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Query: [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst METIGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLADLVAKGLKTVSGHAAVAKAADIIITMVPDTPQVADVLFGDNGVASGLTRGKLVIDMSSISPIETKVFAGKINELGCDYLDAPVSGGEVGAKAASLTIMVGGEEKAFERAKPVFEKMGKNITLVGPNGVGQTTKVANQIVVALTIEAVAEALVFASKAGADPARVRQALMGGLAASRILEVHGERMVKRTFAPGFRIELHQKDLNLALEGAKALGVSLPNTSTTQQLFNSCAANGGAREDHSALVRALERMANFEVGGAVAEVKGKAALast
1 -101.000[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali  100  1METIGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLADLVAKGLKTVSGHAAVAKAADIIITMVPDTPQVADVLFGDNGVASGLTRGKLVIDMSSISPIETKVFAGKINELGCDYLDAPVSGGEVGAKAASLTIMVGGEEKAFERAKPVFEKMGKNITLVGPNGVGQTTKVANQIVVALTIEAVAEALVFASKAGADPARVRQALMGGLAASRILEVHGERMVKRTFAPGFRIELHQKDLNLALEGAKALGVSLPNTSTTQQLFNSCAANGGAREDHSALVRALERMANFEVGGAVAEVKGKAA 305
2 -59.900[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  18  2SADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANEAKGATSIEDFISKLKRPRKVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKGILFVGSGVSGGEEGARYG-PSLMPGGSEEAWPHIKNIFQSISAKCEWVGPAGAGHYVKMVHNGIEYGDMQLICEAYDIMKRLGGFTSDVFAKWNNGVLDSFLVEITRDILKFDDVDGKPLVEKIMDTAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSALKNERIR....................... 297
3 -59.300[G] COG0362 6-phosphogluconate dehydrogenase  ali follow..  18  5.GDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKGAYSLEDLAAKLEKPRKVMLMVRAGDVVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAEKGIRFIGSGVSGGEEGARHG-PSIMPGGNQEAWQYVKPIFQAISAKCDWVGGEGAGHFVKMVHNGIEYGDMQLICEAYQFLKEGLGLSQAIFAEWKNTELDSYLIDITTDILGYKDASGEPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKDQRV........................ 299
4 -56.700[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  21  2..QLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEGVASLRELSQRLSAPRVVWVMVPAGNITTAVI---EELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERG-YCLMIGGDGDAFARAEPIFATVAPGYLHCGPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPLPNPECYQYDFDIPRGSVIGSWLLDLTAIALRETAIAAIDEGVPAPVLTTALQSFASRDLDDFANKALSAMRKQF.................... 331
5 -25.000[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  14  5..KVAVYGAGNQGSRMAIEFAEAGHDVVLAEPARDMLDDVEDAGVTVTDNDAEAASEAEIAVLFTPFGKKTFEIA---KNITNHLPEGAVIANTCTVSPVVLYYVLERELRRKDLGIASMHPAAVPGTPQHGHYVIGGHTDEQISRCVELAESCGKVAYVVPADVSSAVADMG-SLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQILMTLQASLVETSGVNGMLKAMNPELLVRSAQEELDAALNTLSDLDDEVNKWIEKGEIRHTDLVA------AQALAKEIKNLMG............... 327
6 -20.800[M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase  ali follow..  16  16.ALIGIVGLGYVGLPLMLRYNAIGFDVLGIDIDDVKVDKLNAASGFEATTDFSRVSECDALILCVPTPPDMSFVINTTDALKPYLRVGQVVSLESTTYPGTTEEELLPRVQEDIYLVYSP-PGNPNFETRTIPKVIGGHTPQCLEVGIALYEQAIDRVVPVSSTKAAEMTKLLENIHRAVNIGLVNEMKIVADRMGIDIFEVVDAAATKPFGFTPYY-----------GPGLGGHCIPIDPFYLTWKAREYGLHTRFIELSGEVNQAMPEY------LGKLMDGLNEVLGIAYKKNVDDMRESPS 348
7 -18.900[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  21  7..SIAILGAGRVGSSLARSAVAAGYEVKVAGSGAVDKIALTAEPGAVPSTADQAVKDADIVFLAVPLHKFRS--------VNPATLEGKIVIDTMSTSEIIAEFFAGSTMVKSFNHIGYHEI--EQDAGTGRAIAYATDDVDAGAQVAQLIKSFGFVPLNIGALENGRILE...................................................................................................................................... 186
8 -18.400[M] COG1004 Predicted UDP-glucose 6-dehydrogenase  ali follow..  17  2..KVTVFGIGYVGLVQATVLAEVGHDVLCIDIDANKVADLKKGRIQFSTDAQAGVAHGVIQFIAVGTPADLKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKVHQVIQAILEQRIDFSVVSNPEFLKEGAAV-IVIGIDTDDSGALELISELYEPFMLVMDIRSAELTKYAANGMLATKISFMNEIANIAERLGADIEKVRQGIGSDSRIGYHFIYSG---------CGYGGSCFPKDIQALIRTAEDKGYKPQLLQAVEQI---------NNQQKYKLTEFIKSHFNSQLAGKT........ 320
