current user: public
If you have questions about the server, please let us know.

Query: [E] COG1748 Saccharopine dehydrogenase and related proteins, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370    .  380    .  390    .  400    .  410
# Score Template Links and tools%idFirst MKKNVLIIGAGGVAQVVAHKCAQNSDVLGDIHIASRTVDKCRKIVESVREKKSLKTEVKLEAHALDALDVEATKALIVSTGSQIVINVGSAFVNMSVLRACMDTGVAYMDTAIHEEPNKICETPPWYGNYEWKRAAECKEKGITAILGVGFDPGVVNAYARLAKDEYFDKITDVDIVDINAGNHGKYFATNFDPEINFREFTGVVYSWQKGAWQTNRMFEVGKEFDLPVVGKRQAYMTGHDEVHSLSKNMDGADVRFWMGFGDHYINVFTVLKNLGLLSEQPVKTAEGLEVVPLKVVKAVLPDPASLAPGYEGKTCIGDFVKGLKDGREREVFIYNVADHRQAYEEVGSQGISYTAGVPPVAAAMLIASGEWDVRQMANVEELPPRPFLDILNRIGLPTRIKDEQGDRPLSFSLast
1 -101.000[E] COG1748 Saccharopine dehydrogenase and related proteins  ali  100  1MKKNVLIIGAGGVAQVVAHKCAQNSDVLGDIHIASRTVDKCRKIVESVREKKSLKTEVKLEAHALDALDVEATKALIVSTGSQIVINVGSAFVNMSVLRACMDTGVAYMDTAIHEEPNKICETPPWYGNYEWKRAAECKEKGITAILGVGFDPGVVNAYARLAKDEYFDKITDVDIVDINAGNHGKYFATNFDPEINFREFTGVVYSWQKGAWQTNRMFEVGKEFDLPVVGKRQAYMTGHDEVHSLSKNMDGADVRFWMGFGDHYINVFTVLKNLGLLSEQPVKTAEGLEVVPLKVVKAVLPDPASLAPGYEGKTCIGDFVKGLKDGREREVFIYNVADHRQAYEEVGSQGISYTAGVPPVAAAMLIASGEWDVRQMANVEELPPRPFLDILNRIGLPTRIKDEQGDRPLSFS 413
2 -55.800[Q] COG5310 Homospermidine synthase  ali follow..  12  16ITGPVVMIGFGSIGRGTLPLIERHFKFDSRMTVLDPRDTDRKLLDER---------GIAFVQEAVTENNYKKLLTPLNGGGQGFCVNLSVDTGSVDLMRLCRKLGVLYIDTVVEDAKADNASRTNYALREAMIKEKHDKPGGATVVSTCGANPGMVSWFVKQALVNLATDIAERDTQRTKKPKPMDVFWNTWSVEGFISEGLQPAELGWGTHEKWMPKNGKKHKHGCPTPGAQYGLLVTHNEAISIADFFTVRSKKGKVQYRPT-CHYAYHPSNDAMLSLDEMFGAAGKPQPVHHVLDE--------NELVDGVDELGVLLYGHDKNA----YWYGSQLSLAEARKLAPYQNATGMQVTSAVLAGMVWALENPDAGIVEADEMDYKRCLDVQSPYLGPVKGYYTD........ 456
3 -50.300[E] KOG0172 Lysine-ketoglutarate reductase/saccharopine dehydrogenase  ali follow..  12  479TRRKVLVLGSGYISEPVLEYLSRDGNI--EITVGSDMKNQIEQLGKKYNI---------NPVSMDICKQEEKLGFLVA--KQDLVISLLPYVLHPLVAKACITNKVNMVTAS-------------YITPALKELEKSVEDAGITIIGELGLDPGLDHMLAMETIDKAKEVGATIESYISYCGNNPLRYKFSWSPVGVLMNVMQSATYLLDGKVVNVAGLDAVTSMDFFPGLNLEGYPNRDSTKYAEIYGISAHTLLRGTLRYKGYMKALNGFVKLGLINREALPAFRPEANSILDALSKHLVMKLSYGPEEKDMIVMRDSFGIRHPSGHLEHKTIDLVAYGD---INGFSAMAKTVGLPTAMAAKMLLDGEIGAKGLMGPFSKEIGPILERIKAEGIIYTTQST......... 923
4 -34.100[S] KOG2733 Uncharacterized membrane protein  ali follow..  9  1MSGDVIIFGAGFTGKYTVFEAVTVLR-GLRWGIAGRNREKLEAVLKEMGAKAK-KDLSQVPIFIADVNDQASLLEMAKKCR--IVVNTAGPYHGENVVKCCIESGTHHVDVSG---------EPQYMETMQLRYDQLAREKGVYVVSACGFDSIPADMGVVFVEKNFDGVVNSVETFLETGIKEGGSGGGTAGLNYGTWESAVRKQIYPQRLPRFYPFLKPRPLVFRSTEVDKVCLPFPGSDRSVVMRSQRFLYDQDKYVGFSSWLVAGGVIFFATIFGLLSKFKLGRTLLLNYPGLFSGGLASPSEESMERTYFKMTFKASGWLKSDRLAESSNQYTESPTMVRVSGMNPGYGATCVAVLSAALTILRESDKTGGVLPPAAFSKTGLISELEKHDHGIKFEILANK...... 430
5 -31.800[S] COG3268 Uncharacterized conserved protein  ali follow..  10  1MSPDIVLYGAGFSGKLTAEHLALSES-TARIALAGRSSERLRNVRALLGPNA-----QDWPLIVADASQPSTLEAMAGRAQ--VVLTTVGPYYGLPLVAACARTGTDYADLTG---------ELMFCRNSIDLHHKQAAATGARIILACGFDSVPSDLNVYQLYRRVIEDRTELCDTDLVLRSFSQRWVSGGSVAAYSEAMLTTSNDPEALRLVTDPYTLTTDRDAEPDLGPQPDFVQAQFNTRIVRRSNALQNWSYETMSLGKSWAAPVASAAVTSVVAGAVGLGNKYFNRLPRRVVERVTPKSGTGPSRKTQARGHYTFETYTTTTTGARYMATFAHNVDA---------YKSTAGLLAASGLTLALDRDRLRGVLTPAAAMGEALLTRLPSAGVVIGTTRLS........ 418
6 -16.700[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  13  1M-LKIGIVGCGFIGGQICRAIDGGEVSAELYALCDSSESKALELAASLKTCKPSYMKIEELIRGVD-----------------LIIESASQNAVRFIVPQALKAGCDVM-----------ILSVGALADEELRLFGLAKEHNCKLYFPSGAVVGIDGLNSASAAG........................................................................................................................................................................................................................................................ 138
