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Query: [J] COG1530 Ribonucleases G and E, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSNKMLIDASHPEETRVIVTRGNKIEEFDFESEHKKQLKGNIYLARVTRVEPSLQAAFVEYGGNRHGFLAFSEIHPDYYQIPVADRLALLEAEAKAARAEDDEDEPRAKSDRSERNDRARRNRRRGGRRDGQNGEAQANGADKDLPAAEPVGPGFADYVAGTPAAALTQKGDIISEALDNGDDDDVENEEDMVESVGSEDALEELPTHTRTHRRQYNIQEVIKRRQILLVQVVKEERGNKGAALTTYLSLAGRYSVLMPNTARGGGISRKITNPQDRKRLKEIVKELEVPQGMGVILRTAGANRTKAEVKRDYEYLMRLWENVRTLTLQSTAPALVYEEGSLIKRSIRDIYNKDITEILVSGENGYREAKDFMRMLMPSHAKVVQPYRDHIPIFTRNGVEAQLDRMLVPQVTLKSGGYLIINQTEALVAIDVNSGRSTREHSIEDTALQTNLEAAEEVARQLRLRDLAGLIVVDFIDMEEKRNNRAVEKKMKECLKDDRARIQVGRISHFGLLEMSRQRIRASVLESTMQVCPHCGGTGHIRSDSSMALHIIRGIEDYLLRHSGFDIHVRTPAASALYVLNHKRQILADLEGRFGVEISIDADESVGNQHFVIDKGAPSTRPVTPSAVQPMVYEDDIEDPEIPVEEDETEEEARTDVQAGEERSEENDRKRRRRRRRRGGRERDGRDLSAQEEAVSEEASEEDNETDQANEAVSSASMSEEDRRKKRRRGRRGGRKNRREDDNRARRIPDPEFVGYTPVLPVKAEESIGEVVETVETVEAPVVEAAPEEKPEKPARKTRTRKKAVDEAPADEAAAPAEEVVPEKPKRRTRKAAAKPVVEAEDVAEVKETVAAETQVETIAEPKSTEPVVTSSESEDRKPKRSGWWQKKGFFLast
1 -174.000[J] COG1530 Ribonucleases G and E  ali  100  1MSNKMLIDASHPEETRVIVTRGNKIEEFDFESEHKKQLKGNIYLARVTRVEPSLQAAFVEYGGNRHGFLAFSEIHPDYYQIPVADRLALLEAEAKAARAEDDEDEPRAKSDRSERNDRARRNRRRGGRRDGQNGEAQANGADKDLPAAEPVGPGFADYVAGTPAAALTQKGDIISEALDNGDDDDVENEEDMVESVGSEDALEELPTHTRTHRRQYNIQEVIKRRQILLVQVVKEERGNKGAALTTYLSLAGRYSVLMPNTARGGGISRKITNPQDRKRLKEIVKELEVPQGMGVILRTAGANRTKAEVKRDYEYLMRLWENVRTLTLQSTAPALVYEEGSLIKRSIRDIYNKDITEILVSGENGYREAKDFMRMLMPSHAKVVQPYRDHIPIFTRNGVEAQLDRMLVPQVTLKSGGYLIINQTEALVAIDVNSGRSTREHSIEDTALQTNLEAAEEVARQLRLRDLAGLIVVDFIDMEEKRNNRAVEKKMKECLKDDRARIQVGRISHFGLLEMSRQRIRASVLESTMQVCPHCGGTGHIRSDSSMALHIIRGIEDYLLRHSGFDIHVRTPAASALYVLNHKRQILADLEGRFGVEISIDADESVGNQHFVIDKGAPSTRPVTPSAVQPMVYEDDIEDPEIPVEEDETEEEARTDVQAGEERSEENDRKRRRRRRRRGGRERDGRDLSAQEEAVSEEASEEDNETDQANEAVSSASMSEEDRRKKRRRGRRGGRKNRREDDNRARRIPDPEFVGYTPVLPVKAEESIGEVVETVETVEAPVVEAAPEEKPEKPARKTRTRKKAVDEAPADEAAAPAEEVVPEKPKRRTRKAAAKPVVEAEDVAEVKETVAAETQVETIAEPKSTEPVVTSSESEDRKPKRSGWWQKKGFF 891
2 -11.600[A] KOG2937 Decapping enzyme complex, predicted pyrophosphatase DCP2  ali follow..  10  1.............................................................................................................................................................................................................................MSFTNATFSQVLDD--------------LSARFILNLPA--------------EEQSSVERLCFQIEQAH----------------------------W---------------FYE----------DFINDQLPSL---------GLRVFSAKLF-----------AHCPLLWKWVHEEAFDDFLRYKTRIPVRGAIMLDMSQQCVLVGFPKGKIDKDESDVDCAIR---EVYEETG------DCSSRI--EFIDMTIRGQNVRLY--IIPGISLDRTRKEISKIEWHNLMDLPTFK------------------------------------KNKPQTMKNKFYMVIPFLAPLKKWIKKRNIANNTTKEKNISVDVDADASSQLLSLLKSSTAPSDLATPQPSTFPQPPVESHSSFDIKQKILHLLNEGNEPKSPIQLPPVSNLPLNPPIQSSNSRLSHDNNSFDPFAYLGLDPKNPSASFPRVVSQNNMLTNKPVLNNHFQQSMYSNLLKDQNSVQHLFAASDMPSPMELPSPSTVYHQVFYPPTSTSVSSYGLGKTPQPAYGSSSPYVNGHQTQQISSLPPFQSQTQFLARNSDNSGQSYNSEGDSNSKRLLSMLSQQDTTPSSSTLSKEANVQLANLFLTPNSLETKKFSDNSQGE......... 535