9 -16.300[E] COG0287 Prephenate dehydrogenase  ali follow..  19  7FERIALIGIGLIGSSIARDVRELGLHVVISTRSEDTLKRAEELALDYTVSAAEAVKDADLVIVSVPVGASESVA----QQIAPYLKPSAIVTDVGSTKASVIAQMAPHMPENVHFIPGHPLAGTEKSGPDAGFTPLPGTDAAALERLKDFWRALGSRVDEMDAEHHDKVLAIVSHL----HIIAYNIVGTADDLETVTESEVIKYSASGFRDFTRLAASDPTM.................................................................................. 237
10 -15.000[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  16  364RLKIGIVGFGNFGQFLGKTMVKQGHTVLAYSRSDYTDEAAKLGVSYFSDLDDLFEEHPEVIILCTS--LSTEKVL--ESLPFQRLKRSTLFVDVLSVKEFPRNLFLQTLPQ-DFDILCTPMFGPESGKNGWNNLAFVDRRKSRCNSFLDIFAREGCRMVEMSCAEHDWHAAGSQFITVGRLLEKLS....................................................................................................................... 557
11 -14.400[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  11  49MGAELKELAGVDEVVVADPVFDNQFTVID-PEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDMQPGII---DKFIDDIKPGAIVTHACTIPTTKFYKIFEEKHGETLNVTSYPGAVPEMKGQV--YIAEGYASEEAINTLFELGQKARGNAYRLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLG............................................................................................................. 281
12 -13.900[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  13  38.KKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEAIAEK-ATENGFKVGTYEELIPTADLVVNLTPDKQHSKVV----ADVMPLMKKDSAFGYSHGFNRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIA-VHPENDPKGEGMAIAKAWAAATGGHKAGVLESSFVAEVKSEQTILCGMLQAGSIVCYDKLVADGKDPAYAGKLIQYG................................................................................................ 257
13 -13.300[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  17  3.QHIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLISPNLSFTTDMKEAIHNAFMIVEGVT-SAGIRPVA---EQLKQITDLSVPFVITSKIEQNTGLLLSEIMLEPYLGYLSGPSIAKEVLNGSPCSVVVSAYDSQTLKQIHEAFDIKGKNVIAIA-CGIAEGLSFGNNAKAGLVTRGLHEMRKLAAIMDCKPETLNGLAGLGDLCVTCFSESSRLRFGHLLAQGLTFEQAKAKIGMVVEVAKHHKIDMPITTGIYRVL........................................ 311
14 -13.100[H] COG1893 Ketopantoate reductase  ali follow..  13  5..RVAVIGSGSIGLLLYAYLKLANWPALLVTNRPEQADHLNKEGVTATPLSSFSAEEAEVGFITVKSFAVKALL----PQLQRKKWDGLVFFQNGMTHLEILRQIPARAICCGIVEIGAKRESDVRVQHTGDGAIWIGGDSKNFDPMWACLHNAGLKAQKVTNWQDKMERKLIANAAINTGLFRVKNGALIENQLFSLLKELVKEACVTLGREREVDEHLAYTRAICDKTANNLSSMYMDLGYLIKEAAKKGIEIPNTSFVYHAVMGMDEEGRKVR............................. 306
15 -12.800[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  23  4.QKIGFIGAGKMGSALMQGTIKAGINIGASDVYEPFLKDLQAKGIRVSTDNAVIVRESDILILAV-KPQTLSSVL---SNLKNEITSEKLVI--SIAAGVPLSTYEDALLEGTRVVRVMPNIAATVSEAASGIAPGKNATPEDLKAALEIFSAVGTAVAVTGLSGSGPA------------IFPVIEAMA-AVLEGMDRKSALTLAAQTVLGAAKM......................................................................................... 215
16 -12.500[S] COG5495 Uncharacterized conserved protein  ali follow..  14  13..NIAILSTGRVGVALE----RADQVVVCSAVSHASRQWVQFRPETSVASPPEVASSAELLLLAVPD-CEFAGLMSG----TSVPRPGTIVAHTS----ANGVGILAQLGKDGCIPLAIPAMMFSGSDEDDTYFGITKTDDVGYAIAQSLVLEMGGEPFCVVEYAR-SVSPHVGNHIVTV----LADALEVRRSALRGSELLGLGVPP------ACRGEVVDDQLDVIVERIVGSLARAACENTLQRGQAGLTKLVARGDLDALAGHLVALMRIGPELAQAYRVNALRK-TQRAHAPYDVVEALA 308
17 -11.800[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali follow..  17  22INNVTIIGAGLMGSGIAQVSANAKLNVTVVDSNQSALEKAQQG-IKMSTNVSDSVKDADLVIEAIVENIDIKRKLFAE---VEVAAKPTTLITTNTSSADIGLNLKDKSRFGGLHFFN-PVP---------KLLEVVRHSDATFNQLVDYGKTVGKTTVACKDTPG-----IVNRLLVPY----MFEALRLYERGDASMEDIDVAMKLGAG.............................................................................................. 248