7 -16.500[S] COG3804 Uncharacterized conserved protein related to dihydrodipicolinate reductase  ali follow..  13  1MAIPVVQLGTGNVGVHSLRALIADPE----FELTGVWVSSDAKAGKDAAELAGLADSTGVRA----STDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAAGINIVGSG---PVFLQYPWQVIPDEIIKPLQDAARAGNSS-LYVNGIDPGFANDLLPMALAGTCESIEQIRC............................................................................................................................................................................................................................................. 164
8 -15.500[Q] COG4569 Acetaldehyde dehydrogenase (acetylating)  ali follow..  12  1MSKKVAIIGSGNIGTDLMIKILRHGQHLEMAVMVGIDPQDGLARARRMG-------------VATTHEGVIGLMNMPEFADIDIVFDATSAGAHVKNDAALREAKPDIRLIDLTPAAVPVVNLEANVDQLNVNMVTCGGQATIPMVAAVSRVARVHYAEIIASIAS....................................................................................................................................................................................................................................................... 160
9 -15.200[E] COG4091 Predicted homoserine dehydrogenase  ali follow..  12  19.PIRIGLIGAGEMGTDIVTQVARMQGIEV-GALSARRLPNTFKAIRTAYGDEENARGATTESAMTRAIETDDNDLILSNPLIDVIIDATGPEVGAETGIAAIRNGKHLVMMNVEADVTIG------------YLKAQADKQGVIYSLGAGDEPSSCMELIEFV.......................................................................................................................................................................................................................................................... 175
10 -12.800[I] KOG1478 3-keto sterol reductase  ali follow..  12  1MRKVVLITGASSIGLALCKRLLAEDD-ELHLCLACRNMSKAEAVCAALLASHP---TAEVTIVQVDVSNLQSVFRASKEQRLDCIYNVFGHFILIRELEPLLCHSFSLEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNV---ACPGTALT............................................................................................................................................................................................................................................................... 228
11 -12.300[R] KOG2742 Predicted oxidoreductase  ali follow..  12  1MLPGVGVFGTGEIANVLVPLLREKG-----RAIWGRTLKEAKETATTQNVQFHT----------------NVIDDVLLRKDVDLVFIVCQPFLHAEISVKALGIGKHVV------------KPAGLHQQDALKMVRASQYYPTLISLPLRFLPAFTHM............................................................................................................................................................................................................................................................... 133
12 -12.200[Q] COG4693 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis  ali follow..  11  8.KQRVLIVGAK-FGEMYLNAFMQPPEGLELVGLLAQGSARSRELAHAFG-----------------IPLYTSPEQITRMPDIACIVSTVAGGTGTQLARHFLTRGVHVI-------------EHPLHPDDISSLQTLAQEQGCCYWVN--HTRAGRTWL.............................................................................................................................................................................................................................................................. 139
13 -11.800[MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases  ali follow..  14  34LPPLVTVFGGGFVGRHVVRMLAKRG---YRIRVAVRRPDLAGFL-------QPLGNVGQISFAQANLRYRDSIIKAVE--DADHVVNCVGILAEKAIAEAARDTGATLTHISA-----ADANSQTGYGRTKGRAEAAIHSVLPGAVI---LRPSI.................................................................................................................................................................................................................................................................. 185