3 -10.400[R] KOG2350 Zn-finger protein joined to JAZF1 (predicted suppressor)  ali follow..  8  541...........................................................................................................................................................................................................................................................................................................................................................................................................................................................KELDIDSEGESDPLWLRQKTIQMID-----EFSDVNEGE--KELMKLWNLHVMRHGGDCQLPICEMF---EIVRKNLYRNFILHMCS-------YGLIA--AETVYKTVQKLQGLLSKYAAGQELMQ----------RQREEQLKYWLDV-------MHKKQEDPKTLKSPQKPAPPADQASTSSASTSGSGSGSSSMQPPKRMPAHLKRGSAASSPGVQSKGTENGTNGSNSSSSNSKNVAKKSADQPLSTLANTRERRSEYGQKRNVSGSRLAATPASKRKLSSKDVEQAADAPEVLTHSDNAVDVGIIDDECGGFGAVGVMNGVASPVANNSEMDTEAEVEAEPTATKAITIHCQQPVTTPVAAAATANERLPGVAPHRRGPRRADRREEELVASAPGYRCRPSMRGADAGAAAAAAAAPTHPHPHRPPPPPPPQ.......... 955
4 -10.300[R] KOG3253 Predicted alpha/beta hydrolase  ali follow..  9  40..........................................................................................................................................................................................................................................................................VNRTGWTMAQNKLFNKILKALQ-------LARLANEGACNEPV-------------LRRVAVDKCA------------RRVRQALAS-LHTTLVET-AAYLDALQTLKGKIPTLIDRLVSSNTKTGAAGAEALSLLLKRPWDPAVKLPGSPLILIASS-KVIPVATHLLNNGSGVGVLQGAVRSKVLEIHSVACHVSVMEVTAVVCLGFPLLTVDGPRGDVDDPLLD--------MKTPVLFVIG-MEDFREKIRAE--------------NSLV-ADDNLRISKAKKKSEGLTQSMVDRCIQD---EIVDFLTG----------------VLTRAEGHMGSEPRDQDAEKKKKPRDVARRDLAFEVPERGSRPASPAAKLPASPSGSEDLSSVSSSPTSSPKTKVTTVTSAQKSSQIGSSQLLKRHVQRTEAVLTHKQAQVPISSEPPEEGEKEDLRVQLKRHHPSSPLPGSKTSKRPKIKVSLISQGDTAGGPCAPSQGSAPEAAGGKPITMTLGQASAGAKELTGLLTTAKSSSSEGGVSASPVPSVVSSSTAPSALHTLQSRLVATSPGSSLPGATSASSLLQGLSFSLQDISSKTSGLPANPSPGPAPQ........... 666
5 -9.350[K] KOG2150 CCR4-NOT transcriptional regulation complex, NOT5 subunit  ali follow..  