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Query: [M] COG1970 Large-conductance mechanosensitive channel, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSIIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAVTLRDAQGDIPAVVMHYGVFIQNVFDFLIVAFAIFMAIKLINKLNRKKEEPAAAPAPTKEEVLLTEIRDLLKEQNNRSLast
1 -75.800[M] COG1970 Large-conductance mechanosensitive channel  ali  100  1MSIIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAVTLRDAQGDIPAVVMHYGVFIQNVFDFLIVAFAIFMAIKLINKLNRKKEEPAAAPAPTKEEVLLTEIRDLLKEQNNRS 136
2 -8.210[S] COG3477 Predicted periplasmic/secreted protein  ali follow..  14  102.............VGVTHIIFSIVFGLLAGALAQLFVHMISFPLMGLTPPLFDLP-------------------WYENVSEIFGHLVWFWSIEIIRRDLRNRITHEPDPEIP---------LGSNR.......... 204
3 -7.720[D] KOG2073 SAP family cell cycle dependent phosphatase-associated protein  ali follow..  14  1MLLFYMLICSLRERAQVEQLLRFIVEESFPFISSEVLTCEIDVILKTLVDEEELMNLLFSFLEPNRSHSVMLAGYQNVFQQLVDLIGITSIMEVLIRLVGADDHVYPNHLDVMQWLADSNLLEMIVDKLSPSNSLE 152
4 -7.430[S] KOG4619 Uncharacterized conserved protein  ali follow..  13  105FGVLDNM--MILAGEYIDQKLGAVLAAALGNLISDIAGVGLAHYVEVAVQRVGIKHPVLTSQQLDSGKARFTTNAARAAGLTVGCLLGMFPLLFFSDDEDDEKKKKKELKA......................... 220
5 -7.280[MU] COG0597 Lipoprotein signal peptidase  ali follow..  19  83..LVVMMYRSKATQKLNNIAYALIIGGALGNLFDRLWHGFVVDMIDFYVGDWHFATF-----------------------NLADTAICVGAALIVLEGFLPSKAKKQ............................. 164
6 -6.920[P] KOG3733 Mucolipidin and related proteins (TRML subfamily of transient receptor potential proteins)  ali follow..  11  477...APNIMRFMTCAIVLYAGFLIAGWVIIGPYSMKFLAESSEALFSLLNGDDMFATFYTINDSNTVIKVFGTVYIYLFV-SLFIYVVLSLFIAIIMDAYEVVKDRYSDGLR------AIEKRGCLRDFVESNPPPS 604
7 -6.830[S] COG4317 Uncharacterized protein conserved in bacteria  ali follow..  17  2......LKGMTMKMYLLSLGAGLLVGVIYSLL----VRSPAPPVIALV........................................................................................ 40
8 -6.580[H] COG4064 Tetrahydromethanopterin S-methyltransferase, subunit G  ali follow..  24  49.............GRDIGILYGIVIGLIILAVTNILFAGLLKGLLKSLFG...................................................................................... 85
9 -6.290[S] COG3216 Uncharacterized protein conserved in bacteria  ali follow..  13  27RSFSRSFQYVSKRATPTAVAAGVAAGVFASFFPLGSHFAIAAIVCWLISGNMVAAGLGTFVFGNPLTLPFVTWETGKIMGAVPLGLVFGLLFYGITRCGMTAFREKRRKRLAEKGSLLQQQEDIVLSPPLPTRHRR 206
10 -6.250[E] COG0531 Amino acid transporters  ali follow..  13  21....HHLNKTLGAFDLTMLGVGAVVGGGIFILPGQVASVIAGP-IACCLAALCYSEFASKLPVAGSAYTYSYHVFGEGVAWILGWSLI................................................ 113
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Igarashi Y, Eroshkin A, Gramatikova S, Gramatikoff K, Zhang Y, Smith JW,Osterman AL, Godzik A. CutDB: a proteolytic event database. Nucleic Acids Res. 2007 Jan;35(Database issue):D546-9. Epub 2006 Nov 16.