14 -11.800[E] KOG4777 Aspartate-semialdehyde dehydrogenase  ali follow..  11  1MAIKVGILGAGTVGQRFITLLSDHPEFKIAVLGASAR-SAGKPYAVATKWKQSIAMPKEISQMSVKACDPKEFS------ECDIVFSGLDADFAGEIEKSFRDANLVIVSNAKNYRREPTVPLVVPTVNKYQRQENKLDRGCIIT------NSNCSTAAVVVPLKALQDAFGPIAQTNVVSMQAISGAGYPGVSSLDILDNIVP................................................................................................................................................................................................................. 200
15 -11.500[Q] KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  12  47..LVAVVTGSNCIGFETVRELNLRK---ADVYMLCRSEEKANEAKRMLVRQGC--DATRLHFIECDLTDFESVRRAAKEDTIDILINNAG-HLGPFLLTELFSSYARIINVSSRIHLKSEKINLATVDDKARALTKELRKDGAEHVTVNSLHPGVVNT............................................................................................................................................................................................................................................................... 248
16 -11.400[M] COG3967 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)  ali follow..  12  1MKNTVLITGGSAIGLELAKRLLELG---NEVIICGRSEARLAEAKQQLPN---------IHTKQCDVADRSQREALYEWANLNVLVNNAGIQKEIDFKKGTEEPEAAIVQVTSGLAFNPLAVYPVYCATKSLTLRHHVRDTSVEVIE---MAPPMVDT............................................................................................................................................................................................................................................................... 187
17 -11.400[R] COG0673 Predicted dehydrogenases and related proteins  ali follow..  13  1MKTNIGLIGAGRIGQLHASNIISSPYMEL-KAVSDVQLDHLKGTEIERSVEIMT----------------TNPDELFSNRDIDAIFICSSTDTHAAFIKAAALAGKHIF------------KPISFHVTETKGALNIVNEAGVKFQVG--YDKHFRRV............................................................................................................................................................................................................................................................... 134
18 -11.300[R] COG0300 Short-chain dehydrogenases of various substrate specificities  ali follow..  14  3.KKTIFITGASSLGRQLAIDFSWEE---TVLCLFARSQERLENVQRIVVEN-----GGEAHIYPVDLADPQSIDRSFAEAVVDVLINNAGYGVFEPFCDSQMDESGHIINIASQAGKIATAKSAIYSATKTNSLRMELKGTGIHVSA---VNPGPIQT............................................................................................................................................................................................................................................................... 187
19 -11.200[C] KOG2865 NADH:ubiquinone oxidoreductase, NDUFA9/39kDa subunit  ali follow..  11  67SGIVATVFGAGFLGRYLVQQLAKMG---SQVLVPFRGSEDSPRHLKLMGDL------GQVVPMKFDPRDEDSIKAVMA--KANVVINLIGREYETRLALVCEHGGIRYIQVSC-----ASVSSPSRMLRAKAAAEEAVLNALPEATI---MRPAT.................................................................................................................................................................................................................................................................. 220
20 -11.200[H] COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1  ali follow..  15  34RAAHVCVIGIGGVGSWAVEALARTG--IGELTLIDMDDVCVTNINRQIHAMTGTIGKSKIEV----------MAERVKLINPECKVNLVDDFITPDNQHLYLNKSFDYVDAIDSLKA-------------KASLLAYCRSNKIKVITVGGAG..................................................................................................................................................................................................................................................................... 161
