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Query: [S] COG1808 Predicted membrane protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKMRQLIIQVPRGNGKAVIDIAKFHNGTNLARFEGNADEPIDVVIVHVSNREVGKVIEELQDLPKVHITLIPTGVMALQPPASEAPQQVVDVEERSPIEILLSGLQSVGSWQGFLSYAALAGFVVWIGLYTNTTYLLVAAMLIAPFAGPAMNTAIATAWGDRSLLGRSILRYFAALTVTIFTTWLLSLILRQEIPTSLMLDNSQVSAVAVILPLAAGAAGALNLVQSERSSLVSGAATGMLVAASLAPPAGIIGMASAIGRWDMVISGVFLLFLQLCGINLSAALLFRMFGLSAQGTRYQRGKKQVFFSALVITVITLAGLLTWQFINSPNLQRSSLAQRANAQVQKTVEQVGLAKLVESNVRFTRANIEGQETLLCVIYVQRQPQVTLSSAEISDRLTQAIQTQLLKQAFNVTPLVDVNVLETPLENTGVLast
1 -79.900[S] COG1808 Predicted membrane protein  ali  100  1MKMRQLIIQVPRGNGKAVIDIAKFHNGTNLARFEGNADEPIDVVIVHVSNREVGKVIEELQDLPKVHITLIPTGVMALQPPASEAPQQVVDVEERSPIEILLSGLQSVGSWQGFLSYAALAGFVVWIGLYTNTTYLLVAAMLIAPFAGPAMNTAIATAWGDRSLLGRSILRYFAALTVTIFTTWLLSLILRQEIPTSLMLDNSQVSAVAVILPLAAGAAGALNLVQSERSSLVSGAATGMLVAASLAPPAGIIGMASAIGRWDMVISGVFLLFLQLCGINLSAALLFRMFGLSAQGTRYQRGKKQVFFSALVITVITLAGLLTWQFINSPNLQRSSLAQRANAQVQKTVEQVGLAKLVESNVRFTRANIEGQETLLCVIYVQRQPQVTLSSAEISDRLTQAIQTQLLKQAFNVTPLVDVNVLETPLENTGV 431
2 -9.100[S] COG4732 Predicted membrane protein  ali follow..  12  6.....................................................................................................................VAYLAVFTGLGLALAPLSFPVGPTRAFPFVNGVAGVVIGPWALAVAFLISLIRNMLGLGTVFAFPGSIPG-------------------------ALVVWLAATALRRFGKAHYAPLFEPLGTLGLGFPA-YVVAPLLGVGERFITGLIPIFIGWAASTITGSIAAFFVAVAL............................................................................................................................................. 157
3 -8.350[O] COG0785 Cytochrome c biogenesis protein  ali follow..  9  1..................................................................................................................MDVGLVTAFLG--GTLA----------LLSPCAALLLPAFFASSVGAGPRMILHGVVFYAGLLVLLPLGLGAGILGELFITQRQTIIVVS-----VLIILGFVQIFGGGFSKATVTSGLGKSFLLGMTSSIAGFPILGAVLTLAATSGNSITSALILSA-----YGAGMVLPLMAIAALWAKLGQRGQQHIVSVISGALIIAVGILFWS............................................................................................................ 220
4 -7.770[V] COG0842 ABC-type multidrug transport system, permease component  ali follow..  14  92..................................................................................................................AVFSLFQSMFGAVGVVFDRRIGYLTRLLASPI--PRFSIFASKVLG-------TLFRITVLSLILLAIAYPLGLHLKPGITIIDLVMAWLVLMLMSLGLSSLFTGMAFNITHQEVLFALANLINSALFPIDLMPPITHAYYLVGKPLEDPVMSIAYLAVLTLFLLAAGYTLA................................................................................................................................................. 276
5 -7.610[S] COG1289 Predicted membrane protein  ali follow..  11  23.................................................................................................................YALRNTIAMCLAYLNLDEPYWAMTSAAVVSFPTVGGVISKSLGRIAG-----------SLLGATAALIIAGHTL---------------NEPWLFLFSMAAWIGFCTWACAHFTNNAA--AFQLSGYTAAIIAFPMVNIVE---ITQLWDIAQARVCEVIVGILCGGMMMMILP................................................................................................................................................ 171
6 -7.490[S] COG2707 Predicted membrane protein  ali follow..  14  7......................................................................................................................LILLGLAALGFISHNTTVAVSILVL-----------IIVRVTPLSTFFPWIEKQGLSIGIIILTIGVMAPIASGTLPPSTLIHSFLN-----LVAIAVGVIVSWLGGRGSQPQLVAGLLVGTVLGVALF-PLIAAGLV............................................................................................................................................................................... 141
7 -7.450[S] COG2119 Predicted membrane protein  ali follow..  17  20..................................................................................................................LAISITTVALAEIGDKTQLLSLLLASIIAAIFLATLANHALAAWLG--VVVADYLSPDILKWVLVVSFLAMAGWILIPDKLDGEESISTRGPFVASFIAFFMAEIGATSILGAQYADALSWVIVGTTLGMLLANVPV------------VLIGKLSADKMPLGLIRKVTAGLFLLMAL........................................................................................................................................... 195
8 -7.400[U] KOG3225 Mitochondrial import inner membrane translocase, subunit TIM22  ali follow..  12  42........................................................................................................................................CPGKSVVSGVTGFALGGVLGLFMASMAYDTPLANTAATATAGNIGVGGISRTVQQISDLPFRQQMKLQFT-FGYIGMIYAGVECVIESLRAKNNGVTAGFFTGAGLAYKAGPQAALMG----------AGFAAFSAAIDLY.......................................................................................................................................................... 192
9 -7.320[S] COG1285 Uncharacterized membrane protein  ali follow..  17  4........................................................................................................................................LLMKLSIALFFGLLIG------------IDRQLKHKPLGLMVICVASCLVTIVSVESFHRFATPMFNNMDPMRLAAQIVSGVAGVILRKRND-------VISGLTTAAMI---ASGLGIAVGAGFYIEAGYMVVLLMLAINVF........................................................................................................................................................ 133
10 -7.260[U] KOG1652 Mitochondrial import inner membrane translocase, subunit TIM17  ali follow..  20  12......................................................................................................................................................................RIVDDCGGAFTMGTIGGGIFQAIKGFRNSPVGVNHRLRGSLFAVWGGLFSMIDCSMVQVRGKENSITSGALTGAILAARNGPVAMVGS----------AMGGILLALIEGAGILLTRFA.................................................................................................................................................. 137
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.