18 -11.700[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  21  2IKTVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAGLATSLIKGSGDINDLAQADLVIEAVTEDETVKRKIYGQ---VCPVMRPDAILATNTSSLSITRLASATDRPEGIHFMN-PVP---------KLVELVRGEEETFKAAKEFVAHLDKTVTVAEDFPA-----IVNRILLPM----INEAIYTLYEGVGTVDAIDTAMKLGAN.............................................................................................. 222
19 -11.700[S] COG4408 Uncharacterized protein conserved in bacteria  ali follow..  9  1MSKLLMIGTGPVAIQLANICYLKSDYIDMVGRASTSEKSKRLYQARLYKDVKNVKGEYETVVMACTADAYYDTL----QQLSLETLQSVKHVILISPTFGSQMIVEQFMSKFSIVDKEAPNHVLTTGVKKKLYMGSTHSNSTMCQRISALAEQLKIQLEVVESP-EGPITMTLIREMRLMW----KEMMAILQAFRVPSVNLLQFMVENGHYFDFSAVPFKQVYKNEQDVVQIPRMPSEDTAMIQHIGKMLGIKTPMIDQFLTRYEASCQA.................................. 396
20 -11.500[E] KOG3124 Pyrroline-5-carboxylate reductase  ali follow..  14  2..SVGFIGAGQLAYALARGFTAAGIKIIASSPEMNLPTVSALRGVNLTRSNKETVKHSDVLFLAV-KPHIIPFIL---DEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRCTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTAVTGLSGSGPA------------AFMALDALA-GVKMGLPRRLAIQLGAQALLGAAKM......................................................................................... 216
21 -10.800[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  17  1MLKIGIVGCGFIGGQICRAIDGVSAELYLCDSSESKALELAASCKPSYMKIEELIRGVDLIIESASQNAVRF--------VPQALKAGCDVM-GALADEELRDTLFGLAKEHNCKLFPSGAVVGIDGLNSASA............................................................................................................................................................................ 136
22 -9.990[K] KOG0067 Transcription factor CtBP  ali follow..  15  181.ETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQD-GIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLI--NDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIR-LDVPFSFAQGPLKDAPNLICT--AWYSEQASLEMREAAATEIRRA----TGRIPESLRNCVNKEFFVTSAPWSVIDQQAIHPELNGATYRYPP................................................................................................ 389
23 -9.400[MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases  ali follow..  12  36.PLVTVFGSGFVGRHVVRMLAKRGYRIRVAVRRPDLAGFLQPLGN---------VGQISFAQANLRYRDSIIKAVEDADHVVNGILAESGRNTFDAVQEFGAKAIAEAARDTGATLTHISAIGADANSQTGYGRTKGRAEAAIHSVLPGAVILRPSIIFGPEDDFFNKFAKMARNLFQPVYVEDVAEAVARSVDGKLKPGAIYEL.................................................................................................... 245
24 -9.330[Q] COG5310 Homospermidine synthase  ali follow..  13  18.GPVVMIGFGSIGRGTLPLIERHF-RMTVLDPRDTDRKLLDERGIAFVQEAVTENNYKKLL-----------------TPLLTNGGGQGFCVNLSV--DTGSVDLMRLCRKLGVLYIDTVVEPWLGFYFDAKADNASRTNYALREAMIKEKHDKPGGATVVSTCGANP----MVSWFVKQALVNLATDLGL.................................................................................................................. 189
25 -9.060[CHR] COG1052 Lactate dehydrogenase and related dehydrogenases  ali follow..  14  147.SRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPNDAAKE----WLTYVSMDELLSTSDVISLHMPATKDSHHLI--NAKTIAQMKDGVYLVNTARGAVIDSQALLDSLDKGKIAGAALDA........................................................................................................................................................................................ 260
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhang B, Jaroszewski L, Rychlewski L, Godzik A. Similarities and differences between nonhomologous proteins with similar folds: evaluation of threading strategies. Fold Des. 1997;2(5):307-17.