21 -11.200[R] COG4221 Short-chain alcohol dehydrogenase of unknown specificity  ali follow..  10  1MSESLVITGAASIGLATTEALLEQG---ATVVMVDWNEKALNDLAAKLGE--------RAIPQVTNLLDADSCNAMIPEIHIDILYCNAGTYIGGDLTETTPEATGDIIVTCSIAGHFPTYWEPVYSGSKVQGMRRQMIPHGVRV----QVSPGPVVS............................................................................................................................................................................................................................................................... 188
22 -11.200[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  16  4TKPSIAILGAGRVGSSLARSAVAAGY---EVKVAGSGVDKIALTAEILMPGAVPSTADQA------------------VKDADIVFLAVPLHKFRSVNPATLEGKI-VIDTMSTSEIIAEFFAGSTMVKSFNHIDVDAGAQVAQLIKSFGFVP.................................................................................................................................................................................................................................................................... 173
23 -11.100[R] COG2910 Putative NADH-flavin reductase  ali follow..  18  2..AKIALIGAGNAGSRILKELSDRGH---QVTAIARNPEKIAA-------------LPNVVAKKGDVFDQAALSELLK--GHDAVISSVHFTASATLIEAVRASGVQRY................................................................................................................................................................................................................................................................................................................ 93
24 -10.900[R] KOG4288 Predicted oxidoreductase  ali follow..  10  1..MKIVVLGGGFLGHNICKLAIAKG----EVVSVSRRGAGGLHNKEPWMD--------DVEWETLDAKDPNSLLPVLR--DASAVVNSVGILMENNLSSNMFKTGQNPLKPEEAKQSKNKVTFEAINRDLAIETAKIAAKANVPVYCYVSAHAAAPGLDPRYIKTKREAE................................................................................................................................................................................................................................................... 177
25 -10.900[M] COG1089 GDP-D-mannose dehydratase  ali follow..  11  1MTKVALITGTGQDGSYLAEFLLDKG---YEVHGIKRRASSFNTERIDHIYQDPHGSNPNFHLHYGDLTDSSNLTRILKEVQPDEVYNLAAMSH-EYTADVDAIGTLRLLEAIRFLGLENKTRFYQASTSELYGLVQEIPQKESTPF----RSPAVAKLYAYWITVNYRESYGNGILFNHESPRRGETFVTRKITRGLANIAQGLESCLYLGNMDSLRDWGHAKDY---QQEQPEDFVIATGVQYSVRQFVEM................................................................................................................................................................. 265
26 -10.900[M] COG1088 dTDP-D-glucose 4,6-dehydratase  ali follow..  8  1MRKILITGGAGFIGSALVRYIINETS--DAVVVVDK------TYAGNLMSLAPVAQSERFAFEKVDICDRAELARVFTEHQPDCVMHLAAESHTYTLLEAARAYWNALTEDKKSAFRFHHISTDEVYGDLHSTDDFFTETTPYAPSSPYSASKASSDHLVRAWLRTYGLPTLITNCSNNYGPYHFPEKLIPLMILNALA--GKPLPVYGNGQQIR...................................................................................................................................................................................................... 224
27 -10.900[E] COG0169 Shikimate 5-dehydrogenase  ali follow..  20  123.GATILLIGAGGAARGVLKPLLDQQ--PASITVTNRTFAKAEQLAELVAAYG-----------EVKAQAFEQLKQ-----SYDVIINSTSASLDPAIDPVIFSSRSVCYDMM--------------YGKGYTVFNQWARQHGCAQAID-----GL-GMLVGQAAESFM..................................................................................................................................................................................................................................................... 254