8  1.....................................................................................................................................................................................................................................................................................................................................................MAHRKLQQEVDRVFKKI--EGLEIFNSYYERHESCTNNPSQKDKLESD---------LKREVKKLQRLREQIKS-----------QSSPDIKDKDSLLDY---RRSVEIAMEKYKAVEKASKEKAYSSLKKSETLDPQE-RERRDISEYLSQMIDELERQYDSLQVEIDKLLLLNKKKKTSS------------------TTNDEKKEQYKRFQARYRWHQQQMELALRL-------LANEE-QDVKNVQDDINYFVESNQDPDFVEDETIYDGLNLQSNEAIAHEVAQYFASQNAEDNNTSDANESLQDISKLSKKEQRKLEREAKKAAKLAAKNATGAAIPVAGPSSTPSPVIPVADASKETERSPSSSPIHNATKPEEAVKTSIKSPRSSADNLLPSLQKSPSSATPETPTNVHTHIHQTPNGITGATTLKPATLPAKPAGELKWAVAASQAVEKDRKVTSASSTISNTSTKTPTTAAATTTSSNANSRIGSALNTPKLSTSSLSLQPDNTGASSSAATAAAVLAAGAAAVHQNN............ 493
6 -9.320[K] KOG2169 Zn-finger transcription factor  ali follow..  7  302............................................................................................................................................................................................................................................................................................QKDDFPLNCYARVDDSVVQLPNVIPT----------NKTNAEPKRPSRPV-------------------NITSNMNRYKKEHT--------VAVEWLADKRVWAAGVYFVHRVNSDILFKRLNQNVS---------RHRSLEVTKQEVIKKLSGGEDDIAMDRLNISLLCKTRMTTPSRCQDCTHLQCFDYLMMNEKKPT----------------------------------------------QCPVCSSNCPYDRVDDYFLDMLAKVDKNTTE------------------------------------VELKED-----GSYDVIKEEAFCISDDDDDDVVPATVNGTASCSSTNGNGLANEAAKKKPADDDIITLSDDDDEELNRGIMNSLNDSFSPGRHTASAELAAQKTPPQQKKKTKDDDIEIITLDDTPPRPVAASANLPMRQMSQQNQMPVGSSPSGMASTQMGMNEGASKTIRDALNKIGEPMINQAPHFQMQNGLIGRNNQMVHMQQHHLQQQQQQQQSPQIMSPSFYAQQQMSNGDTNNIQPPRILSMAEIQANASRLLVNGHLMIDHSGVTMRNPRGSR............. 771
7 -9.150[A] KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1)  ali follow..  10  409.............................................................................................................................................................................................................................LNSSQSNAVSHVLQRQGPPGTGKTTSATIKDRILVCAPSNVAVDHLAAKLRDAKSREDVESSVSNLALHNKADVVCCTC-VGAGDKRLDTKFRTVL-----IDESTQASEPECLI--------------IVKGAKQVILVGDH---------QQLGPVLERKAADAGLKQSLFERYRMNPYLSEFPSNMFSLQNGVTIEQRTVPNMMFWAN-YGREEISANGTSFLNRIEAMNCERIITKLKPEQIG--VITPY-----EGQRAYILQYMQMN-KDLYIKVEVASVDAF-------------------------QG----REKDYIILSCVRANEQQAI-----------------FLRDPRRLNVGLTRAKYGLVI-LGNPRSLARNTL-LIHFREKGCLVEGTLDNLQLCTVQLVRPQPRKTERPMNAQFNVESEMGDFPKFQDFDAQSMVSFSGQIGDFGNAFVDNTELSSYINNEYWNFENFKSAFSQKQNRNEIDDRNLYQEEASHLNSNFARELQREEQKHELSKDFSN....................................................................................................................................... 968
