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Query: [H] COG1893 Ketopantoate reductase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEKPRVAVIGSGSIGLLLYAYLKLANWPALLVTNRPEQADHLNKEGLTFVAKSGEHQPISVTATPLSSFSAEEAEVGFITVKSFAVKALLPQLQRKKWDGLVFFQNGMTHLEILRQIPARAICCGIVEIGAKRESDVRVQHTGDGAIWIGDMVGDSKNFDPMWACLHNAGLKAQKVTNWQDKMERKLIANAAINPLTGLFRVKNGALIENQLFSLLLKELVKEACVTLGREREVDEHLAYTRAICDKTANNLSSMYMDLTHHRRTEIESITGYLIKEAAKKGIEIPNTSFVYHAVMGMDEEGRKVRMGLast
1 -100.000[H] COG1893 Ketopantoate reductase  ali  100  1MEKPRVAVIGSGSIGLLLYAYLKLANWPALLVTNRPEQADHLNKEGLTFVAKSGEHQPISVTATPLSSFSAEEAEVGFITVKSFAVKALLPQLQRKKWDGLVFFQNGMTHLEILRQIPARAICCGIVEIGAKRESDVRVQHTGDGAIWIGDMVGDSKNFDPMWACLHNAGLKAQKVTNWQDKMERKLIANAAINPLTGLFRVKNGALIENQLFSLLLKELVKEACVTLGREREVDEHLAYTRAICDKTANNLSSMYMDLTHHRRTEIESITGYLIKEAAKKGIEIPNTSFVYHAVMGMDEEGRKVRMG 308
2 -18.400[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  13  2..KQHIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERRH-PLAPNVVISPNLSFTTDMKEAIHNAFMIVEGVTSAGIRPVAEQLKQITSVPFVITSKGINTGLLLSEIMLEVLGDSVTPYLGYLSGPSIAKEVLNGSCSVVVSAYDSQTLKQIHEAFSLPTFRVYPNTDIKGA-----LGGALKNVIAIACGIAEGLSFGNNAKAGLVTRGLHEMRKLAAIMDCKPETLDLCVTCFSESSRNLRLTFEQAKAKIGMVVEGAYTSAYQVAKHHKIDMPITTGIYRVL............. 311
3 -17.800[S] COG4408 Uncharacterized protein conserved in bacteria  ali follow..  12  3....KLLMIGTGPVAIQLANICYLKSDYIDMVGRASTSEKSKREKQFEVKIQNEAHQHLE-RLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETVKHVILISPTFGSQMIVEQFMSKF--YLGDTRIVDKEAPNHVLTTGKKKLYMGSTHSNSTMCQRISALAEQLKIQLEVVESPLHAETRN--SSLYVHPPLFMNDFSLKAIFETMTLIREMRLMWKEMMAILQA--GDIEHFEILPDILQEYLLYVRYTAILIDPFSQPDSEDYYRTIQHIGKMLGIKTPMIDQFLTRYEAS.......... 393
4 -14.600[C] KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase  ali follow..  11  23.KLISVGIIGSGNWGTAIAKICGENAKKIQHEGKECNLTEVFNTTHENVKYLKGIKCPSNVFANPDIRDVGSRSDILVWVLPHQFVVRICNQLKGCLDAVAISCIKGVSVTKDRVRLFSDIIEENTGMYCGVLSGANIASEVAQEETTIGYLPNPRYTPKTIQALFNRPYFRVNIVEDVPGV-----LGGALKNIVAVAAGIIDGLELGDNTKSAVMRIGLLEMQKFGRMFFDCKPLTDLITTCLGGRNHKCAVAFVKTGKPMHVEQELLDGQKLQDNQNKVSEFPLFTAVYRIV............. 360
5 -14.100[S] COG5495 Uncharacterized conserved protein  ali follow..  11  10.ARLNIAILSTGRVGV----ALERADQVVVCSAVSHASRQWVQF-------------RLPETSVASPPEVASSAELLLLAVPDCEFAGLMSGVAVTRPGTIVAHTSWANGVGILAQLGKDGCIPLAIH--MFSGSDEDLSQCQLRDTYFGITKTDDVGYAIAQSLVLEMGGEPFCVVEYARILYHSVSPHVG-NHIVTVLADALEVRRSALRGSELLGLGVPPACRGEVVDDQLDVIVERIVGLARAACENTLQRGQAGLTKARGDLDALAGHLVALMRIGPELAQAYRVNALRKTQRAHAPYDVV.. 304
6 -13.100[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  13  3....TIGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLADLVAKG--------------LKTVSGHAAVAKAADIIITMVPDTPQVADVNGVASGLTRGKLVIDMSSISPIETKVFAGKINELGCDYLDAPVSGGEVGAKAASLTIMVG---GEEKAFERAKPVFEKMGKNITLVGPNGVGQTTKVANQIVVA--LTIEAVAEALVFASKAGAD-PARVRQALMGGLAASRILEVHGERMVKRTFAPGFRIELHQKDL------------NLALEGAKALGVSLPNTSTTQQLFNSCAANGGARE.. 276