28 -10.800[Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related dehydrogenases  ali follow..  11  7.SPVVLITGCGGIGHALAREFTEKG----RVVATSRSRSTMTDLEQD----------SRLFVKELDVQSDQNVSKVLSEVKIDVLVNNAGVQCVGPLAETPISAMENTFNTNGNKDLIFSFNNSSGSMRMTQAVVPHMVSKKKGKIVNVGSITVMAPGATKAAIHALTDTLR................................................................................................................................................................................................................................................. 187
29 -10.800[H] COG2099 Precorrin-6x reductase  ali follow..  13  23MTRSILILGGTADARILAGRLAEDSGYRILLSMAGRTLSPVEQ---------------PVPMRSGGFGGAAGLADFIRAEGFDILVDATHPYISANAVEAARLANIPLVVLSRPVWPRQPGDTWQSV-HTVGQAVTALGTTGKRVFLALG-RQELLPFEAAPQHSYLIRSVDPVEPPLRAPDARYITARGPFVTERMLEENRIEVVISKNGGSASYGKIEAARRLGLP......................................................................................................................................................................................... 240
30 -10.500[R] KOG0725 Reductases with broad range of substrate specificities  ali follow..  11  1MSCALVIGATSTLGKAVVRRLAFTG---YKVAAAADCPNSVGKVAEDNIKV-----GGDVTAFSLDVANAEHRKELITKVGLDTLIIVPPQNEVLGLSQAAMSQNGSIIYLTSCFGFTPSIDMGLYSVASTKSVAQSAAKQGVRV----SVVSGIEGDGTGAVWDHASGEEARQIKQHLESMIPLGRLGRPSDVASYVEFLASTKARYITGENCIVGG................................................................................................................................................................................................... 247
31 -10.400[Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11  ali follow..  8  53..EVAVVTGAGHLGRAISLELAKKG---CHIAVVDINVSGAEDTVKQIQDIYKV----RAKAYKANVTNYDDLVELNSKVPVTVLVNNAGVMMHRNMFNPMINVNLFIVTISSLAGVFPLPYSATYTTTKMRTLRMELDLENQKDIHVTTVLPSFLRT............................................................................................................................................................................................................................................................... 240
32 -10.300[Q] KOG1204 Predicted dehydrogenase  ali follow..  12  1MGKVILITGASRIGLQLVKTVIEED---DECIVYGVARTE-----AGLQSLQREYGADKFVYRVLDITDRSRMEALVEEIKLDGIVANAGSEHDIKQWERLFDVNFNIVFVSSGASVKPYNGWSAYGCSKAMDIASEEPSDKVRAV---CIAPGVVDT............................................................................................................................................................................................................................................................... 192
33 -10.200[R] COG4015 Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family  ali follow..  10  18.RGEVTLVGAGRLGLRTALNLMQIHRGGERINVIDGQRVSADDLIFRL--------GATPGEYKVKFIES------LATPGFSRTVRGIPEYIDRDNLHLLRGDVVCVIAGGDT-------------LPVTAEIIKYAQKRGSATISTMGV...................................................................................................................................................................................................................................................................... 143
34 -10.200[E] COG0002 Acetylglutamate semialdehyde dehydrogenase  ali follow..  11  1..MKVGIIGAGYTGGELLRLLVSHPDVRLELATSRSLAKPVSSTHRHLTGFLDLKYENPVSEEIRE--------------RCDVVFVAVPHGTAMNYVPELLDGSTKVIDLSADYRLDTPVFENIYGIKHLVELHPEAAREEFVA------NPGCFPTGANLAAAPLAAA-GLIDIAVFDSKTGISGAGISPTETSHYPNIAENIIPYKLTAHRHRAEILQ................................................................................................................................................................................................ 209