8 -9.110[UD] COG5079 Nuclear protein export factor  ali follow..  10  49.....................................................................................................................................................................................................DVEAQDSRQKRFSSTLEGNRFEELRSLREKEREVAIQNGL-TKPRQLDEAVTFVGTCPDMCPEYER---EQREYQNNLERWEINPETGRVDKNLAVKAFHRPAAGNRPPPVLKKSLDYLVDVRDRT---------------------RSIRDFTLQNCERIALCEKKQFSAQQEVEQLRKGILQSLCEFYDDNEPEFRSYAIITHLRDVVRQSQILPI----IFDDQRVQLALRLSA--AQKNNERVGHILPRNTEACPKLVQSPAVTYLMACLLESHFM----SIRKGALKAMRKAFMSAHANFPCGDLKR--ILHF----------DTVEQAASFSRYYGLEVSDDNGELSINLNKTAFFNDSKPD-----FRQLFSQTLVESKLQNRSFADIINGSRY-----------------NIDRVSPNTAFSTNIPLSLPFANKEPQPIAGFKKNTPETSVVSKNLSTFNGKFNVNAPVFTPRSFPTKPFSATDISSVQPTNLPNGSTNGTETFIPPVQNSITSNKEAVKPIKNKPKPISFESLSAVGNLIISDSLSRIVRQILQNLYTEWVHEKTNLVFATMFRTIFREVLLDGIASEVYLKSLKKHAISQISVRAHHSWVKKQEKMMLEMREKNRQEKYFSVLNSVVKAESSNITRLPIKRTFYGDTRNLDKASEKLRAEHDRTRRLWKP.... 735
9 -8.880[A] COG5180 Protein interacting with poly(A)-binding protein  ali follow..  7  52..............................................................................................................................................................................................................................................................................................................................................QDYLLANSIGSDV---------TVTVTSGVKYT-------------------------LLVSCNLESTIDVVLRFPRVADSGVTLLIHGED-VAELNIDLSLDEKWENSKAQETTPARTNIEKERVNGESNEVTKF-----TDVDSGSGREIKERKLEK----DQFAVN----KKFGVKSTFDEHLYTTKINKDDPN---------YSKRLQEAERIAKEIESQGTSGNI-------------HIAEDRGIIIDD-EDLYS--------------------DRRGDELLAALKSNSKPNSNKGNRYVPPTLRQQPHHMDPAIISSSNSNKNENAVSTDTSTPAAAGAPEGKPPQKTSKNKKSLSSKEAQIEELKKFSEKFKVPYDIPKDMLEVLKRSSSTLKSNSSLPPKPISKTPSAKTVSPTTQISAGKSESRRSGSNISQGQSSTGHTTRSSTSLRRRNHGSFFGAKNPHTNDAKRVLFGKSFNMFIKSKEAHDEKKKGDDASENMEPFFIEKPYFTAPTWLNTIEESYKTFFPDEDTAIQE............ 559
10 -8.690[K] KOG2181 LIM domain binding protein LDB1/NLI/CLIM  ali follow..  8  3..................................................................................................................................................................................................................................................................................................................................................................................................................................VVI--LKFLFSDNGNNQHGT--------------EAA-RLAQSYRIQDLLFIIVIFF--LKSLQATALGKPGMRSQATEPQPIGNTVSPLEFRIHDMNR-RLYIFSSTGVSENDQQ--NRQFIRSIDSGMRELQYVLRGPSRECTLANGSQAYENENVLQITRYDQSSQFEVNTEGKLYVEFAPFDEVM--NYRIKAWTLELKRSNEFVYNQNTADYRVEAQNPEQENKPRMGFFKSTFNLMTMLKILDPMQSIMSSAKSAPAITPREVMKRTLFQHHQVRQQNMRQQQLNQQMMIPAPEPEKPKPARKRQRKPAANPRGSKKATAAAAAAAAAATNGVPPTVPTASPANNQQFPPNPMTSQFQQMSYPDVMVVGEPSMMGSEFGENDERTISRVENSQYDPNAMQMQSLGQGPNSSMNINGRNMMNQHHPGMQPPPGQQHMPPHSMGSQMPTSMHNPMHMP........... 507
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;