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Query: [C] COG1927 Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVVKVGVLKMGAIGTALLVEYLLDERADREDIEVRVVTSGAKMQPEEAVVAEKLKEFDPDVVIVVSPNAALPGPKAAREAFEGKPVIVISDAPAKKAKDELKEKGFGYILINADSMIGARREFLDPTEMALFNADVVKVLAATGAFRLVQEAIDKVIEDIKAGKQPELPQIVVTAEKAVEAGKFSNPYAKAKAMAAFYIAEKVADIDVKGCFIEKDPEKYIPLVASAHEMMRIAAILADQAREIEKSNDTVFRNPHAKDGKILGKTQLMAKPELast
1 -130.000[C] COG1927 Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase  ali  100  1MVVKVGVLKMGAIGTALLVEYLLDERADREDIEVRVVTSGAKMQPEEAVVAEKLKEFDPDVVIVVSPNAALPGPKAAREAFEGKPVIVISDAPAKKAKDELKEKGFGYILINADSMIGARREFLDPTEMALFNADVVKVLAATGAFRLVQEAIDKVIEDIKAGKQPELPQIVVTAEKAVEAGKFSNPYAKAKAMAAFYIAEKVADIDVKGCFIEKDPEKYIPLVASAHEMMRIAAILADQAREIEKSNDTVFRNPHAKDGKILGKTQLMAKPE 273
2 -8.360[T] COG0394 Protein-tyrosine-phosphatase  ali follow..  14  1..MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVF-GKATPHAVEALFEKHIAL--------NHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKVFTLKEYVTGSHGDVLDPFSIDIYKQ----------TRDELEELLRQLAKQLKKDRR............................................................................................................ 150
3 -7.460[S] COG4641 Uncharacterized protein conserved in bacteria  ali follow..  13  1..MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMI------ADKPEAESLMKIEAFQPDFTLMMVGDRVPHD-DISLQVIKLADAILTIEQNAALYYQELGYQNVYYVPIPVNHIIGYRVQLMKEATVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRPYHFAFNQN----TMRIKNASFNNRTFDIAACERFQLTDLPAAIISYHGMNDFKEKAAFYIEERQKAAAANYKETVPAFTFDELPAKLKAIHLA.. 315
4 -7.160[T] COG3707 Response regulator with putative antiterminator output domain  ali follow..  15  17..................ILVIDENAIRASIIEEGLREAGYQR-HEVNGVARTIETLQPDVIFIDLENPNRDMMEHLFQLTRTRPIAMFVDRSDTASIEAAVEAGVAYVV--------------DGLKKERVKPILDMAVSRFNAFSRLQRELADAKSALEERKVIERAKILMKMRGLSEEEAFARQTAMNEKKKISEIAQSV...................................................................... 196
5 -6.170[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  11  365..LKIGIVGFGNFGQFLGKTMVKQGHTVLAYSRSDYTDEAAKLGVSYFSDLDDLFEEHPEVIILCTSILSTEKVLESLPFQRLKRSTLFVDVLSVKEF--LQTLPQDFDILCTHPMFGPESGIGMDDRRKSRCNSFLDIFAREGMVEMSCAEHDWHAAGSQF-----ITHTV--GRLLEKLSLESTPIDTKGYETLLKLVENTAG---------DSFDLYYGLFLYNPNAMEQLERFHVAFESLKTQ.......................... 613
6 -6.160[KT] COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain  ali follow..  10  74....................LIVDDSPDNIAFMSQGLAQYYRI-RSGKVALEILAQYPIDLVLLDIVMPEMSGYEVINQITEHIPVIFLTGKSNPEDEQLGFELGAVDYVFKP----------VSIPLLKSRVHTHLQNKRSKDILLNQNDYLETEVLRRSGELDRMQDAVVFALASLAETRD-TGNHLLRTQHYVKVLAQRLATTDKYRDVLSPTVIDTYFKAAPLHDILLKPGKLTPDEFTTMRN--------HALLGKLALEK....... 318
7 -5.540[KT] COG3279 Response regulator of the LytR/AlgR family  ali follow..  13  6....................IVDDEQPAREDLGIEIVAECS----NALEAIPAIQRLQPDVVFLDIQMPRINGLELASML-ESMPHIVFVTAYDEYAIRAFEEHAFDYL--------------LKPLDHQRLAKTLTRLSRDLIVKNNLHKVIKPILRHIPCSGHNRIFLLKIEEVEYLSSEL-VQSGYTQLSLKTLEEKTPFIRCHRQYMVNTEQLGEIQLMDNGAAEVITRSGKHIPVSRRYLKS.......................... 230
8 -5.410[E] COG0287 Prephenate dehydrogenase  ali follow..  13  6MFERIALIGIGLIGSSIARDV------RELGLARHVVISTRSEDTLKRAEELALGT-DADLVIVSVPVGASESVAQQIAPYLKPSAIVTDVGSTKASVIAQMAPHMNVHFIPGHPLAGTEKSGPDAGFAGLFRERWCIFTPLPGTDAAALERLKDFWRALGSAIVSHLPHIIAYNGTADDLETVTESEVIKYSASGFRDFTRLAA---------SDPTMWRDVCLHNKDAI--LEMLARFSEDLASLQRAIRWGEGDKLFELFSRTRSIRR.. 287
9 -5.250[M] COG1663 Tetraacyldisaccharide-1-P 4`-kinase  ali follow..  15  58.VVVVGNIHAGGTGKTPIVAALV-SGLQEKGVKVGIISRGAESRAEDAGDEPLLLFRKTGAPTAVGSS-RAEAGRALLAAHPDIGLIVADD-------------GLQHYALRRDVEI-----VFPAADTGRTDLDLLP----NGNLREPLLRLDSVDAVVVSGGKADLDTGRLKNQTVVAVAGIAKPFFDSLRNMGITVKRTVALPDHAD-ISAADLPDADAVIITEKDAVKFSDGICTD................................. 314
10 -5.220[S] COG2237 Predicted membrane protein  ali follow..  14  9....................................................KLKTQKPDKIYFRKRTGSPGEKYLHKNDRGDMQTLVIC-----------RDNDLGEKAKMETPIVGREANVRAAVALGIADPEDSDTNTIFGGIRILD-------ELLEKGVDAEIVSFAGDKNVGVI----------SDQKIAEQLELYLQMNEVKRAVFVSD-ETLVPIVQSRMKIDSVKRIVVMQSENLESTYYILKH.................... 186
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.