35 -10.200[I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3  ali follow..  14  47MGQWAVITGADGIGKAYSFELAKRG---LNVVLISRTLEKLEAIATEIERTTGR----SVKIIQADFTKDDHIKEKLAGLEIGILVNNVGMLPNLSLIHCNITSVVKMLNISSGIALSMYSASKAFVCAFSKALQEEYKAKEVIIQV---LTPYAVST............................................................................................................................................................................................................................................................... 233
36 -10.200[G] KOG1203 Predicted dehydrogenase  ali follow..  21  122.SGIILVAGAGGVGRRIVDILRKRG----PVKALVRNEEKARKMLGP-----------EIDLIVADITKENTLVPEKFK-GVRKVINAVS................................................................................................................................................................................................................................................................................................................................... 196
37 -10.000[E] COG0289 Dihydrodipicolinate reductase  ali follow..  12  1MTLKIAIAGAGRMGCQLIQAVHSAEGVE---LGAAFERKGSSLVGTDAGELAGIG--------HLGVAVSDDLESQKDK--FDLLIDFTRPEGTLEHIAFCVANNKKMV-----------IGTTGFDENGKVAIKAASDKIAIVFASNFSVGVNLVFKLLEKAAKVMGDYCD................................................................................................................................................................................................................................................. 149
38 -10.000[GQ] KOG2741 Dimeric dihydrodiol dehydrogenase  ali follow..  7  6.QIRIGLLSCTNKVRKLSRAINLSPNATISAIATTSSIEEAKSFAKSNN-------------FPPNTKLHSSYESLLEDPDVDAVYFPIPTRLHVEWATLAAIKGKHIL------------KPVALNVAEFDQIVEACEVNGVQFMDGT-HSPRTDKIKEFVNDLESFGQIKSVYS............................................................................................................................................................................................................................................. 159
39 -9.950[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  13  1..MQLGMIGLGRMGANIVRRLAKGG----DCVVYDHDPDAVKAMAGEDR--------------TTGVASLRELSQRLSAPRVVWVMVPAGNITTAVILANTLEAGDIVIDGGNTY-------------RDDLRHEKLLFKKGIHLL-DCGTSGGVWGR............................................................................................................................................................................................................................................................... 128
40 -9.900[Q] KOG1210 Predicted 3-ketosphinganine reductase  ali follow..  12  32.GAHVVVTGGSSIGKCIAIECYKQG---AFITLVARNEDKLLQAKKEI-EMHSINDKQVVLCISVDVSDYNQVENVIKQAPVDMLVNCAGMAVSGKFEDLEVSTFERLMSIN--------YLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAKFAIRGLAEALQM................................................................................................................................................................................................................................................ 202
41 -9.820[O] KOG2018 Predicted dinucleotide-utilizing enzyme involved in molybdopterin and thiamine biosynthesis  ali follow..  15  125RNSFVIVVGCGGVGSWVINMLARSG--VQKIRIVDFDQVSLSSLNRHSIATLQDVGTPKTLA----------IKKAIKKFAPWIEVDARNALFNPDSADDLLSGNPDFVDAIDNIQT-------------KVDLLSYCYNHKLPVIASTGSA..................................................................................................................................................................................................................................................................... 252