7 -12.700[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  12  3HTKPSIAILGAGRVGSSLARSAVAAGYEVKVAGSGAVDKIALTAEIL------------PGAVPSTADQAVKDADIVFLAVPLHKFRSVNPAT--LEGKIVIDTMNHWTSEIIAEFFAGSTMVKSFNHIGYH-----EIEQDAGTGRAIAYATDDVDAGAQVAQLIKSFGFVPLNIGALENG.............................................................................................................................. 182
8 -12.400[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  15  1MENQKIGFIGAGKMGSALMQGTIKAGENIGASDVYEPFLKDLQAK-------------LGIRVSTDNAVIVRESDILILAVKPQTLSSVLSNLKNEIEKLVISIAAGVPLSTYEDALLEGTRVVRVM--------PNIAATVSEAASGIAPGKNTPEDLKAALEIFSAVGTAVQVPESL-------------MDAVTGLSG-------SGPAFIFPVIEAMADGAVLEGMDRKSALTLAAAAKMALETGMHPGELKDMVTSPAGTTIQGI-----HSLEEAGIRAAFMNAVIRASERSKELGKK.... 270
9 -12.100[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  12  1...MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGED----------RTTGVASLRELSQRLSAPRVVWVMVPA-ITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERGY-CLMIGGDGDAFARAEPIFATVAPGVAAAPRTPGRDGE-FVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPLPNPECYQYDFDIPEVAEVWRRGSVIGSWLLDLTAIRESPDLAEFSGRVAIAAIDEGVPAPVLTTALQS.............. 309
10 -12.000[M] COG1004 Predicted UDP-glucose 6-dehydrogenase  ali follow..  12  1...MKVTVFGIGYVGLVQATVLAEVGHDVLCIDIDANKVADLKKGRIAIFEPGLAPLVKELQFSTDAQAGVAHGVIQFIAVGTKYVLDVASTIGTYMDSPKVIIDKSVGTADKVHQVIQAILEQRGEKIDFSVVSNPEFLKEGAARIVIGIDTDDSGALELISELYEPRNHDRMLVMDIRSAELTKYAANG-MNEIANIAERLGADIEKVRQGIGSDSRI-KDIQALIRTAEDKGYKPQLLQAVEQINNQQKYKLTEFIKSHFNSQLAGKTFAVWGLAFKPNTDDMREAPSRVVMESLWEAGATIQ.. 355
11 -11.100[M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase  ali follow..  11  14.RQALIGIVGLGYVGLPLMLRYNAIGFDVLGIDIDDVKVDKLNAGQCYIEHIPQAKIAKARAEATTDFSRVSECDALILCVPTSFVINTTDALKPYLRVQVVSLESGTTEEELLPRVQEGGLVVGRLVYSPEREDPGNPNFETIPKVIGGHTPQCLEVGIALYEQAIDRVVPV---SSTKAAEMTKLLENGLVNEMKIVMGIDIFEVVDAAATKPFGFTPYYPGPGLGGHCIPIDRFIELSGEVNQAMPEYVLGKLMDGLNEAGRALKGSRVLVLGIAYKKNVDDMRESPSVEIMELIEAKGGMVA.. 363
12 -10.500[E] KOG3124 Pyrroline-5-carboxylate reductase  ali follow..  12  1...MSVGFIGAGQLAYALARGFTAAG--------------ILSAHKIIASSPEMNLPTMGVNLTRSNKETVKHSDVLFLAVKPHIIPFILDEIGADVRHIVVSCAAGVTISSVEKKLMAFQPAPKVI-----RCMTNTPVVVQEGATVYATGTHLVEDGQLLEQLMSSVGFCTEVEEDL-------------IDAVTGLSG-------SGPAYAFMALDALADGGVKMGLPRRLAIQLGAAAKMLLDSEQHPCQLKDNVCSPGGATIHAL-----HFLESGGFRSLLINAVEASCIRTRELQSMAD.. 273
