGI----AGLGGAGFPTASKLQGGLNGIITLIINAAECEPYITADDRLMQEHADEVITGIHIHLLQPQQVLIGIE------DNKPEAIAALQRALR--GQDDIHLRVVPTKYPSGGAKQLTKILTG--KEVPFGKHSSSIGVLMQNVGTVV----------------------------AIKRAVIDD------EPLIERVVTLTGDALSSPGNFWARIGTPVLYLLKLAGFKPQNPPMVIMGGPLMGFTLPSLDVPIVKISNCI------LAPAETEMGLSEPEQSCIRCGLCVDCPAGLLPQQLYWFSR-------------------GEEHEKARNHNLFDCIECGACAYVCPSNIPLVQYYRQEKAEIRALDQES............. 450
23 -9.800[C] COG1142 Fe-S-cluster-containing hydrogenase components 2  ali follow..  16  82.......................................................................................................................................................................................................................................................................................................CVSCKLCGACPFGASGSRPLDIPANANTPKAPPAPPAPARISTLLDWVPGIRAIAVKCDLCSACVRMCPTKALHLVDNTDIARVSKRKRELTFNTDFG....... 189
24 -9.570[C] COG2440 Ferredoxin-like protein  ali follow..  12  1.....................................................................................................................................................................................................................................................................MTMAVTKLRVEEKLYQNRYLVDPGRPHIKVRPHERPSANLLTHCPAKC----------------------------YELNDKGQVETTSDGCMECGTCRVLCEASGEI............................... 83
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.