42 -9.800[H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2  ali follow..  13  141.MLRVGVIGCGGTGSAIAMLLPKMG--IRNIALFDKDSPKVEVVAKSLVE---LGLGVQVRTYQAWIGEADCRDPL---KACDVIFCCTDDHTGRLMLRFAYYYATPVFDMGLAIENPVIARDEALKRSNPDEYERRKAEAYVIGEGN---SPAFTTEVAIMAMQELVHRLQGF............................................................................................................................................................................................................................................... 362
43 -9.750[R] COG2344 AT-rich DNA-binding protein  ali follow..  10  85.MTDVILIGVGNLGTAFLHYNFTKNNNTKISMAFDINESKIGTEVGGVP-----------------VYNLDDLEQHVKD--ESVAILTVPAVAAQSITDRLVALGIKGI-NVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEI.............................................................................................................................................................................................................................................................................. 214
44 -9.720[R] KOG1611 Predicted short chain-type dehydrogenase  ali follow..  10  1MSPKVVVTGSNRLGFGLVQQFLKDPN-VQHVIATARDVDKATALKGICDP--------RLHILQLSLGSDESIANFAEKSGLTLLINNAAVMLPYVLTQSLVSRGAIINIASEFLGSISENTTKCAVNQFTKTLSIDLKDDHILTAG---ICPG-TDMSKGKGQLTIEESSSQILAAFNKLGATHNG.................................................................................................................................................................................................................................. 239
45 -9.680[E] COG0136 Aspartate-semialdehyde dehydrogenase  ali follow..  12  18MGFKVAVAGAGNVGREMLNILEERGFPADEVVPLASRRSQGTEVSYG---------DKTLKVRALDTYDFSDT---------DICLMSAGGSVSQEWSPKIGRQGCVVIDNSSAWRYDADVP----VPEVNPDAIAGFTKKNIIA------NPNCSTAQLVVALKPLHDAAKIKRVVVSTYQ------SVSGAGKEGMDELFEQSRAVFVADPISTKKFTKRIAFNIPHIDVFMEDGYTKEEWKMVAETKKMLDPKIKLTATAVRVPVFI-----GHSEAVNIEFENPITPEEAREILREAPGCQVIDKHENGGYITPYESAGEDATFISRIREDITVENGLAMWVVSDNLRKGAALNAIQIAELLVARGLIKPKAL.................................... 359
46 -9.640[E] COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog  ali follow..  11  136.ARTMAIIGNGAQSEFQAIAFKALAGVD-RLRLYDIDRSASLKCAKNLAG------------MGFDITICETGQEAVE--GAGIITTVTADKQCATILTD-VGAGVHINAVGGDCPGKTELHRDILLRSDIFFPPQTRIEGEIQQLDPNHPVTELWQVVAAKVPGRRDAKQITL............................................................................................................................................................................................................................................... 296
47 -9.530[I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase  ali follow..  10  76.SPVVVITGASRIGKAIALALGKAG---CKVLVNYRSAKEAEEVAKQIEEY-----GGQAITFGGDVSKATDVDAMMKTATIDVVVNNAGITRDTLLIRMKQSQWDEVIALN-TQGRIINISSVVGLIGNIGQANYAAAKGGVISFSKTVVCPGFSDMTAELGEDMEKKILGTIPLGRYGKAEEVAGLVEFLALSPAASYITGQAFTIDGG.......................................................................................................................................................................................................... 305
48 -9.380[IE] KOG1430 C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases  ali follow..  10  1MGEVLLVTGGGFLGQHLIKQLLERKE---ELGIKEIRSLDIVPYKNNIGHEET---SLLRTYVADIGGDLKALSPIFN--GVDGVFHCAASV-TLAVVDLCIQNNVKRLVYTSCTSVCFVPFKGRSTFSAVINSTESK................................................................................................................................................................................................................................................................................... 152