13 -10.400[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  10  35LKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRKRASFQRATENGFKVGTY---------------EELIPTADLVVNLTPDKQHSKVVADVMPMKKDSAFGYSHGF-NIVEVGEEIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIGSIVCYDKLVADGKDPAYAGKLIQYGWETITEALKQAKLRAFELAEQIKESLGFLYYKHMDDIISG-------HFSATMMADWANGDKDLFAWREATGKTAFENAPKYDGKISEQ............................ 352
14 -10.100[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  11  2..SADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANEAKGKSIIGATSIEDFISKLKRPRK-----VMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKGILFVGSGVSGGEEGARYGPS-LMPG---GSEEAWPHIKNIFQSISAKSDGEPCCEWV-YVKMVHNGIE--------------------YGDMQLICEAYDIMKRLGGFTDKEISDVFAKWNNGVLD--SFLVEITRDILKFDDVDGKPLVEK............................... 251
15 -9.980[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  12  1MSTMKVAVYGAGNQGSRMAIEFAEAGHDVVLAEPARDMLDDAHWKVVE---------DAGVTVTDNDAEAASEAEIAVLFTPGKKTFEIAKNITNHLPEGAVIANTCTVSPVVLYYVLERELIASMHPAAVPGTPQHGH-YVIGGHSSSELDIATDEQISRCVELAESCGKVAYVVPADVSSAVADMGSLVTAVTLSGVLDYYYASLVETSGVNGMLKAMNPELLVRSAKSMHLLEEQEELDAALNTLSDLDDEVNKWIEKGEHTDLVAAQALAKEIKNLMG-----GKAAEGTIRRCMRK....... 341
16 -9.950[G] COG0362 6-phosphogluconate dehydrogenase  ali follow..  11  3.VKGDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKGTNIIGAYSLEDLAAKLEKPRK-----VMLMVRAGDVVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAEKGIRFIGSGVSGGEEGARHGPS-IMPG---GNQEAWQYVKPIFQAISAKTEQGEPCCDWVFVKMVHNGIE--------------------YGDMQLICEAYQFLKEGLGLSYEEMQAIFAEWKNTELD--SYLIDITTDILGYKDASGEPLVEKKWTGINALDFGIPLTLITESVFARC...... 290
17 -9.500[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  10  362GSRLKIGIVGFGNFGQFLGKTMVKQGHTVLAYSRSDYTDEAAKLG---------------SYFSDLDDLFEEHPEVIILCTSILSTEKVLESLPQRLKRSTLFVDVLSVKEFPRNLFLQ-DILCTHPMFGPESGKNGWNNLA-FDKVRIGMDDRRKSRCNSFLDIFAREGCRMV---EMSCAEHDWHA--AGSQFITHTVGRLLEKLSLESTPIDT-------------------KGYETLLKLVENTAGDSFDLYYGLFLYNPNAMEQLERFHVAFESKTQLFGRLHSQHSHELAKSSSPKTT.... 635
18 -9.420[Q] COG4569 Acetaldehyde dehydrogenase (acetylating)  ali follow..  19  1MSKRKVAIIGSGNIGTDLMIKILRHGQHLEMAVMVGIDPQS---DGLARARRMGVATTHEGVIGLMNMPEFADIDIVFDATSAGAHVKNDAALREAKPDIRLI............................................................................................................................................................................................................. 100
19 -9.250[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  12  2...LKIGIVGCGFIGGQICRAIDGGEVSAELYDSSESKALELAAS-------------TCKPSYMKIEELIRGVDLIIESASQNAVRFIVPQA----------LKAGCD---------------------VMILSVGALA--------------DEELRDTLFGLAKEHNCKLYFPSGAVVGI--DGLNSASAAGISSVTLSTR-ELEKLEKKTVLFEGPASEAVKAFPANVNVAATISLAGIGFERTRVKVIADPSLFRNVHEIIVEGEFGKFTRVENLPSPENPKTSYLLSAVSTLKKILNPVQIG 270
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.