49 -9.260[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  11  1MSADFGLIGLAVMGQNLILNAADHG----TVCAYNRTQSKVDHFLANEAKGKSIIGATSIEDFISKLK-INQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKGILFVGSGVS--------------------GEEGARYGPSLMPG-GSEEAWPHI............................................................................................................................................................................................................................................................... 152
50 -9.170[M] KOG1371 UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase  ali follow..  11  94VTHVLVTGGAGYIGSHAALRLLRDS---YRVTIVDNLSRGNLGAVKTLQQLFP--QTGRLQFIYADLGDPLAVEKIFSENAFDAVMHFAAVAYTLGVLEAMARHKVKKLIYSST--------CATYGEPEKMPITEDTPQV---------INPGKAKKMAEDMILDFSKN................................................................................................................................................................................................................................................... 261
51 -9.110[MG] COG0451 Nucleoside-diphosphate-sugar epimerases  ali follow..  9  1..MRYLVTGAGFIGFYVAKRLLDAGH---FVTGFD-GMTKYYDVSLKEKRHAILARSNGFRAEIGMLEDTDALKRAAEAAEPEIIIHLAA----RAYIDSNLIGSFNMLELARSLKVKHLMASTSSIYGANEKIPFAESDKADEPMTLYAATKKSMELMAHSYAHLHKLPTTAFRFFTVYGPWGRPDMAPIKFVDAVSN--GQPIDIYGQGNMSR...................................................................................................................................................................................................... 216
52 -9.110[IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  12  7..KTALITGASQIGEGIARVFARHG---ANLILLDIS-DEIEKLADELGGR-----GHRCTAVKADVRDFASVQAAVARARIDILVNNAGVCRLGNFLDMSEEDRDFHIDINKDGRIVMMSSVTGDMVADPGETAYALSKAAIVGLTKSAICPGVRTPMAESIARQSNPDDPESVLTEMAKAIPLRRLADPLEVGELAAFLASDESSYLTGTQNVIDG................................................................................................................................................................................................... 251
53 -9.060[Q] KOG1205 Predicted dehydrogenase  ali follow..  14  47.GKVVIITGSSSIGEHLAYEYARRG---AYLTLVARREDRLQVVADRCRKLGS----PDVAVVRGDVSVIKDCKRFVQETRLDHLVN-----------NAGIAEAKFFEDYSSDVLPIVNTNFWGPVYATHFAIPHLKKTKGVASPAGWSGVPRMSIYAAKAAMINFYETLRI................................................................................................................................................................................................................................................ 213
54 -9.050[P] COG0569 K+ transport systems, NAD-binding component  ali follow..  12  1..MKIIILGAGQVGTTLAENLVSEDN---DITLVDNESPQLQTLQEKHDLRVVQGSPSSPKVLDAGAADADLMVAVTASDEINMVACQMGYTLFNTPTRIARIRNSEYLREKDKLFNNENIPIDHLISPENLVTDEITRLIAYPGALQV-FANNRISIVVVKAYYG....................................................................................................................................................................................................................................................... 163
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 5 1 8   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lukasz Jaroszewski, Zhanwen Li, S. Sri Krishna, Constantina Bakolitsa, John Wooley, Ashley M. Deacon, Ian A. Wilson, Adam Godzik, Exploration of Uncharted Regions of the Protein Universe. Plos Biology. 2009 Sep. 7(9):e1000205